CA3128940A1

CA3128940A1 - Pharmaceutical compositions comprising meloxicam

Info

Publication number: CA3128940A1
Application number: CA3128940A
Authority: CA
Inventors: Herriot TABUTEAU
Original assignee: Axsome Therapeutics Inc
Current assignee: Axsome Therapeutics Inc
Priority date: 2019-02-06
Filing date: 2020-02-06
Publication date: 2020-08-13
Anticipated expiration: 2040-02-06
Also published as: ECSP21060962A; CR20210420A; EP3920909A4; JP2024026732A; AU2023202545A1; AU2020218253A1; EP3920909A1; IL285389A; JP2023062144A; BR112021015467A2; CO2021010380A2; JP7420990B2; CN113423397A; SG11202107926XA; PE20212157A1; WO2020163620A1; CA3128940C; AU2020218253B2; JP7237386B2; MA54904A

Abstract

Disclosed herein are compositions comprising an NSAID such as meloxicam and/or rizatriptan in combination with a cyclodextrin and/or a carbonate or a bicarbonate. These compositions may be orally administered, for example, to improve the bioavailability or pharmacokinetics of the NSAID for the treatment of pain such as migraine, arthritis, and other conditions. Also disclosed herein are methods of treating pain, such as migraine, comprising administering meloxicam and rizatriptan to a human being suffering from pain, such as migraine. For migraine, these methods may be particularly useful when the meloxicam and rizatriptan are administered while the human being is suffering from an acute attack of migraine pain or migraine aura. In some embodiments, the combination of meloxicam and rizatriptan may be administered in a manner that results in a Tmax of meloxicam of 3 hours or less.

Description

PHARMACEUTICAL COMPOSITIONS COMPRISING MELOXICAM
Inventor: Herriot Tabuteau CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application claims benefit of U.S. Provisional Pat. App. Nos.
62/802,198, filed February 6, 2019; 62/803,756, filed February 11, 2019; 62/835,613, filed April 18, 2019;
62/846,311, filed May 10, 2019; 62/860,705, filed June 12, 2019; 62/895,933, filed September 4, 2019; 62/895,956, filed September 4, 2019; 62/955,905, and filed December 31, 2019; all of which are incorporated by reference in their entirety.
BACKGROUND

[0002] Meloxicann, which has the structure:
CH, -OH 0 S'N
H

is a nonsteroidal anti-inflammatory (NSAID) drug that exhibits anti-inflammatory, analgesic, and antipyretic activities. The nneloxicann mechanism of action may be related to prostaglandin synthetase (cyclo-oxygenase, COX) inhibition which is involved in the initial steps of the arachidonic acid cascade, resulting in the reduced formation of prostaglandins, thronnboxanes and prostacylin.
SUMMARY

[0003] Meloxicann and some other NSAIDs have poor aqueous solubility which may reduce bioavailability and slow the onset of pain relief resulting from their use. One means of increasing the solubility and bioavailability of nneloxicann is through the use of cyclodextrins. Cyclodextrin (also known as cycloannyloses) are generally cyclic polysaccharides which form a bucket-like shape. Cyclodextrins help to increase bioavailability of other molecules because cyclodextrins are hydrophobic on the inside and hydrophilic on the inside which helps to facilitate the transport of molecules. The naturally occurring cyclodextrins include six, seven, and eight glucose units (a, p, and y-cyclodextrin, respectively). However, synthetic cyclodextrins containing more or less glucose units are possible. In aqueous solutions, cyclodextrins can form complexes (i.e., an inclusion complex) with drugs by incorporating the drug into the center/hydrophobic portion of the cyclodextrin ring; although cyclodextrin compounds are also known to aggregate around a drug in a micelle-type structure. This ability of cyclodextrins may allow them to act as carriers to increase the bioavailability of less soluble drugs.

[0004] Some embodiments include a method of treating migraine comprising:
selecting a human migraine patient with a history of inadequate response to prior migraine treatments, and orally administering a dosage form to the migraine patient, wherein the dosage form comprises a combination of: 1) a complex of nneloxicann with a sulfobutyl ether p-cyclodextrin (SBE(3CD), 2) a bicarbonate, and 3) a rizatriptan.

[0005] Some embodiments include an inclusion complex of nneloxicann in a cyclodextrin.

[0006] Some embodiments include a dosage form comprising: 1) an inclusion complex of nneloxicann and a cyclodextrin, or 2) nneloxicann and a carbonate or a bicarbonate.

[0007] Some embodiments include a method of administering nneloxicann orally, comprising orally administering a dosage form described herein to a patient in need of treatment.

[0008] Some embodiments include a method of administering nneloxicann intravenously, comprising intravenously administering a dosage form described herein to a patient in need of treatment.

[0009] Disclosed herein are formulations for an inclusion complex of cyclodextrin and nneloxicann with bicarbonate and methods of use thereof.

[0010] Disclosed herein are formulations and methods for delivering nneloxicann with cyclodextrin to a subject by oral, enteral, intravenous, intramuscular, subcutaneous, intranasal, or other parenteral means.

[0011]
Disclosed also are methods for treating pain and pain associated with conditions by delivering a dosage form with nneloxicann, cyclodextrin, and bicarbonate by oral, enteral, intravenous, intramuscular, subcutaneous, intranasal, or other parenteral means to a subject.

[0012] A
combination of rizatriptan and nneloxicann (referred to herein for convenience as a "subject combination") may be used to treat a variety of pain conditions.

Rizatriptan has the structure as shown below.
N ,N
Rizatriptan

[0013] Some embodiments include a subject combination comprising: 1) an inclusion complex of nneloxicann and a cyclodextrin, 2) rizatriptan, and 3) a bicarbonate for treating migraine in a human being. The migraine may be treatment-resistant migraine.
The human being may have a history of inadequate response to prior treatments.

[0014] Some embodiments include a subject combination comprising rizatriptan and nneloxicann that has rapid, sustained, substantial and statistically significant efficacy as compared to placebo, rizatriptan, or nneloxicann in the acute treatment of migraine in patients with a history of inadequate response to prior acute treatments.

[0015] Some embodiments include a subject combination comprising rizatriptan and nneloxicann that requires significantly less use of rescue medication as compared to rizatriptan, nneloxicann, or placebo.
BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 is a depiction of the results described in Example 2 and contained in Table 6.

[0017] Figure 2 is another depiction of the results described in Example 2 and contained in Table 6.

[0018] Figure 3 is another depiction of the results described in Example 2 and contained in Table 6.

[0019] Figure 4 is another depiction of the results described in Example 2 and contained in Table 6.

[0020] Figure 5 is another depiction of the results described in Example 2 and contained in Table 6.

[0021] Figure 6 is another depiction of the results described in Example 2 and contained in Table 6.

[0022] Figure 7 is another depiction of the results described in Example 2 and contained in Table 6.

[0023] Figure 8 is another depiction of the results described in Example 2 and contained in Table 6.

[0024] Figure 9 is another depiction of the results described in Example 2 and contained in Table 6.

[0025] Figure 10 is another depiction of the results described in Example 2 and contained in Table 6.

[0026] FIG. 11 is a plot of nneloxicann plasma concentration at various time points over the first 24 hours for an embodiment of a dosage form described herein and a commercially available nneloxicann dosage form.

[0027] FIG. 12 is a plot of nneloxicann plasma concentration at various time points over the first 24 hours for a dosage form of Meloxicann/Rizatriptan described in Example 6 and a commercially available nneloxicann dosage form.

[0028] FIG. 13 is a plot of rizatriptan plasma concentration at various time points over the first 12 hours for a dosage form of Meloxicann/Rizatriptan described in Example 6 and a commercially available nneloxicann dosage form.

[0029] Fig. 14 shows plots of the percentages of subjects reporting pain relief at various time points over the first 4 hours post dose of the dosage forms of Meloxicann/Rizatriptan, rizatriptan, MoSEIC nneloxicann, and placebo described in Example 11.

[0030] Fig. 15 shows the percentages of subjects achieving pain freedom at 2 hours, 4 hours, 12 hours, and 16 hours post dose of the dosage forms of Meloxicann/Rizatriptan, rizatriptan, MoSEIC nneloxicann, and placebo described in Example 11.

[0031] Fig. 16A
shows the percentages of subjects achieving sustained pain freedom from 2 hours to 24 hours post dose of the dosage forms of Meloxicann/Rizatriptan, rizatriptan, MoSEIC nneloxicann, and placebo described in Example 11.

[0032] Fig. 168 shows the percentages of subjects achieving sustained pain relief from 2 hours to 24 hours post dose of the dosage forms of Meloxicann/Rizatriptan, rizatriptan, MoSEIC nneloxicann, and placebo described in Example 11.

[0033] Fig. 17A
shows the percentages of subjects achieving sustained pain freedom from 2 hours to 48 hours post dose of the dosage forms of Meloxicann/Rizatriptan, rizatriptan, MoSEIC nneloxicann, and placebo described in Example 11.

[0034] Fig. 178 shows the percentages of subjects achieving sustained pain relief from 2 hours to 48 hours post dose of the dosage forms of Meloxicann/Rizatriptan, rizatriptan, MoSEIC nneloxicann, and placebo described in Example 11.

[0035] Fig. 18 shows the percentages of subjects who took rescue medication through hour 24 post dose of the dosage forms of Meloxicann/Rizatriptan, rizatriptan, MoSEIC
nneloxicann, and placebo described in Example 11.
DETAILED DESCRIPTION

[0036] Provided herein are dosage forms with NSAIDs (such as nneloxicann) and cyclodextrin (optionally in an inclusion complex), and/or bicarbonate, and methods of treatment using the dosage form.

[0037] A dosage form may be given enterally including, but not limited to, oral, sublingual, or rectal delivery, or parenterally including, but not limited to, intravenous, intramuscular, intranasal, or subcutaneous delivery.

[0038] Some methods include administration of a product that combines an NSAID that is formulated with: a) a cyclodextrin and/or b) a buffering agent. In some embodiments, the method involves treating a patient with a pharmaceutical formulation comprising nneloxicann and a cyclodextrin and/or a carbonate/bicarbonate. Method embodiments may also include treating a patient to increase the bioavailability of nneloxicann in the patient or increase the rate at which the nneloxicann becomes bioavailable.

[0039] The combination of nneloxicann, a cyclodextrin (such as SBE6CD), and a bicarbonate (such as sodium bicarbonate) may substantially increase the solubility and rate of absorption of nneloxicann after oral administration, while maintaining its extended plasma concentration half-life in mammals, such as humans after oral administration.

[0040] The combination of nneloxicann, a cyclodextrin (such as SBE6CD), and a bicarbonate (such as sodium bicarbonate) may substantially increase the oral bioavailability of nneloxicann in mammals, such as humans, after oral administration.

[0041] Unless otherwise indicated, any reference to a compound herein, such as nneloxicann or rizatriptan, by structure, name, or any other means, includes pharmaceutically acceptable salts, alternate solid forms, such as polynnorphs, solvates, hydrates, enantionners, tautonners, deuterium-modified forms, or any other chemical species, such as precursors, prodrugs, or any other chemical species that may rapidly convert to a compound described herein under conditions in which the compounds are used as described herein.

[0042] A
subject combination may be given enterally including, but not limited to, oral, sublingual, or rectal delivery, or parenterally including, but not limited to, intravenous, intramuscular, intranasal, or subcutaneous delivery. In some embodiments, both nneloxicann and rizatriptan are administered orally. In some embodiments, nneloxicann is administered intravenously and rizatriptan is administered orally. In some embodiments, nneloxicann is administered intramuscularly and rizatriptan is administered orally.

[0043]
Normally, the combination of nneloxicann and rizatriptan is administered so that the human being receives the nneloxicann and rizatriptan within a short period of time with respect to one another. For example, the nneloxicann and rizatriptan may be administered within about 2 hours, within about 1 hour, within about 30 minutes, within about 20 minutes, within about 15 minutes, within about 10 minutes, within about 5 minutes, or within about 1 minute of one another. In some embodiments, the nneloxicann and rizatriptan are administered simultaneously, which for the purpose of this disclosure includes administration within about 5 minutes. In some embodiments, the nneloxicann and rizatriptan are administered in a single dosage form.

[0044] The term "treating" or "treatment" broadly includes any kind of treatment activity, including the diagnosis, cure, mitigation, or prevention of disease in man or other animals, or any activity that otherwise affects the structure or any function of the body of man or other animals.

[0045] The dosage form or the subject combination may be used to treat, or provide relief of, any type of pain including, but not limited to, migraine and other types of headache, inflammatory pain, nnusculoskeletal pain, neuropathic pain, chronic pain, acute pain, localized pain, systemic pain, cancer-related pain, acute pain, pain due to injury, pain due to illness (e.g., fever), post-operative pain, etc. In some instances, pain relief may be palliative, or pain relief may be provided independent of improvement of the disease or condition or the underlying cause of the disease or condition. For example, although the underlying disease may not improve, or may continue to progress, an individual suffering from the disease may experience pain relief. In some embodiments, the pain affects a muscle, nerve, cartilage, bone, ligament, tendon, tendon sheaths, bursae, or joint.

[0046] Migraine is a disabling neurological disorder characterized by recurrent attacks of pulsating head pain accompanied by nausea and sensitivity to light and sound.
This pain may be moderate to severe, but is often severe and incapacitating, requiring bed rest. The headaches may affect one half of the head, may be pulsating in nature, and may last from 2 to 72 hours. Associated symptoms may include nausea, vomiting, and sensitivity to light (photophobia), sound (phonophobia), or smell. The pain can be made worse by physical activity. Migraines may be associated with an aura, which may be a short period of visual disturbance which signals that the headache will soon occur. Some migraine patients may not have aura.

[0047] In some embodiments, the human being who is being treated for migraine pain suffers from allodynia with their migraine attacks. Allodynia, which is pain from normally non-painful stimuli (such as brushing hair, wearing glasses, taking a shower, etc.). Patients having allodynia are believed to be less likely to respond well to triptan medications.

[0048] Current treatments are suboptimal, with more than 70% of sufferers reporting dissatisfaction with existing acute treatments. The most commonly reported reasons for patient dissatisfaction are slow onset of pain relief, inconsistent pain relief, and recurrence of pain during the same day. Suboptimal acute treatment is associated with a significantly increased risk of new-onset chronic migraine, which may be prevented by improving acute treatment outcomes.

[0049]
Administering a subject combination to a human being suffering from migraine, such as an acute attack of migraine pain or aura, may quickly result in a reduction in a migraine symptom, such as pain, nausea, vomiting, photophobia, or phonophobia, such as at or within about 5 minutes (intended as a shorthand for "at about 5 minutes, or within about 5 minutes"), at or within about 10 minutes, at or within about 30 minutes, at or within about 1 hour, at or within about 90 minutes, at or within about 2 hours, at or within about 2.5 hours, or at or within about 3 hours. In some embodiments, a human being experiences a reduction of, or complete relief from, pain, such as headache pain or migraine pain, nausea, vomiting, photophobia, and/or phonophobia, at or within about 1 hour, at or within about 90 minutes, at or within about 2 hours, at or within about 2.5 hours, or at or within about 3 hours. In some embodiments, the relief experienced, is greater than would be experienced by receiving the same amount of rizatriptan without nneloxicann. In some embodiments, the relief experienced, is greater than would be experienced by receiving the same amount of nneloxicann without rizatriptan.

[0050] The combination of nneloxicann and rizatriptan may have distinct dual mechanisms of action for the acute treatment of migraine. Meloxicann is a potent, COX-2 preferential NSAID which is limited by slow absorption. Rizatriptan is a potent 5-HT1B/Dagonist believed to have efficacy in migraine.

[0051]
Observation of relief or reduction in a symptom at a specific period of time, such as "at 2 hours," is useful because it allows the effectiveness of the treatment to be evaluated at a specific or consistent time point, which facilitates comparison between patients.

Observation of relief or reduction in a symptom within a specific period of time, such as "within about 2 hours," is useful because it is desirable for relief or reduction of a symptom to occur as early as possible, and specifying that relief occur within a specified time sets a guideline in which it is desirable that relief occur.

