CA3201080A1 - 3-cyclic amine-indole derivatives as serotonergic agents for the treatment of cns disorders - Google Patents
3-cyclic amine-indole derivatives as serotonergic agents for the treatment of cns disordersInfo
- Publication number
- CA3201080A1 CA3201080A1 CA3201080A CA3201080A CA3201080A1 CA 3201080 A1 CA3201080 A1 CA 3201080A1 CA 3201080 A CA3201080 A CA 3201080A CA 3201080 A CA3201080 A CA 3201080A CA 3201080 A1 CA3201080 A1 CA 3201080A1
- Authority
- CA
- Canada
- Prior art keywords
- optionally substituted
- substituted
- hydrogen atoms
- available
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063122181P | 2020-12-07 | 2020-12-07 | |
| US63/122,181 | 2020-12-07 | ||
| PCT/CA2021/051755 WO2022120475A1 (en) | 2020-12-07 | 2021-12-07 | 3-cyclic amine-indole derivatives as serotonergic agents for the treatment of cns disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3201080A1 true CA3201080A1 (en) | 2022-06-16 |
Family
ID=81973031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3201080A Pending CA3201080A1 (en) | 2020-12-07 | 2021-12-07 | 3-cyclic amine-indole derivatives as serotonergic agents for the treatment of cns disorders |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20240051978A1 (cg-RX-API-DMAC10.html) |
| EP (1) | EP4255913A4 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2023553094A (cg-RX-API-DMAC10.html) |
| KR (1) | KR20230117597A (cg-RX-API-DMAC10.html) |
| CN (1) | CN116917305A (cg-RX-API-DMAC10.html) |
| AU (1) | AU2021394129A1 (cg-RX-API-DMAC10.html) |
| CA (1) | CA3201080A1 (cg-RX-API-DMAC10.html) |
| IL (1) | IL303467A (cg-RX-API-DMAC10.html) |
| MX (1) | MX2023006652A (cg-RX-API-DMAC10.html) |
| WO (1) | WO2022120475A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3519816A4 (en) | 2016-09-29 | 2020-05-06 | The Regents of the University of California | CONNECTIONS FOR INCREASING NEURONAL PLASTICITY |
| KR102946120B1 (ko) | 2019-02-27 | 2026-03-30 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 뇌 장애를 치료하기 위한 아제피노-인돌 및 다른 헤테로사이클 |
| WO2022221415A2 (en) | 2021-04-13 | 2022-10-20 | The Regents Of The University Of California | Tetracyclic compounds for treating brain disorders |
| KR20240017363A (ko) * | 2021-06-02 | 2024-02-07 | 세인트 조셉스 유니버시티 | 플루오린화 트립타민 화합물, 이의 유사체 및 이를 사용하는 방법 |
| JP2025502615A (ja) | 2021-12-15 | 2025-01-28 | デリックス セラピューティクス，インク． | フェノキシおよびベンジルオキシ置換サイコプラストゲンならびにその使用 |
| EP4447954A4 (en) * | 2021-12-16 | 2025-12-03 | Icahn School Med Mount Sinai | HETEROCYCLIC COMPOUNDS AS POLARIZED 5HT2A AGONISTS |
| WO2023168023A1 (en) | 2022-03-04 | 2023-09-07 | Reset Pharmaceuticals, Inc. | Co-crystals or salts comprising psilocin |
| EP4551211A1 (en) * | 2022-07-08 | 2025-05-14 | Institut Curie | Serotonin analogues for use in treating metalloptosis-associated disorders |
| US12396981B2 (en) | 2023-03-09 | 2025-08-26 | William Shulman | Methods of using DMT |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5789402A (en) * | 1995-01-17 | 1998-08-04 | Eli Lilly Company | Compounds having effects on serotonin-related systems |
| US5846982A (en) * | 1996-06-14 | 1998-12-08 | Eli Lilly And Company | Inhibition of serotonin reuptake |
| US6133287A (en) * | 1998-03-24 | 2000-10-17 | Allelix Biopharmaceuticals Inc. | Piperidine-indole compounds having 5-HT6 affinity |
| GB9810886D0 (en) * | 1998-05-13 | 1998-07-22 | Lilly Industries Ltd | Pharmaceutical compounds |
| EP1173432B9 (en) * | 1999-04-21 | 2008-10-15 | NPS Allelix Corp. | Piperidine-indole compounds having 5-ht6 affinity |
| EA200300717A1 (ru) * | 2000-12-22 | 2003-12-25 | Уайт | Гетероциклилиндазольные и -азаиндазольные соединения в качестве 5-гидрокситриптамин-6-лигандов |
| WO2004069828A1 (ja) * | 2003-02-04 | 2004-08-19 | Mitsubishi Pharma Corporation | ピペリジン化合物およびその医薬用途 |
| WO2005066157A1 (en) * | 2004-01-02 | 2005-07-21 | Suven Life Sciences | 3-(pyrolidin-3-l) indoles as 5-ht6 receptor modulators |
| EP1984351A1 (en) * | 2006-02-17 | 2008-10-29 | Memory Pharmaceuticals Corporation | Compounds having 5-ht6 receptor affinity |
| US8912220B2 (en) * | 2009-08-10 | 2014-12-16 | Galenea Pharmaceuticals | Compounds and methods of use thereof |
| US20230405026A1 (en) * | 2020-11-06 | 2023-12-21 | Mynd Life Sciences Inc. | A Method of Treating Depression by Immune Modulation |
-
2021
- 2021-12-07 US US18/265,286 patent/US20240051978A1/en active Pending
- 2021-12-07 JP JP2023534880A patent/JP2023553094A/ja active Pending
- 2021-12-07 AU AU2021394129A patent/AU2021394129A1/en active Pending
- 2021-12-07 KR KR1020237023111A patent/KR20230117597A/ko active Pending
- 2021-12-07 EP EP21901751.4A patent/EP4255913A4/en active Pending
- 2021-12-07 IL IL303467A patent/IL303467A/en unknown
- 2021-12-07 CA CA3201080A patent/CA3201080A1/en active Pending
- 2021-12-07 CN CN202180092982.XA patent/CN116917305A/zh active Pending
- 2021-12-07 MX MX2023006652A patent/MX2023006652A/es unknown
- 2021-12-07 WO PCT/CA2021/051755 patent/WO2022120475A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP4255913A1 (en) | 2023-10-11 |
| KR20230117597A (ko) | 2023-08-08 |
| IL303467A (en) | 2023-08-01 |
| EP4255913A4 (en) | 2024-11-06 |
| AU2021394129A1 (en) | 2023-07-20 |
| CN116917305A (zh) | 2023-10-20 |
| US20240051978A1 (en) | 2024-02-15 |
| WO2022120475A1 (en) | 2022-06-16 |
| JP2023553094A (ja) | 2023-12-20 |
| MX2023006652A (es) | 2023-09-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US12054505B2 (en) | Psilocin derivatives as serotonergic psychedelic agents for the treatment of CNS disorders | |
| US12054504B2 (en) | 3-pyrrolidine-indole derivatives as serotonergic psychedelic agents for the treatment of CNS disorders | |
| US20240051978A1 (en) | 3-cyclic amine-indole derivatives as serotonergic agents for the treatment of cns disorders | |
| US20240166630A1 (en) | Indole derivatives as serotonergic agents useful for the treatment of disorders related thereto | |
| AU2022328466A1 (en) | 3-cycloamino-indole compounds as serotonergic agents useful for the treatment of disorders related thereto |
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