CA3140627A1 - Oral care composition - Google Patents
Oral care composition Download PDFInfo
- Publication number
- CA3140627A1 CA3140627A1 CA3140627A CA3140627A CA3140627A1 CA 3140627 A1 CA3140627 A1 CA 3140627A1 CA 3140627 A CA3140627 A CA 3140627A CA 3140627 A CA3140627 A CA 3140627A CA 3140627 A1 CA3140627 A1 CA 3140627A1
- Authority
- CA
- Canada
- Prior art keywords
- oral care
- care composition
- weight
- eugenol
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 240
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 claims abstract description 124
- 239000003242 anti bacterial agent Substances 0.000 claims abstract description 65
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 claims abstract description 62
- 239000005770 Eugenol Substances 0.000 claims abstract description 62
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 claims abstract description 62
- 229960002217 eugenol Drugs 0.000 claims abstract description 62
- MIJYXULNPSFWEK-GTOFXWBISA-N 3beta-hydroxyolean-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C MIJYXULNPSFWEK-GTOFXWBISA-N 0.000 claims abstract description 50
- MIJYXULNPSFWEK-UHFFFAOYSA-N Oleanolinsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4=CCC3C21C MIJYXULNPSFWEK-UHFFFAOYSA-N 0.000 claims abstract description 50
- MXEMKMNFLXVQBW-UHFFFAOYSA-N oleanoic acid Natural products C1CCC(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4=CCC3C21C MXEMKMNFLXVQBW-UHFFFAOYSA-N 0.000 claims abstract description 48
- 238000000034 method Methods 0.000 claims description 16
- ZYEMGPIYFIJGTP-UHFFFAOYSA-N O-methyleugenol Chemical compound COC1=CC=C(CC=C)C=C1OC ZYEMGPIYFIJGTP-UHFFFAOYSA-N 0.000 claims description 14
- 230000000844 anti-bacterial effect Effects 0.000 claims description 14
- NNWHUJCUHAELCL-SNAWJCMRSA-N Methyl isoeugenol Natural products COC1=CC=C(\C=C\C)C=C1OC NNWHUJCUHAELCL-SNAWJCMRSA-N 0.000 claims description 7
- NNWHUJCUHAELCL-UHFFFAOYSA-N cis-Methyl isoeugenol Natural products COC1=CC=C(C=CC)C=C1OC NNWHUJCUHAELCL-UHFFFAOYSA-N 0.000 claims description 7
- BJIOGJUNALELMI-ARJAWSKDSA-N cis-isoeugenol Chemical compound COC1=CC(\C=C/C)=CC=C1O BJIOGJUNALELMI-ARJAWSKDSA-N 0.000 claims description 7
- 229940116837 methyleugenol Drugs 0.000 claims description 7
- PRHTXAOWJQTLBO-UHFFFAOYSA-N methyleugenol Natural products COC1=CC=C(C(C)=C)C=C1OC PRHTXAOWJQTLBO-UHFFFAOYSA-N 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 description 23
- -1 alkyl hydrogen peroxides Chemical class 0.000 description 18
- 239000000796 flavoring agent Substances 0.000 description 13
- 239000004094 surface-active agent Substances 0.000 description 13
- 230000000052 comparative effect Effects 0.000 description 12
- 230000002087 whitening effect Effects 0.000 description 12
- 235000002639 sodium chloride Nutrition 0.000 description 11
- 239000004615 ingredient Substances 0.000 description 10
- 235000013355 food flavoring agent Nutrition 0.000 description 9
- 239000000463 material Substances 0.000 description 9
- 150000003839 salts Chemical class 0.000 description 9
- 239000002562 thickening agent Substances 0.000 description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 8
- 239000003082 abrasive agent Substances 0.000 description 8
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 8
- 235000003599 food sweetener Nutrition 0.000 description 8
- 239000003765 sweetening agent Substances 0.000 description 8
- 210000000214 mouth Anatomy 0.000 description 7
- 239000003755 preservative agent Substances 0.000 description 7
- IUTCEZPPWBHGIX-UHFFFAOYSA-N tin(2+) Chemical compound [Sn+2] IUTCEZPPWBHGIX-UHFFFAOYSA-N 0.000 description 7
- 229910019142 PO4 Inorganic materials 0.000 description 6
- 230000002272 anti-calculus Effects 0.000 description 6
- 239000003906 humectant Substances 0.000 description 6
- 235000021317 phosphate Nutrition 0.000 description 6
- 229910052708 sodium Inorganic materials 0.000 description 6
- 239000011734 sodium Substances 0.000 description 6
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 6
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 6
- 239000002253 acid Substances 0.000 description 5
- 239000003963 antioxidant agent Substances 0.000 description 5
- 235000006708 antioxidants Nutrition 0.000 description 5
- 229940043256 calcium pyrophosphate Drugs 0.000 description 5
- 239000003086 colorant Substances 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 150000002978 peroxides Chemical class 0.000 description 5
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 5
- 159000000000 sodium salts Chemical class 0.000 description 5
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
- 239000003513 alkali Substances 0.000 description 4
- 150000001342 alkaline earth metals Chemical class 0.000 description 4
- 125000000129 anionic group Chemical group 0.000 description 4
- 239000011575 calcium Substances 0.000 description 4
- 229910052791 calcium Inorganic materials 0.000 description 4
- 235000001465 calcium Nutrition 0.000 description 4
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 4
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 4
- 235000019634 flavors Nutrition 0.000 description 4
- 208000007565 gingivitis Diseases 0.000 description 4
- 125000000864 peroxy group Chemical group O(O*)* 0.000 description 4
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 3
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 3
- 206010018276 Gingival bleeding Diseases 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 239000007844 bleaching agent Substances 0.000 description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 3
- 229920001525 carrageenan Polymers 0.000 description 3
- 235000011180 diphosphates Nutrition 0.000 description 3
- 239000000975 dye Substances 0.000 description 3
- 208000011759 gum bleeding Diseases 0.000 description 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 3
- 229940074371 monofluorophosphate Drugs 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- XHXUANMFYXWVNG-ADEWGFFLSA-N (-)-Menthyl acetate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(C)=O XHXUANMFYXWVNG-ADEWGFFLSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 2
- 239000000120 Artificial Saliva Substances 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 235000005881 Calendula officinalis Nutrition 0.000 description 2
- 240000001432 Calendula officinalis Species 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
- 208000006558 Dental Calculus Diseases 0.000 description 2
- JKLISIRFYWXLQG-UHFFFAOYSA-N Epioleonolsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4CCC3C21C JKLISIRFYWXLQG-UHFFFAOYSA-N 0.000 description 2
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- YBRJHZPWOMJYKQ-UHFFFAOYSA-N Oleanolic acid Natural products CC1(C)CC2C3=CCC4C5(C)CCC(O)C(C)(C)C5CCC4(C)C3(C)CCC2(C1)C(=O)O YBRJHZPWOMJYKQ-UHFFFAOYSA-N 0.000 description 2
- DLRVVLDZNNYCBX-UHFFFAOYSA-N Polydextrose Polymers OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(O)O1 DLRVVLDZNNYCBX-UHFFFAOYSA-N 0.000 description 2
- 229920000388 Polyphosphate Polymers 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- 239000004376 Sucralose Substances 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 240000008042 Zea mays Species 0.000 description 2
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 2
- 239000002535 acidifier Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 229910052788 barium Inorganic materials 0.000 description 2
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 2
- 239000002610 basifying agent Substances 0.000 description 2
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 description 2
- 239000006172 buffering agent Substances 0.000 description 2
- 235000010418 carrageenan Nutrition 0.000 description 2
- 239000000679 carrageenan Substances 0.000 description 2
- 229940113118 carrageenan Drugs 0.000 description 2
- QBWCMBCROVPCKQ-UHFFFAOYSA-N chlorous acid Chemical class OCl=O QBWCMBCROVPCKQ-UHFFFAOYSA-N 0.000 description 2
- 235000005822 corn Nutrition 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 description 2
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical class [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 235000019820 disodium diphosphate Nutrition 0.000 description 2
- GYQBBRRVRKFJRG-UHFFFAOYSA-L disodium pyrophosphate Chemical compound [Na+].[Na+].OP([O-])(=O)OP(O)([O-])=O GYQBBRRVRKFJRG-UHFFFAOYSA-L 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000010642 eucalyptus oil Substances 0.000 description 2
- 229940044949 eucalyptus oil Drugs 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 229960002737 fructose Drugs 0.000 description 2
- 229910021485 fumed silica Inorganic materials 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Chemical class Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 description 2
- 239000002054 inoculum Substances 0.000 description 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 229910052744 lithium Inorganic materials 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- WWOYCMCZTZTIGU-UHFFFAOYSA-L magnesium;2-carboxybenzenecarboperoxoate;hexahydrate Chemical compound O.O.O.O.O.O.[Mg+2].OOC(=O)C1=CC=CC=C1C([O-])=O.OOC(=O)C1=CC=CC=C1C([O-])=O WWOYCMCZTZTIGU-UHFFFAOYSA-L 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- 235000013615 non-nutritive sweetener Nutrition 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 229940100243 oleanolic acid Drugs 0.000 description 2