[0052] For some methods, administration of the subject combination may achieve a reduction in migraine pain, nausea, vomiting, photophobia, or phonophobia that lasts at least about one hour, at least about two hours, at least about three hours, at least about four hours, at least about six hours, at least about eight hours, about 8-24 hours, about 24 hours, or more than 24 hours.

[0053] In some embodiments, the nneloxicann and the rizatriptan are administered simultaneously (e.g. in a single dosage form, such as a single oral dosage form), and two hours after the nneloxicann and the rizatriptan are administered, the human being experiences greater pain relief than the human being would have experienced two hours after receiving the same amount of nneloxicann without the rizatriptan.

[0054] In some embodiments, the nneloxicann and the rizatriptan are administered simultaneously (e.g. in a single dosage form, such as a single oral dosage form), and twenty-four hours after the nneloxicann and the rizatriptan are administered, the human being experiences greater pain relief than the human being would have experienced twenty-four hours after receiving the same amount of nneloxicann without the rizatriptan.

[0055] In some embodiments, the nneloxicann and the rizatriptan are administered simultaneously (e.g. in a single dosage form, such as a single oral dosage form), and two hours after the nneloxicann and the rizatriptan are administered, the human being experiences greater pain relief than the human being would have experienced two hours after receiving the same amount of rizatriptan without the nneloxicann.

[0056] In some embodiments, the nneloxicann and the rizatriptan are administered simultaneously (e.g. in a single dosage form, such as a single oral dosage form), and twenty-four hours after the nneloxicann and the rizatriptan are administered, the human being experiences greater pain relief than the human being would have experienced twenty-four hours after receiving the same amount of rizatriptan without the nneloxicann.

[0057] In some embodiments, the nneloxicann and the rizatriptan are administered simultaneously (e.g. in a single dosage form, such as a single oral dosage form), and two hours after the nneloxicann and the rizatriptan are administered, the human being experiences greater relief from nausea than the human being would have experienced two hours after receiving the same amount of nneloxicann without the rizatriptan.

[0058] In some embodiments, the nneloxicann and the rizatriptan are administered simultaneously (e.g. in a single dosage form, such as a single oral dosage form), and twenty-four hours after the nneloxicann and the rizatriptan are administered, the human being experiences greater relief from nausea than the human being would have experienced twenty-four hours after receiving the same amount of nneloxicann without the rizatriptan.

[0059] In some embodiments, the nneloxicann and the rizatriptan are administered simultaneously (e.g. in a single dosage form, such as a single oral dosage form), and two hours after the nneloxicann and the rizatriptan are administered, the human being experiences greater relief from nausea than the human being would have experienced two hours after receiving the same amount of rizatriptan without the nneloxicann.

[0060] In some embodiments, the nneloxicann and the rizatriptan are administered simultaneously (e.g. in a single dosage form, such as a single oral dosage form), and twenty-four hours after the nneloxicann and the rizatriptan are administered, the human being experiences greater relief from nausea than the human being would have experienced twenty-four hours after receiving the same amount of rizatriptan without the nneloxicann.

[0061] In some embodiments, the nneloxicann and the rizatriptan are administered simultaneously (e.g. in a single dosage form, such as a single oral dosage form), and two hours after the nneloxicann and the rizatriptan are administered, the human being experiences greater relief from vomiting than the human being would have experienced two hours after receiving the same amount of nneloxicann without the rizatriptan.

[0062] In some embodiments, the nneloxicann and the rizatriptan are administered simultaneously (e.g. in a single dosage form, such as a single oral dosage form), and twenty-four hours after the nneloxicann and the rizatriptan are administered, the human being experiences greater relief from vomiting than the human being would have experienced twenty-four hours after receiving the same amount of nneloxicann without the rizatriptan.

[0063] In some embodiments, the nneloxicann and the rizatriptan are administered simultaneously (e.g. in a single dosage form, such as a single oral dosage form), and two hours after the nneloxicann and the rizatriptan are administered, the human being experiences greater relief from vomiting than the human being would have experienced two hours after receiving the same amount of rizatriptan without the nneloxicann.

[0064] In some embodiments, the nneloxicann and the rizatriptan are administered simultaneously (e.g. in a single dosage form, such as a single oral dosage form), and twenty-four hours after the nneloxicann and the rizatriptan are administered, the human being experiences greater relief from vomiting than the human being would have experienced twenty-four hours after receiving the same amount of rizatriptan without the nneloxicann. In some embodiments, the nneloxicann and the rizatriptan are administered simultaneously (e.g.
in a single dosage form, such as a single oral dosage form), and two hours after the nneloxicann and the rizatriptan are administered, the human being experiences greater relief from photophobia than the human being would have experienced two hours after receiving the same amount of nneloxicann without the rizatriptan.

[0065] In some embodiments, the nneloxicann and the rizatriptan are administered simultaneously (e.g. in a single dosage form, such as a single oral dosage form), and twenty-four hours after the nneloxicann and the rizatriptan are administered, the human being experiences greater relief from photophobia than the human being would have experienced twenty-four hours after receiving the same amount of nneloxicann without the rizatriptan.

[0066] In some embodiments, the nneloxicann and the rizatriptan are administered simultaneously (e.g. in a single dosage form, such as a single oral dosage form), and two hours after the nneloxicann and the rizatriptan are administered, the human being experiences greater relief from photophobia than the human being would have experienced two hours after receiving the same amount of rizatriptan without the nneloxicann.

[0067] In some embodiments, the nneloxicann and the rizatriptan are administered simultaneously (e.g. in a single dosage form, such as a single oral dosage form), and twenty-four hours after the nneloxicann and the rizatriptan are administered, the human being experiences greater relief from photophobia than the human being would have experienced twenty-four hours after receiving the same amount of rizatriptan without the nneloxicann.

[0068] In some embodiments, the nneloxicann and the rizatriptan are administered simultaneously (e.g. in a single dosage form, such as a single oral dosage form), and two hours after the nneloxicann and the rizatriptan are administered, the human being experiences greater relief from phonophobia than the human being would have experienced two hours after receiving the same amount of nneloxicann without the rizatriptan.

[0069] In some embodiments, the nneloxicann and the rizatriptan are administered simultaneously (e.g. in a single dosage form, such as a single oral dosage form), and twenty-four hours after the nneloxicann and the rizatriptan are administered, the human being experiences greater relief from phonophobia than the human being would have experienced twenty-four hours after receiving the same amount of nneloxicann without the rizatriptan.

[0070] In some embodiments, the nneloxicann and the rizatriptan are administered simultaneously (e.g. in a single dosage form, such as a single oral dosage form), and two hours after the nneloxicann and the rizatriptan are administered, the human being experiences greater relief from phonophobia than the human being would have experienced two hours after receiving the same amount of rizatriptan without the nneloxicann.

[0071] In some embodiments, the nneloxicann and the rizatriptan are administered simultaneously (e.g. in a single dosage form, such as a single oral dosage form), and twenty-four hours after the nneloxicann and the rizatriptan are administered, the human being experiences greater relief from phonophobia than the human being would have experienced twenty-four hours after receiving the same amount of rizatriptan without the nneloxicann.

[0072] In some embodiments, the human being receiving the subject combination has a history of inadequate response to prior migraine treatments. For example, if the human being is asked whether he or she was pain-free within two hours of treatment for most attacks, and given the option of answering "never," "rarely," "less than half the time," or "half the time or more;" and the human being answers "never," "rarely," or "less than half the time," then the human being has had an inadequate response to the treatment.
Similarly, if the human being is asked whether one dose of medication usually relieved the human being's headache and kept it away for at least 24 hours, and given the option of answering "never,"
"rarely," "less than half the time," or "half the time or more;" and the human being answers "never," "rarely," or "less than half the time," then the human being has had an inadequate response to the treatment.

[0073] In some embodiments, the human being receiving the subject combination has indicated that he or she was "never" pain-free within two hours of treatment for most attacks.
In some embodiments, the human being receiving the subject combination has indicated that he or she was "rarely" pain-free within two hours of treatment for most attacks. In some embodiments, the human being receiving the subject combination has indicated that he or she was pain-free within two hours of treatment for most attacks "less than half the time."

[0074] In some embodiments, the human being receiving the subject combination has indicated that one dose of medication "never" relieved the respondent's headache and kept it away for at least 24 hours. In some embodiments, the human being receiving the subject combination has indicated that one dose of medication "rarely" relieved the respondent's headache and kept it away for at least 24 hours. In some embodiments, the human being receiving the subject combination has indicated that one dose of medication relieved the respondent's headache and kept it away for at least 24 hours "less than half the time."

[0075] In some embodiments, the human being receiving the subject combination has a history of inadequate response to prior migraine treatments as assessed by a total mean score of less than 7, less than 6, less than 5, less than 4, less than 3, less than 2, 1-2, 2-3, 3-4, 4-5, 5-6, or 6-7 on the Migraine Treatment Optimization Questionnaire (nnT0Q-4). In some embodiments, the human being has had prior triptan use before receives the subject combination, such as a combination comprising nneloxicann and rizatriptan.

[0076] In some embodiments, the human being receiving the subject combination, such as a combination comprising nneloxicann and rizatriptan, has migraine, and may have a history of inadequate response to prior migraine treatments. In some embodiments, the human being having migraine does not have cluster headaches or other types of migraines. In some embodiments, the human being having migraine does not have chronic daily headache. In some embodiments, the human being having migraine does not have more than 15, 15-20, 20-25, 25-28, 28-30, or 30-31 non-migraine headache days per month. In some embodiments, the human being having migraine does not have a history of significant cardiovascular disease. In some embodiments, the human being having migraine does not have uncontrolled hypertension.

[0077] In some embodiments, the dosage form may also be administered to relieve arthritis pain. In some embodiments the dosage form may be administered to relieve other signs and/or symptoms of arthritis. Examples of arthritis include, but are not limited to, rheumatoid arthritis, juvenile rheumatoid arthritis (pauciarticular and polyarticular course), osteoarthritis, erosive osteoarthritis, sero-negative (non-rheumatoid), arthropathies, non-articular rheumatism, peri-articular disorders, axial spondyloarthritis, transient osteoarthritis of the hip, vertebral crush fractures, osteoporosis, and neuropathic arthropathies including Charcot's foot, axial spondyloarthritis including ankylosing spondylitis, and SAPHO syndrome.
In other embodiments, the arthritis pain may be chronic or acute. In some embodiments the dosage form may be administered to relief the signs and/or symptoms of an arthritis including but not limited osteoarthritis

[0078] For some methods, administration of the dosage form may achieve a reduction in pain that lasts at least about one hour, two hours, three hours, four hours, six hours, at least about eight hours, about eight to about 24 hours, or about 24 hours. In other embodiments, administration of the dosage form may achieve a reduction in pain that is observed at about minutes, at about 30 minutes, at about one hour, at about two hours, at about three hours, at about four hours, at about five hours, at about six hours, at less than 15 minutes, at less than 20 minutes, 30 minutes, at less than one hour, at less than two hours, at less than three hours, at about 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, or 60 minutes, or other time period bound by these ranges, after administration of the dosage form.

[0079] In some embodiments, the dosage form may also be administered to relieve neuropathic pain, including diabetic peripheral neuropathy, post-herpetic neuralgia, trigenninal neuralgia, nnonoradiculopathies, phantom limb pain, sciatica, pudendal neuralgia, and central pain. Other causes of neuropathic pain may include, but are not limited to, cancer-related pain, lumbar nerve root compression, spinal cord injury, post-stroke pain, central multiple sclerosis pain, HIV-associated neuropathy, and radio-therapy or chemo-therapy associated neuropathy. The neuropathic pain treated may be chronic or acute.

[0080] In some methods, the dosage form may be administered to relieve inflammatory pain including inflammatory nnusculoskeletal pain, pain due to injury, arthritis pain, and complex regional pain syndrome. In other embodiments, the inflammatory pain may be chronic or acute.

[0081]
Arthritis refers to inflammatory joint diseases that can be associated with pain.
Examples of arthritis pain include but are not limited to pain associated with osteoarthritis, erosive osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, sero-negative (non-rheumatoid) arthropathies, non-articular rheumatism, peri-articular disorders, neuropathic arthropathies including Charcot's foot, axial spondyloarthritis including ankylosing spondylitis, and SAPHO syndrome. The inflammatory joint disease treated may be chronic or acute.

[0082] For some methods, the nneloxicann may be administered to relieve nnusculoskeletal pain. Examples of nnusculoskeletal pain may include, but are not limited to, back pain, low back pain (e.g., lunnbosacral pain), neck pain, infection, cramps, tendonitis, epidondylitis, carpal tunnel syndrome, joint pain, fibronnyalgia, pain due to injury, Tunnel syndromes, pain associated with bone fractures, sprains, fibrous dysplasia, osteogenesis inn perfecta, Paget's disease of bone, transient osteoporosis, and transient osteoporosis of the hip. In other embodiments, the nnusculoskeletal pain may be chronic or acute.

[0083] For some methods, administration of the dosage form or the subject combination may achieve a reduction in pain that lasts at least about one hour, at least about two hours, at least about three hours, at least about four hours, at least about six hours, at least about eight hours, about 8 to about 24 hours, or about 24 hours. In other embodiments, administration of the subject combination may achieve a reduction in pain that is observed at about 10 minutes, at about 30 minutes, at about one hour, at about two hours, at about three hours, at about four hours, at about five hours, at about six hours, at or within about 5 minutes, at or within about 10 minutes, at or within about 15 minutes, at or within about 20 minutes, at or within about 25 minutes, at or within about 30 minutes, at or within about 35 minutes, at or within about 40 minutes, at or within about 45 minutes, at or within about 50 minutes, or at or within about 60 minutes, at two hours or less, at three hours or less, or other time period bound by these ranges, after administration of the subject combination.

[0084] A human being that is treated for a disease or condition with the dosage forms described herein may be of any age. For example the person may have an age of about 10 years to about 90 years, about 20 years to about 80 years, about 30 years to about 75 years, about 40 years to about 70 years, about 1 year to about 16 years, about 80 years to about 95 years, about 18 years or more, about 20 years or more, about 25 years or more, about 30 years or more, about 40 years or more, about 45 years or more, about 50 years or more, about 55 years or more, about 60 years or more, about 65 years or more, or any other age in a range bounded by, or between, these values.

[0085] In some embodiments, a human being who is treated for migraine with the dosage forms described herein, for example comprising nneloxicann, rizatriptan, SBE(3CD, and a bicarbonate such as sodium bicarbonate, may be of 18 years to 65 years of age, about 18-20 years of age, about 20-25 years of age, about 25-30 years of age, about 30-40 years of age, about 40-45 years of age, about 40-50 years of age, about 50-60 years of age, about 60-65 years of age, or any other age in a range bounded by, or between, these values.

[0086] In some embodiments, a human being who is treated for migraine with a dosage forms described herein, such as a dosage form comprising nneloxicann, rizatriptan, SBE(3CD, and a bicarbonate such as sodium bicarbonate, may be white, black or African American, or Asian.

[0087] In some embodiments, a human being that is treated for a disease or condition with a dosage form comprising nneloxicann or another NSAID has suffered from the pain or condition associated with the pain for at least 1 day, at least one week, at least 2 weeks, at least 1 month, at least 6 weeks, at least 2 months, at least 3 months, at least 6 months, or at least 1 year, or any duration in a range bounded by, or between, these values.

[0088] In some embodiments, a human being that is treated for migraine with a dosage form comprising nneloxicann and rizatriptan has been diagnosed of migraine with or without aura as defined by the ICHD-3 criteria for at least 3 months, at least 6 months, at least 1 year, at least 2 years, about 1-2 years, 2-3 years, or longer, or at least 1 year, or any duration in a range bounded by, or between, these values.

[0089] In some embodiments, a human being has an average 2 to 8, 2-3, 3-4, 4-5, 5-6, 6-7, or 7-8 moderate to severe migraines per month.

