CA3149602A1 - Tryptamines d'ammonium quaternaire d'alkyle et leurs utilisations therapeutiques - Google Patents
Tryptamines d'ammonium quaternaire d'alkyle et leurs utilisations therapeutiques Download PDFInfo
- Publication number
- CA3149602A1 CA3149602A1 CA3149602A CA3149602A CA3149602A1 CA 3149602 A1 CA3149602 A1 CA 3149602A1 CA 3149602 A CA3149602 A CA 3149602A CA 3149602 A CA3149602 A CA 3149602A CA 3149602 A1 CA3149602 A1 CA 3149602A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- iodide
- formula
- xrpd pattern
- crystalline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 230000001225 therapeutic effect Effects 0.000 title abstract description 5
- 125000000217 alkyl group Chemical group 0.000 title description 10
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- 150000001875 compounds Chemical class 0.000 claims abstract description 90
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- HFTAFOQKODTIJY-UHFFFAOYSA-N umbelliferone Natural products Cc1cc2C=CC(=O)Oc2cc1OCC=CC(C)(C)O HFTAFOQKODTIJY-UHFFFAOYSA-N 0.000 description 1
- WCTNXGFHEZQHDR-UHFFFAOYSA-N valencene Natural products C1CC(C)(C)C2(C)CC(C(=C)C)CCC2=C1 WCTNXGFHEZQHDR-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 229960004688 venlafaxine Drugs 0.000 description 1
- PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 description 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
- 229960002263 vortioxetine Drugs 0.000 description 1
- YQNWZWMKLDQSAC-UHFFFAOYSA-N vortioxetine Chemical compound CC1=CC(C)=CC=C1SC1=CC=CC=C1N1CCNCC1 YQNWZWMKLDQSAC-UHFFFAOYSA-N 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- USDOQCCMRDNVAH-KKUMJFAQSA-N β-cadinene Chemical compound C1C=C(C)C[C@H]2[C@H](C(C)C)CC=C(C)[C@@H]21 USDOQCCMRDNVAH-KKUMJFAQSA-N 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne un composé de formule (I) : L'invention concerne également des composés cristallins de formule (I). L'invention concerne des compositions comprenant un composé de formule (I) et un excipient, essentiellement constituées de ceux-ci, ou constituées de ceux-ci. L'invention concerne également des compositions pharmaceutiques comprenant une quantité thérapeutiquement efficace d'un composé de formule (I), l'excipient étant un support pharmaceutiquement acceptable. L'invention concerne en outre des utilisations thérapeutiques de composés de formule (I).
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962891388P | 2019-08-25 | 2019-08-25 | |
| US62/891,388 | 2019-08-25 | ||
| US202063007653P | 2020-04-09 | 2020-04-09 | |
| US63/007,653 | 2020-04-09 | ||
| US202063053976P | 2020-07-20 | 2020-07-20 | |
| US63/053,976 | 2020-07-20 | ||
| PCT/US2020/047791 WO2021041407A1 (fr) | 2019-08-25 | 2020-08-25 | Tryptamines d'ammonium quaternaire d'alkyle et leurs utilisations thérapeutiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3149602A1 true CA3149602A1 (fr) | 2021-03-04 |
Family
ID=74684268
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3149602A Pending CA3149602A1 (fr) | 2019-08-25 | 2020-08-25 | Tryptamines d'ammonium quaternaire d'alkyle et leurs utilisations therapeutiques |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP4017859A4 (fr) |
| AU (1) | AU2020337903A1 (fr) |
| CA (1) | CA3149602A1 (fr) |
| WO (1) | WO2021041407A1 (fr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210069170A1 (en) | 2016-07-23 | 2021-03-11 | Paul Edward Stamets | Tryptamine compositions for enhancing neurite outgrowth |
| US11701348B1 (en) | 2016-07-23 | 2023-07-18 | Turtle Bear Holdings, Llc | Psilocybin compositions |