- 239000007800 oxidant agent Substances 0.000 description 2
- 239000003002 pH adjusting agent Substances 0.000 description 2
- 150000004965 peroxy acids Chemical class 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 229920005646 polycarboxylate Polymers 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 229920000098 polyolefin Polymers 0.000 description 2
- 239000001205 polyphosphate Substances 0.000 description 2
- 235000011176 polyphosphates Nutrition 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- XXQBEVHPUKOQEO-UHFFFAOYSA-N potassium superoxide Chemical compound [K+].[K+].[O-][O-] XXQBEVHPUKOQEO-UHFFFAOYSA-N 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- HZLWUYJLOIAQFC-UHFFFAOYSA-N prosapogenin PS-A Natural products C12CC(C)(C)CCC2(C(O)=O)CCC(C2(CCC3C4(C)C)C)(C)C1=CCC2C3(C)CCC4OC1OCC(O)C(O)C1O HZLWUYJLOIAQFC-UHFFFAOYSA-N 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 2
- 239000001488 sodium phosphate Substances 0.000 description 2
- 235000019832 sodium triphosphate Nutrition 0.000 description 2
- 235000010356 sorbitol Nutrition 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 235000019408 sucralose Nutrition 0.000 description 2
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 239000006188 syrup Substances 0.000 description 2
- 235000020357 syrup Nutrition 0.000 description 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
- FWPIDFUJEMBDLS-UHFFFAOYSA-L tin(II) chloride dihydrate Chemical compound O.O.Cl[Sn]Cl FWPIDFUJEMBDLS-UHFFFAOYSA-L 0.000 description 2
- 239000000606 toothpaste Substances 0.000 description 2
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- MVJLKNMWTBNBQH-UHFFFAOYSA-N (2,3-diamino-4,5-diethylphenyl)-(2,3-dibenzylphenyl)-phenylmethanol Chemical compound C(C1=CC=CC=C1)C=1C(=C(C=CC=1)C(O)(C1=C(C(=C(C(=C1)CC)CC)N)N)C1=CC=CC=C1)CC1=CC=CC=C1 MVJLKNMWTBNBQH-UHFFFAOYSA-N 0.000 description 1
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 1
- 239000001605 (5-methyl-2-propan-2-ylcyclohexyl) acetate Substances 0.000 description 1
- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 1
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
- WEEGYLXZBRQIMU-UHFFFAOYSA-N 1,8-cineole Natural products C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 1
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 description 1
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- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
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- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
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- 239000004299 sodium benzoate Substances 0.000 description 1
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- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
- 229940079862 sodium lauryl sarcosinate Drugs 0.000 description 1
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- 150000003512 tertiary amines Chemical class 0.000 description 1
- CWERGRDVMFNCDR-UHFFFAOYSA-M thioglycolate(1-) Chemical compound [O-]C(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-M 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
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- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
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- 229960003500 triclosan Drugs 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 235000019801 trisodium phosphate Nutrition 0.000 description 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 1
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 1
- VSJRDSLPNMGNFG-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate;trihydrate Chemical compound O.O.O.[Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O VSJRDSLPNMGNFG-UHFFFAOYSA-H 0.000 description 1
- 229960003165 vancomycin Drugs 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 239000011746 zinc citrate Substances 0.000 description 1
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- 235000006076 zinc citrate Nutrition 0.000 description 1
- 229940085658 zinc citrate trihydrate Drugs 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 229960001296 zinc oxide Drugs 0.000 description 1
- 235000014692 zinc oxide Nutrition 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
An oral care composition, including a mixture of antibacterial agents, the mixture of antibacterial agents including oleanic acid and eugenol at a 2:1 to 3:1 weight ratio.
Description
ORAL CARE COMPOSITION
BACKGROUND
[0001] Gum bleeding is associated with many common oral conditions, such as gingivitis. Gum bleeding may be caused by a buildup of plaque, a soft, sticky, colorless film of bacteria that forms on the teeth and gums, and produces toxins that may inflame or infect the gum tissue to cause gingivitis. Gingivitis is the initial stage of gum disease and, if left untreated, may cause periodontitis.
BACKGROUND
[0001] Gum bleeding is associated with many common oral conditions, such as gingivitis. Gum bleeding may be caused by a buildup of plaque, a soft, sticky, colorless film of bacteria that forms on the teeth and gums, and produces toxins that may inflame or infect the gum tissue to cause gingivitis. Gingivitis is the initial stage of gum disease and, if left untreated, may cause periodontitis.
[0002] Among other uses, antibacterial agents have been used in oral care products to reduce plaque and gingivitis, and hence reduce gum bleeding. However, the antibacterial efficacy of compounds may be affected by other active ingredients in the oral care product, or by limits on the amounts of an antibacterial agent that can be used.
[0003] Accordingly, it would be useful to develop oral care compositions, such as toothpastes and mouthwashes, configured to provide improved antibacterial efficacy.
Additionally, it would be useful to develop oral care composition with natural or botanically-based active ingredients.
BRIEF SUMMARY
Additionally, it would be useful to develop oral care composition with natural or botanically-based active ingredients.
BRIEF SUMMARY
[0004] This summary is intended merely to introduce a simplified summary of some aspects of one or more embodiments of the present disclosure. Further areas of applicability of the present invention will become apparent from the detailed description provided hereinafter. This summary is not an extensive overview, nor is it intended to identify key or critical elements of the present teachings, nor to delineate the scope of the disclosure. Rather, its purpose is merely to present one or more concepts in simplified form as a prelude to the detailed description below.
[0005] The foregoing and/or other aspects and utilities embodied in the present disclosure may be achieved by providing an oral care composition, including from 0.04 weight %
to 2.80 weight %
of a mixture of antibacterial agents, based on a total weight of the oral care composition, wherein the mixture of antibacterial agents includes oleanic acid and eugenol at a 2:1 to 3:1 weight ratio.
to 2.80 weight %
of a mixture of antibacterial agents, based on a total weight of the oral care composition, wherein the mixture of antibacterial agents includes oleanic acid and eugenol at a 2:1 to 3:1 weight ratio.
[0006] Eugenol may include one or more of eugenol, methyl eugenol, iso-eugenol, or mixtures thereof.
[0007] The oral care composition may include from 0.10 weight % to 1.0 weight % of the mixture of antibacterial agents.
[0008] The mixture of antibacterial agents may include oleanic acid and eugenol at a 2:1 weight ratio.
[0009] The mixture of antibacterial agents may consist essentially of oleanic acid and eugenol at a2:1 weight ratio.
[0010] The oral care composition may include from 0.02 weight % to 2.0 weight % of oleanic acid, based on the total weight of the oral care composition; and from 0.01 weight % to 1.0 weight % of eugenol, based on the total weight of the oral care composition.
[0011] The oral care composition may include from 0.05 weight % to 0.50 weight % of oleanic acid; and from 0.025 weight % to 0.25 weight % of eugenol.
[0012] The oral care composition may include 0.10 weight % of oleanic acid;
and 0.05 weight %
of eugenol.
and 0.05 weight %
of eugenol.
[0013] Other than the mixture of antibacterial agents, the oral care composition may lack another antibacterial agent.
[0014] The foregoing and/or other aspects and utilities embodied in the present disclosure may also be achieved by providing a method for increasing the antibacterial effect of an oral care composition, including adding a mixture of antibacterial agents to the oral care composition, wherein the mixture of antibacterial agents includes oleanic acid and eugenol at a 2:1 to 3:1 weight ratio.
[0015] Eugenol may include one or more of eugenol, methyl eugenol, iso-eugenol, or mixtures thereof.
[0016] The mixture of antibacterial agents may include oleanic acid and eugenol at a 2:1 weight ratio.
[0017] The mixture of antibacterial agents may consist essentially of oleanic acid and eugenol at a2:1 weight ratio.
[0018] Other than the mixture of antibacterial agents, the oral care composition may lack another antibacterial agent.
DETAILED DESCRIPTION
DETAILED DESCRIPTION
[0019] Reference will now be made in detail to the various embodiments in the present disclosure.
