CA3144869C - Thieno[3,2-b]thiophene-2-carboxylic acid compounds having bckdk inhibiting activity - Google Patents

Thieno[3,2-b]thiophene-2-carboxylic acid compounds having bckdk inhibiting activity Download PDF

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Publication number
CA3144869C
CA3144869C CA3144869A CA3144869A CA3144869C CA 3144869 C CA3144869 C CA 3144869C CA 3144869 A CA3144869 A CA 3144869A CA 3144869 A CA3144869 A CA 3144869A CA 3144869 C CA3144869 C CA 3144869C
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CA
Canada
Prior art keywords
compound
diabetes
pharmaceutically acceptable
carboxylic acid
acceptable salt
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CA3144869A
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English (en)
French (fr)
Other versions
CA3144869A1 (en
Inventor
Samit Kumar Bhattacharya
Leanne Marie BUZON
Kevin James Filipski
David Andrew Griffith
Bethany Lyn KORMOS
Luis Angel MARTINEZ-ALSINA
Russell Alan MILLER
Matthew Richard Reese
Rachel Jane ROTH FLACH
Yuan Zhang
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Pfizer Inc
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Pfizer Inc
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Publication of CA3144869C publication Critical patent/CA3144869C/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA3144869A 2019-06-28 2020-06-26 Thieno[3,2-b]thiophene-2-carboxylic acid compounds having bckdk inhibiting activity Active CA3144869C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962868057P 2019-06-28 2019-06-28
US62/868,057 2019-06-28
US202062960817P 2020-01-14 2020-01-14
US62/960,817 2020-01-14
US202063031719P 2020-05-29 2020-05-29
US63/031,719 2020-05-29
PCT/IB2020/056066 WO2020261205A1 (en) 2019-06-28 2020-06-26 Thieno[3,2-b]thiophene-2-carboxylic acid compounds having bckdk inhibiting activity

Publications (2)

Publication Number Publication Date
CA3144869A1 CA3144869A1 (en) 2020-12-30
CA3144869C true CA3144869C (en) 2023-12-05

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA3144869A Active CA3144869C (en) 2019-06-28 2020-06-26 Thieno[3,2-b]thiophene-2-carboxylic acid compounds having bckdk inhibiting activity

Country Status (8)

Country Link
US (2) US11542270B2 (https=)
EP (1) EP3990461A1 (https=)
JP (1) JP2022540000A (https=)
CA (1) CA3144869C (https=)
PY (1) PY2030111A (https=)
TW (1) TW202115086A (https=)
UY (1) UY38768A (https=)
WO (1) WO2020261205A1 (https=)

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JP7826324B2 (ja) * 2021-01-27 2026-03-09 コーニンクレッカ フィリップス エヌ ヴェ 肝線維症をモニタリングする磁気共鳴及び超音波せん断波エラストグラフィの解釈の向上のための装置及び方法
WO2022175959A1 (en) * 2021-02-21 2022-08-25 Ramino-Bio Thiophene based compounds and use thereof as bckdk inhibitors
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Also Published As

Publication number Publication date
EP3990461A1 (en) 2022-05-04
UY38768A (es) 2021-01-29
US20210024536A1 (en) 2021-01-28
US11542270B2 (en) 2023-01-03
US11059833B2 (en) 2021-07-13
US20210087204A1 (en) 2021-03-25
TW202115086A (zh) 2021-04-16
JP2022540000A (ja) 2022-09-14
CA3144869A1 (en) 2020-12-30
WO2020261205A1 (en) 2020-12-30
PY2030111A (es) 2021-12-20

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