CA3174557A1 - Class ii, type v crispr systems - Google Patents
Class ii, type v crispr systemsInfo
- Publication number
- CA3174557A1 CA3174557A1 CA3174557A CA3174557A CA3174557A1 CA 3174557 A1 CA3174557 A1 CA 3174557A1 CA 3174557 A CA3174557 A CA 3174557A CA 3174557 A CA3174557 A CA 3174557A CA 3174557 A1 CA3174557 A1 CA 3174557A1
- Authority
- CA
- Canada
- Prior art keywords
- sequence
- endonuclease
- engineered
- guide rna
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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CA3174557A1 (en) | 2020-03-06 | 2021-09-10 | Metagenomi, Inc. | Class ii, type v crispr systems |
AU2021368740A1 (en) * | 2020-10-30 | 2023-06-01 | Arbor Biotechnologies, Inc. | Compositions comprising an rna guide targeting trac and uses thereof |
US11332742B1 (en) * | 2021-01-07 | 2022-05-17 | Inscripta, Inc. | Mad nucleases |
BR112023024983A2 (pt) * | 2021-06-02 | 2024-04-30 | Metagenomi Inc | Sistemas crispr classe ii, tipo v |
EP4408995A1 (en) * | 2021-09-28 | 2024-08-07 | Acrigen Biosciences | Compositions and methods for nucleic acid modifications |
CN115851666B (zh) * | 2021-10-29 | 2023-09-08 | 山东舜丰生物科技有限公司 | 新型Cas酶和系统以及应用 |
WO2023092132A1 (en) * | 2021-11-22 | 2023-05-25 | Mammoth Biosciences, Inc. | Effector proteins and uses thereof |
WO2023141590A2 (en) * | 2022-01-21 | 2023-07-27 | Mammoth Biosciences, Inc. | Effector proteins and methods of use |
WO2023230579A2 (en) * | 2022-05-25 | 2023-11-30 | Metagenomi, Inc. | Supplementation of liver enzyme expression |
WO2024020346A2 (en) * | 2022-07-18 | 2024-01-25 | Renagade Therapeutics Management Inc. | Gene editing components, systems, and methods of use |
WO2024042168A1 (en) * | 2022-08-26 | 2024-02-29 | UCB Biopharma SRL | Novel rna-guided nucleases and nucleic acid targeting systems comprising such rna-guided nucleases |
WO2024107665A1 (en) * | 2022-11-14 | 2024-05-23 | Mammoth Biosciences, Inc. | Effector proteins, compositions, systems and methods of use thereof |
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US9790490B2 (en) * | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
US20190264186A1 (en) * | 2016-01-22 | 2019-08-29 | The Broad Institute Inc. | Crystal structure of crispr cpf1 |
EP3445856A1 (en) * | 2016-04-19 | 2019-02-27 | The Broad Institute Inc. | Novel crispr enzymes and systems |
AU2017407272B2 (en) * | 2017-03-30 | 2024-06-13 | Kyoto University | Method for inducing exon skipping by genome editing |
EP3612551B1 (en) * | 2017-04-21 | 2024-09-04 | The General Hospital Corporation | Variants of cpf1 (cas12a) with altered pam specificity |
EP3635113A4 (en) * | 2017-06-05 | 2021-03-17 | Fred Hutchinson Cancer Research Center | GENOMIC SAFE HARBORS FOR GENETIC THERAPIES IN HUMAN STEM CELLS AND MANIPULATED NANOPARTICLES TO DELIVER TARGETED GENETIC THERAPIES |
US9982279B1 (en) * | 2017-06-23 | 2018-05-29 | Inscripta, Inc. | Nucleic acid-guided nucleases |
AU2018330197B2 (en) | 2017-09-07 | 2022-09-01 | Intima Bioscience, Inc. | Nuclease systems for genetic engineering |
SG11202003464VA (en) | 2017-10-17 | 2020-05-28 | Crispr Therapeutics Ag | Compositions and methods for gene editing for hemophilia a |
US10253365B1 (en) | 2017-11-22 | 2019-04-09 | The Regents Of The University Of California | Type V CRISPR/Cas effector proteins for cleaving ssDNAs and detecting target DNAs |
CN111954715A (zh) | 2018-03-29 | 2020-11-17 | 菲特治疗公司 | 工程改造的免疫效应细胞和其用途 |
CA3109083A1 (en) | 2018-08-09 | 2020-02-13 | G+Flas Life Sciences | Compositions and methods for genome engineering with cas12a proteins |
WO2020123887A2 (en) | 2018-12-14 | 2020-06-18 | Pioneer Hi-Bred International, Inc. | Novel crispr-cas systems for genome editing |
WO2020142754A2 (en) * | 2019-01-04 | 2020-07-09 | Mammoth Biosciences, Inc. | Programmable nuclease improvements and compositions and methods for nucleic acid amplification and detection |
JP2022520428A (ja) | 2019-02-14 | 2022-03-30 | メタゲノミ アイピー テクノロジーズ,エルエルシー | Ruvcドメインを有する酵素 |
US10982200B2 (en) | 2019-02-14 | 2021-04-20 | Metagenomi Ip Technologies, Llc | Enzymes with RuvC domains |
CN110684823A (zh) | 2019-10-23 | 2020-01-14 | 海南大学 | 一种基于试纸条的Cas12a酶的微生物快速诊断技术 |
CN110904239B (zh) | 2019-12-25 | 2020-11-10 | 武汉博杰生物医学科技有限公司 | 肺癌相关分子标志物基因突变的检测试剂盒与检测方法 |
WO2021178934A1 (en) | 2020-03-06 | 2021-09-10 | Metagenomi Ip Technologies, Llc | Class ii, type v crispr systems |
CA3174557A1 (en) | 2020-03-06 | 2021-09-10 | Metagenomi, Inc. | Class ii, type v crispr systems |
JP2023533417A (ja) | 2020-05-08 | 2023-08-03 | メタゲノミ,インコーポレイテッド | Ruvcドメインを有する酵素 |
MX2023002913A (es) | 2020-09-11 | 2023-06-01 | Metagenomi Inc | Enzimas para edicion de bases. |
WO2022159742A1 (en) | 2021-01-22 | 2022-07-28 | Metagenomi, Inc | Novel engineered and chimeric nucleases |
AU2022210762A1 (en) | 2021-01-22 | 2023-08-24 | Metagenomi, Inc. | Novel engineered and chimeric nucleases |
EP4281567A1 (en) | 2021-01-25 | 2023-11-29 | The Broad Institute Inc. | Reprogrammable tnpb polypeptides and use thereof |
CA3210361A1 (en) | 2021-03-19 | 2022-09-22 | Brian Thomas | Multiplex editing with cas enzymes |
BR112023024983A2 (pt) | 2021-06-02 | 2024-04-30 | Metagenomi Inc | Sistemas crispr classe ii, tipo v |
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EP4114932A2 (en) | 2023-01-11 |
WO2021178933A3 (en) | 2021-12-23 |
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