CA3227109A1 - Methods of treating decreased bone mineral density with cluster of differentiation 109 (cd109) inhibitors - Google Patents

Methods of treating decreased bone mineral density with cluster of differentiation 109 (cd109) inhibitors Download PDF

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Publication number
CA3227109A1
CA3227109A1 CA3227109A CA3227109A CA3227109A1 CA 3227109 A1 CA3227109 A1 CA 3227109A1 CA 3227109 A CA3227109 A CA 3227109A CA 3227109 A CA3227109 A CA 3227109A CA 3227109 A1 CA3227109 A1 CA 3227109A1
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Canada
Prior art keywords
nucleic acid
subject
acid molecule
mineral density
bone mineral
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Pending
Application number
CA3227109A
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English (en)
French (fr)
Inventor
Jonas BOVIJN
Olukayode SOSINA
Sirui ZHOU
Luca Andrea LOTTA
Aris BARAS
John Brent Richards
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Royal Institution for the Advancement of Learning
Regeneron Pharmaceuticals Inc
Original Assignee
Royal Institution for the Advancement of Learning
Regeneron Pharmaceuticals Inc
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Application filed by Royal Institution for the Advancement of Learning, Regeneron Pharmaceuticals Inc filed Critical Royal Institution for the Advancement of Learning
Publication of CA3227109A1 publication Critical patent/CA3227109A1/en
Pending legal-status Critical Current

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    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • AHUMAN NECESSITIES
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    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
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    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
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    • A61K31/662Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
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    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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    • C07K16/2875Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/20Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/531Stem-loop; Hairpin
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA3227109A 2021-08-07 2022-07-29 Methods of treating decreased bone mineral density with cluster of differentiation 109 (cd109) inhibitors Pending CA3227109A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163230707P 2021-08-07 2021-08-07
US63/230,707 2021-08-07
PCT/US2022/074307 WO2023019067A1 (en) 2021-08-07 2022-07-29 Methods of treating decreased bone mineral density with cluster of differentiation 109 (cd109) inhibitors

Publications (1)

Publication Number Publication Date
CA3227109A1 true CA3227109A1 (en) 2023-02-16

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ID=83004518

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CA3227109A Pending CA3227109A1 (en) 2021-08-07 2022-07-29 Methods of treating decreased bone mineral density with cluster of differentiation 109 (cd109) inhibitors

Country Status (9)

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US (3) US11891607B2 (https=)
EP (1) EP4381066A1 (https=)
JP (1) JP2024528284A (https=)
KR (1) KR20240046531A (https=)
CN (1) CN118541481A (https=)
AU (1) AU2022325199A1 (https=)
CA (1) CA3227109A1 (https=)
IL (1) IL310276A (https=)
WO (1) WO2023019067A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024210666A1 (ko) 2023-04-07 2024-10-10 주식회사 케이티 전이중통신에서 하향링크 데이터 채널을 송수신하는 방법 및 장치

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JP2024528284A (ja) 2024-07-26
US11891607B2 (en) 2024-02-06
US20240200079A1 (en) 2024-06-20
KR20240046531A (ko) 2024-04-09
WO2023019067A1 (en) 2023-02-16
US20250236873A1 (en) 2025-07-24
CN118541481A (zh) 2024-08-23
EP4381066A1 (en) 2024-06-12
AU2022325199A1 (en) 2024-02-08
US20230055912A1 (en) 2023-02-23
US12234460B2 (en) 2025-02-25
IL310276A (en) 2024-03-01

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