CA3176958A1 - Co-crystal of gabapentin, ketoprofen and lysine, pharmaceutical compositions and their medical use - Google Patents
Co-crystal of gabapentin, ketoprofen and lysine, pharmaceutical compositions and their medical useInfo
- Publication number
- CA3176958A1 CA3176958A1 CA3176958A CA3176958A CA3176958A1 CA 3176958 A1 CA3176958 A1 CA 3176958A1 CA 3176958 A CA3176958 A CA 3176958A CA 3176958 A CA3176958 A CA 3176958A CA 3176958 A1 CA3176958 A1 CA 3176958A1
- Authority
- CA
- Canada
- Prior art keywords
- ketoprofen
- crystal
- lysine
- gabapentin
- pain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 239000013078 crystal Substances 0.000 title claims abstract description 185
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 title claims abstract description 72
- 229960000991 ketoprofen Drugs 0.000 title claims abstract description 70
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 title claims abstract description 52
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20170740.3A EP3900716A1 (de) | 2020-04-21 | 2020-04-21 | Co-kristall von gabapentin, ketoprofen und lysin, pharmazeutische zusammensetzungen und ihre medizinische verwendung |
| EP20170740.3 | 2020-04-21 | ||
| PCT/EP2021/060421 WO2021214158A1 (en) | 2020-04-21 | 2021-04-21 | Co-crystal of gabapentin, ketoprofen and lysine, pharmaceutical compositions and their medical use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3176958A1 true CA3176958A1 (en) | 2021-10-28 |
Family
ID=70390939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3176958A Pending CA3176958A1 (en) | 2020-04-21 | 2021-04-21 | Co-crystal of gabapentin, ketoprofen and lysine, pharmaceutical compositions and their medical use |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20230181507A1 (de) |
| EP (2) | EP3900716A1 (de) |
| CN (1) | CN115697315B (de) |
| BR (1) | BR112022019493A2 (de) |
| CA (1) | CA3176958A1 (de) |
| IL (1) | IL296856A (de) |
| WO (1) | WO2021214158A1 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4169903A1 (de) * | 2021-10-25 | 2023-04-26 | Dompe' Farmaceutici S.P.A. | Co-kristalle von nichtsteroidalen entzündungshemmenden arzneimitteln, lysin und gabapentin, pharmazeutische zusammensetzungen und deren medizinische verwendung |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1497044A (en) | 1974-03-07 | 1978-01-05 | Prodotti Antibiotici Spa | Salts of phenyl-alkanoic acids |
| IT1104556B (it) | 1977-05-12 | 1985-10-21 | Medea Res Srl | Sale di lisina dell'acido meta-benzoil-idratropico,processo per la sua preparazione e composizione farmaceutiche che lo contengono |
| AU2004308962A1 (en) * | 2003-12-24 | 2005-07-14 | Sepracor Inc. | Melatonin combination therapy for improving sleep quality |
| CA2680792A1 (en) * | 2007-03-15 | 2008-09-18 | Biogen Idec Ma Inc. | Treatment of autoimmune disorders |
| KR20110126747A (ko) * | 2009-03-06 | 2011-11-23 | 제노포트 인코포레이티드 | 고용량의 가바펜틴 프로드러그를 갖는 경구 투여 제형 |
| US9169279B2 (en) * | 2009-07-31 | 2015-10-27 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| AU2010330747B2 (en) * | 2009-12-18 | 2016-08-11 | Achelios Therapeutics, Inc. | Methods and compositions for treating and preventing trigeminal autonomic cephalgias, migraine, and vascular conditions |
| PT3650439T (pt) * | 2010-07-23 | 2021-03-03 | Gruenenthal Gmbh | Sais ou cocristais de 3-(3-dimetilamino-1-etil-2-metilpropil)fenol |
| NO3057589T3 (de) * | 2014-05-09 | 2017-12-30 | ||
| NZ740616A (en) * | 2015-09-14 | 2023-05-26 | Infinity Pharmaceuticals Inc | Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same |
-
2020
- 2020-04-21 EP EP20170740.3A patent/EP3900716A1/de not_active Withdrawn
-
2021
- 2021-04-21 US US17/920,085 patent/US20230181507A1/en active Pending
- 2021-04-21 CA CA3176958A patent/CA3176958A1/en active Pending
- 2021-04-21 BR BR112022019493A patent/BR112022019493A2/pt unknown
- 2021-04-21 EP EP21720272.0A patent/EP4138807A1/de active Pending
- 2021-04-21 CN CN202180029579.2A patent/CN115697315B/zh active Active
- 2021-04-21 IL IL296856A patent/IL296856A/en unknown
- 2021-04-21 WO PCT/EP2021/060421 patent/WO2021214158A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| IL296856A (en) | 2022-11-01 |
| EP3900716A1 (de) | 2021-10-27 |
| BR112022019493A2 (pt) | 2023-01-10 |
| CN115697315B (zh) | 2024-05-24 |
| CN115697315A (zh) | 2023-02-03 |
| US20230181507A1 (en) | 2023-06-15 |
| EP4138807A1 (de) | 2023-03-01 |
| WO2021214158A1 (en) | 2021-10-28 |
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