CA3203372A1 - Systeme de traitement chimique, instrument et cartouche d'echantillon - Google Patents
Systeme de traitement chimique, instrument et cartouche d'echantillonInfo
- Publication number
- CA3203372A1 CA3203372A1 CA3203372A CA3203372A CA3203372A1 CA 3203372 A1 CA3203372 A1 CA 3203372A1 CA 3203372 A CA3203372 A CA 3203372A CA 3203372 A CA3203372 A CA 3203372A CA 3203372 A1 CA3203372 A1 CA 3203372A1
- Authority
- CA
- Canada
- Prior art keywords
- vessel
- channel
- sample
- fluid
- pneumatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 238000003908 quality control method Methods 0.000 claims description 259
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- 239000011324 bead Substances 0.000 claims description 97
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- 108020004707 nucleic acids Proteins 0.000 claims description 40
- 102000039446 nucleic acids Human genes 0.000 claims description 40
- 150000007523 nucleic acids Chemical class 0.000 claims description 40
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- 108091093094 Glycol nucleic acid Proteins 0.000 claims description 2
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- 230000033001 locomotion Effects 0.000 description 90
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- 239000003570 air Substances 0.000 description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 16
- 238000003466 welding Methods 0.000 description 16
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 15
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- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 10
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- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 4
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
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- 229920002594 Polyethylene Glycol 8000 Polymers 0.000 description 2
- 239000007983 Tris buffer Substances 0.000 description 2
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- 239000006166 lysate Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000002861 polymer material Substances 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 2
- 101000617550 Dictyostelium discoideum Presenilin-A Proteins 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 229920002449 FKM Polymers 0.000 description 1
- 108091006629 SLC13A2 Proteins 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 238000011166 aliquoting Methods 0.000 description 1
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- 239000012620 biological material Substances 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
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- 230000008859 change Effects 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
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- 229920001971 elastomer Polymers 0.000 description 1
- 239000013536 elastomeric material Substances 0.000 description 1
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- 230000005484 gravity Effects 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 229920001600 hydrophobic polymer Polymers 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000013610 patient sample Substances 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 229920013730 reactive polymer Polymers 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
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- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/04—Exchange or ejection of cartridges, containers or reservoirs
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0605—Metering of fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/16—Reagents, handling or storing thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/041—Connecting closures to device or container
- B01L2300/043—Hinged closures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
- B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0605—Valves, specific forms thereof check valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Sampling And Sample Adjustment (AREA)
- Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
La présente invention concerne une cartouche d'échantillon pour un instrument de traitement chimique. La cartouche d'échantillon comprend un réacteur primaire conçu pour recevoir un échantillon de fluide pour un traitement et conçu pour recevoir un couvercle pour fermer une partie supérieure ouverte du réacteur primaire, et un réacteur conçu pour recevoir un ou plusieurs réactifs fluides par l'intermédiaire d'une partie supérieure ouverte du réacteur. Le réacteur est relié au réacteur primaire par l'intermédiaire d'un canal de réactif primaire avec une valve de réactif primaire disposée dans le canal de réactif primaire pour réguler l'écoulement de fluide à travers le canal de réactif primaire. La cartouche d'échantillon comprend en outre un orifice pneumatique primaire en communication fluidique avec le réacteur primaire et conçu pour être relié à un module pneumatique pour ajuster sélectivement une pression à l'intérieur du réacteur primaire lorsque le couvercle est fermé pour aspirer le contenu de fluide du réacteur dans le réacteur primaire.
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063130450P | 2020-12-24 | 2020-12-24 | |
| US63/130,450 | 2020-12-24 | ||
| US202163241167P | 2021-09-07 | 2021-09-07 | |
| US63/241,167 | 2021-09-07 | ||
| US202163292314P | 2021-12-21 | 2021-12-21 | |
| US63/292,314 | 2021-12-21 | ||
| US29/820,394 | 2021-12-21 | ||
| US202129820394 | 2021-12-21 | ||
| PCT/US2021/065045 WO2022140652A1 (fr) | 2020-12-24 | 2021-12-23 | Système de traitement chimique, instrument et cartouche d'échantillon |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3203372A1 true CA3203372A1 (fr) | 2022-06-30 |
Family
ID=82160118
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3203372A Pending CA3203372A1 (fr) | 2020-12-24 | 2021-12-23 | Systeme de traitement chimique, instrument et cartouche d'echantillon |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JP2024501003A (fr) |
| KR (1) | KR20230149808A (fr) |
| AU (1) | AU2021410016A1 (fr) |
| CA (1) | CA3203372A1 (fr) |
| WO (1) | WO2022140652A1 (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116964457A (zh) * | 2020-12-24 | 2023-10-27 | 英维沃斯珂瑞股份有限公司 | 化学处理系统和仪器 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2374423C (fr) * | 1999-05-28 | 2013-04-09 | Cepheid | Appareil et methode d'analyse d'un echantillon de liquide |
| RU2542235C2 (ru) * | 2009-10-21 | 2015-02-20 | Биокартис Нв | Микроструйный картридж с параллельной пневматической интерфейсной платой |
| WO2011094577A2 (fr) * | 2010-01-29 | 2011-08-04 | Micronics, Inc. | Cartouche microfluidique « de l'échantillon au résultat » |
| WO2013166857A1 (fr) * | 2012-05-07 | 2013-11-14 | Capitalbio Corporation | Dispositifs microfluidiques pour détection biochimique multi-indices |
| EP3307670B1 (fr) * | 2015-06-12 | 2020-12-09 | Cytochip Inc. | Unités fluidiques et cartouches pour une analyse de multiples analytes |
-
2021
- 2021-12-23 WO PCT/US2021/065045 patent/WO2022140652A1/fr active Application Filing
- 2021-12-23 CA CA3203372A patent/CA3203372A1/fr active Pending
- 2021-12-23 KR KR1020237025341A patent/KR20230149808A/ko unknown
- 2021-12-23 AU AU2021410016A patent/AU2021410016A1/en active Pending
- 2021-12-23 JP JP2023539182A patent/JP2024501003A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20230149808A (ko) | 2023-10-27 |
| WO2022140652A1 (fr) | 2022-06-30 |
| JP2024501003A (ja) | 2024-01-10 |
| AU2021410016A1 (en) | 2023-07-20 |
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