[0090] A
cyclodextrin used in a dosage form with nneloxicann could include a cyclodextrin, a cyclodextrin derivative, and/or a salt thereof. An inclusion complex of nneloxicann and cyclodextrin may be more water-soluble relative to the non-connplexed nneloxicann. The cyclodextrin may be a naturally-occurring cyclodextrin (e.g., a, p, or y-cyclodextrins) or a synthetic cyclodextrin. In some embodiments, a-cyclodextrins, derivatives, or salts thereof may be used. a-Cyclodextrins may include, but are not limited to, (2,3,6-tri-0-acetyI)-a-cyclodextrin, (2,3,6-tri-O-methyl)-a-cyclodextrin, (2,3,6-tri-O-octy1)-a-cyclodextrin, 6-bronno-6-deoxy-a-cyclodextrin, 6-iodo-6-deoxy-a-cyclodextrin, (6-0-tertbutyl-dinnethylsilyI)-a-cyclodextrin, butyl-a-cyclodextrin, succinyl-a-cyclodextrin, (2-hydroxypropyI)-a-cyclodextrin, or combinations thereof.

[0091] In some embodiments, p-cyclodextrins, derivatives, or salts thereof may be used.
p-cyclodextrins may include, but are not limited to, hydroxypropyl-(3-cyclodextrin, 6-nnonodeoxy-6-nnonoannino-(3-cyclodextrin, glucosyl-(3-cyclodextrin, nnaltosyl-(3-cyclodextrin, 6-0-a-D-glucosyl-(3-cyclodextrin, 6-0-a-nnaltosyl-(3-cyclodextrin, 6-azido-6-deoxy-(3-cyclodextrin, (2,3-di-O-acetyl-6-0-sulfo)-(3-cyclodextrin, methyl-(3-cyclodextrin, dinnethyl-(3-cyclodextrin (DM CD), trinnethyl-(3-cyclodextrin (TM13CD), (2,3-di-O-methy1-6-0-sulfo)-(3-cyclodextrin, (2,6-di-O-methyl)-(3-cyclodextrin, (2,6-di-0-ethyl)-(3-cyclodextrin, (2,3,6-tri-0-methyl)-(3-cyclodextrin, (2,3,6-tri-O-acetyl)-(3-cyclodextrin, -(2,3,6-tri-O-benzoy1)-(3-cyclodextrin, (2,3,6-tri-0-ethyl)-(3-cyclodextrin, 6-iodo-6-deoxy-(3-cyclodextrin, 6-(dinnethyl-tert-butylsily1)-6-deoxy-(3-cyclodextrin, 6-bronno-6-deoxy-(3-cyclodextrin, nnonoacetyl-(3-cyclodextrin, diacetyl-(3-cyclodextrin, triacetyl-(3-cyclodextrin, (3-0-acety1-2,6-di-O-methyl)-(3-cyclodextrin, (6-0-ma Itosyl)-(3-cyclodextrin, (6-0-sulfo)-(3-cyclodextrin, (6-0-t-butyldinnethylsily1-2,3-di-0-acety1)-(3-cyclodextrin, succinyl-(2-hydroxypropyI)-(3-cyclodextrin, (2,6-di-0-)ethyl-(3-cyclodextrin, (2-carboxyethyl)-(3-cyclodextrin (CME(3CD), hydroxyethyl-(3-cyclodextrin (HEPCD), (2-hydroxypropyI)-(3-cyclodextrin, (2-hydroxypropyI)-(3-cyclodextrin (HP(3CD), (3-hydroxypropyI)-(3-cyclodextrin (3HP(3CD), (2,3-hydroxypropyI)-(3-cyclodextrin (DHP(3CD), butyl-(3-cyclodextrin, methyl-(3-cyclodextrin, sily1((6-0-tert-butyldinnethyl)-2,3,-di-0-acetyl)-(3-cyclodextrin, succinyl-(3-cyclodextrin, (2-hydroxyisobuty1)- p-cyclodextrin, randomly methylated-(3-cyclodextrin, branched-(3-cyclodextrin, or combinations thereof.

[0092] In other embodiments, a p-cyclodextrin may be a sulfoalkyl ether cyclodextrin, derivative, or salt thereof. Examples of sulfoalkyl ether cyclodextrin derivatives may include, but are not limited to, sulfobutyl ether-(3-cyclodextrin (e.g., SBE(3CD, betadex, CAPTISOL ). In some embodiments, a SBEKD may have about 4-8, about 5-8, about 4-7, about 6-7, or about 6.5 sulfobutyl ether groups per cyclodextrin molecule.

[0093] In some embodiments, y-cyclodextrins, derivatives, or salts thereof may be used.
y-cyclodextrins may include carboxynnethyl-y-cyclodextrin, (2,3,6-tri-0-acetyl)-y-cyclodextrin, (2,3,6-tri-0-methyl)-y-cyclodextrin, (2,6-di-0-penty1)-y-cyclodextrin, 6-(dinnethyl-tert-butylsilyI)-6-deoxy-y-cyclodextrin, 6-bronno-6-deoxy-y-cyclodextrin, 6-iodo-6-deoxy-y-cyclodextrin, (6-0-t-butyldinnethylsilyI)-y-cyclodextrin, succinyl-y-cyclodextrin, hydroxypropyl-y-cyclodextrin (2-hydroxypropyI)-y-cyclodextrin, acetyl-y-cyclodextrin, butyl-y-cyclodextrin, or combinations thereof.

[0094] In some embodiments, the dosage form may include a bicarbonate, such as sodium bicarbonate, potassium bicarbonate, magnesium bicarbonate, calcium bicarbonate, ammonium bicarbonate, or a combination thereof. A bicarbonate may help to increase bioavailability of the nneloxicann.

[0095] In other embodiments, the dosage form may include a carbonate, derivatives, or salts thereof. Examples of carbonates may include aluminum carbonate, ammonium carbonate, barium carbonate, calcium carbonate, cobalt(II) carbonate, lanthanum carbonate, lithium carbonate, magnesium carbonate, manganese(II) carbonate, potassium carbonate, sodium carbonate, or combinations thereof.

[0096] In some embodiments, enhanced bioavailability of the dosage form may be achieved in treating one of these conditions by administering a dosage form comprising a salt form of the nneloxicann, by creating an inclusion complex with nneloxicann and cyclodextrin, and/or by including a bicarbonate. This may allow a reduced molar amount of the nneloxicann to be used as compared to other nneloxicann dosage forms.

[0097] Unless otherwise indicated, any reference to a compound herein, such as nneloxicann or a cyclodextrin, by structure, name, or any other means, includes pharmaceutically acceptable salts, alternate solid forms, such as polynnorphs, solvates, hydrates, enantionners, tautonners, deuterium-modified forms, or any other chemical species that may rapidly convert to a compound described herein under conditions in which the compounds are used as described herein.

[0098] In some embodiments, use of a cyclodextrin, a carbonate, or a bicarbonate may improve the oral bioavailability of nneloxicann by at least about 10%, at least about 20%, at least about 30%, at least about 40%, at least about 50%, at least about 60%, at least about 70%, at least about 80%, at least about 90%, up to about 100%, up to about 200%, or any amount in a range bounded by, or between, these values as compared to administration of nneloxicann alone.

[0099] Due to the improved bioavailability, the dosage form may contain, or a subject may receive, on a molar basis, less of the nneloxicann than would otherwise be administered.
For example, a dosage form may contain, or a mammal may receive, at least about 10 mole%
less, at least about 20 mole% less, at least about 30 mole% less, at least about 40 mole% less, at least about 50 mole% less, at least about 60 mole% less, at least about 70 mole% less, at least about 80 mole% less, at least about 85 mole% less, and/or up to about 90 mole% less, 95 mole% less, or any amount in a range bounded by, or between, these values as would otherwise be administered of nneloxicann.

[0100] In other embodiments, use of other NSAIDs, opioids, or other pain medications may be reduced by at least about 5%, at least about 10%, at least about 15%, at least about 20%, at least about 25%, at least about 30%, at least about 35%, at least about 40%, at least about 45%, at least about 50%, at least about 60%, at least about 70%, at least about 80%, or at least about 90%, up to about 100%, as compared to the use of other NSAIDs, opioids or other pain medications without administration of nneloxicann with cyclodextrin, carbonate, and/or bicarbonate.

[0101] In some embodiments, a dosage form may contain nneloxicann in an amount from about 1-50 mg; about 1-10 mg; about 1-5 mg; about 10-40 mg; about 1-35 mg;
about 1-25 mg; about 1-15 mg; about 5-20 mg; about 5-10 mg; about 5-15 mg; about 10-20 mg; about 20-30 mg; about 30-40 mg; about 40-50 mg; about 5 mg; about 7.5 mg; about 10 mg; about 15 mg; about 30 mg; or any amount in a range bounded by, or between, any of these values.
These doses may be a safe dose for repeated administration, such as once hourly dosing to once daily dosing, twice daily dosing, dosing one to 12 times daily, doing 3, 4, 5, or 6 times daily, etc. In some embodiments, the nneloxicann may be safely administered 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15 times, or about 3 to about 10 times a day, once a day, or less frequently, such as once a week, once every two weeks, once a month, etc.

[0102] For some dosage forms, nneloxicann forms a complex with the substituted-p-cyclodextrin or other another cyclodextrin which may be formulated into a solid dosage form.
Such a dosage form may be suitable for oral administration. A nneloxicann-cyclodextrin inclusion complex may also be dissolved in water or another solvent to form a parenteral formulation. However, physical mixtures of nneloxicann and the substituted--cyclodextrin or other cyclodextrins may also be used in oral or parenteral dosage forms.

[0103]
Formation of an inclusion complex of nneloxicann and a cyclodextrin may help to improve the properties of a dosage form. For some inclusion complexes, the nneloxicann and the cyclodextrin (e.g., SBE(3CD) may have a molar ratio of about 0.5-2 (a molar ratio of 0.5 is 0.5 moles of nneloxicann to 1 mole of cyclodextrin), about 0.5-0.7, about 0.6-0.8, about 0.7-0.9, about 0.8-1, about 0.9-1.1, about 1-1.2, about 1.1-1.3, about 1.2-1.4, about 1.3-1.5, about 1.4-1.6, about 1.5-1.7, about 1.6-1.8, about 1.7-1.9, about 1.8-2, about 0.8-1.2, about 1, or any ratio in a range bounded by any of these values.

[0104] For some dosage forms, a cyclodextrin (e.g., SBE(3CD) may be employed in a weight ratio to the nneloxicann within the range from about 1-1000 (e.g. 1 g of cyclodextrin per 1 g of nneloxicann is a weight ratio of 1); about 1-20; about 1-10; about 1-15; about 2-4, about 3-5, about 4-6, about 5-7, about 6-8, about 7-9, about 8-10, or any weight ratio in a range bounded by, or between, any of these values. For some dosage forms, a cyclodextrin (e.g., SBE(3CD) may be employed in a weight ratio to the nneloxicann within the range from about 0.001-1 (e.g. 0.1 g of cyclodextrin per 1 g of nneloxicann is a weight ratio of 0.1);
about 0.01-1; about 0.05-1; about 0.1-1; about 0.2-1; about 0.3-1, about 0.4-1, about 0.5-1, about 0.6-1, about 0.7-1, about 0.8-1, or any weight ratio in a range bounded by, or between, any of these values.
Each type of cyclodextrin employed may have a different ratio.

[0105] For some dosage forms, the cyclodextrin may be present in an amount from about 1-200 mg; 25-175 mg; about 50-150 mg; about 25-100 mg; about 75-150 mg; about mg; about 20-80 mg; about 25-50 mg; about 60-100 mg; about 80-100 mg; about 80-120 mg;
about 100-120 mg; about 100-140 mg; about 120-160 mg; about 140-180 mg; about mg; about 40-80 mg; about 50-70 mg, about 55-65 mg, about 60-62 mg, or any amount in a range bounded by, or between, any of these values.

[0106] For some methods, the inclusion complex of nneloxicann and cyclodextrin such as a substituted-(3-cyclodextrin is delivered orally (for example by tablet, capsule, elixir, or the like). Other potential routes of administration include intravenous, intramuscular, intranasal, lyophilized parenteral, subcutaneous, transdernnal, transnnucosal, or through other parenteral means. The nneloxicann may also be delivered alone or non-connplexed with cyclodextrin.

[0107] Some dosage forms contain a bicarbonate (e.g., sodium bicarbonate) in amount from about 1-2000 mg; about 1-1000 mg; about 100-1000 mg; about 200-800 mg;
about 1-500 mg; about 1-200 mg; about 1-100 mg; about 50-750 mg; about 500-1000 mg;
about 100-500 mg; about 100-300 mg; about 500-1000 mg; about 300-700 mg; about 400-600 mg; about 50-250 mg; about 250-750 mg; about 100-200 mg; about 200-300 mg; about 300-400 mg;
about 400-500 mg; about 410-510 mg; about 420-520 mg; about 430-530 mg; about mg; about 450-550 mg; about 460-560 mg; about 470-570 mg; about 480-580 mg;
about 490-590 mg; about 500-600 mg; about 600-700 mg; about 700-800 mg; about 800-900 mg; about 150-650 mg; about 350-850 mg; or any amount in a range bounded by, or between, any of these values.

[0108] Some dosage forms contain a carbonate in amount from about 1-1000 mg; about 1-500 mg; about 1-200 mg; about 1-100 mg; about 50-750 mg; about 500-1000 mg;
about 100-500 mg; about 100-300 mg; about 200-800 mg; about 500-1000 mg; about 300-700 mg;
about 400-600 mg; about 50-250 mg; about 250-750 mg; about 100-200 mg; about mg; about 300-400 mg; about 400-500 mg; about 500-600 mg; about 600-700 mg;
about 700-800 mg; about 800-900 mg; about 150-650 mg; about 350-850 mg; or any amount in a range bounded by, or between, any of these values.

[0109] In some embodiments, the daily dose of nneloxicann (e.g., an oral dose, a parenteral dose, etc.) is about 2-5 mg, about 2-6 mg, about 2-7 mg, about 2-8 mg, about 2-9 mg, about 2-10 mg, about 2-11 mg, about 2-12 mg, about 2-13 mg, about 2-14 mg, about 2-15 mg, about 2-16 mg, about 2-17 mg, about 2-18 mg, about 2-19 mg, about 2-20 mg, about 2-21 mg, about 2-22 mg, about 2-23 mg, about 2-24 mg, about 2-25 mg, about 2-26 mg, about 2-27 mg, about 2-28 mg, about 2-29 mg, about 2-30 mg, about 2-35 mg, about 2-40 mg, about 5-10 mg, about 10-15 mg, about 15-20 mg, about 20-25 mg, about 25-30 mg, about 30-35 mg, or any amount in a range bounded by any of these values.

[0110] In some embodiments, the weekly dose of nneloxicann (e.g., an oral dose) is about 1-1000 mg; about 1-500 mg; about 10-250 mg; about 100-300 mg; about 10-100 mg;
about 10-150 mg; about 10-300 mg; about 20-150 mg; about 20-60 mg; about 30-70 mg;
about 40-60 mg; about 50-70 mg; about 70-90 mg; about 90-110 mg; about 50 mg; about 55 mg; about 100-150 mg; about 30-100 mg; or any amount in a range bounded by, or between, any of these values. The weekly dose may be given as a single dose, given once during the week, or may be given in 2, 3, 4, 5, 6, or 7 individual doses during the week.