The embodiments are described below to provide a more complete understanding of the components, processes, compositions, and apparatuses disclosed herein. Any examples given are intended to be illustrative, and not restrictive. However, it will be apparent to one of ordinary skill in the art that the invention may be practiced without these specific details.
In other instances, well-known methods, procedures, and components have not been described in detail so as not to unnecessarily obscure aspects of the embodiments.
The embodiments are described below to provide a more complete understanding of the components, processes, compositions, and apparatuses disclosed herein. Any examples given are intended to be illustrative, and not restrictive. However, it will be apparent to one of ordinary skill in the art that the invention may be practiced without these specific details.
In other instances, well-known methods, procedures, and components have not been described in detail so as not to unnecessarily obscure aspects of the embodiments.
[0020] Throughout the specification and claims, the following terms take the meanings explicitly associated herein, unless the context clearly dictates otherwise. Phrases such as "in an embodiment," "in certain embodiments," and "in some embodiments" as used herein do not necessarily refer to the same embodiment(s), though they may. Furthermore, the phrases "in another embodiment" and "in some other embodiments" as used herein do not necessarily refer to a different embodiment, although they may. As described below, various embodiments may be readily combined, without departing from the scope or spirit of the present disclosure.
[0021] As used herein, the term "or" is an inclusive operator, and is equivalent to the term "and/or," unless the context clearly dictates otherwise. The term "based on"
is not exclusive and allows for being based on additional factors not described, unless the context clearly dictates otherwise. In the specification, the recitation of "at least one of A, B, and C," includes embodiments containing A, B, or C, multiple examples of A, B, or C, or combinations of A/B, A/C, B/C, A/B/B/ B/B/C, A/B/C, etc. In addition, throughout the specification, the meaning of "a," "an," and "the" include plural references. The meaning of "in" includes "in" and "on."
is not exclusive and allows for being based on additional factors not described, unless the context clearly dictates otherwise. In the specification, the recitation of "at least one of A, B, and C," includes embodiments containing A, B, or C, multiple examples of A, B, or C, or combinations of A/B, A/C, B/C, A/B/B/ B/B/C, A/B/C, etc. In addition, throughout the specification, the meaning of "a," "an," and "the" include plural references. The meaning of "in" includes "in" and "on."
[0022] It will also be understood that, although the terms first, second, etc.
may be used herein to describe various elements, these elements should not be limited by these terms. These terms are only used to distinguish one element from another. For example, a first object, component, or step could be termed a second object, component, or step, and, similarly, a second object, component, or step could be termed a first object, component, or step, without departing from the scope of the invention. The first object, component, or step, and the second object, component, or step, are both, objects, components, or steps, respectively, but they are not to be considered the same object, component, or step. It will be further understood that the terms "includes,"
"including,"
"comprises" and/or "comprising," when used in this specification, specify the presence of stated features, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, steps, operations, elements, components, and/or groups thereof. Further, as used herein, the term "if" may be construed to mean "when" or "upon" or "in response to determining" or "in response to detecting," depending on the context.
may be used herein to describe various elements, these elements should not be limited by these terms. These terms are only used to distinguish one element from another. For example, a first object, component, or step could be termed a second object, component, or step, and, similarly, a second object, component, or step could be termed a first object, component, or step, without departing from the scope of the invention. The first object, component, or step, and the second object, component, or step, are both, objects, components, or steps, respectively, but they are not to be considered the same object, component, or step. It will be further understood that the terms "includes,"
"including,"
"comprises" and/or "comprising," when used in this specification, specify the presence of stated features, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, steps, operations, elements, components, and/or groups thereof. Further, as used herein, the term "if" may be construed to mean "when" or "upon" or "in response to determining" or "in response to detecting," depending on the context.
[0023] All physical properties that are defined hereinafter are measured at 20 to 25 Celsius unless otherwise specified.
[0024] When referring to any numerical range of values herein, such ranges are understood to include each and every number and/or fraction between the stated range minimum and maximum, as well as the endpoints. For example, a range of 0.5-6% would expressly include all intermediate values of, for example, 0.6%, 0.7%, and 0.9%, all the way up to and including 5.95%, 5.97%, and 5.99%, among many others. The same applies to each other numerical property and/or elemental range set forth herein, unless the context clearly dictates otherwise.
[0025] Additionally, all numerical values are "about" or "approximately" the indicated value, and take into account experimental error and variations that would be expected by a person having ordinary skill in the art. It should be appreciated that all numerical values and ranges disclosed herein are approximate values and ranges, whether "about" is used in conjunction therewith.
[0026] Unless otherwise specified, all percentages and amounts expressed herein and elsewhere in the specification should be understood to refer to percentages by weight.
The amounts given are based on the active weight of the material.
The amounts given are based on the active weight of the material.
[0027] With regard to procedures, methods, techniques, and workflows that are in accordance with some embodiments, some operations in the procedures, methods, techniques, and workflows disclosed herein may be combined and/or the order of some operations may be changed.
[0028] The inventors have surprisingly discovered a new, synergistic, mixture of antibacterial agents that lead to improve antibacterial efficacy. An oral care composition as disclosed herein includes a mixture of antibacterial agents. The mixture of antibacterial agents provides an improved antibacterial effect. The mixture of antibacterial agents includes oleanic acid and eugenol. In particular, the mixture of antibacterial agents includes oleanic acid and eugenol at a 2:1 to 3:1 ratio by weight. For example, the mixture of antibacterial agents may include oleanic acid and eugenol at a 2:1 ratio by weight.
[0029] In some embodiments, the mixture of antibacterial agents consists essentially of oleanic acid and eugenol. For example, the mixture of antibacterial agents may consist essentially of oleanic acid and eugenol at a 2:1 to 3:1 ratio by weight. For example, the mixture of antibacterial agents may consist essentially of oleanic acid and eugenol at a 2:1 ratio by weight.
[0030] In some embodiments, the mixture of antibacterial agents is derived from or based upon compounds or extracts isolated from plants.
[0031] Formula 1 illustrates a chemical structure of oleanic acid. Oleanic or oleanolic acid (30-hydroxy-olea-12-en-28-oic) is a pentacyclic triterpenoid that is widely distributed in plants. For example, oleanic acid may be extracted from a number of medicinal plants, such as Calendula officinalis L. (marigold), Ligustrum lucidum Ait (oleaceae), and Hemsleya Chinensis Cogn.
Formula 1:
, 1 , -...--' ,....----õ, ,---SCOOH
"--HO."',;(.1t ---/ \H
Formula 1:
, 1 , -...--' ,....----õ, ,---SCOOH
"--HO."',;(.1t ---/ \H
[0032] Formula 2 illustrates a chemical structure of eugenol. Eugenol (4-ally1-2-methoxyphenol), is a naturally occurring phenol essential oil extracted from, for example, cloves, nutmeg, cinnamon, basil, and bay leaf. Eugenol may also be provided as methyl eugenol or iso-eugenol.
Formula 2:
OH
:
Ts-1,
Formula 2:
OH
:
Ts-1,
[0033] As described above, the inventors have surprisingly discovered that the combination of oleanic acid and eugenol has increased antibacterial effects. In some embodiments, the antibacterial effects of oleanic acid combined with eugenol are greater than those of oleanic acid or eugenol separately. In other embodiments, the antibacterial effects of oleanic acid combined with eugenol at a 2:1 ratio are greater than those of oleanic acid combined with eugenol at other ratios, such as 3:1 or greater.
[0034] In certain embodiments, the mixture of antibacterial agents including oleanic acid and eugenol is the only antibacterial agent present in the oral care composition.
In other embodiments, the oral care composition includes no other antibacterial agents apart from the mixture of antibacterial agents.
In other embodiments, the oral care composition includes no other antibacterial agents apart from the mixture of antibacterial agents.
[0035] In certain embodiments, the oral care composition includes from about 0.04 weight % to about 2.8 weight % mixture of antibacterial agents, based on the total weight of the oral care composition. For example, the oral care composition includes from about 0.05 weight % to about 2.0 weight % mixture of antibacterial agents, from about 0.1 weight % to about 1 weight % mixture of antibacterial agents, or from about 0.1 weight % to about 0.5 weight %
mixture of antibacterial agents, based on the total weight of the oral care composition. In one implementation, the oral care composition includes about 0.15 weight % mixture of antibacterial agents.
mixture of antibacterial agents, based on the total weight of the oral care composition. In one implementation, the oral care composition includes about 0.15 weight % mixture of antibacterial agents.
[0036] As described above, the mixture of antibacterial agents includes oleanic acid and eugenol.
Eugenol may also be provided as eugenol, methyl eugenol, iso-eugenol, or combinations thereof.
