CA3149381A1 - Systemes et procedes de recherche et de traitement de trouble mental bases sur des donnees - Google Patents

Systemes et procedes de recherche et de traitement de trouble mental bases sur des donnees Download PDF

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Publication number
CA3149381A1
CA3149381A1 CA3149381A CA3149381A CA3149381A1 CA 3149381 A1 CA3149381 A1 CA 3149381A1 CA 3149381 A CA3149381 A CA 3149381A CA 3149381 A CA3149381 A CA 3149381A CA 3149381 A1 CA3149381 A1 CA 3149381A1
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CA
Canada
Prior art keywords
data
patient
gene
clinical
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3149381A
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English (en)
Inventor
Hailey B. Lefkofsky
Christopher N. Vlangos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tempus AI Inc
Original Assignee
Tempus Labs Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tempus Labs Inc filed Critical Tempus Labs Inc
Publication of CA3149381A1 publication Critical patent/CA3149381A1/fr
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/16—Devices for psychotechnics; Testing reaction times ; Devices for evaluating the psychological state
    • A61B5/165—Evaluating the state of mind, e.g. depression, anxiety
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/40—Population genetics; Linkage disequilibrium
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/30—Unsupervised data analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H70/00—ICT specially adapted for the handling or processing of medical references
    • G16H70/40—ICT specially adapted for the handling or processing of medical references relating to drugs, e.g. their side effects or intended usage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Data Mining & Analysis (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Pathology (AREA)
  • Software Systems (AREA)
  • Evolutionary Computation (AREA)
  • Databases & Information Systems (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Bioethics (AREA)
  • Wood Science & Technology (AREA)

Abstract

La présente invention concerne un système de traitement de trouble dépressif personnalisé. Le système comprend un serveur configuré pour communiquer avec des ressources de soins de santé existantes et recevoir des données de patient correspondant à un patient, le serveur comprenant un module analytique. Le système comprend en outre une première base de données configurée pour stocker des résultats de patients empiriques et, en outre, configurée pour communiquer avec le module analytique. De plus, le système comprend un dispositif utilisateur ayant une interface utilisateur graphique (GUI) configurée pour communiquer avec le serveur et afficher au moins une sortie générée par le module analytique. Le module analytique est configuré pour déterminer au moins un parmi un traitement de dépression personnalisé et une prédiction d'état de dépression personnalisée sur la base des résultats de patients empiriques et des données de patient.
CA3149381A 2019-08-02 2020-08-03 Systemes et procedes de recherche et de traitement de trouble mental bases sur des donnees Pending CA3149381A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962882466P 2019-08-02 2019-08-02
US62/882,466 2019-08-02
PCT/US2020/044795 WO2021026097A1 (fr) 2019-08-02 2020-08-03 Systèmes et procédés de recherche et de traitement de trouble mental basés sur des données

Publications (1)

Publication Number Publication Date
CA3149381A1 true CA3149381A1 (fr) 2021-02-11

Family

ID=74504485

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3149381A Pending CA3149381A1 (fr) 2019-08-02 2020-08-03 Systemes et procedes de recherche et de traitement de trouble mental bases sur des donnees

Country Status (5)

Country Link
EP (1) EP4007522A4 (fr)
JP (1) JP2022543240A (fr)
AU (1) AU2020326626A1 (fr)
CA (1) CA3149381A1 (fr)
WO (1) WO2021026097A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110305949A (zh) * 2019-05-07 2019-10-08 中国人民解放军联勤保障部队第九0四医院 精神分裂症小鼠模型海马mRNA序列分析及试剂盒
CN113355408A (zh) * 2021-06-29 2021-09-07 山西医科大学第一医院 一种用于检测/疗效评价早发型精神分裂症的分子标志物及其应用
CN113466467A (zh) * 2021-06-17 2021-10-01 中国人民解放军军事科学院军事医学研究院 一种用于检测焦虑抑郁的标志物及其应用
CN114699080A (zh) * 2022-04-28 2022-07-05 电子科技大学 一种基于融合特征的驾驶员精神紧张程度识别方法

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114736961B (zh) * 2022-05-23 2024-06-11 武汉儿童医院 基于转录因子识别老年期抑郁症的诊断试剂、应用及系统
CN116559451B (zh) * 2023-04-07 2023-12-05 山东大学 Fbxl20在抑郁症诊治中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070031853A1 (en) * 1999-02-22 2007-02-08 Variagenics, Inc., A Delaware Corporation Gene sequence variations with utility in determining the treatment of neurological or psychiatric disease
US20080118918A1 (en) * 2004-08-13 2008-05-22 The Regents Of The University Of California Compositions and Methods For Determining and Predicting Treatment Responses For Depression and Anxiety
WO2007120480A2 (fr) * 2006-04-03 2007-10-25 President And Fellows Of Harvard College Systemes et procedes permettant de prevoir l'efficacite d'un traitement destine a des troubles psychiatriques, dont la depression
WO2007121319A2 (fr) * 2006-04-14 2007-10-25 University Of California Compostions et procédés destinés à déterminer et à prevoir des réponses aux traitements de la dépression et de l'anxiété
EP3399450A1 (fr) * 2006-05-18 2018-11-07 Caris MPI, Inc. Système et procédé permettant de déterminer une intervention médicale individualisée pour un état pathologique
CN108780663B (zh) * 2015-12-18 2022-12-13 科格诺亚公司 数字个性化医学平台和系统

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110305949A (zh) * 2019-05-07 2019-10-08 中国人民解放军联勤保障部队第九0四医院 精神分裂症小鼠模型海马mRNA序列分析及试剂盒
CN113466467A (zh) * 2021-06-17 2021-10-01 中国人民解放军军事科学院军事医学研究院 一种用于检测焦虑抑郁的标志物及其应用
CN113355408A (zh) * 2021-06-29 2021-09-07 山西医科大学第一医院 一种用于检测/疗效评价早发型精神分裂症的分子标志物及其应用
CN114699080A (zh) * 2022-04-28 2022-07-05 电子科技大学 一种基于融合特征的驾驶员精神紧张程度识别方法
CN114699080B (zh) * 2022-04-28 2023-04-25 电子科技大学 一种基于融合特征的驾驶员精神紧张程度识别方法

Also Published As

Publication number Publication date
WO2021026097A1 (fr) 2021-02-11
EP4007522A4 (fr) 2024-01-24
JP2022543240A (ja) 2022-10-11
EP4007522A1 (fr) 2022-06-08
AU2020326626A1 (en) 2022-03-10

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