[0111] In some embodiments, the monthly dose of nneloxicann (e.g., an oral dose), or a dose administered over a period of a month, is about 5000 mg or less; about 4000 mg or less;
about 3000 mg or less; about 2000 mg or less; about 1000 mg or less; about 700 mg or less;
about 600 mg or less; about 1-4000 mg; about 1-1000 mg; about 10-1000 mg;
about 50-1000 mg; about 10-600 mg; about 40-600 mg; about 50-600 mg; about 40-400 mg; about mg; about 200-240 mg; about 240-280 mg; about 280-320 mg; about 320-360 mg;
about 360-400 mg; about 400-450 mg; about 450-500 mg; about 500-600 mg; about 250-350 mg; about 100-600 mg; about 40-2000 mg; about 40-800 mg; about 100-900 mg; about 100-800 mg;
about 40-1000 mg; about 50-1000 mg; about 100-1000 mg; or any monthly dose in a range bounded by, or between, any of these values. A monthly dose may be given as a single dose, or as two or more individual doses administered during the month. In some embodiments, the monthly dose is administered in 2 or 3 bi-weekly doses. In some embodiments, the monthly dose is administered in 4 or 5 weekly doses. In some embodiments, the monthly dose is administered in 28 to 31 daily doses, or in 56 to 62 daily doses or more. In some embodiments, the monthly dose is administered in 5 to 15 individual doses during the month.
The monthly dose may be administered for only 1 month, or may be repeatedly administered for 2 or more months.

[0112] In other embodiments, the dosage form may be administered weekly for about one, two, three, four, or more consecutive weeks, every other week or bi-weekly, or once every three weeks. This regimen may be repeated once weekly, twice in a month, three times in a month, once monthly, once every two months, once every three months, or as directed by a medical professional.

[0113] In certain embodiments, the pharmaceutical composition results in increased bioavailability (e.g., reduced Tmax, increased Cmax, increased AUC, etc.) of the nneloxicann from the dosage form as compared to a dosage form containing nneloxicann but not containing a cyclodextrin, an acid inhibitor, or a buffering agent (such as a bicarbonate).
In some embodiments, the bioavailability of nneloxicann will increase with multiple dosing. For example, the bioavailability of nneloxicann in the dosage form may increase after about 1-10 days of dosing; about 2-6 days of dosing; about 3-5 days of dosing; about 4-6 days of dosing;
about 5-8 days of dosing; about 5 days of dosing; about 6 days of dosing;
about 7 days of dosing; about 8 days of dosing; about 10 days of dosing; about 15 days of dosing; or time in any range bounded by, or between, any of these values; as compared to the bioavailability of nneloxicann in a dosage form not containing a cyclodextrin, an acid inhibitor, or a buffering agent (such as a bicarbonate).

[0114] Some of the dosage forms may result in a desired range for an area under the plasma concentration curve (AUC) of nneloxicann. For example the dosage with nneloxicann may result in an AUC of nneloxicann of about 1-150 g=hr/nnL; about 10-30 g=hr/nnL; about 20-40 g=hr/nnL; about 30-50 g=hr/nnL; about 40-60 g=hr/nnL; about 50-70 g=hr/nnL; about 60-80 g=hr/nnL; about 70-90 g=hr/nnL; about 80-100 g=hr/nnL; about 10-100 g=hr/nnL;
about 50-150 g=hr/nnL; about 25-125 g=hr/nnL; about 75-150 g=hr/nnL; about g=hr/nnL; about 40-70 g=hr/nnL; about 60-90 g=hr/nnL; about 80-110 g=hr/nnL; about 100-130 g=hr/nnL; about 120-150 g=hr/nnL; or any AUC in a range bounded by, or between, any of these values.

[0115] Unless otherwise indicated, the AUC refers to the AUC calculated to the last measured concentration (AUCo_t), such as, over a period of 6 hours (AU C06), over a period of 12 hours (AUC042), over a period of 24 hours (AUC0_24), or extrapolated to infinity (AUCo-inf).

[0116] In Example 3 below, the AUC0_24of nneloxicann in human beings for an oral dosage form containing sodium bicarbonate and sulfobutylether p-cyclodextrin (SBE(3CD) was about 27 g=hr/nnL. This dosage form contained 15 mg of nneloxicann.

[0117] The 15 mg IV and intramuscular doses also provide an AUC0_24 of nneloxicann in human beings that is about 27 g=hr/nnL. The AUC of nneloxicann is believed to be approximately dose proportional. So for this oral dosage form, or for an IV or intramuscular dosage form, a nneloxicann dose of, for example, approximately 17 mg to about 30 mg would be expected to result in an AUC0_24of nneloxicann of about 30-50 g=hr/nnL.

[0118] For some acute pain conditions, such as migraine and other types of headache, the AUC for a short period after oral administration, such as an AUC measured over 6 hours (or AUC0_6), may be of particular interest. For example, some dosage forms may result in an AUCo_ 6 of at least about 6 g=hr/nnL; at least about 7 g=hr/nnL; at least about 8 g=hr/nnL; at least about 9 g=hr/nnL; about 6-10 g=hr/nnL; about 7-11 g=hr/nnL; about 8-12 g=hr/nnL; about 9-13 g=hr/nnL; or any AUC in a range bounded by, or between, any of these values.

[0119] In some embodiments, the dosage form may result in a Cmax of nneloxicann of about 10-2500 ng/nnL; about 100-2250 nennL; about 500-2000 ng/nnL; about 1000-2500 ng/nnL;
about 1000-2000 ng/nnL; about 100-900 nennL; about 750-1500 nennL; about 1250-ng/nnL; about 1500-2300 ng/nnL; about 800-1200 ng/nnL; about 1900-2400 ng/nnL;
about 50-500 ng/nnL; about 400-950 ng/nnL; about 900-1500 ng/nnL; about 1100-2200 ng/nnL; about 1300-1600 ng/nnL; about 1200-1500 ng/nnL; about 1400-2100 ng/nnL; about 1500-ng/nnL; about 1600-2100 ng/nnL; about 1700-2000 nennL; about 1800-2000 ng/nnL;
about 1900-2500 ng/nnL; about 150-1700 ng/nnL; about 1600-1800 ng/nnL; about 1700-1900 ng/nnL;
about 1800-2000 ng/nnL; about 1900-2100 nennL; about 2000-2200 nennL; about ng/nnL; about 2200-2400 ng/nnL; about 2300-2500 ng/nnL; about 2500-3000 ng/nnL; or any Cmax in a range bounded by, or between, any of these values.

[0120] For example, a method described herein may reduce the Tmax of nneloxicann. In some embodiments, the method may include treating a patient to achieve the Tmax of nneloxicann in the patient within about 10 minutes; about 20 minutes; about 30 minutes;
about 40 minutes; about 50 minutes; about 60 minutes; about 70 minutes; about 80 minutes;
about 90 minutes; about 100 minutes; about 110 minutes; about 120 minutes;
about 180 minutes; about 1-10 hr; about 2-9 hr; about 3-7 hr; about 4-6 hr; about 1-5 hr; about 2-7 hr;
about 3-8 hr; about 4-9 hr; about 1-4 hr; about 2-5 hr; about 3-6 hr; about 4-7 hr; about 5-8 hr; about 6-9 hr; about 7-10 hr; after administration or any Tmax in a range bounded by, or between, any of these values.

[0121] In some embodiments, an oral dosage form may have a Tmax of nneloxicann that is shorter than would be achieved by administering nneloxicann by intramuscular injection. In some embodiments, an oral dosage form may have a Tmax of nneloxicann that is shorter, or may increase nneloxicann plasma levels at a faster rate, by a factor of at least about 1.5, about 2, about 3, about 4, about 5, about 6, about 7, about 8, about 9, about 10, about 12, about 15, about 20, or by a factor of about 1.5-1000, about 2-100, about 3-100, about 4-100, about 5-100, about 6-100, about 7-100, about 8-100, about 9-100, about 10-100, about 12-100, about 15-100, about 20-100, or by a factor in a range bounded by any of these values.

[0122] In some embodiments, a dosage form comprising nneloxicann may result in a plasma concentration of nneloxicann at 12 hours that is about 0.01-0.5 ug/nnL;
about 0.5-0.7 ug/nnL; about 0.6-0.8 ug/nnL; about 0.7-0.9 ug/nnL; about 0.8-1 ug/nnL; about 0.9-1.1 ug/nnL;

about 1-1.2 ug/nnL; about 1.1-1.3 ug/nnL; about 1.2-1.4 ug/nnL; about 1.3-1.5 ug/nnL; about 1.4-1.6 ug/nnL; about 1.5-1.7 ug/nnL; about 1.6-1.8 ug/nnL; about 1.7-1.9 ug/nnL; about 1.8-2 ug/nnL; about 1.9-2.1 ug/nnL; about 2-2.2 ug/nnL; about 2.1-2.3 ug/nnL; about 2.2-2.4 ug/nnL;
about 2.3-2.5 ug/nnL; about 2.4-2.6 ug/nnL; about 2.5-2.7 ug/nnL; about 2.6-2.8 ug/nnL; about 2.7-2.9 ug/nnL; about 2.8-3 ug/nnL; about 2.9-3.1 ug/nnL; about 3-3.2 ug/nnL;
about 3.1-3.3 ug/nn L; about 3.2-3.4 ug/nn L; about 3.3-3.5 ug/nn L; about 3.4-3.6 ug/nn L;
about 3.5-3.7 ug/nn L;
about 3.6-3.8 ug/nnL; about 3.7-3.9 ug/nnL; about 3.8-4 ug/nnL; or any plasma concentration in a range bounded by, or between, any of these values.

[0123] In some embodiments, nneloxicann is administered at a dose that results in a nneloxicann plasma level (such as a Cavg, or average plasma level) of about 0.01-0.5 ug/nnL;
about 0.5-0.7 ug/nnL; about 0.6-0.8 ug/nnL; about 0.7-0.9 ug/nnL; about 0.8-1 ug/nnL; about 0.9-1.1 ug/nnL; about 1-1.2 ug/nnL; about 1.1-1.3 ug/nnL; about 1.2-1.4 ug/nnL; about 1.3-1.5 ug/nn L; about 1.4-1.6 ug/nn L; about 1.5-1.7 ug/nn L; about 1.6-1.8 ug/nn L;
about 1.7-1.9 ug/nn L;
about 1.8-2 ug/nnL; about 1.9-2.1 ug/nnL; about 2-2.2 ug/nnL; about 2.1-2.3 ug/nnL; about 2.2-2.4 ug/nnL; about 2.3-2.5 ug/nnL; about 2.4-2.6 ug/nnL; about 2.5-2.7 ug/nnL;
about 2.6-2.8 ug/nnL; about 2.7-2.9 ug/nnL; about 2.8-3 ug/nnL; about 2.9-3.1 ug/nnL; about 3-3.2 ug/nnL;
about 3.1-3.3 ug/nnL; about 3.2-3.4 ug/nnL; about 3.3-3.5 ug/nnL; about 3.4-3.6 ug/nnL; about 3.5-3.7 ug/nnL; about 3.6-3.8 ug/nnL; about 3.7-3.9 ug/nnL; about 3.8-4 ug/nnL; about 0.1-20 ug/nnL; about 0.5-15 ug/nnL; about 0.5-10 ug/nnL; about 5-15 ug/nnL; about 10-20 ug/nnL;
about 7.5-15 ug/nnL; about 2-10 ug/nn L; about 1-8 ug/nn L; about 1-6 ug/nn L;
about 1-2 ug/nnL;
about 0.5-3.5 ug/nnL; about 0.5-7 ug/nnL; about 12-20 ug/nnL; about 8-12 ug/nnL; about 1-4 ug/nnL; about 4-7 ug/nnL; about 7-11 ug/nnL; about 11-15 ug/nnL; about 15-19 ug/nnL; about 16-20 ug/nnL; or any amount of nneloxicann plasma level in a range bounded by, or between, any of these values.

[0124]
Administration of a dosage form described herein may result in a decreased time to therapeutic plasma concentration of nneloxicann. The therapeutic plasma concentration is the Cavg for a 15 mg dose of Mobic nneloxicann. In some embodiments, the time to therapeutic plasma concentration of nneloxicann (T ) i about 10-30 minutes, about 10-15 thera, .s minutes, about 15-20 minutes, about 20-25 minutes, about 25-30 minutes, about minutes, about 20-30 minutes, about 16-18 minutes, or about 17 minutes.

[0125] A method described herein may reduce the Tmax of rizatriptan. For example, the method may achieve a Tmax of rizatriptan in the patient within about 50 minutes; within about 60 minutes; within about 70 minutes; within about 80 minutes; or within about 90 minutes;
at about 40-60 minutes, at about 40-45 minutes, at about 45-50 minutes, at about 50-55 minutes, or about 55-60 minutes after administration, or any Tmax in a range bounded by any of these values.

[0126] In some embodiments, the nneloxicann and the rizatriptan are administered simultaneously (e.g. in a single dosage form, such as a single oral dosage form), and two hours after the nneloxicann and the rizatriptan are administered, the human being experiences greater relief from allodynia than the human being would have experienced two hours after receiving the same amount of nneloxicann without the rizatriptan.

[0127] In some embodiments, the nneloxicann and the rizatriptan are administered simultaneously (e.g. in a single dosage form, such as a single oral dosage form), and twenty-four hours after the nneloxicann and the rizatriptan are administered, the human being experiences greater relief from allodynia than the human being would have experienced twenty-four hours after receiving the same amount of nneloxicann without the rizatriptan.

[0128] In some embodiments, the nneloxicann and the rizatriptan are administered simultaneously (e.g. in a single dosage form, such as a single oral dosage form), and two hours after the nneloxicann and the rizatriptan are administered, the human being experiences greater relief from allodynia than the human being would have experienced two hours after receiving the same amount of rizatriptan without the nneloxicann.

[0129] In some embodiments, the nneloxicann and the rizatriptan are administered simultaneously (e.g. in a single dosage form, such as a single oral dosage form), and twenty-four hours after the nneloxicann and the rizatriptan are administered, the human being experiences greater relief from allodynia than the human being would have experienced twenty-four hours after receiving the same amount of rizatriptan without the nneloxicann.

[0130] One embodiment is a method for reducing the risk of gastrointestinal side effects in people taking NSAIDs for pain relief and for other conditions, particularly during chronic treatment, and improving the bioavailability of the NSAID. In one embodiment, the method involves the administration of a product that combines: a) an agent that actively raises intragastric pH; and b) an NSAID that is formulated with a cyclodextrin. In another embodiment, the method involves the administration of a product that combines:
a) an agent that actively raises intragastric pH; b) an NSAID that is formulated with a cyclodextrin; and c) a buffering agent. Either short or long acting acid inhibitors can be effectively used in the dosage forms. This method has the added benefit of being able to protect patients from other gastrointestinal ulcerogens whose effect may otherwise be enhanced by the disruption of gastroprotective prostaglandins due to NSAID therapy.

[0131] The nneloxicann formulation in an aqueous parenteral form may include a buffer to adjust the pH of an aqueous formulation, within a range of about 2 to about 5;
about 3.5 to about 5; about 5 to about 11; about 6 to about 9; about 6 to about 8; about 6 to about 7; or any other pH in a range bounded by, or between, any of these values. The nneloxicann formulation in an oral form may include a buffer to adjust the pH of stomach fluid within a range of about 2 to about 5; about 3.5 to about 5; about 5 to about 11; about 6 to about 9;
about 6 to about 8; about 6 to about 7; or any other pH in a range bounded by, or between, any of these values. Examples of buffers suitable for use herein include sulfate buffers, phosphate buffers, borate buffers, carbonate buffers, citrate buffers, etc.

[0132] In some embodiments, the dosage form may be formulated for oral administration, for example, with an inert diluent or with an edible carrier, or it may be enclosed in hard or soft shell gelatin capsules, compressed into tablets, or incorporated directly with the food of the diet. For oral therapeutic administration, the active compound may be incorporated with an excipient and used in the form of ingestible tablets, buccal tablets, coated tablets, troches, capsules, elixirs, dispersions, suspensions, solutions, syrups, wafers, patches, and the like.