The mixture of antibacterial agents includes oleanic acid and eugenol at a 2:1 ratio by weight. In some embodiments, the mixture of antibacterial agents may include additional antibacterial agents.
In other embodiments, the mixture of antibacterial agents only includes oleanic acid and eugenol.
Eugenol may also be provided as eugenol, methyl eugenol, iso-eugenol, or combinations thereof.
The mixture of antibacterial agents includes oleanic acid and eugenol at a 2:1 ratio by weight. In some embodiments, the mixture of antibacterial agents may include additional antibacterial agents.
In other embodiments, the mixture of antibacterial agents only includes oleanic acid and eugenol.
[0037] For example, the oral care composition may include from about 0.02 weight % to about 2.0 weight %, from about 0.05 weight % to about 0.5 weight %, from about 0.1 weight % to about 0.25 weight %, or from about 0.1 weight % to about 0.2 weight % oleanic acid, based on the total weight of the oral care composition. In one preferred embodiment, the oral care composition may include 0.10 weight % oleanic acid. Correspondingly, the oral care composition may include from 0.01 weight % to 1.0 weight % eugenol, based on the total weight of the oral care composition.
For example, the oral care composition includes from about 0.025 weight % to about 0.25 weight %, from about 0.02 weight % to about 0.6 weight %, from about 0.04 weight % to about 0.2 weight %, or from about 0.05 weight % to about 0.10 weight % eugenol, based on the total weight of the oral care composition. In a preferred embodiment, the oral care composition may include 0.05 weight % eugenol. In some embodiments, the oral care composition may include methyl eugenol and/or iso eugenol instead of or in addition to eugenol.
For example, the oral care composition includes from about 0.025 weight % to about 0.25 weight %, from about 0.02 weight % to about 0.6 weight %, from about 0.04 weight % to about 0.2 weight %, or from about 0.05 weight % to about 0.10 weight % eugenol, based on the total weight of the oral care composition. In a preferred embodiment, the oral care composition may include 0.05 weight % eugenol. In some embodiments, the oral care composition may include methyl eugenol and/or iso eugenol instead of or in addition to eugenol.
[0038] Generally, viscosity is an important parameter for oral care compositions, such as toothpastes or whitening gels. For example, when the viscosity of an oral care composition is too low, it may become too runny and physical phase separation may take place. In some cases, this will not only affect the aesthetics of the oral care composition but also the homogeneity of the ingredients in the oral care composition. On the other hand, if the viscosity of the oral care compositions is too high, the oral care composition will be difficult to manufacture and package.
In addition, oral care compositions with high viscosity are very difficult for users to evacuate from commonly used packages, such as tubes or syringes. Accordingly, it's important to select ingredients for oral care compositions that achieve a desirable range of viscosity to ensure product manufacturability, stability, and quality, as well as consumer acceptance.
In addition, oral care compositions with high viscosity are very difficult for users to evacuate from commonly used packages, such as tubes or syringes. Accordingly, it's important to select ingredients for oral care compositions that achieve a desirable range of viscosity to ensure product manufacturability, stability, and quality, as well as consumer acceptance.
[0039] In some embodiments, the viscosity of the oral care composition is from about 10,000 centipoise (cPs) to about 500,000 cPs at 25 C. For example, the viscosity of the oral care composition is from about 50,000 cPs to about 400,000 cPs at 25 C. In one embodiment, the viscosity of the oral care composition is from about 125,000 cPs to about 300,000 cPs at 25 C.
[0040] In some embodiments, the oral care composition may include additional ingredients common to oral care compositions, such as carriers, dispersants, whitening agents, flavoring agents, tartar control agents, surfactants, sweeteners, humectants, colorants, antibacterial agents, preservatives, dyes, and pigments.
[0041] All ingredients used in the compositions described herein should be orally acceptable.
"Orally acceptable" means an ingredient which is present in the composition as described in an amount and form which does not render the composition unsafe, unpalatable, or otherwise unsuitable for use in the oral cavity. In addition, the additional ingredients should not substantially inhibit the efficacy of the mixture of antibacterial agents described above.
"Orally acceptable" means an ingredient which is present in the composition as described in an amount and form which does not render the composition unsafe, unpalatable, or otherwise unsuitable for use in the oral cavity. In addition, the additional ingredients should not substantially inhibit the efficacy of the mixture of antibacterial agents described above.
[0042] In various embodiments of the present disclosure, the oral care composition includes an orally acceptable carrier. As used herein, an "orally acceptable carrier"
refers to a material or combination of materials that are safe for use in the oral care compositions of the present disclosure while retaining significant efficacy for the mixture of antibacterial agents.
In certain embodiments, the carrier is specifically selected to ensure that there is no substantially reduction in efficacy for the mixture of antibacterial agents. For example, the oral care composition may use water as the carrier. In certain embodiments, the oral care composition includes 90 weight % or less, 70 weight % or less, or 50 weight % or less carrier, based on the total weight of the oral care composition.
refers to a material or combination of materials that are safe for use in the oral care compositions of the present disclosure while retaining significant efficacy for the mixture of antibacterial agents.
In certain embodiments, the carrier is specifically selected to ensure that there is no substantially reduction in efficacy for the mixture of antibacterial agents. For example, the oral care composition may use water as the carrier. In certain embodiments, the oral care composition includes 90 weight % or less, 70 weight % or less, or 50 weight % or less carrier, based on the total weight of the oral care composition.
[0043] In certain embodiments, the oral care composition may include one or more humectants.
In some embodiments, the humectant is a mixture of humectants, such as glycerin and sorbitol, and a polyhydric alcohol, such as propylene glycol, butylene glycol, hexylene glycol, polyethylene glycol. In certain embodiments, the oral care composition includes from 5 weight % to 40 weight % or from 10 weight % to 30 weight % humectant, based on a total weight of the oral care composition.
In some embodiments, the humectant is a mixture of humectants, such as glycerin and sorbitol, and a polyhydric alcohol, such as propylene glycol, butylene glycol, hexylene glycol, polyethylene glycol. In certain embodiments, the oral care composition includes from 5 weight % to 40 weight % or from 10 weight % to 30 weight % humectant, based on a total weight of the oral care composition.
[0044] The oral care composition may include one or more whitening agent. As used herein, a "whitening agent" is a material that affects whitening of a tooth surface to which it is applied. For example, in some embodiments, the whitening agent is an oxidizing agent. In its broadest sense, "oxidizing agent" is intended to include those compounds which can accept an electron from another molecule in the environment of the oral cavity without having a deleterious or unacceptably harmful effect on the oral cavity in normal and accepted use.
[0045] In some embodiments, the whitening agent may include peroxides and hydroperoxides, such as hydrogen peroxide, peroxides of alkali and alkaline earth metals, organic peroxy compounds, peroxy acids, salts thereof, and mixtures thereof. Peroxides of alkali and alkaline earth metals include lithium peroxide, potassium peroxide, sodium peroxide, magnesium peroxide, calcium peroxide, barium peroxide, and mixtures thereof. Organic peroxy compounds include urea peroxide, carbamide peroxide (also known as urea hydrogen peroxide), glyceryl hydrogen peroxide, alkyl hydrogen peroxides, dialkyl peroxides, alkyl peroxy acids, peroxy esters, diacyl peroxides, benzoyl peroxide, and monoperoxyphthalate, and mixtures thereof.
Peroxy acids and their salts include organic peroxy acids such as alkyl peroxy acids, and monoperoxyphthalate and mixtures thereof, as well as inorganic peroxy acid salts such as percarbonate, perphosphate, perborate and persilicate salts of alkali and alkaline earth metals such as lithium, potassium, sodium, magnesium, calcium and barium, and mixtures thereof. In some embodiments a non-peroxide whitening agent may be provided. Whitening agents among those useful herein include non-peroxy compounds, such as chlorine dioxide, chlorites and hypochlorites.
Chlorites and hypochlorites include those of alkali and alkaline earth metals such as lithium, potassium, sodium, magnesium, calcium and barium. Non-peroxide whitening agents also include colorants, such as titanium dioxide and hydroxyapatite.
Peroxy acids and their salts include organic peroxy acids such as alkyl peroxy acids, and monoperoxyphthalate and mixtures thereof, as well as inorganic peroxy acid salts such as percarbonate, perphosphate, perborate and persilicate salts of alkali and alkaline earth metals such as lithium, potassium, sodium, magnesium, calcium and barium, and mixtures thereof. In some embodiments a non-peroxide whitening agent may be provided. Whitening agents among those useful herein include non-peroxy compounds, such as chlorine dioxide, chlorites and hypochlorites.
