CA3224859A1 - Traitement de l'hyperinsulinisme congenital avec de l'avexitide - Google Patents
Traitement de l'hyperinsulinisme congenital avec de l'avexitide Download PDFInfo
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- CA3224859A1 CA3224859A1 CA3224859A CA3224859A CA3224859A1 CA 3224859 A1 CA3224859 A1 CA 3224859A1 CA 3224859 A CA3224859 A CA 3224859A CA 3224859 A CA3224859 A CA 3224859A CA 3224859 A1 CA3224859 A1 CA 3224859A1
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- avexitide
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
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- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne des procédés de traitement de l'hyperinsulinisme congénital (HI). En particulier, la présente invention concerne le traitement de l'HI par l'administration d'avexitide à un sujet atteint d'HI. Les procédés selon l'invention peuvent impliquer l'administration sous-cutanée d'avexitide à un sujet atteint d'HI. Dans certains cas, une réduction du taux de perfusion de glucose (GIR) nécessaire pour maintenir l'euglycémie chez le sujet est obtenue par l'administration d'avexitide au sujet. Dans certains cas, l'administration d'avexitide réduit le taux d'événements d'hypoglycémie chez un sujet souffrant d'HI.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163213051P | 2021-06-21 | 2021-06-21 | |
| US63/213,051 | 2021-06-21 | ||
| PCT/US2022/034415 WO2022271753A1 (fr) | 2021-06-21 | 2022-06-21 | Traitement de l'hyperinsulinisme congénital avec de l'avexitide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3224859A1 true CA3224859A1 (fr) | 2022-12-29 |
Family
ID=82655134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3224859A Pending CA3224859A1 (fr) | 2021-06-21 | 2022-06-21 | Traitement de l'hyperinsulinisme congenital avec de l'avexitide |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20240307501A1 (fr) |
| EP (1) | EP4358996A1 (fr) |
| CA (1) | CA3224859A1 (fr) |
| WO (1) | WO2022271753A1 (fr) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013120022A2 (fr) * | 2012-02-08 | 2013-08-15 | Seneb Biosciences, Inc. | Traitement de l'hypoglycémie |
| WO2017152014A1 (fr) * | 2016-03-04 | 2017-09-08 | Eiger Biopharmaceuticals, Inc. | Traitement de l'hypoglycémie hyperinsulinémique avec des dérivés de l'exendine-4 |
| JP2019535734A (ja) | 2016-11-21 | 2019-12-12 | アイガー・バイオファーマシューティカルズ・インコーポレイテッドＥｉｇｅｒ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | エキセンディン（９−３９）の緩衝製剤 |
| IL314504A (en) | 2018-10-15 | 2024-09-01 | Eiger Biopharmaceuticals Inc | Abexitide for the treatment of hyperinsulinemic hypoglycemia |
-
2022
- 2022-06-21 US US18/572,074 patent/US20240307501A1/en active Pending
- 2022-06-21 EP EP22744570.7A patent/EP4358996A1/fr active Pending
- 2022-06-21 CA CA3224859A patent/CA3224859A1/fr active Pending
- 2022-06-21 WO PCT/US2022/034415 patent/WO2022271753A1/fr active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| EP4358996A1 (fr) | 2024-05-01 |
| WO2022271753A1 (fr) | 2022-12-29 |
| US20240307501A1 (en) | 2024-09-19 |
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