[0133] Tablets, troches, pills, capsules and the like may also contain one or more of the following: a binder such as gum tragacanth, acacia, corn starch or gelatin; an excipient, such as dicalciunn phosphate; a disintegrating agent such as corn starch, potato starch, alginic acid and the like; a lubricant such as magnesium stearate; a sweetening agent such as sucrose, lactose or saccharin; or a flavoring agent such as peppermint, oil of wintergreen or cherry flavoring. When the unit dosage form is a capsule, it may contain, in addition to materials of the above type, a liquid carrier. Various other materials may be present as coating, for instance, tablets, pills, or capsules may be coated with shellac, sugar or both. A syrup or elixir may contain the active compound, sucrose as a sweetening agent, methyl and propylparabens as preservatives, a dye and flavoring, such as cherry or orange flavor. It may be desirable for material in a dosage form or pharmaceutical composition to be pharmaceutically pure and substantially non-toxic in the amounts employed.

[0134] Some compositions or dosage forms may be a liquid, or may comprise a solid phase dispersed in a liquid.

[0135] The dosage form may further comprise a second therapeutically active agent, such as an acid inhibitor or an analgesic.

[0136] In some embodiments, the dosage form may further comprise an acid inhibitor present in an amount effective to raise the gastric pH of a patient to at least 2, to at least 2.5, to at least 3, to at least 3.5, to at least 4, and more to at least 5, when one or more unit dosage forms are administered. The term "acid inhibitor" refers to agents that inhibit gastric acid secretion and increase gastric pH. Specific H2 blockers, also referred to as H2 antagonists or histamine H2 blockers or antagonists, that may be used include but are not limited to cinnetidine, ranitidine, ebrotidine, pabutidine, lafutidine, loxtidine, fannotidine, or combinations thereof.

[0137] Other agents that may be effectively used as acid inhibitors are the proton pump inhibitors such as onneprazole, esonneprazole, pantoprazole, lansoprazole, dexlansoprazole, rabeprazole, pariprazole, lenninoprazole and tenatoprazole. In some embodiments the daily dose of the acid inhibitor is about 1-200 mg, about 1-100 mg, about 1-50 mg, about 40-80 mg, about 5-50 mg, about 20-40 mg, about 10-50 mg, about 10-20 mg, about 20-40 mg, about 15-50 mg, about 30-60 mg, about 10 mg, about 20 mg, about 30 mg, about 40 mg or any other amount in a range bounded by, or between, any of these values.

[0138] Examples of particular proton pump inhibitors include esonneprazole, present in unit dosage forms in an amount of between 5 mg and 50 mg; onneprazole, present in unit dosage forms in an amount of between 5 mg and 50 mg; lansoprazole, present in unit dosage forms in an amount of between 5 mg and 150 mg (and preferably at between 5 mg and 30 mg); and pantoprazole, present in unit dosage forms in an amount of between 10 mg and 200 mg. In some embodiments, the proton pump inhibitor is present in the dosage form in an amount of about 10-30 mg, about 20-40 mg, about 30-50 mg, about 40-60 mg, about 50-70 mg, about 60-80 mg, about 70-90 mg, or about 80-100 mg. Recently, a newer class of acid inhibitor has been developed which competes with potassium at the acid pump.
The compounds in this class have been referred to as "reversible proton pump inhibitors" or "acid pump antagonists" and may also be used. Examples include AZD-0865, AR-H047108, CS-526, punnaprazole, revaprazan and soraprazan (see W09605177 and W09605199). Other compounds in this group are H-335/25 (AstraZeneca, Dialog file 128, accession number 020806); Sch-28080 (Schering Plough, Dialog file 128, accession number 009663); Sch-32651 (Schering Plough, Dialog file 128, accession number 006883) and SK&F-96067 (CAS Registry no. 115607-61-9).

[0139] The second therapeutically active agent may include an analgesic such as a second non-steroidal anti-inflammatory drug, an opioid, a steroid, a triptan, etc.
In some embodiments, the dosage form or treatment also further comprises administering a second non-steroidal anti-inflammatory drug in an amount effective to reduce or eliminate pain or inflammation. The NSAID may include, but is not limited to, celecoxib, rofecoxib, lunniracoxib, valdecoxib, parecoxib, etoricoxib, CS-502, JTE-522, L-745,337, NS398, aspirin, acetaminophen (considered to be an NSAID for the purposes of the present disclosure), ibuprofen, flurbiprofen, ketoprofen, naproxen, oxaprozin, etodolac, indonnethacin, ketorolac, lornoxicann, nneloxicann, piroxicann, droxicann, tenoxicann, nabunnetone, diclofenac, nneclofenannate, nnefenannic acid, diflunisal, sulindac, tolnnetin, fenoprofen, suprofen, benoxaprofen, aceclofenac, tolfenannic acid, oxyphenbutazone, azapropazone, phenylbutazone, or combinations thereof. It will be understood that, for the purposes of the present disclosure, reference to an acid inhibitor, NSAID, or analgesic agent will include all of the common forms of these compounds and, in particular, their pharmaceutically acceptable salts. The amounts of NSAIDs which are therapeutically effective may be lower in the current embodiments than otherwise found in practice due to potential positive kinetic interaction and NSAID absorption in the presence of an acid inhibitor, and or in the presence of a buffering agent.

[0140] In other embodiments, the dosage form or treatment may further comprise administering an opioid in an amount effective to reduce or eliminate pain or inflammation.
The opioid may include, but is not limited to, (dextro)propoxyphene, A-nnethylfentanyl, alfentanil, allylprodine, bezitrannide, buprenorphine, butorphanol, carfentanyl, desnnethylprodine, dextronnorannide, dezocine, diacetylmorphine, dihydrocodeinone, dihydroetorphine, dinnorphone, diphenoxylate, dipipanone, etorphine, fentanyl, ketobennidone, lefetannine, levacetylnnethadol, levonnethorphan, levorphanol, loperannide, nneperidine, nneptazinol, methadone, nnethylnnorphine, morphine, nalbuphine, nalnnefene, naloxone, naltrexone, niconnorphine, ohnnefentanyl, oripavine, oxycodone, oxynnorphone, PEPAP, parannorphine, pentazocine, phenazocine, piritrannide, prodine, rennifentanil, sufentanil, tapentadol, tilidine, trannadol, or combinations thereof.

[0141] Useful triptans may include sunnatriptan, rizatriptan, naratriptan, eletriptan, donitriptan, alnnotriptan, frovatriptan, alvitriptan, zolnnatriptan, etc. In some embodiments, the triptan comprises rizatriptan. In some embodiments, the dosage form may contain about 1-5 mg, about 2-6 mg, about 3-7 mg, about 4-8 mg, about 5-10 mg, about 6-11 mg, about 7-12 mg, about 8-13 mg, about 9-14 mg, about 10-15 mg, about 15-20 mg, or about 20-30 mg, of the triptan, such as rizatriptan, or any amount in a range bounded by any of these values.

[0142] In some embodiments; a dosage form comprising the subject combination may contain rizatriptan in an amount of about 1-50 mg; about 1-10 mg; about 10-20 mg; about 20-30 mg; about 30-40 mg; or about 40-50 mg; about 10-40 mg; about 1-35 mg;
about 1-25 mg; about 1-15 mg; about 1-10 mg; about 5-20 mg; about 1-5 mg; about 2-6 mg;
about 3-7 mg; about 4-8 mg; about 5-10 mg; about 6-11 mg; about 7-12 mg; about 8-13 mg;
about 9-11 mg; about 9-14 mg; about 10-15 mg; about 11-16 mg; about 12-17 mg; about 13-18 mg; about 14-19 mg; about 15-20 mg; about 5-15 mg; about 0.5 mg; about 1 mg; about 1.5 mg; about 2 mg; about 2.5 mg; about 3 mg; about 3.5 mg; about 4 mg; about 4.5 mg; about 5 mg; about 6 mg; about 7 mg; about 7.5 mg; about 8 mg, about 9 mg, about 10 mg; about 15 mg; about 20 mg, about 25 mg, about 30 mg; or any amount in a range bounded by, or between, any of these values.

[0143] For acute migraines, the amount of nneloxicann and/or rizatriptan in a single dose, or the AUC of the nneloxicann and/or rizatriptan associated with a single dose, is of particular interest. For example, after a single dose, the symptoms may be relieved for an extended period of time, such that, in the short term, repeated doses may not be needed. For more continuous conditions, including more chronic, continuous, or frequent migraine symptoms, daily, weekly, or monthly doses may be of particular interest.

[0144] For any amounts of rizatriptan described herein, salt forms of rizatriptan may be present in the amounts recited above, or amounts that are molar equivalents to these amounts for the rizatriptan free base. For example, assuming that the molecular weight of rizatriptan free base is 269.3 g/nnol, 10 mg of rizatriptan is 37.1 nnnnol of rizatriptan. Thus, a molar equivalent of 10 mg of rizatriptan free base would be the mass of 37.1 nnnnol of that salt form. For example, for the benzoate salt (mw = 391.2 g/nnol), the molar equivalent of 10 mg of the free base (or 37.1 nnnnol), would be 14.5 mg. These doses may be safe for repeated administration, such as 1, 2, 3, or 4 times a day, or repeated at an interval of 2 days, 3 days, 4 days, 5 days, 6 days, 7 days, 8 days, 9 days, 10 days, 11 days, 12 days, 13 days, 14 days, 15 days, 16 days, 17 days, 18 days, 19 days, 20 days, 21 days, 22 days, 23 days, 24 days, 25 days, 26 days, 27 days, 28 days, 29 days, 30 days, 31 days, 4 weeks, 4-6 weeks, about 1-2 months, about 6 weeks, about 2-3 months, about 3-4 months, about 4-5 months, about 5-6 months, about 6-7 months, about 7-8 months, about 8-9 months, about 9-10 months, about months, about 11-12 months, etc.

[0145] A
pharmaceutical composition may be in the form of a tablet or capsule that has:
(a) the acid inhibitor; and/or (b) a buffering agent; and (c) the non-steroidal anti-inflammatory drug (NSAID) present in an amount effective to reduce or eliminate pain or inflammation in a patient upon administration of one or more of said unit dosage forms. The components of the pharmaceutical composition may be in an immediate or extended release form individually or in total.

[0146] The term "unit dosage form" as used herein refers to a single entity for drug administration. For example, a single tablet or capsule combining both an acid inhibitor and an NSAID would be a unit dosage form. A "unit dosage form" (or "unit dose form") may also be referred to as a "fixed dosage form" (or "fixed dose form") or "fixed dosage combination"
(or "fixed dose combination") and are otherwise interchangeable. In one embodiment, the unit dosage form is a nnultilayer tablet.

[0147] In another embodiment, the unit dosage form is suitable for oral administration to a patient. In yet another embodiment, the unit dosage form is a tablet. In still another embodiment, the unit dosage form is a nnultilayer tablet comprising a single core and one or more layers outside of the core.

[0148] Some dosage forms may comprise a first layer comprising nneloxicann, an SBE(3CD, and a bicarbonate; and a second layer comprising a second therapeutically active agent and a bicarbonate.

[0149] The first layer may contain, for example, any amount of nneloxicann in one of the ranges recited above. For example, all of the nneloxicann in the dosage form may be present in the first layer. The second layer may contain all of the second therapeutically active agent, such that any amount in the ranges recited above with respect to the second therapeutically active agent may apply to the second layer.

[0150] In some embodiments, the first layer contains about 10-200 mg, about 50-150 mg, about 50-100 mg, about 70-120 mg, about 90-140 mg, or about 100 mg of the bicarbonate, such as sodium bicarbonate, or any amount of the bicarbonate in a range bounded by any of these values.

[0151] In some embodiments, the second layer contains about 100-500 mg, about 200-500 mg, about 300-500 mg, about 350-450 mg, about 380-420 mg, or about 400 mg of the bicarbonate, such as sodium bicarbonate, or any amount of the bicarbonate in a range bounded by any of these values.

[0152] In some embodiments, the pharmaceutical composition may have an effective amount of nneloxicann, a cyclodextrin, and a carbonate or bicarbonate to increase bioavailability of nneloxicann. In other embodiments, the pharmaceutical composition may have an effective amount of nneloxicann, sulfobutylether-(3-cyclodextrin (SBE(3CD), and sodium bicarbonate to increase bioavailability of nneloxicann or reduce the Tmax of nneloxicann.

[0153] Some oral dosage forms may have enteric coatings or film coatings. In some embodiments, a dosage form may comprise a tablet or a capsule having an enteric coating.
In some embodiments, a dosage form may comprise a tablet or a capsule having a film coating.

[0154] An embodiment of the present disclosure is directed to a pharmaceutical composition in unit dosage form suitable for administration to a patient, comprising:
(a) esonneprazole, which may or may not be surrounded by an enteric coating;
(b) sodium or potassium bicarbonate and/or sodium or potassium carbonate;
and (c) nneloxicann, which may or may not be formulated with a cyclodextrin, and which may or may not be surrounded by an enteric coating

[0155] An embodiment of the present disclosure is directed to a pharmaceutical composition in unit dosage form suitable for administration to a patient for treat a disease, a condition, or disorder, such as migraine, comprising:
(1) an inclusion complex of a nneloxicann and a sulfobutyl ether p-cyclodextrin (S BE
(2) a bicarbonate, such as sodium bicarbonate or potassium bicarbonate; and (3) a triptan, such as rizatriptan.

[0156] In certain embodiments, the pharmaceutical composition results in faster release or dissolution of the nneloxicann from the dosage form as compared to a dosage form containing nneloxicann but not containing the acid inhibitor, or not containing the buffering agent.

[0157] A dosage form comprising a combination of rizatriptan and nneloxicann (a "subject combination") may be used to treat migraine. The subject combination may be used for the acute treatment of migraine. The subject combination may provide substantially greater and more sustained migraine pain relief compared to rizatriptan, nneloxicann, or placebo. The subject combination may provide rapid relief of migraine pain. The subject combination may significantly reduce the use of rescue medication compared to rizatriptan, nneloxicann and placebo. The migraine patients being treated with a combination of rizatriptan and nneloxicann described herein may have a history of inadequate response to prior acute treatments. The migraine patients being treated with a combination of rizatriptan and nneloxicann described herein may have allodynia. The migraine patients being treated with a combination of rizatriptan and nneloxicann described herein may have severe pain intensity.
The migraine patients being treated with a combination of rizatriptan and nneloxicann described herein may have obesity. The migraine patients being treated with a combination of rizatriptan and nneloxicann described herein may have morning migraine. The migraine patients being treated with a combination of rizatriptan and nneloxicann described herein may have a total mean score of the Migraine Treatment Optimization Questionnaire (nnT0Q-4) of less than 7, such as 1-2, 2-3, 3-4, 4-5, 5-6, or 6-7. The migraine patients being treated with a combination of rizatriptan and nneloxicann described herein may have allodynia, severe pain intensity, obesity, morning migraine, a total mean score of the nnT0Q-4 of less than 7, and a history of inadequate response to prior acute treatments. A dosage form comprising a combination of rizatriptan and nneloxicann described herein is safe and well tolerated in the migraine patients being treated.

[0158] A dosage form comprising a combination of rizatriptan and nneloxicann described herein may provide rapid relief of migraine pain in less than 15 minutes, about 15 minutes, less than 30 minutes, 15-30 minutes, less than 1 hour, 0.5-0.75 hour, or 0.75-1 hour post dose.
The combination of rizatriptan and nneloxicann described herein may provide relief of migraine pain that is numerically greater than rizatriptan at less than 15 minutes, about 5 minutes, about 5-10 minutes, about 10-15 minutes, about 15 minutes, about 15-30 minutes, about 30-45 minutes, about 45-60 minutes, about 1-1.5 hours, about 1.5-2 hours, about 2-2.5 hours, about 2.5-3 hours, about 3-3.5 hours, about 3.5-4 hours, about 4-5 hours, about 5-6 hours, about 6-8 hours, about 8-10 hours, about 10-12 hours, about 12-24 hours, about 24-48 hours, or longer, post dose. The percentage of migraine patients reporting pain relief with the treatment of a combination of rizatriptan and nneloxicann described herein may be 1-100%, 3-100%, 4-100%, 5-100%, 3-5%, 5-10%, 10-20%, 20-30%, 30-40%, 40-50%, 50-60%, 60-70%, 70-80%, 80-90%, 90-95%, or 95-100%.