Chlorites and hypochlorites include those of alkali and alkaline earth metals such as lithium, potassium, sodium, magnesium, calcium and barium. Non-peroxide whitening agents also include colorants, such as titanium dioxide and hydroxyapatite.
[0046] In some embodiments, the oral care composition includes from about 0.01% to about 50%
whitening agent based on a total weight of the oral care composition. For example, the oral care composition includes from about 0.05 weight % to about 40 weight % whitening agent. In one embodiment, the oral care composition includes about 0.1 weight % whitening agent based on a total weight of the oral care composition.
whitening agent based on a total weight of the oral care composition. For example, the oral care composition includes from about 0.05 weight % to about 40 weight % whitening agent. In one embodiment, the oral care composition includes about 0.1 weight % whitening agent based on a total weight of the oral care composition.
[0047] In one embodiment, the oral care composition includes one or more surfactants. In some embodiments, the surfactants enhance stability of the composition, help clean the oral cavity surfaces through detergency, and provide foam upon agitation, e.g., during brushing with an oral care composition of the disclosure. Surfactants or surface active agents generally achieve increased whitening action by thoroughly dispersing the whitening agent throughout the oral cavity. In various embodiments, suitable surface active agents may function as a surface active agent, emulsifier, and/or foam modulator.
[0048] Any orally acceptable surfactant, most of which are anionic, nonionic, cationic, or amphoteric, may be used. A combination of surfactants may also be used.
Suitable anionic surfactants include without limitation water-soluble salts of C8_20 alkyl sulfates, sulfonated monoglycerides of C8_20 fatty acids, sarcosinates, taurates and the like.
Illustrative examples of these and other classes include sodium lauryl sulfate, sodium cocoyl monoglyceride sulfonate, sodium lauryl sarcosinate, sodium lauryl isoethionate, sodium laureth carboxylate, and sodium dodecyl benzenesulfonate. Suitable nonionic surfactants include without limitation poloxamers, polyoxyethylene sorbitan esters, fatty alcohol ethoxylates, alkylphenol ethoxylates, tertiary amine oxides, tertiary phosphine oxides, dialkyl sulfoxides and the like. Suitable amphoteric surfactants include, without limitation, derivatives of C8_20 aliphatic secondary and tertiary amines having an anionic group such as carboxylate, sulfate, sulfonate, phosphate or phosphonate. A suitable example is cocoamidopropyl betaine.
Suitable anionic surfactants include without limitation water-soluble salts of C8_20 alkyl sulfates, sulfonated monoglycerides of C8_20 fatty acids, sarcosinates, taurates and the like.
Illustrative examples of these and other classes include sodium lauryl sulfate, sodium cocoyl monoglyceride sulfonate, sodium lauryl sarcosinate, sodium lauryl isoethionate, sodium laureth carboxylate, and sodium dodecyl benzenesulfonate. Suitable nonionic surfactants include without limitation poloxamers, polyoxyethylene sorbitan esters, fatty alcohol ethoxylates, alkylphenol ethoxylates, tertiary amine oxides, tertiary phosphine oxides, dialkyl sulfoxides and the like. Suitable amphoteric surfactants include, without limitation, derivatives of C8_20 aliphatic secondary and tertiary amines having an anionic group such as carboxylate, sulfate, sulfonate, phosphate or phosphonate. A suitable example is cocoamidopropyl betaine.
[0049] In some embodiments, the oral care composition includes from about 0.01% to about 20.0% surfactant based on a total weight of the oral care composition. For example, the oral care composition includes from about 1.0 weight % to about 10.0 weight %
surfactant. In one embodiment, the oral care composition includes about 2 weight % surfactant based on a total weight of the oral care composition. For example, the oral care composition may include about 2 weight % sodium lauryl sulfate.
surfactant. In one embodiment, the oral care composition includes about 2 weight % surfactant based on a total weight of the oral care composition. For example, the oral care composition may include about 2 weight % sodium lauryl sulfate.
[0050] In certain embodiments, the oral care composition may include thickening agents or thickeners. Any orally acceptable thickening agent may be used, including without limitation carbomers, also known as carboxyvinyl polymers, carrageenans, also known as Irish moss and more particularly carrageenan (iota-carrageenan), high molecular weight polyethylene glycols (such as CARBOWAXTM, available from The Dow Chemical Company), cellulosic polymers such as hydroxyethylcellulose, carboxymethylcellulose ("CMC") and salts thereof, e.g., CMC sodium, natural gums such as karaya, xanthan, gum arabic and tragacanth, colloidal magnesium aluminum silicate, and colloidal or fumed silica and mixtures of the same. The thickening agent may be a combination of one or more orally acceptable thickening agents.
[0051] In some embodiments, the oral care composition includes from about 0.01% to about 30%
thickening agent based on a total weight of the oral care composition. For example, the oral care composition includes from about 0.1 weight % to about 20 weight % thickening agent. In yet another example, the oral care composition includes from about 0.5 weight % to about 10 weight % thickening agent based on a total weight of the oral care composition. For example, the oral care composition may include about 3 weight % fumed silica.
thickening agent based on a total weight of the oral care composition. For example, the oral care composition includes from about 0.1 weight % to about 20 weight % thickening agent. In yet another example, the oral care composition includes from about 0.5 weight % to about 10 weight % thickening agent based on a total weight of the oral care composition. For example, the oral care composition may include about 3 weight % fumed silica.
[0052] In some embodiments, the oral care composition includes an antioxidant.
Acceptable antioxidants include BHA, BHT, vitamin A, carotenoids, vitamin E, flavonoids, polyphenols, ascorbic acid, herbal antioxidants, chlorophyll, melatonin and mixtures thereof. In some embodiments, the oral care composition includes from about 0.001% to about 1%
antioxidants based on a total weight of the oral care composition. In one embodiment, the oral care composition includes about 0.03 weight % antioxidant by weight.
Acceptable antioxidants include BHA, BHT, vitamin A, carotenoids, vitamin E, flavonoids, polyphenols, ascorbic acid, herbal antioxidants, chlorophyll, melatonin and mixtures thereof. In some embodiments, the oral care composition includes from about 0.001% to about 1%
antioxidants based on a total weight of the oral care composition. In one embodiment, the oral care composition includes about 0.03 weight % antioxidant by weight.
[0053] In certain embodiments, the oral care composition includes one or more flavoring agents.
Useful flavoring agents include any material or mixture of materials operable to enhance the taste of the oral care composition. Any orally acceptable natural or synthetic flavoring agent may be used, such as flavoring oils, flavoring aldehydes, esters, alcohols, similar materials, and combinations thereof. Flavoring agents include vanillin, sage, marjoram, parsley oil, spearmint oil, cinnamon oil, oil of wintergreen (methylsalicylate), peppermint oil, clove oil, bay oil, anise oil, eucalyptus oil, citrus oils, fruit oils and essences including those derived from lemon, orange, lime, grapefruit, apricot, banana, grape, apple, strawberry, cherry, pineapple, etc., bean- and nut-derived flavors such as coffee, cocoa, cola, peanut, almond, etc., adsorbed and encapsulated flavorants, and mixtures thereof. Also encompassed within flavoring agents herein are ingredients that provide fragrance and/or other sensory effect in the mouth, including cooling or warming effects. Such ingredients include menthol, menthyl acetate, menthyl lactate, camphor, eucalyptus oil, eucalyptol, anethole, eugenol, cassia, oxanone, x-irisone, propenyl guaiethol, thymol, linalool, benzaldehyde, cinnamaldehyde, N-ethyl-p-menthan-3 -c arboxamine, N,2,3-trimethy1-2-isopropylbutanamide, 3-1-menthoxypropane-1,2-diol, cinnamaldehyde glycerol acetal (CGA), methone glycerol acetal (MGA) and mixtures thereof.
Useful flavoring agents include any material or mixture of materials operable to enhance the taste of the oral care composition. Any orally acceptable natural or synthetic flavoring agent may be used, such as flavoring oils, flavoring aldehydes, esters, alcohols, similar materials, and combinations thereof. Flavoring agents include vanillin, sage, marjoram, parsley oil, spearmint oil, cinnamon oil, oil of wintergreen (methylsalicylate), peppermint oil, clove oil, bay oil, anise oil, eucalyptus oil, citrus oils, fruit oils and essences including those derived from lemon, orange, lime, grapefruit, apricot, banana, grape, apple, strawberry, cherry, pineapple, etc., bean- and nut-derived flavors such as coffee, cocoa, cola, peanut, almond, etc., adsorbed and encapsulated flavorants, and mixtures thereof. Also encompassed within flavoring agents herein are ingredients that provide fragrance and/or other sensory effect in the mouth, including cooling or warming effects. Such ingredients include menthol, menthyl acetate, menthyl lactate, camphor, eucalyptus oil, eucalyptol, anethole, eugenol, cassia, oxanone, x-irisone, propenyl guaiethol, thymol, linalool, benzaldehyde, cinnamaldehyde, N-ethyl-p-menthan-3 -c arboxamine, N,2,3-trimethy1-2-isopropylbutanamide, 3-1-menthoxypropane-1,2-diol, cinnamaldehyde glycerol acetal (CGA), methone glycerol acetal (MGA) and mixtures thereof.
