CA3202137A1 - Compositions pour une meilleure administration d'inhibiteurs de cgrp - Google Patents
Compositions pour une meilleure administration d'inhibiteurs de cgrpInfo
- Publication number
- CA3202137A1 CA3202137A1 CA3202137A CA3202137A CA3202137A1 CA 3202137 A1 CA3202137 A1 CA 3202137A1 CA 3202137 A CA3202137 A CA 3202137A CA 3202137 A CA3202137 A CA 3202137A CA 3202137 A1 CA3202137 A1 CA 3202137A1
- Authority
- CA
- Canada
- Prior art keywords
- pharmaceutical composition
- composition according
- cgrp
- weight
- pain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 238000009827 uniform distribution Methods 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 229960001722 verapamil Drugs 0.000 description 1
- KGKJZEKQJQQOTD-UHFFFAOYSA-N vinylbital Chemical compound CCCC(C)C1(C=C)C(=O)NC(=O)NC1=O KGKJZEKQJQQOTD-UHFFFAOYSA-N 0.000 description 1
- 229960005392 vinylbital Drugs 0.000 description 1
- 238000003260 vortexing Methods 0.000 description 1
- 238000004457 water analysis Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229960001360 zolmitriptan Drugs 0.000 description 1
- UTAZCRNOSWWEFR-ZDUSSCGKSA-N zolmitriptan Chemical compound C=1[C]2C(CCN(C)C)=CN=C2C=CC=1C[C@H]1COC(=O)N1 UTAZCRNOSWWEFR-ZDUSSCGKSA-N 0.000 description 1
- FYGDTMLNYKFZSV-BYLHFPJWSA-N β-1,4-galactotrioside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@H](CO)O[C@@H](O[C@@H]2[C@@H](O[C@@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-BYLHFPJWSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2063—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
L'invention concerne une composition pharmaceutique comprenant un Inhibiteur du peptide lié au gène de la calcitonine (CGRP) et une quantité augmentant l'absorption d'une substance pharmaceutiquement acceptable, telle qu'un tensioactif de carbohydrate . L'invention concerne également un procédé pour augmenter la biodisponibilité d'un inhibiteur de peptide lié au gène de la calcitonine (CGRP) chez un sujet, comprenant l'administration par voie orale pour augmenter la biodisponibilité de l'inhibiteur de CGRP chez le sujet.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063115789P | 2020-11-19 | 2020-11-19 | |
| US63/115,789 | 2020-11-19 | ||
| US202063126550P | 2020-12-17 | 2020-12-17 | |
| US63/126,550 | 2020-12-17 | ||
| PCT/US2021/059801 WO2022109077A1 (fr) | 2020-11-19 | 2021-11-18 | Compositions pour une meilleure administration d'inhibiteurs de cgrp |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3202137A1 true CA3202137A1 (fr) | 2022-05-27 |
Family
ID=81709748
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3202137A Pending CA3202137A1 (fr) | 2020-11-19 | 2021-11-18 | Compositions pour une meilleure administration d'inhibiteurs de cgrp |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP4247364A4 (fr) |
| JP (1) | JP2023551146A (fr) |
| KR (1) | KR20230088442A (fr) |
| AU (1) | AU2021385052A1 (fr) |
| CA (1) | CA3202137A1 (fr) |
| IL (1) | IL302948A (fr) |
| MX (1) | MX2023005846A (fr) |
| WO (1) | WO2022109077A1 (fr) |
| ZA (1) | ZA202304727B (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115154469A (zh) * | 2022-07-22 | 2022-10-11 | 中国科学院广州生物医药与健康研究院 | 瑞美吉泮或其药学上可接受的盐在制备预防或治疗肥胖的药物中的应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8715715B2 (en) * | 2008-11-03 | 2014-05-06 | Nal Pharmaceuticals Ltd. | Dosage form for insertion into the mouth |
| US8481546B2 (en) * | 2010-03-30 | 2013-07-09 | Bristol-Myers Squibb Company | CGRP receptor antagonist |
| US20160346198A1 (en) * | 2014-02-05 | 2016-12-01 | Merck Sharp & Dohme Corp. | Novel disintegration systems for pharmaceutical dosage forms |
| SG11201808630WA (en) * | 2016-04-15 | 2018-10-30 | Alder Biopharmaceuticals Inc | Humanized anti-pacap antibodies and uses thereof |
| WO2020150703A1 (fr) * | 2019-01-20 | 2020-07-23 | Biohaven Pharmaceutical Holding Company Ltd. | Antagonistes du cgrp pour le traitement d'une migraine intense |
| EA202192793A1 (ru) * | 2019-04-11 | 2022-01-12 | Ар.Пи. ШЕРЕР ТЕКНОЛОДЖИЗ, ЭлЭлСи | Композиция для пероральной доставки белков, пептидов и малых молекул со слабой проницаемостью |
| WO2020232379A1 (fr) * | 2019-05-16 | 2020-11-19 | Aegis Therapeutics, Llc | Compositions contenant des médicaments solubles dans l'huile et méthodes d'utilisation de ces compositions |
| AU2020355233A1 (en) * | 2019-09-25 | 2022-05-19 | Allergan Pharmaceuticals International Limited | Combination therapy with CGRP antagonists |
| IL293647A (en) * | 2019-12-17 | 2022-08-01 | Biohaven Pharm Holding Co Ltd | Intranasal pharmaceutical preparations of calcitonin gene-related peptide inhibitors |
-
2021
- 2021-11-18 WO PCT/US2021/059801 patent/WO2022109077A1/fr active Application Filing
- 2021-11-18 JP JP2023529881A patent/JP2023551146A/ja active Pending
- 2021-11-18 EP EP21895549.0A patent/EP4247364A4/fr active Pending
- 2021-11-18 MX MX2023005846A patent/MX2023005846A/es unknown
- 2021-11-18 IL IL302948A patent/IL302948A/en unknown
- 2021-11-18 AU AU2021385052A patent/AU2021385052A1/en active Pending
- 2021-11-18 CA CA3202137A patent/CA3202137A1/fr active Pending
- 2021-11-18 KR KR1020237016343A patent/KR20230088442A/ko active Search and Examination
-
2023
- 2023-04-24 ZA ZA2023/04727A patent/ZA202304727B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2022109077A1 (fr) | 2022-05-27 |
| AU2021385052A9 (en) | 2024-05-02 |
| IL302948A (en) | 2023-07-01 |
| ZA202304727B (en) | 2023-12-20 |
| KR20230088442A (ko) | 2023-06-19 |
| JP2023551146A (ja) | 2023-12-07 |
| AU2021385052A1 (en) | 2023-06-01 |
| EP4247364A4 (fr) | 2024-10-23 |
| EP4247364A1 (fr) | 2023-09-27 |
| MX2023005846A (es) | 2023-06-02 |
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