[0159] The migraine patients receiving a dosage form comprising a combination of rizatriptan and nneloxicann described herein ("subject combination") may achieve pain freedom at less than 2 hours, about 2 hours, about 2-3 hours, about 3-4 hours, about 4-6 hours, about 6-8 hours, about 8-10 hours, about 10-12 hours, about 12-16 hours, about 16-20 hours, about 20-24 hours, about 24-30 hours, about 30-36 hours, about 36-40 hours, about 40-44 hours, about 44-48 hours, or longer post dose.

[0160] The percentage of migraine patients achieving pain freedom increases over time after receiving a dose of a combination of rizatriptan and nneloxicann described herein. For example, at 2 h post dose, the percentage of migraine patients achieving pain freedom may be about 15-25%, about 15-20%, about 20%, about 20-25%. At 4 h post dose, the percentage of migraine patients achieving pain freedom may be about 30-50%, about 30-40%, about 40%, about 40-45%, about 45-47%, about 47-50%. At 12 h post dose, the percentage of migraine patients achieving pain freedom may be about 45-70%, about 45-50%, about 50-55%, about 55-60%, about 56-57%, about 60-65%, about 65-70%. At 16 h post dose, the percentage of migraine patients achieving pain freedom may be about 45-70%, about 45-50%, about 50-55%, about 55-60%, about 58-59%, about 60-65%, about 65-70%. The combination of rizatriptan and nneloxicann described herein may provide significant improvement over rizatriptan in pain freedom in the migraine patients. There may be about 2-10%, 2-3%, 3-5%, 5-7%, 6-7%, 7-8%, 8-9%, or 9-10% more migraine patients receiving the combination of rizatriptan and nneloxicann described herein achieving pain freedom than the migraine patients receiving rizatriptan at 2-16 hours post dose with an improvement of about 10-25%, 10-15%, 14-15%, 15-16%, 16-17%, 17-18%, 18-19%, 19-20%, 20-21%, or 21-25%. For example, at 4 hours post dose, if about 40% migraine patients receiving the subject combination achieve pain freedom, while 33% migraine patients receiving rizatriptan achieve pain freedom, then the improvement of the subject combination is about 21%
[((40-33)/33)x100%]. The improvement with the subject combination over nneloxicann may be bigger than over rizatriptan in migraine patients achieving pain freedom. For example, The improvement with the subject combination over nneloxicann in migraine patients achieving pain freedom may be about 25-75%, 25-30%, 27-28%, 28-29%, 30-40%, 40-50%, 50-60%, 55-50%, 60-70%, 65-75%, or 70-75% at 2-16 hours post dose.

[0161] There may be at least 50%, at least 60%, at least 70%, at least 80%, about 70-80%, about 80-90%, about 90-95%, about 80% of migraine patients receiving the combination of rizatriptan and nneloxicann described herein ("subject combination") achieving pain freedom at 2 hours may maintain it through 24 hours post dose. The increase of the number of migraine patients (or improvement) achieving sustained pain freedom from 2-24 hours post dose of the subject combination may be about 35-55%, about 35-40%, about 40-45%, about 45-50%, or about 50-55% as compared to administering rizatriptan. The increase of the number of migraine patients (or improvement) achieving sustained pain freedom from 2-24 hours post dose of the subject combination may be about 100-165%, about 100-110%, about 110-120%, about 120-130%, about 130-140%, about 140-150%, about 150-160%, or about 160-165% as compared to administering nneloxicann.

[0162] The increase of the number of migraine patients (or improvement) achieving sustained pain relief from 2-24 hours post dose of the subject combination may be about 15-30%, about 15-20%, about 20-25%, about 25-30%, about 20-22%, or about 21% as compared to administering rizatriptan. The increase of the number of migraine patients (or improvement) achieving sustained pain relief from 2-24 hours post dose of the subject combination may be about 20-35%, about 20-25%, about 25-30%, about 30-35%, about 25-26%, about 26-27%, about 27-28%, about 28-30%, or about 27% as compared to administering nneloxicann.

[0163] There may be at least 50%, at least 60%, at least 70%, at least 80%, about 70-80%, about 80-90%, about 90-95%, or about 77% of migraine patients receiving the combination of rizatriptan and nneloxicann described herein ("subject combination") achieving pain freedom at 2 hours may maintain it through 48 hours post dose. The increase of the number of migraine patients (or improvement) achieving sustained pain freedom from 2-48 hours post dose of the subject combination may be about 60-90%, about 60-70%, about 70-75%, about 75-80%, about 80-90%, or about 75% as compared to administering rizatriptan. The increase of the number of migraine patients (or improvement) achieving sustained pain freedom from 2-48 hours post dose of the subject combination may be about 70-110%, about 70-80%, about 80-90%, about 90-100%, about 100-110%, or about 90% as compared to administering nneloxicann.

[0164] The increase of the number of migraine patients (or improvement) achieving sustained pain relief from 2-48 hours post dose of the subject combination may be about 20-35%, about 20-25%, about 25-30%, about 30-35%, about 25-26%, about 26-27%, about 27-28%, about 28-20%, or about 27% as compared to administering rizatriptan. The increase of the number of migraine patients (or improvement) achieving sustained pain relief from 2-48 hours post dose of the subject combination may be about 15-30%, about 15-20%, about 20-25%, about 25-30%, about 20-21%, about 21-22%, about 22-23%, about 23-24%, about 24-25%, or about 23% as compared to administering nneloxicann.

[0165] There may be at least 50%, at least 60%, at least 70%, about 60-65%, about 65-70%, about 70-75%, about 75-80%, about 80-85%, about 85-90%, about 90-95%, or about 77% of migraine patients receiving the combination of rizatriptan and nneloxicann described herein ("subject combination") may not require rescue medication. The decrease of the number of migraine patients who took rescue medication through 24 hours post dose of the subject combination may be about 35-60%, about 35-40%, about 40-45%, about 45-50%, about 50-55%, about 55-60%, about 47-48%, or about 47% as compared to administering placebo. The decrease of the number of migraine patients who took rescue medication through 24 hours post dose of the subject combination may be about 25-45%, about 25-30%, about 30-35%, about 35-40%, about 40-45%, about 34-36%, or about 35% as compared to administering nneloxicann. The decrease of the number of migraine patients who took rescue medication through 24 hours post dose of the subject combination may be about 25-40%, about 25-30%, about 30-35%, about 35-40%, about 33-35%, or about 34% as compared to administering rizatriptan.

[0166] The following embodiments are contemplated:
Embodiment 1. An inclusion complex of nneloxicann in a cyclodextrin.
Embodiment 2. A dosage form comprising: 1) the inclusion complex of embodiment 1, or 2) nneloxicann and a carbonate or a bicarbonate.
Embodiment 3. The dosage form of embodiment 2 comprising the inclusion complex, wherein the cyclodextrin comprises substituted p-cyclodextrin.
Embodiment 4. The dosage form of embodiment 3, wherein the substituted 13-cyclodextrin is a sulfobutyl ether 13-cyclodextrin (SBEPCD) or hydroxypropyl 13-cyclodextrin (HPBCD).
Embodiment 5. The dosage form of embodiment 4, wherein the cyclodextrin is the SBEPCD.
Embodiment 6. The dosage form of embodiment 5, wherein the SBEPCD has about 6 to about 7 sulfobutyl ether groups for each molecule of 13-cyclodextrin.
Embodiment 7. The dosage form of embodiment 6, wherein the nneloxicann and the SBEPCD have a molar ratio of about 0.8 to about 1.2.
Embodiment 8. The dosage form of embodiment 6, wherein the nneloxicann and the SBEPCD have a molar ratio of about 1.
Embodiment 9. The dosage form of embodiment 2, 3, 4, 5, 6, 7, or 8, comprising a bicarbonate.
Embodiment 10. The dosage form of embodiment 9, wherein the bicarbonate comprises sodium bicarbonate.

Embodiment 11. The dosage form of embodiment 2, 3, 4, 5, 6, 7, 8, 9, or 10, which is an oral dosage form.
Embodiment 12. The dosage form of embodiment 2, 3, 4, 5, 6, 9, 10, or 11, wherein about 50 mg to about 200 mg of SBEPCD is present in the dosage form.
Embodiment 13. The dosage form of embodiment 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12, wherein the carbonate or bicarbonate is present in an amount in a range of about 400 mg to about 600 mg.
Embodiment 14. The dosage form of embodiment 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, or 13, wherein the Tmax of nneloxicann is decreased as compared to a dosage form not having a carbonate, a bicarbonate, or a cyclodextrin.
Embodiment 15. The method of embodiment 14, wherein the Tmax of nneloxicann is achieved in the patient at a time in a range of about 10 minutes to about 180 minutes after administration.
Embodiment 16. The dosage form of embodiment 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15, having an oral bioavailability of nneloxicann that is higher than a dosage form not having a carbonate, a bicarbonate, or a cyclodextrin.
Embodiment 17. The dosage form of embodiment 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20, further comprising an acid inhibitor.
Embodiment 18. The dosage form of embodiment 17, wherein the acid inhibitor is a proton pump inhibitor.
Embodiment 19. The dosage form of embodiment 18, wherein the proton pump inhibitor is esonneprazole.
Embodiment 20. The dosage form of embodiment 19, wherein about 30 mg to about 50 mg of esonneprazole is present in the dosage form.
Embodiment 21. A method of administering nneloxicann orally, comprising orally administering a dosage form of embodiment 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20 to a patient in need of treatment.
Embodiment 22. The method of embodiment 21, wherein the dosage form is administered to treat pain.

Embodiment 23. The method of embodiment 21, wherein the dosage form is administered to treat inflammatory pain.
Embodiment 24. The method of embodiment 21, wherein the dosage form is administered to treat osteoarthritis, rheumatoid arthritis, or juvenile rheumatoid arthritis.
Embodiment 25. A method of administering nneloxicann intravenously, comprising intravenously administering a dosage form of embodiment 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 13, 14, or 15, to a patient in need of treatment.
Embodiment 26. The method of embodiment 21, wherein the dosage form is administered to treat migraine.
Embodiment 27. A dosage form comprising: 1) the inclusion complex of nneloxicann in a cyclodextrin, 2) a bicarbonate, and 3) a triptan.
Embodiment 28. The dosage form of embodiment 27, wherein the triptan is rizatriptan.
Embodiment 29. The dosage form of embodiment 27, wherein the bicarbonate comprises sodium bicarbonate.
Embodiment 30. The dosage form of embodiment 27, wherein the cyclodextrin is a sulfobutyl ether p-cyclodextrin (SBEPCD).
Embodiment 31. The dosage form of embodiment 30, wherein the SBEPCD has about 6 to about 7 sulfobutyl ether groups for each molecule of p-cyclodextrin.
Embodiment 32. The dosage form of embodiment 30, wherein the nneloxicann and the SBEPCD have a molar ratio of about 0.8 to about 1.2.
Embodiment 33. The dosage form of embodiment 32, wherein the nneloxicann and the SBEPCD have a molar ratio of about 1.
Embodiment 34. The dosage form of embodiment 27, 28, 29, 30, 31, 32, or 33, which is an oral dosage form.
Embodiment 35. The dosage form of embodiment 27, 28, 29, 30, 31, 32, 33, or 34, wherein about 50 mg to about 200 mg of SBEPCD is present in the dosage form.

Embodiment 36. The dosage form of embodiment 27, 28, 29, 30, 31, 32, 33, 34, or 35, wherein the bicarbonate is present in an amount of about 400 mg to about 1000 mg.
Embodiment 37. A method of treating migraine, comprising administering a dosage form comprising nneloxicann, at least 400 mg of a bicarbonate, and a rizatriptan to a human being suffering from migraine; wherein the Tmax of rizatriptan in the dosage form is shorter than that in a reference dosage form comprising a) same amount of rizatriptan; 2) no nneloxicann;
and c) no bicarbonate.
Embodiment 38. A method of treating migraine, comprising administering nneloxicann and about 8 mg to about 13 mg of rizatriptan, based upon the weight of the rizatriptan in the free base form, to a human being who is suffering from an acute attack of migraine pain or migraine aura, wherein the nneloxicann and the rizatriptan are administered within about 30 minutes of one another, wherein administering the nneloxicann to the human being results in a Tmax of nneloxicann of 110 minutes or less, and an AUC0_24of nneloxicann of about 30 ug=hr/nnL
to about 50 ug=hr/nnL.
Embodiment 39. A
pharmaceutical dosage form comprising: 1) about 0.028 nnnnol to about 0.085 nnnnol of nneloxicann in a free acid or a salt form, 2) about 0.019 nnnnol to about 0.056 nnnnol of rizatriptan in a free base or a salt form, 3) about 100 mg to about 175 mg of a sulfobutylether-(3-cyclodextrin (SBE(3CD), and 4) about 400 mg to about 600 mg of sodium bicarbonate.
Embodiment 40. A method of treating migraine comprising: selecting a human migraine patient with a history of inadequate response to prior migraine treatments, and orally administering a dosage form to the migraine patient, wherein the dosage form comprises a combination of: 1) nneloxicann (optionally in a complex with a sulfobutyl ether p-cyclodextrin (SBE(3CD)), 2) a bicarbonate, and 3) a rizatriptan.
Embodiment 41. The method of embodiment 40, wherein the human migraine patient experiences relief of the migraine pain as a result of orally administering the dosage form to the migraine patient.

Embodiment 42. The method of embodiment 40 or 41, wherein the human migraine patient is free of migraine pain two hours after the dosage form is orally administered to the human migraine patient.
Embodiment 43. The method of embodiment 40, 41, or 42, wherein the migraine patient experiences a reduction in nausea as a result of orally administering the dosage form to the migraine patient.
Embodiment 44. The method of embodiment 40, 41, 42, or 43, wherein the human migraine patient is free of nausea two hours after the dosage form is orally administered to the human migraine patient.
Embodiment 45. The method of embodiment 40, 41, 42, 43, or 44, wherein the migraine patient experiences a reduction in photophobia as a result of orally administering the dosage form to the migraine patient.
Embodiment 46. The method of embodiment 40, 41, 42, 43, 44, or 45, wherein the human migraine patient is free of photophobia two hours after the dosage form is orally administered to the human migraine patient.
Embodiment 47. The method of embodiment 40, 41, 42, 43, 44, 45, or 46, wherein the migraine patient experiences a reduction in phonophobia as a result of orally administering the dosage form to the migraine patient.
Embodiment 48. The method of embodiment 40, 41, 42, 43, 44, 45, 46, or 47, wherein the human migraine patient is free of phonophobia two hours after the dosage form is orally administered to the human migraine patient.
Embodiment 49. The method of embodiment 40, 41, 42, 43, 44, 45, 46, 47, or 48, wherein the dosage form contains 400 mg to 600 mg of the bicarbonate.
Embodiment 50. The method of embodiment 40, 41, 42, 43, 44, 45, 46, 47, 48, or 49, wherein the dosage form contains about 5 mg to about 50 mg of nneloxicann.
Embodiment 51. The method of embodiment 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, or 50, wherein the dosage form contains about 50 mg to about 200 mg of the SBEPCD.

Embodiment 52. The method of embodiment 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, or 51, wherein the dosage form is a solid oral dosage form having a shorter Tnnax of nneloxicann in the human being than a reference dosage form that: 1) contains the same amount of nneloxicann, 2) does not contain an SBEPCD, and 3) does not contain a bicarbonate.
Embodiment 53. The method of embodiment 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, or 52, wherein about 1 mg to about 50 mg of the rizatriptan is present in the oral dosage form based upon the weight of the rizatriptan in the free base form.
Embodiment 54. The method of embodiment 53, wherein the rizatriptan is present in a salt form in an amount that is a molar equivalent of about 10 mg of the rizatriptan in the free base form.
Embodiment 55. The method of embodiment 53 or 54, wherein the rizatriptan is present as rizatriptan benzoate.
Embodiment 56. The method of embodiment 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, or 55, wherein the oral dosage form contains about 10 mg to about 30 mg of nneloxicann.
Embodiment 57. The method of embodiment 56, wherein the oral dosage form contains about 20 mg of nneloxicann.
Embodiment 58. The method of embodiment 56, wherein the oral dosage form contains about 15 mg of nneloxicann.
Embodiment 59. The method of embodiment 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, or 58, wherein the SBEPCD has about 6 to about 7 sulfobutyl ether groups for each molecule of p-cyclodextrin.
Embodiment 60. The method of embodiment 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, or 59, wherein the oral dosage form contains about 50 mg to about 150 mg of the SBEPCD.
Embodiment 61. The method of embodiment 60, wherein the oral dosage form contains about 100 mg of the SBEPCD.