[0054] In some embodiments, the oral care composition includes from about 0.01% to about 5%
flavoring agents based on a total weight of the oral care composition. For example, the oral care composition includes from about 0.05 weight % to about 3 weight % flavoring agents. In yet another embodiment, the oral care composition includes from about 0.1 weight %
to about 3 weight %, from about 0.2 weight % to about 2.5 weight %, or about 1.5 weight %
flavoring agents based on a total weight of the oral care composition. For example, the oral care composition may include about 1.5 weight % of dental cream flavor.
flavoring agents based on a total weight of the oral care composition. For example, the oral care composition includes from about 0.05 weight % to about 3 weight % flavoring agents. In yet another embodiment, the oral care composition includes from about 0.1 weight %
to about 3 weight %, from about 0.2 weight % to about 2.5 weight %, or about 1.5 weight %
flavoring agents based on a total weight of the oral care composition. For example, the oral care composition may include about 1.5 weight % of dental cream flavor.
[0055] In some embodiments, the oral care composition may also include one or more sweeteners.
Sweeteners among those useful herein include orally acceptable natural or artificial, nutritive or non-nutritive sweeteners. Such sweeteners include dextrose, polydextrose, sucrose, maltose, dextrin, dried invert sugar, mannose, xylose, ribose, fructose, levulose, galactose, corn syrup (including high fructose corn syrup and corn syrup solids), partially hydrolyzed starch, hydrogenated starch hydrolysate, sorbitol, mannitol, xylitol, maltitol, isomalt, aspartame, neotame, saccharin and salts thereof, sucralose, dipeptide-based intense sweeteners, cyclamates, dihydrochalcones and mixtures thereof. Some embodiments may include one or more sweeteners.
In some embodiments, the oral care composition includes from about 0.005% to about 5%
sweeteners based on a total weight of the oral care composition. In other embodiments, the oral care composition includes from about 0.01% to about 1% sweeteners based on a total weight of the oral care composition. For example, the oral care composition may include about 0.5 weight % sodium saccharin and about 0.04 weight % sucralose.
Sweeteners among those useful herein include orally acceptable natural or artificial, nutritive or non-nutritive sweeteners. Such sweeteners include dextrose, polydextrose, sucrose, maltose, dextrin, dried invert sugar, mannose, xylose, ribose, fructose, levulose, galactose, corn syrup (including high fructose corn syrup and corn syrup solids), partially hydrolyzed starch, hydrogenated starch hydrolysate, sorbitol, mannitol, xylitol, maltitol, isomalt, aspartame, neotame, saccharin and salts thereof, sucralose, dipeptide-based intense sweeteners, cyclamates, dihydrochalcones and mixtures thereof. Some embodiments may include one or more sweeteners.
In some embodiments, the oral care composition includes from about 0.005% to about 5%
sweeteners based on a total weight of the oral care composition. In other embodiments, the oral care composition includes from about 0.01% to about 1% sweeteners based on a total weight of the oral care composition. For example, the oral care composition may include about 0.5 weight % sodium saccharin and about 0.04 weight % sucralose.
[0056] In some embodiments, the oral care composition may include colorants.
Colorants, such as dyes or pigments, may be food color additives presently certified under the Food Drug &
Cosmetic Act for use in food and ingested drugs, including dyes such as FD&C
Red No. 3 (sodium salt of tetraiodofluorescein), Food Red 17, disodium salt of 6-hydroxy-5-{ (2-methoxy-5-methy1-4-sulphophenyl)azo}-2-naphthalenesulfonic acid, Food Yellow 13, sodium salt of a mixture of the mono and disulphonic acids of quinophtalone or 2-(2-quinoly1) indanedione, FD&C Yellow No.
(sodium salt of 4-p-sulfophenylazo- 1-p- sulfopheny1-5-hydroxypyrazole-3 carboxylic acid), FD&C Yellow No. 6 (sodium salt of p-sulfophenylazo-B-naphto1-6-monosulfonate), FD&C Green No. 3 (disodium salt of 4-1 [4-(N-ethyl-p- sulfobenzylamino)-phenyl] -(4-hydroxy-2-sulfoniumpheny1)-methylene } -[1-(N-ethyl-N-p-sulfobenzy1)-DELTA-3,5-cycl-ohexadienimine] , FD&C Blue No. 1 (disodium salt of dibenzyldiethyl-diamino- triphenylcarbinol trisulfonic acid anhydrite), FD&C Blue No. 2 (sodium salt of disulfonic acid of indigotin) and mixtures thereof in various proportions. Typically, colorants, if included, are present in very small quantities.
Colorants, such as dyes or pigments, may be food color additives presently certified under the Food Drug &
Cosmetic Act for use in food and ingested drugs, including dyes such as FD&C
Red No. 3 (sodium salt of tetraiodofluorescein), Food Red 17, disodium salt of 6-hydroxy-5-{ (2-methoxy-5-methy1-4-sulphophenyl)azo}-2-naphthalenesulfonic acid, Food Yellow 13, sodium salt of a mixture of the mono and disulphonic acids of quinophtalone or 2-(2-quinoly1) indanedione, FD&C Yellow No.
(sodium salt of 4-p-sulfophenylazo- 1-p- sulfopheny1-5-hydroxypyrazole-3 carboxylic acid), FD&C Yellow No. 6 (sodium salt of p-sulfophenylazo-B-naphto1-6-monosulfonate), FD&C Green No. 3 (disodium salt of 4-1 [4-(N-ethyl-p- sulfobenzylamino)-phenyl] -(4-hydroxy-2-sulfoniumpheny1)-methylene } -[1-(N-ethyl-N-p-sulfobenzy1)-DELTA-3,5-cycl-ohexadienimine] , FD&C Blue No. 1 (disodium salt of dibenzyldiethyl-diamino- triphenylcarbinol trisulfonic acid anhydrite), FD&C Blue No. 2 (sodium salt of disulfonic acid of indigotin) and mixtures thereof in various proportions. Typically, colorants, if included, are present in very small quantities.
[0057] In some embodiments, the oral care composition may also include one or more pH
modifying agents. The pH modifying agents among those useful herein include acidifying agents to lower pH, basifying agents to raise pH and buffering agents to control pH
within a desired range.
For example, one or more compounds selected from acidifying, basifying and buffering agents can be included to provide a pH of 2 to 10, or in various embodiments from about 2 to about 8, from about 3 to about 9, from about 4 to about 8, from about 5 to about 7, from about 6 to about 10, and from about 7 to about 9. Any orally acceptable pH modifying agent may be used, including without limitation carboxylic, phosphoric and sulfonic acids, acid salts (e.g., monosodium citrate, disodium citrate, monosodium malate, etc.), alkali metal hydroxides such as sodium hydroxide, carbonates such as sodium carbonate, bicarbonates, sesquicarbonates, borates, silicates, phosphates (e.g., monosodium phosphate, trisodium phosphate, pyrophosphate salts, etc.), imidazole and mixtures thereof. One or more pH modifying agents are optionally present in a total amount effective to maintain the composition in an orally acceptable pH range.
In some embodiments, the oral care composition includes from about 0.01% to about 10%
pH modifier agents based on a total weight of the oral care composition. For example, the oral care composition may include about 0.9 weight % sodium acid pyrophosphate (SAPP) and about 2 weight %
tetrasodium pyrophosphate (TSPP) as a pH modifier.
modifying agents. The pH modifying agents among those useful herein include acidifying agents to lower pH, basifying agents to raise pH and buffering agents to control pH
within a desired range.
For example, one or more compounds selected from acidifying, basifying and buffering agents can be included to provide a pH of 2 to 10, or in various embodiments from about 2 to about 8, from about 3 to about 9, from about 4 to about 8, from about 5 to about 7, from about 6 to about 10, and from about 7 to about 9. Any orally acceptable pH modifying agent may be used, including without limitation carboxylic, phosphoric and sulfonic acids, acid salts (e.g., monosodium citrate, disodium citrate, monosodium malate, etc.), alkali metal hydroxides such as sodium hydroxide, carbonates such as sodium carbonate, bicarbonates, sesquicarbonates, borates, silicates, phosphates (e.g., monosodium phosphate, trisodium phosphate, pyrophosphate salts, etc.), imidazole and mixtures thereof. One or more pH modifying agents are optionally present in a total amount effective to maintain the composition in an orally acceptable pH range.
