CA3215633A1 - Chimeric antigen receptor-modified granulocyte-macrophage progenitors for cancer immunotherapy - Google Patents

Chimeric antigen receptor-modified granulocyte-macrophage progenitors for cancer immunotherapy Download PDF

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Publication number
CA3215633A1
CA3215633A1 CA3215633A CA3215633A CA3215633A1 CA 3215633 A1 CA3215633 A1 CA 3215633A1 CA 3215633 A CA3215633 A CA 3215633A CA 3215633 A CA3215633 A CA 3215633A CA 3215633 A1 CA3215633 A1 CA 3215633A1
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Prior art keywords
cancer
gmps
car
cells
cell
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CA3215633A
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English (en)
French (fr)
Inventor
Qi-Long Ying
Shi Yue
Xueyuan JING
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University of Southern California
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University of Southern California
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0642—Granulocytes, e.g. basopils, eosinophils, neutrophils, mast cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/17—Monocytes; Macrophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24—Antigen-presenting cells [APC]
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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CA3215633A 2021-05-19 2022-05-19 Chimeric antigen receptor-modified granulocyte-macrophage progenitors for cancer immunotherapy Pending CA3215633A1 (en)

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US202163190387P 2021-05-19 2021-05-19
US63/190,387 2021-05-19
PCT/US2022/030109 WO2022246112A1 (en) 2021-05-19 2022-05-19 Chimeric antigen receptor-modified granulocyte-macrophage progenitors for cancer immunotherapy

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CA3215633A1 true CA3215633A1 (en) 2022-11-24

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US (1) US20240240147A1 (cg-RX-API-DMAC7.html)
EP (1) EP4340871A4 (cg-RX-API-DMAC7.html)
JP (1) JP2024521025A (cg-RX-API-DMAC7.html)
KR (1) KR20240009461A (cg-RX-API-DMAC7.html)
CN (1) CN117295515A (cg-RX-API-DMAC7.html)
AU (1) AU2022275952A1 (cg-RX-API-DMAC7.html)
CA (1) CA3215633A1 (cg-RX-API-DMAC7.html)
WO (1) WO2022246112A1 (cg-RX-API-DMAC7.html)

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WO2024123682A1 (en) * 2022-12-05 2024-06-13 Shoreline Biosciences, Inc. Methods and compositions for generating modified pluripotent cells and derivates thereof
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