Embodiment 62. The method of embodiment 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, or 61, wherein the molar ratio of the SBEPCD to nneloxicann is about 0.5 to about 2.
Embodiment 63. The method of embodiment 62, wherein the molar ratio of the SBEPCD
to nneloxicann is about 0.8 to about 1.2.
Embodiment 64. The method of embodiment 62, wherein the molar ratio of the SBEPCD
to nneloxicann is about 1.
Embodiment 65. The method of embodiment 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, or 64, wherein the oral dosage form contains about 10 mg to about 40 mg of nneloxicann, and about 5 mg to about 50 mg of rizatriptan.
Embodiment 66. The method of embodiment 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, or 65, wherein the oral dosage form contains SBEPCD that is in a weight ratio to rizatriptan that is within a range of about 1 to about 100.
Embodiment 67. The method of embodiment 66, wherein the oral dosage form contains SBEPCD that is in a weight ratio to rizatriptan that is about 10.
Embodiment 68. The method of embodiment 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, or 67, wherein the bicarbonate comprises sodium bicarbonate.
Embodiment 69. The method of embodiment 68, wherein the oral dosage form contains 500 mg of sodium bicarbonate.
Embodiment 70. The method of embodiment 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, or 69, wherein the oral dosage form has been shown to have a median Tnnax of nneloxicann that is less than about 90 minutes in fasted human subjects.

Embodiment 71. The method of embodiment 70, wherein the oral dosage form has been shown to have a median Tnnax of nneloxicann that is less than about 2 hours in fasted human subjects.
Embodiment 72. The method of embodiment 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, or 71, wherein the oral dosage form has been shown to have faster time to therapeutic plasma concentration in the human being as compared to the reference dosage form.
Embodiment 73. A method of treating migraine comprising: selecting a human migraine patient with a history of inadequate response to prior migraine treatments, and orally administering a dosage form to the migraine patient, wherein the dosage form comprises a combination of: 1) nneloxicann (optionally in a complex with a sulfobutyl ether p-cyclodextrin (SBE(3CD)), 2) a bicarbonate, and 3) a rizatriptan, wherein the human migraine patient experiences relief of the migraine pain as a result of orally administering the dosage form to the migraine patient.
Embodiment 74. A method of treating migraine comprising: selecting a human migraine patient with a history of inadequate response to prior migraine treatments, and orally administering a dosage form to the migraine patient, wherein the dosage form comprises a combination of: 1) nneloxicann (optionally in a complex with a sulfobutyl ether p-cyclodextrin (SBE(3CD)), 2) a bicarbonate, and 3) a rizatriptan, wherein the human migraine patient is free of migraine pain two hours after the dosage form is orally administered to the human migraine patient.
Embodiment 75. A method of treating migraine comprising: selecting a human migraine patient with a history of inadequate response to prior migraine treatments, and orally administering a dosage form to the migraine patient, wherein the dosage form comprises a combination of: 1) nneloxicann (optionally in a complex with a sulfobutyl ether p-cyclodextrin (SBE(3CD)), 2) a bicarbonate, and 3) a rizatriptan, wherein the migraine patient experiences a reduction in nausea as a result of orally administering the dosage form to the migraine patient.

Embodiment 76. A method of treating migraine comprising: selecting a human migraine patient with a history of inadequate response to prior migraine treatments, and orally administering a dosage form to the migraine patient, wherein the dosage form comprises a combination of: 1) nneloxicann (optionally in a complex with a sulfobutyl ether p-cyclodextrin (SBE(3CD)), 2) a bicarbonate, and 3) a rizatriptan, wherein the human migraine patient is free of nausea two hours after the dosage form is orally administered to the human migraine patient.
Embodiment 77. A method of treating migraine comprising: selecting a human migraine patient with a history of inadequate response to prior migraine treatments, and orally administering a dosage form to the migraine patient, wherein the dosage form comprises a combination of: 1) nneloxicann (optionally in a complex with a sulfobutyl ether p-cyclodextrin (SBE(3CD)), 2) a bicarbonate, and 3) a rizatriptan, wherein the migraine patient experiences a reduction in photophobia as a result of orally administering the dosage form to the migraine patient.
Embodiment 78. A method of treating migraine comprising: selecting a human migraine patient with a history of inadequate response to prior migraine treatments, and orally administering a dosage form to the migraine patient, wherein the dosage form comprises a combination of: 1) nneloxicann (optionally in a complex with a sulfobutyl ether p-cyclodextrin (SBE(3CD)), 2) a bicarbonate, and 3) a rizatriptan, wherein the human migraine patient is free of photophobia two hours after the dosage form is orally administered to the human migraine patient.
Embodiment 79. A method of treating migraine comprising: selecting a human migraine patient with a history of inadequate response to prior migraine treatments, and orally administering a dosage form to the migraine patient, wherein the dosage form comprises a combination of: 1) nneloxicann (optionally in a complex with a sulfobutyl ether p-cyclodextrin (SBE(3CD)), 2) a bicarbonate, and 3) a rizatriptan, wherein the migraine patient experiences a reduction in phonophobia as a result of orally administering the dosage form to the migraine patient.

Embodiment 80. A method of treating migraine comprising: selecting a human migraine patient with a history of inadequate response to prior migraine treatments, and orally administering a dosage form to the migraine patient, wherein the dosage form comprises a combination of: 1) nneloxicann (optionally in a complex with a sulfobutyl ether p-cyclodextrin (SBE(3CD)), 2) a bicarbonate, and 3) a rizatriptan, wherein the human migraine patient is free of phonophobia two hours after the dosage form is orally administered to the human migraine patient.
Example 1

[0167] The effect of varying amounts of potassium carbonate (K2CO3) and sodium bicarbonate (NaHCO3) on the pH of acidic media was tested. The acidic media was chosen to simulate gastric conditions. K2CO3 or NaHCO3 was added to 50 nnL of a 0.01 N
HCI solution (pH 2). The pH of the solution was measured after addition of the K2CO3 or NaHCO3. Deionized water (240 nnL) was then added to the mixture and pH was measured again. The results are shown in Tables 1-4.
Table 1. Results with K2CO3 (0.01 N HCI) K2CO3 (mg) pH
25 2.84 35 6.29 45 8.05 50 8.29 100 9.43 200 10.14 300 10.39 400 10.55 450 10.58 Table 2. Results with K2CO3 (0.01 N HCI + Water) K2CO3 (mg) pH
200 10.27 300 10.46 400 10.57 450 10.63 Table 3. Results with NaHCO3 (0.01 N HCI) NaHCO3 (mg) pH
200 5.28 300 5.90 400 6.44 450 6.86 500 8.23 750 8.30 1000 8.36 Table 4. Results with NaHCO3 (0.01 N HCI + Water) NaHCO3 (mg) pH
200 5.41 300 5.89 400 6.11 450 6.46 500 8.33 750 8.54 1000 8.60 Example 2

[0168] Tablets containing nneloxicann and combinations of a sulfobutylether-(3-cyclodextrin (5130CD) (a cyclodextrin, containing about 6 to about 7 sulfobutyl ether groups for each molecule of p-cyclodextrin), K2CO3, or NaHCO3 were manufactured and tested for dissolution. Tablets containing nneloxicann alone (MOBIC ) were purchased and also tested for dissolution. The tested tablets are listed in Table 5. Meloxicann in the form of nneloxicann/
513E(3CD inclusion complexes was used in the tablets containing nneloxicann and 5130CD. The inclusion complexes were formed by mixing nneloxicann and 513E(3CD in an aqueous pH-adjusted solution. The pH of the solution was adjusted using buffering agents.
The resulting soluble nneloxicann/ 513E(3CD inclusion complexes were then spray dried. This spray-dried dispersion was used in the manufacture of the tablets containing 5130CD.

Table 5. Tablets Tablet A 15 mg nneloxicann + 25 mg K2CO3 Tablet B 15 mg nneloxicann + 50 mg K2CO3 Tablet C 15 mg nneloxicann + 100 mg K2CO3 Tablet D 15 mg nneloxicann + 150 mg K2CO3 Tablet E 15 mg nneloxicann + 500 mg NaHCO3 Tablet F 15 mg nneloxicann + 100 mg SBEBCD
Tablet G 15 mg nneloxicann + 100 mg SBEBCD + 25 mg K2CO3 Tablet H 15 mg nneloxicann + 100 mg SBEBCD + 50 mg K2CO3 Tablet I 15 mg nneloxicann + 100 mg SBEBCD + 100 mg K2CO3 Tablet J 15 mg nneloxicann + 100 mg SBEBCD + 150 mg K2CO3 Tablet K 15 mg nneloxicann + 100 mg SBEBCD + 500 mg NaHCO3 Tablet L 15 mg nneloxicann (MOBIC )

[0169]
Dissolution testing in acidic medium (chosen to simulate gastric conditions) was performed by placing the tablets in a 0.01 N HCI solution, at an agitation rate of 75 RPM, and vessel temperature of approximately 37 'C. The results are presented in Tables 6 and in Figures 1-10. Results at various time points (0, 15, 30, 45, 60, 90, and 120 minutes) are presented as percent (%) of nneloxicann dissolved.
Table 6. Dissolution Results 0 mins mins mins mins mins mins mins Tablet A 0% 23% 17% 15% 13% 12% 11%
Tablet B 0% 27% 20% 17% 16% 17% 15%
Tablet C 0% 31% 26% 25% 24% 23% 21%
Tablet D 0% 30% 26% 25% 24% 23% 22%
Tablet E 0% 50% 66% 77% 84% 92% 95%
Tablet F 0% 26% 17% 14% 12% 11% 10%
Tablet G 0% 48% 39% 26% 20% 16% 14%
Tablet H 0% 44% 30% 22% 17% 16% 13%
Tablet I 0% 32% 33% 27% 21% 16% 15%
Tablet J 0% 26% 27% 19% 15% 12% 11%
Tablet K 0% 85% 86% 86% 86% 86% 86%
Tablet L 0% 2% 2% 2% 2% 2% 2%

[0170]
Dissolution of nneloxicann was greater with the tablets containing various combinations of nneloxicann and SBEBCD, K2CO3, or NaHCO3, as compared to tablets containing nneloxicann alone. For example, after 120 minutes, dissolution of nneloxicann tablets containing NaHCO3 was 95% as compared to 2% for tablets containing nneloxicann alone.

[0171]
Dissolution of nneloxicann increases with increasing amounts of K2CO3 in the absence of SBE(3CD. However, in the presence of SBE(3CD, increasing amounts of K2CO3 did not appear to increase nneloxicann dissolution. At the highest dose of potassium carbonate tested, nneloxicann dissolution in the presence of SBEKD was reduced by approximately 50%
as compared to nneloxicann dissolution in the absence of SBEKD at 120 minutes.

[0172]
Dissolution of nneloxicann with NaHCO3 was significantly greater than that observed with the highest dose of K2CO3 at 15 minutes (50% versus 30%), and at 120 minutes (92% versus 23%). Meloxicann dissolution in the presence of SBE(3CD was also significantly greater with NaHCO3 as compared to the highest dose of K2CO3 at 15 minutes (85% versus 26%), and at 120 minutes (86% versus 12%). NaHCO3 in the presence of SBEKD
increased nneloxicann dissolution more at 15 minutes as compared to potassium carbonate, which resulted in a reduction in dissolution.
Example 3

[0173] A
bilayer tablet containing 1) an inclusion complex of SBEKD with nneloxicann, prepared as described below, and 2) sodium bicarbonate was prepared (SBEKD-Meloxicann/Bicarbonate). The first layer contained an inclusion complex of 15 mg nneloxicann and 100 mg SBE(3CD, and 100 mg of sodium bicarbonate. The second layer contained 40 mg of esonneprazole and 400 mg of sodium bicarbonate.

[0174] A total of 20 human subjects were randomly assigned in a 1:1 ratio to treatment with the SBEKD-Meloxicann/Bicarbonate tablets described above or Mobic tablets (15 mg nneloxicann), once daily for 6 days under fasting conditions.

[0175] On the first day of dosing, plasma samples were collected for concentration analysis of nneloxicann at several time points. Concentrations of nneloxicann were determined using LC-MS/MS. Pharnnacokinetic parameters were calculated. The results are depicted in FIG. 11.

[0176] The median Tmax for nneloxicann, the trial's primary endpoint, was 9 times faster for the SBEBCD-Meloxicann/Bicarbonate tablets as compared to Mobic (0.5 hour versus 4.5 hours respectively, p<0.0001).

[0177] The SBEBCD-Meloxicann/Bicarbonate tablets also demonstrated higher mean maximum plasma concentration (Cmax) (p=0.0018), faster time to therapeutic plasma concentration (p<0.0001), and faster time to half-maximal plasma concentration (p<0.0001) as compared to Mobic .

[0178]
Meloxicann in the form of nneloxicann/SBEBCD inclusion complexes was used in the tablets containing nneloxicann and SBEBCD. The inclusion complexes were formed by mixing nneloxicann and SBEBCD in an aqueous pH-adjusted solution. The pH of the solution was adjusted using buffering agents. The resulting soluble nneloxicann/SBEBCD
inclusion complexes were then spray dried. This spray-dried dispersion was used in the manufacture of the tablets containing SBEBCD.
Example 4 A nnonolayer tablet containing 1) the inclusion complex of SBEBCD with nneloxicann; 2) rizatriptan; and 3) sodium bicarbonate was prepared (SBEBCD-Meloxicann/rizatriptan/Bicarbonate). The nnonolayer tablet contained 20 mg of nneloxicann, mg of rizatriptan, and 500 mg of sodium bicarbonate. The inclusion complex was the same as the inclusion complex of Example 3.
Dissolution testing of the tablets in acidic medium (chosen to simulate gastric conditions) was performed by placing the tablets in a 0.01 N HCI solution, at an agitation rate of 75 RPM, and vessel temperature of approximately 37 C. The results are presented in Table 7. Results at various time points (0, 15, 30, 45, 60, 90, and 120 minutes) are presented as percent (%) of nneloxicann, and percent (%) of rizatriptan dissolved.
Table 7. Dissolution Results Time-point (minutes) 0 min 15 min 30 min 45 min 60 min 90 min 120 min Rizatriptan 0% 89% 102% 103% 103% 103% 103%
Meloxicann 0% 79% 92% 93% 93% 93% 94%

As shown in Table 7, the dissolution results of the tablets in Example 4 are very similar to the dissolution result of Example 3. Therefore, we expected the pharnnacokinetic properties, including bioavailability, Tmax of nneloxicann, etc., of the tablets in Example 4 to be similar to those described in Example 3 and FIG. 11. This expectation turned out to be correct, as shown in the examples below.
Example 5

[0179] The nnonolayer tablet of Example 4 was administered to six human subjects. On the first day of dosing, plasma samples were collected for concentration analysis of rizatriptan at several time points. Concentrations of rizatriptan and nneloxicann were determined using LC-MS/MS. Pharnnacokinetic parameters were calculated. The results for nneloxicann were comparable to those reported for the bilayer dosage form of Example 3. The median Tmax of rizatriptan was 0.75 hours and the mean Cirax of rizatriptan was 20.710 ng/nnL. By comparison, the reported Tmax of the commercial rizatriptan dosage form, Maxalt , is 1.0-1.5 hours.
Example 6

[0180] A Phase 1, randomized, single-dose, parallel-group clinical study was conducted to evaluate the PK, safety and tolerability of 1) a combination of nneloxicann (20 mg), rizatriptan (10 mg), SBEBCD, and sodium bicarbonate (nneloxicann/rizatriptan), as compared to 2) and Maxalt (10 mg rizatriptan), in healthy human volunteers after oral administration under fasted conditions. A total of 20 healthy, adult male or female volunteers were randomized in a 1:1 ratio to receive a single dose of nneloxicann/rizatriptan, or Maxalt (10 mg rizatriptan).