In some embodiments, the oral care composition includes from about 0.01% to about 10%
pH modifier agents based on a total weight of the oral care composition. For example, the oral care composition may include about 0.9 weight % sodium acid pyrophosphate (SAPP) and about 2 weight %
tetrasodium pyrophosphate (TSPP) as a pH modifier.
[0058] The oral care composition may include one or more preservatives. In some embodiments, the preservatives improve an antimicrobial characteristic of the oral care composition to improve storage life or prevent decay.
[0059] In certain embodiments, the one or more preservatives include at least one of sodium benzoate, methyl paraben, ethyl paraben, zinc citrate, zinc oxide, triclosan, stannum salts, and combinations thereof.
[0060] The oral care composition may include an effective amount of preservatives. For example, the oral care composition may include an amount of preservatives effective to reduce a spoilage of the oral care composition during storage or use.
[0061] However, in some implementations, other than the mixture of antibacterial agents, the oral care composition lacks additional antibacterial agents or preservatives.
[0062] The oral care composition of the present disclosure may also include one or more additional active ingredients, which are operable for the prevention or treatment of a condition or disorder of hard or soft tissue of the oral cavity, the prevention or treatment of a physiological disorder or condition, or to provide a cosmetic benefit.
[0063] Some embodiments of the present disclosure include a dental abrasive or combination of dental abrasive agents. As used herein, the term "abrasive" or "abrasive agent" also includes materials commonly referred to as "polishing agents." Any orally acceptable abrasive may be used, but typically, type, fineness (particle size) and amount of abrasive should be selected so that tooth enamel is not excessively abraded in normal use of the composition.
Suitable abrasives include without limitation silica (in the form of silica gel, hydrated silica or precipitated silica), alumina, insoluble phosphates, calcium carbonate, resinous abrasives such as urea-formaldehyde condensation products and the like.
Suitable abrasives include without limitation silica (in the form of silica gel, hydrated silica or precipitated silica), alumina, insoluble phosphates, calcium carbonate, resinous abrasives such as urea-formaldehyde condensation products and the like.
[0064] Among insoluble phosphates useful as abrasives are orthophosphates, polymetaphosphates and pyrophosphates. Illustrative examples are dicalcium orthophosphate dihydrate, calcium pyrophosphate, n-calcium pyrophosphate, tricalcium phosphate, calcium polymetaphosphate and insoluble sodium polymetaphosphate.
[0065] Average particle size of an abrasive, if present, is generally from about 0.1 to 100 about p.m. For example, the particle size may be from about 1 to about 80 p.m or from about 5 to about 60 p.m. In some embodiments, one or more abrasives are present in an amount of from about 0.01 % to about 70% by weight, based on the total weight of the oral care composition. In other embodiments, the oral care composition includes from about 0.1 weight % to about 60 weight %
abrasives. In some embodiments, the abrasive is calcium pyrophosphate. In some embodiments, the oral care composition includes from 0.01 weight % to about 70 weight %
calcium pyrophosphate based on a total weight of the oral care composition. In another embodiment, the oral care composition includes about 20 weight % calcium pyrophosphate.
abrasives. In some embodiments, the abrasive is calcium pyrophosphate. In some embodiments, the oral care composition includes from 0.01 weight % to about 70 weight %
calcium pyrophosphate based on a total weight of the oral care composition. In another embodiment, the oral care composition includes about 20 weight % calcium pyrophosphate.
[0066] In various embodiments of the present disclosure, the oral care composition includes an anticalculus agent. Suitable anticalculus agents include without limitation phosphates and polyphosphates (for example pyrophosphates), polyaminopropanesulfonic acid (AMPS), hexametaphosphate salts, zinc citrate trihydrate, polypeptides, polyolefin sulfonates, polyolefin phosphates, diphosphonates. In some embodiments, the anticalculus agent is present in an amount of from about 0.01% to about 30% weight based on the total weight of the oral care composition.
In some embodiments, the oral care composition includes a mixture of anticalculus agents. In some embodiments, tetrasodium pyrophosphate (TSPP) and sodium tripolyphosphate (STPP) are used as the anticalculus agents. In some embodiments, the anticalculus agent includes from 0.1%
to 10 weight % TSPP, or about 2 weight % TSPP.
In some embodiments, the oral care composition includes a mixture of anticalculus agents. In some embodiments, tetrasodium pyrophosphate (TSPP) and sodium tripolyphosphate (STPP) are used as the anticalculus agents. In some embodiments, the anticalculus agent includes from 0.1%
to 10 weight % TSPP, or about 2 weight % TSPP.
[0067] The oral care compositions of the present disclosure may also include a synthetic anionic polymeric polycarboxylate. The synthetic anionic polymeric polycarboxylate may act as a stabilizer for the polyphosphate anti-tartar agent and may help to block access of painful or pain-causing materials, such as sugars, to the tooth nerves.
[0068] In some embodiments, the oral care composition optionally includes a source of fluoride ions. In some embodiments, the source of fluoride ions is selected from:
fluoride, monofluorophosphate (MFP), and fluorosilicate salts. In some embodiments, one or more fluoride ion-releasing compounds are optionally present in an amount providing a total of 100 to 20,000 ppm, 200 to 5,000 ppm, or 500 to 2,500 ppm, fluoride ions. If present, in some embodiments, the amount of fluoride source in the oral care composition ranges from about 0.01%
to about 10% by weight, based on the total weight of the oral care composition, typically about 0.5% to about 1.5 weight %. For example, the oral care composition may include about 0.76 weight % MFP.
fluoride, monofluorophosphate (MFP), and fluorosilicate salts. In some embodiments, one or more fluoride ion-releasing compounds are optionally present in an amount providing a total of 100 to 20,000 ppm, 200 to 5,000 ppm, or 500 to 2,500 ppm, fluoride ions. If present, in some embodiments, the amount of fluoride source in the oral care composition ranges from about 0.01%
to about 10% by weight, based on the total weight of the oral care composition, typically about 0.5% to about 1.5 weight %. For example, the oral care composition may include about 0.76 weight % MFP.
[0069] The compositions also may include a stannous ion or a stannous ion source to mitigate calcium loss. Suitable stannous ion sources include without limitation stannous fluoride, other stannous halides such as stannous chloride dihydrate, stannous pyrophosphate, organic stannous carboxylate salts such as stannous formate, acetate, gluconate, lactate, tartrate, oxalate, malonate and citrate, stannous ethylene glyoxide and the like. In some embodiments, one or more stannous ion sources are included in the oral care composition. For example, the oral care composition may include from about 0.01% to about 10% stannous ion source by weight, based on the total weight of the oral care composition. In one embodiment, the oral care composition includes from about 0.1 weight % to about 7 weight % stannous ion source or from about 0.2 weight % to about 5 weight % stannous ion source.
EXAMPLES
EXAMPLES
[0070] Aspects of the present disclosure may be further understood by referring to the following examples. The examples are illustrative, and are not intended to be limiting embodiments thereof.
Table 1 illustrates an oral care composition according to embodiments of the present disclosure and three comparative examples. The compositions of Table 1 had the same amount for all ingredients except that Oral Care Composition Example 1 included both oleanic acid and eugenol at a 2:1 weight ratio, while Comparative Example A and Comparative Example B
included only oleanic acid or eugenol, respectively. Comparative Example C included both oleanic acid and eugenol at a 3:1 weight ratio.
Oral Care Comparative Comparative Comparative Ingredient Composition Example A Example B Example C
Example 1 Oleanolic Acid 0.1 % 0.1 % 0.15 %
Eugenol 0.05 % 0.05 % 0.05 %
Humectant 31 %
Thickener 1.0 %
Abrasives 45 %
Surfactants 2.55 %
Sodium 1.1%
monofluorophosphate Tetra sodium 1.1%
pyrophosphate Water, flavor, q.s q.s q.s q.s sweetener and minors
Table 1 illustrates an oral care composition according to embodiments of the present disclosure and three comparative examples. The compositions of Table 1 had the same amount for all ingredients except that Oral Care Composition Example 1 included both oleanic acid and eugenol at a 2:1 weight ratio, while Comparative Example A and Comparative Example B
included only oleanic acid or eugenol, respectively. Comparative Example C included both oleanic acid and eugenol at a 3:1 weight ratio.