| US20180021326A1 (en) | 2016-07-23 | 2018-01-25 | Paul Edward Stamets | Compositions and methods for enhancing neuroregeneration and cognition by combining mushroom extracts containing active ingredients psilocin or psilocybin with erinacines or hericenones enhanced with niacin |
| AU2020386445A1 (en) | 2019-11-19 | 2022-06-02 | Paul Edward Stamets | Tryptamine compositions for enhancing neurite outgrowth |
| WO2021188782A1 (fr) * | 2020-03-19 | 2021-09-23 | Caamtech, Inc. | Dérivés cristallins de psilacétine |
| US11858896B2 (en) | 2020-05-04 | 2024-01-02 | Caamtech, Inc. | Crystalline dimethyl tryptamine analogues |
| EP4153564A4 (fr) | 2020-05-19 | 2024-06-19 | Cybin IRL Limited | Dérivés de tryptamine deutérés et procédés d'utilisation |
| WO2021250434A1 (fr) | 2020-06-12 | 2021-12-16 | Beckley Psytech Limited | Composition comprenant un sel de benzoate de 5-méthoxy-n, n-diméthyltryptamine |
| AU2022328217A1 (en) | 2021-08-12 | 2024-03-14 | Kuleon Llc | Hallucinogenic and non-hallucinogenic serotonin receptor agonists and methods of making and using the same |
| WO2023023298A1 (fr) * | 2021-08-20 | 2023-02-23 | Psilosterics, Llc | Composés hallucinogènes et non hallucinogènes et leurs procédés de production et d'utilisation |
| AU2022365018A1 (en) * | 2021-10-15 | 2024-05-16 | Caamtech, Inc. | Crystalline tryptamine compounds |
| WO2023168022A1 (fr) | 2022-03-04 | 2023-09-07 | Reset Pharmaceuticals, Inc. | Co-cristaux ou sels comprenant de la psilocybine |
| WO2023173229A1 (fr) * | 2022-03-18 | 2023-09-21 | Enveric Biosciences Canada Inc. | Sels de dérivés de tryptamine à substitution acide c4-carboxylique et c4-carbonothioate et procédés d'utilisation |
| WO2023173196A1 (fr) | 2022-03-18 | 2023-09-21 | Enveric Biosciences Canada Inc. | Dérivés de tryptamine substitués par acide carboxylique en c4 et procédés d'utilisation |
| WO2023205768A2 (fr) * | 2022-04-21 | 2023-10-26 | Caamtech, Inc. | Sels quaternaires cristallins de tryptamines substituées en position 4 |
| WO2023250465A2 (fr) * | 2022-06-24 | 2023-12-28 | Caamtech, Inc. | Dérivés de tryptamine |
| WO2024026291A1 (fr) * | 2022-07-25 | 2024-02-01 | Caamtech, Inc. | Dérivés de tryptamine quaternaire substituée par un méthyle |
| GB202212116D0 (en) | 2022-08-19 | 2022-10-05 | Beckley Psytech Ltd | Pharmaceutically acceptable salts and Compositions thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2783520B1 (fr) * | 1998-09-21 | 2000-11-10 | Oreal | Nouveaux 4-hydroxyindoles cationiques, leur utilisation pour la teinture d'oxydation des fibres keratiniques, compositions tinctoriales et procede de teinture |
| US9440920B2 (en) * | 2014-07-03 | 2016-09-13 | Wisconsin Alumni Research Foundation | Antimicrobial compounds, compositions and methods of use thereof |
| JP7273731B2 (ja) * | 2017-02-09 | 2023-05-15 | カームテック、エルエルシー | シロシビン誘導体を含む組成物及び方法 |
| WO2019099745A1 (fr) * | 2017-11-16 | 2019-05-23 | CaaMTech, LLC | Compositions comprenant un dérivé de psilocybine et un cannabinoïde |
-
2020
- 2020-08-25 WO PCT/US2020/047791 patent/WO2021041407A1/fr unknown
- 2020-08-25 CA CA3149602A patent/CA3149602A1/fr active Pending
- 2020-08-25 EP EP20858480.5A patent/EP4017859A4/fr active Pending
- 2020-08-25 AU AU2020337903A patent/AU2020337903A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP4017859A4 (fr) | 2023-08-23 |
| EP4017859A1 (fr) | 2022-06-29 |
| AU2020337903A1 (en) | 2022-03-31 |
| WO2021041407A1 (fr) | 2021-03-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20231220 |