CA3220934A1 - Biomarqueurs et methodes de classification de sujets suite a une exposition virale - Google Patents

Biomarqueurs et methodes de classification de sujets suite a une exposition virale Download PDF

Info

Publication number
CA3220934A1
CA3220934A1 CA3220934A CA3220934A CA3220934A1 CA 3220934 A1 CA3220934 A1 CA 3220934A1 CA 3220934 A CA3220934 A CA 3220934A CA 3220934 A CA3220934 A CA 3220934A CA 3220934 A1 CA3220934 A1 CA 3220934A1
Authority
CA
Canada
Prior art keywords
disease
biomarker
gene
panel
genes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3220934A
Other languages
English (en)
Inventor
Alexander James MANN
Gareth GUENIGAULT
Aruna BASAL
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Poolbeg Pharma UK Ltd
Original Assignee
Poolbeg Pharma UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Poolbeg Pharma UK Ltd filed Critical Poolbeg Pharma UK Ltd
Publication of CA3220934A1 publication Critical patent/CA3220934A1/fr
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983Viruses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/118Prognosis of disease development
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne des méthodes permettant de prédire si un sujet est susceptible de développer des symptômes aigus de maladie après une exposition, ou une éventuelle exposition, à un virus respiratoire, qui comprennent l'analyse d'un échantillon biologique obtenu à partir du sujet à la recherche d'un biomarqueur et la comparaison du biomarqueur à une référence pour le biomarqueur, le biomarqueur comprenant ou étant dérivé de niveaux d'expression d'un ou plusieurs gènes choisis parmi un panel de gènes comprenant PHF20, ABCA1, APBA2, MORC2, SNU13, DCUN1D2, MAX, NOL9, MPRIP, HP, BST1, TM9SF2, HOMER3, NSUN6, EPHA4 et BMP2K. L'invention concerne également des procédés prédictifs associés, des procédés de réalisation d'une étude clinique ou d'un essai sur le terrain, des programmes informatiques, des algorithmes de classification, des supports lisibles par ordinateur et des procédés mis en ?uvre par ordinateur.
CA3220934A 2021-06-02 2022-06-01 Biomarqueurs et methodes de classification de sujets suite a une exposition virale Pending CA3220934A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB2107883.7 2021-06-02
GBGB2107883.7A GB202107883D0 (en) 2021-06-02 2021-06-02 Biomarkers and method for classifying subjects following viral exposure
PCT/GB2022/051405 WO2022254221A1 (fr) 2021-06-02 2022-06-01 Biomarqueurs et méthodes de classification de sujets suite à une exposition virale

Publications (1)

Publication Number Publication Date
CA3220934A1 true CA3220934A1 (fr) 2022-12-08

Family

ID=76741435

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3220934A Pending CA3220934A1 (fr) 2021-06-02 2022-06-01 Biomarqueurs et methodes de classification de sujets suite a une exposition virale

Country Status (5)

Country Link
EP (1) EP4347891A1 (fr)
CN (1) CN117480262A (fr)
CA (1) CA3220934A1 (fr)
GB (1) GB202107883D0 (fr)
WO (1) WO2022254221A1 (fr)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
CA2439402A1 (fr) 2001-03-02 2002-09-12 University Of Pittsburgh Of The Commonwealth System Of Higher Education Procede de reaction en chaine de la polymerase
US20130165470A1 (en) * 2011-12-21 2013-06-27 The Procter & Gamble Company Methods for Detecting and Treating Rhinovirus Infection
WO2017004390A1 (fr) * 2015-07-01 2017-01-05 Duke University Procédés pour diagnostiquer et traiter des infections respiratoires aiguës
US11884978B2 (en) * 2015-09-30 2024-01-30 Immunexpress Pty Ltd Pathogen biomarkers and uses therefor
US20190194728A1 (en) * 2016-08-24 2019-06-27 Immunexpress Pty Ltd Systemic inflammatory and pathogen biomarkers and uses therefor

Also Published As

Publication number Publication date
GB202107883D0 (en) 2021-07-14
WO2022254221A1 (fr) 2022-12-08
EP4347891A1 (fr) 2024-04-10
CN117480262A (zh) 2024-01-30

Similar Documents

Publication Publication Date Title
Wagenhäuser et al. Clinical performance evaluation of SARS-CoV-2 rapid antigen testing in point of care usage in comparison to RT-qPCR
Sampson et al. A four-biomarker blood signature discriminates systemic inflammation due to viral infection versus other etiologies
US8821876B2 (en) Methods of identifying infectious disease and assays for identifying infectious disease
EP3316875B1 (fr) Procédés pour diagnostiquer des infections respiratoires aiguës
Davenport et al. Transcriptomic profiling facilitates classification of response to influenza challenge
Sintchenko et al. Treat or test first? Decision analysis of empirical antiviral treatment of influenza virus infection versus treatment based on rapid test results
Felt et al. Detection of respiratory syncytial virus defective genomes in nasal secretions is associated with distinct clinical outcomes
Shojaei et al. IFI27 transcription is an early predictor for COVID-19 outcomes, a multi-cohort observational study
Kaforou et al. Transcriptomics for child and adolescent tuberculosis
EP3374523B1 (fr) Biomarqueurs pour la détermination prospective du risque de développement de tuberculose active
US20220298574A1 (en) Blood biomarkers for appendicitis and diagnostics methods using biomarkers
Zimmerman et al. Molecular diagnosis of SARS-CoV-2: assessing and interpreting nucleic acid and antigen tests
Redei et al. Blood transcriptomic markers for major depression: from animal models to clinical settings
Baker et al. Relationships between UBE3A and SNORD116 expression and features of autism in chromosome 15 imprinting disorders
WO2018154075A1 (fr) Procédés de classification de sujets exposés à une infection virale
Li et al. Rapid and accurate detection of SARS coronavirus 2 by nanopore amplicon sequencing
US20190076484A1 (en) Biomarkers For Early Determination Of Severity Of Influenza Related Disease
CA3220934A1 (fr) Biomarqueurs et methodes de classification de sujets suite a une exposition virale
Sahoo et al. An AI-guided signature reveals the nature of the shared proximal pathways of host immune response in MIS-C and Kawasaki disease
Xu et al. Tuberculosis-related miRNAs have potential as disease biomarkers
Lim et al. Longitudinal home self-collection of capillary blood using homeRNA correlates interferon and innate viral defense pathways with SARS-CoV-2 viral clearance
WO2023062377A1 (fr) Procédés permettant d'évaluer si un sujet risque de développer des symptômes graves d'une maladie et/ou de devenir contagieux après une exposition, ou une exposition possible, à un virus respiratoire
Lim et al. homeRNA self-blood collection enables high-frequency temporal profiling of pre-symptomatic host immune kinetics to respiratory viral infection: a prospective cohort study
Long et al. Impact of variants and vaccination on nasal immunity across three waves of SARS-CoV-2
WO2023014598A2 (fr) Diagnostic et traitement à base d'amplification isotherme d'une infection aiguë