Oral Care Comparative Comparative Comparative Ingredient Composition Example A Example B Example C
Example 1 Oleanolic Acid 0.1 % 0.1 % 0.15 %
Eugenol 0.05 % 0.05 % 0.05 %
Humectant 31 %
Thickener 1.0 %
Abrasives 45 %
Surfactants 2.55 %
Sodium 1.1%
monofluorophosphate Tetra sodium 1.1%
pyrophosphate Water, flavor, q.s q.s q.s q.s sweetener and minors
[0071] Table 2 illustrates an antibacterial efficacy of the oral care compositions. The antibacterial composition was measured under the University of Manchester (UoM) biofilm model as follows:
dental plaque was collected from 4 healthy volunteers and pooled together as inoculum. The optical density (OD) of the inoculum was matched to 0.3 absorbance at 610nm.
Sterile HAP disks were incubated under anaerobic conditions at 37 C for 24 hours with 1 ml of sterile artificial saliva (with 0.01% sucrose) and 1 ml of pooled saliva in a 24 well microplate.
Freshly prepared treatment solutions were prepared for each of the composition of Table 1 comprising 1 part composition and 2 parts sterile distilled water. The treatment solutions were then added to the well and allowed to contact with the HAP disks for 10 mins. The treatment solutions were then replaced with 2 ml of sterile PBS and allowed to contact for 1 min. The liquid phase was then removed and replaced by 2 ml of sterile artificial saliva. The disks were treated in triplicates for each composition of Table 1 for 8 days. At intervals of 2, 4, and 8 days the disks were collected aseptically and transferred into half strength pre-reduced thioglycollate medium. 100 Ill of the collected samples were plated in duplicates for each disk on Neomycin-Vancomycin (NV) Agar, for Total Gram negative Anaerobes. Plates were surface spread using a sterile spreader and incubated anaerobically @37 C for 72 hours before counting the colonies. The pH was monitored for the entire period of the study using the liquid phase. The UoM number represents the log CFU/mL of bacterial in the sample. The lower the UoM number, the lower the bacterial concentration and the more effective the antibacterial efficacy of the oral care composition.
Sample Oleanic Acid Eugenol UoM
Oral Care 0.1 % 0.05 % 3.75 Composition #1 Comparative 0.1 % -- 3.92 Example A
Comparative -- 0.05 % 3.88 Example B
Comparative 0.15 % 0.05 % 3.77 Example C
dental plaque was collected from 4 healthy volunteers and pooled together as inoculum. The optical density (OD) of the inoculum was matched to 0.3 absorbance at 610nm.
Sterile HAP disks were incubated under anaerobic conditions at 37 C for 24 hours with 1 ml of sterile artificial saliva (with 0.01% sucrose) and 1 ml of pooled saliva in a 24 well microplate.
Freshly prepared treatment solutions were prepared for each of the composition of Table 1 comprising 1 part composition and 2 parts sterile distilled water. The treatment solutions were then added to the well and allowed to contact with the HAP disks for 10 mins. The treatment solutions were then replaced with 2 ml of sterile PBS and allowed to contact for 1 min. The liquid phase was then removed and replaced by 2 ml of sterile artificial saliva. The disks were treated in triplicates for each composition of Table 1 for 8 days. At intervals of 2, 4, and 8 days the disks were collected aseptically and transferred into half strength pre-reduced thioglycollate medium. 100 Ill of the collected samples were plated in duplicates for each disk on Neomycin-Vancomycin (NV) Agar, for Total Gram negative Anaerobes. Plates were surface spread using a sterile spreader and incubated anaerobically @37 C for 72 hours before counting the colonies. The pH was monitored for the entire period of the study using the liquid phase. The UoM number represents the log CFU/mL of bacterial in the sample. The lower the UoM number, the lower the bacterial concentration and the more effective the antibacterial efficacy of the oral care composition.
Sample Oleanic Acid Eugenol UoM
Oral Care 0.1 % 0.05 % 3.75 Composition #1 Comparative 0.1 % -- 3.92 Example A
Comparative -- 0.05 % 3.88 Example B
Comparative 0.15 % 0.05 % 3.77 Example C
[0072] As illustrated in Table 2, the oral care composition including the mixture of antibacterial agents having a 2:1 ratio of oleanic acid to eugenol displayed enhanced antibacterial efficacy when compared to comparative compositions including oleanic acid or eugenol separately or including other ratios of oleanic acid to eugenol, such as 3:1 as in Comparative Composition C.
[0073] Accordingly, as illustrated in Table 2, Oral care compositions according to embodiments of the present disclosure provide enhanced antibacterial effects due to the synergistic effects of oleanic acid and eugenol when present at a 2:1 weight ratio. In other implementations, oleanic acid and eugenol are present at a weight ratio between 2:1 and 3:1.
[0074] The present disclosure has been described with reference to exemplary embodiments.
Although a few embodiments have been shown and described, it will be appreciated by those skilled in the art that changes may be made in these embodiments without departing from the principles and spirit of preceding detailed description. It is intended that the present disclosure be construed as including all such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.
Although a few embodiments have been shown and described, it will be appreciated by those skilled in the art that changes may be made in these embodiments without departing from the principles and spirit of preceding detailed description. It is intended that the present disclosure be construed as including all such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.
Claims (16)
1. An oral care composition, comprising:
from 0.04 weight % to 2.80 weight % of a mixture of antibacterial agents, based on a total weight of the oral care composition, wherein the mixture of antibacterial agents comprises oleanic acid and eugenol at a 2:1 to 3:1 weight ratio.
from 0.04 weight % to 2.80 weight % of a mixture of antibacterial agents, based on a total weight of the oral care composition, wherein the mixture of antibacterial agents comprises oleanic acid and eugenol at a 2:1 to 3:1 weight ratio.
2. The oral care composition of claim 1, wherein eugenol comprises one or more of eugenol, methyl eugenol, iso-eugenol, or mixtures thereof.
3. The oral care composition of claim 1, comprising from 0.10 weight % to 1.0 weight % of the mixture of antibacterial agents.
4. The oral care composition of claim 1, wherein the mixture of antibacterial agents comprises oleanic acid and eugenol at a 2:1 weight ratio.
5. The oral care composition of claim 1, wherein the mixture of antibacterial agents consists essentially of oleanic acid and eugenol at a 2:1 weight ratio.
6. The oral care composition of claim 1, wherein the oral care composition comprises:
from 0.02 weight % to 2.0 weight % of oleanic acid, based on the total weight of the oral care composition; and from 0.01 weight % to 1.0 weight % of eugenol, based on the total weight of the oral care composition.
from 0.02 weight % to 2.0 weight % of oleanic acid, based on the total weight of the oral care composition; and from 0.01 weight % to 1.0 weight % of eugenol, based on the total weight of the oral care composition.
7. The oral care composition of claim 1, wherein the oral care composition comprises:
from 0.05 weight % to 0.50 weight % of oleanic acid; and from 0.025 weight % to 0.25 weight % of eugenol.
from 0.05 weight % to 0.50 weight % of oleanic acid; and from 0.025 weight % to 0.25 weight % of eugenol.
8. The oral care composition of claim 1, wherein the oral care composition comprises:
0.10 weight % of oleanic acid; and 0.05 weight % of eugenol.
0.10 weight % of oleanic acid; and 0.05 weight % of eugenol.
9. The oral care composition of claim 1, wherein other than the mixture of antibacterial agents, the oral care composition lacks another antibacterial agent.
10. The oral care composition of claim 5, wherein other than the mixture of antibacterial agents, the oral care composition lacks another antibacterial agent.
11. A method for increasing the antibacterial effect of an oral care composition, comprising:
adding a mixture of antibacterial agents to the oral care composition, wherein the mixture of antibacterial agents comprises oleanic acid and eugenol at a 2:1 to 3:1 weight ratio.
adding a mixture of antibacterial agents to the oral care composition, wherein the mixture of antibacterial agents comprises oleanic acid and eugenol at a 2:1 to 3:1 weight ratio.
12. The method of claim 11, wherein eugenol comprises one or more of eugenol, methyl eugenol, iso-eugenol, or mixtures thereof.
13. The method of claim 11, wherein the mixture of antibacterial agents comprises oleanic acid and eugenol at a 2:1 weight ratio.
14. The method of claim 11, wherein the mixture of antibacterial agents consists essentially of oleanic acid and eugenol at a 2:1 weight ratio.
15. The method of claim 11, wherein other than the mixture of antibacterial agents, the oral care composition lacks another antibacterial agent.
16. The method of claim 14, wherein other than the mixture of antibacterial agents, the oral care composition lacks another antibacterial agent.
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MX2020005361A (en) * | 2017-12-01 | 2020-08-13 | Colgate Palmolive Co | Oral care compositions. |
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