[0181] Blood samples for PK analysis were collected pre dose and at multiple time points post dose. The pre-specified primary endpoint was Tthem, the time to reach a therapeutic plasma concentration of nneloxicann, defined as the Cavg of nneloxicann after administration of the highest approved dose (15 mg) of standard nneloxicann, which is approximately 1000 ng/nn L. PK results for the rizatriptan component of nneloxicann/rizatriptan were compared to those for Maxalt (rizatriptan).

[0182] PK
results for the nneloxicann (20 mg) component of nneloxicann/rizatriptan from this trial were compared to PK results for Mobic (15 mg nneloxicann) from Example 3.
Phase 1 Results

[0183] Meloxicann was rapidly absorbed after oral administration of nneloxicann/rizatriptan (20 mg nneloxicann/10 mg rizatriptan), with a median time to therapeutic plasma concentration (Tthera) of 17 minutes, the primary endpoint (Figure 12 and Table 8). Median Tmax was 1 hour compared to 4.5 hours for 15 mg standard nneloxicann (Mobic ). The very short Tmax suggests the potential for nneloxicann/rizatriptan to have rapid onset of action in treating migraine. Mean plasma elimination half-life (Tv2) for nneloxicann was 18.2 hours after administration of nneloxicann/rizatriptan, which compares to 21.5 hours for standard nneloxicann. The long elimination half-life suggests the potential for nneloxicann/rizatriptan to enhanced and sustained efficacy, and to reduce migraine pain recurrence.
Table 8. Meloxicann Pharnnacokinetic Parameters for Meloxicann/Rizatriptan Statistic AU CO-inf 1-312 el (hr) Cmax (ng/mL) Tmax (hr)a Tthera (hr)a (ng=hr/mL) Geometric 46,865 17.5 2,532 1.0 0.29 Mean SD 11,965 5.25 607 0.5-2.5 0.20-0.61 aTmax and Tthera present the value as a median or a range.

[0184] Rizatriptan was rapidly absorbed after oral administration of nneloxicann/rizatriptan, with a T. of 0.64 hour (38 min), which compares to 0.88 hour for the same dose of standard rizatriptan (Maxalt ) (Figure 13 and Table 9). Systemic exposure measured using C. and AUC were also numerically greater for rizatriptan after administration of nneloxicann/rizatriptan versus standard rizatriptan.
Table 9. Rizatriptan Pharnnacokinetic Parameters for Meloxicann/Rizatriptan and Standard Rizatriptan Statistic AU CO-inf 1-112 el Cmax Tmax (hr)a (pg=hr/mL) (hr) (ng/mL) Geometric 83,800 1.98 29,991 0.64 Mean Statistic AU CO-inf T112 el Cmax Tmax (h Oa (pg=hr/mL) (hr) (ng/mL) Meloxicann/Rizatriptan SD 22,787 0.28 11,041 0.5-2.5 (20 mg nneloxicann/10 mg rizatriptan) Standard Rizatriptan N 10 10 10 10 (Maxalt ) (10 mg Geometric 71,811 1.81 23,236 0.88 Mean rizatriptan) SD 24,287 0.11 9,476 0.5-2 aTmax presents the value as a median or a range.

[0185]
Meloxicann/rizatriptan was well tolerated with no relevant differences in safety profile between the two treatment arms. There were no serious adverse events in the study.
Example 7

[0186] A Phase 3, randomized, double-blind, multicenter, active- and placebo-controlled trial is carried out to assess the efficacy and safety of nneloxicann/rizatriptan in the acute treatment of moderate and severe migraine, in patients with a history of inadequate response to prior acute migraine treatments. Eligible patients are randomized in a 2:2:2:1 ratio to treatment with nneloxicann/rizatriptan (20 mg nneloxicann/10 mg rizatriptan, with SBEKD and sodium bicarbonate as described in Example 4 above), rizatriptan (10 mg) (rizatriptan arm), nneloxicann (20 mg) with SBEKD and sodium bicarbonate (nneloxicann arm), or placebo. Co-primary endpoints are freedom from headache pain, and freedom from the most bothersome migraine-associated symptom (nausea, photophobia, or phonophobia), two hours after dosing, for nneloxicann/rizatriptan as compared to placebo.

[0187]
Superiority of nneloxicann/rizatriptan to the rizatriptan and the nneloxicann arms (component contribution) will be established based on sustained freedom from headache pain from 2 hours to 24 hours after dosing (key secondary endpoint).

[0188] Eligible patients must have a history of inadequate response to prior acute migraine treatments, assessed using the Migraine Treatment Optimization Questionnaire (nnT0Q-4). The nnT0Q-4 is a validated questionnaire that assesses efficacy response to prior acute treatments based on four aspects (two-hour pain freedom, efficacy for at least 24 hours with one dose, ability to plan daily activities, and disruption of daily activities).

[0189] It is expected that nneloxicann/rizatriptan will show significant improvement over placebo and superiority over the rizatriptan and the nneloxicann arms because of the rapid absorption and distinct dual mechanisms of action of nneloxicann/rizatriptan described herein.
Example 8

[0190] A female migraine sufferer visits her physician in the hope of having relief from her migraine pain. Her doctor gives her 10 mg rizatriptan (Maxalt ), which she takes during her next acute migraine. It provides some relief of pain, nausea, allodynia, photophobia, and phonophobia, but not complete relief from these symptoms. On her next visit, her doctor gives her 20 mg of nneloxicann in a tablet also containing SBEKD and 500 mg of sodium bicarbonate, which she takes during her next acute migraine. It provides some relief of pain, nausea, allodynia, photophobia, and phonophobia, but not complete relief from these symptoms. On her next visit, her doctor gives her a tablet described in Example 4 above. She reports that at 2 hours and 24 hours after taking the tablet, she has about 10-30%
improvement in pain, nausea, allodynia, photophobia, and/or phonophobia over what she experienced after taking nneloxicann or rizatriptan alone.
Example 9

[0191] A male migraine sufferer visits his physician in the hope of having relief from his migraine pain. His doctor gives him 10 mg rizatriptan (Maxalt ), which he takes during his next acute migraine. It provides some relief of pain, nausea, allodynia, photophobia, and phonophobia, but not complete relief from these symptoms. On his next visit, his doctor gives his 20 mg of nneloxicann in a tablet also containing SBEKD and 500 mg of sodium bicarbonate, which he takes during his next acute migraine. It provides some relief of pain, nausea, allodynia, photophobia, and phonophobia, but not complete relief from these symptoms. On his next visit, his doctor gives him a tablet described in Example 4 above. He reports that at 2 hours and 24 hours after taking the tablet, he has about 30-60% improvement in pain, nausea, allodynia, photophobia, and/or phonophobia over what he experienced after taking nneloxicann or rizatriptan alone.

Example 10

[0192] A female migraine sufferer visits her physician in the hope of having relief from her migraine pain. Her doctor gives her 10 mg rizatriptan (Maxalt ), which she takes during her next acute migraine. It provides some relief of pain, nausea, allodynia, photophobia, and phonophobia, but not complete relief from these symptoms. On her next visit, her doctor gives her 20 mg of nneloxicann in a tablet also containing SBEPCD and 500 mg of sodium bicarbonate, which she takes during her next acute migraine. It provides some relief of pain, nausea, allodynia, photophobia, and phonophobia, but not complete relief from these symptoms. On her next visit, her doctor gives her a tablet described in Example 4 above. She reports that at 2 hours and 24 hours after taking the tablet, she has about 60-100%
improvement in pain, nausea, allodynia, photophobia, and/or phonophobia over what she experienced after taking nneloxicann or rizatriptan alone.
Example 11

[0193] Over 37 million Americans suffer from migraine according to the Centers for Disease Control, and it is the leading cause of disability among neurological disorders in the United States according to the American Migraine Foundation. Migraine is characterized by recurrent attacks of pulsating, often severe and disabling head pain associated with nausea, and sensitivity to light and or sound. It is estimated that migraine accounts for $78 billion in direct (e.g. doctor visits, medications) and indirect (e.g. missed work, lost productivity) costs each year in the United States [Gooch CL, Pracht E, Borenstein AR, The burden of neurological disease in the United States: A summary report and call to action. Ann Neurol.
2017 Apr;
81(4):479-484]. Published surveys of migraine sufferers indicate that more than 70% are not fully satisfied with their current treatment, that nearly 80% would try a new therapy, and that they desire treatments that work faster, more consistently, and result in less symptom recurrence [(1) Smelt AF, Louter MA, Kies DA, Blom JW, Terwindt GM, van der Heijden GJ, De Gucht V, Ferrari MD, Assendelft WJ, What do patients consider to be the most important outcomes for effectiveness studies on migraine treatment? Results of a Delphi study. PLoS
One. 2014 Jun 16;9(6):e98933, 6; and (2) Lipton RB, Stewart WF, Acute migraine therapy: do doctors understand what patients with migraine want from therapy? Headache.
1999;39(suppl 2):520-526].

[0194] The World Health Organization classifies severe migraine attacks as among the most disabling illnesses, comparable to dementia, quadriplegia and active psychosis [(1) Menken et al. Arch Neurol. 2000;57:418-420; and (2) Shapiro and Goadsby.
Cephalalgia.
2007;27:991-4]. Debilitating pain, and the often-constant fear of the next migraine attack, damage family life, social life, and employment [Global Burden of Disease Study. Lancet.
2017;390:1211-1259]. Depression and anxiety are twice as common in people with migraine than in healthy individuals [Antonaci et al. J Headache Pain. 2011;12:115-125]. Widespread misperception of the seriousness of migraine contributes to its under-recognition and under-treatment [Global Burden of Disease Study. Lancet. 2017;390:1211-1259]. The majority of patients are not fully satisfied with their current treatment. Thus, there is an urgent need for new treatments that provide improved efficacy for this serious neurological disease.

[0195] A Phase 3, randomized, double-blind, multicenter, placebo- and active-controlled trial was conducted to assess the efficacy and safety of the combination of nneloxicann and rizatriptan (nneloxicann/rizatriptan) in the acute treatment of moderate and severe migraine.
Eligible patients must have an age of 18 to 65 years, an established diagnosis (at least 1 year) of migraine with or without aura as defined by ICHD-3 criteria, an average of 2 to 8 moderate to severe migraines per month, had a history of inadequate response to prior acute migraine treatments, assessed by a score of 7 using the Migraine Treatment Optimization Questionnaire (nnT0Q-4) (the average score was 3.6), corresponding to poor response to prior acute treatments. Exclusion criteria included cluster headaches or other types of migraines, chronic daily headache 15 non-migraine headache days per month), history of significant cardiovascular disease, and uncontrolled hypertension. In addition to a history of inadequate response, enrolled patients exhibited a high rate of characteristics that are strongly associated with poor treatment outcomes including cutaneous allodynia (75.4%), severe migraine pain intensity (41.2%), obesity (43.7%), and morning migraine (36.6%). A total of 1,594 patients were randomized in a 2:2:2:1 ratio to the nnonolayer tablet of Example 4 (20 mg nneloxicann/10 mg rizatriptan, with SBEBCD and sodium bicarbonate), rizatriptan (10 mg), nneloxicann (20 mg) with SBEBCD (MoSEIC Meloxicann), or placebo, to treat a single migraine attack of moderate or severe intensity. The two co-primary endpoints of the trial were the proportion of patients who are free from headache pain two hours after dosing, and the proportion of patients who no longer suffered from their most bothersome migraine-associated symptom (nausea, photophobia, or phonophobia) two hours after dosing, for nneloxicann/rizatriptan as compared to placebo. Superiority of nneloxicann/rizatriptan to the rizatriptan and nneloxicann arms (component contribution) was to be established based on sustained freedom from headache pain from two to 24 hours after dosing (key secondary endpoint). The study was conducted pursuant to an FDA Special Protocol Assessment (SPA).
Rizatriptan, an active comparator in the trial, is considered to be the fastest acting oral triptan and one of the most effective medications currently available for the acute treatment of migraine. (Ferrari MD, Roon KI, Lipton RB, Goadsby Pi. Oral triptans (serotonin 5-HT(113/1D) agonists) in acute migraine treatment: a meta-analysis of 53 trials. Lancet.
2001 Nov 17;358(9294):1668-75.)

[0196]
Meloxicann/rizatriptan provided rapid relief of migraine pain with the percentage of patients achieving pain relief with nneloxicann/rizatriptan being numerically greater than with rizatriptan at every time point measured starting at 15 minutes, and statistically significant by 60 minutes (p=0.04) (Fig. 14). The proportions of patients experiencing pain relief 1.5 hours after dosing were 60.5% for nneloxicann/rizatriptan compared to 52.5% for rizatriptan and 48.3% for placebo (p=0.019, p=0.04, respectively versus nneloxicann/rizatriptan) (Fig. 14).

[0197]
Meloxicann/rizatriptan met the two regulatory co-primary endpoints by demonstrating, with high statistical significance, a greater percentage of patients as compared to placebo achieving pain freedom (19.9% versus 6.7%, p<0.001, Fig.
15), and absence of most bothersome symptom (36.9% versus 24.4%, p=0.002), 2 hours after dosing.

[0198]
Superiority of nneloxicann/rizatriptan to rizatriptan (active comparator and MoSEICTM nneloxicann (component contribution) was established as specified in the SPA, by the demonstration of a greater percentage of patients receiving nneloxicann/rizatriptan achieving sustained pain freedom from 2 hours to 24 hours after dosing, compared to rizatriptan, MoSEICTM nneloxicann, and placebo (16.1%, 11.2%, 6.8% and 5.3%, respectively;
p=0.038, p=0.001, and p<0.001, respectively versus nneloxicann/rizatriptan, Fig. 16A), the pre-specified key secondary endpoint to demonstrate component contribution. About 80% of the patients treated with nneloxicann/rizatriptan who achieved pain freedom at 2 hours maintained pain freedom through 24 hours. These results demonstrated the significant improvement in pain freedom and superiority of nneloxicann/rizatriptan to rizatriptan in treating migraine.

[0199]
Meloxicann/rizatriptan provided substantially greater and more sustained migraine pain relief compared to placebo and rizatriptan, which translated to a significant reduction in rescue medication use for nneloxicann/rizatriptan compared to placebo and rizatriptan. The percentage of patients experiencing sustained pain relief from 2 hours to 24 hours after dosing was 53.3% for nneloxicann/rizatriptan, compared to 33.5%
for placebo and 43.9% for rizatriptan (p<0.001, p=0.006, respectively versus nneloxicann/rizatriptan) (Fig. 168).

[0200]
Sustained pain relief from 2 hours to 48 hours was also experienced by a statistically significantly greater proportion of nneloxicann/rizatriptan patients (46.5%), compared to placebo (31.1%) and rizatriptan (36.5%) patients (p<0.001, p=0.003, respectively versus nneloxicann/rizatriptan) (Fig. 17B). The sustained pain freedom from 2 hours to 48 hours was also experienced by a statistically significantly greater proportion of nneloxicann/rizatriptan patients (15.4%), compared to placebo (5.3%), and rizatriptan (8.8%), and MoSEICTM nneloxicann (8.1%) patients (p<0.001, p=0.003, p=<0.001, respectively versus nneloxicann/rizatriptan) (Fig. 17A). About 77% of patients treated with nneloxicann/rizatriptan who achieved pain freedom at 2 hours maintained the pain freedom through 48 hours.

[0201] Rescue medication was used by 23.0% patients received nneloxicann/rizatriptan, compared to 43.5% patients received placebo and 34.7% patients received rizatriptan (p<0.001 for each group versus nneloxicann/rizatriptan) (Fig. 18). About 77%
of patients receiving nneloxicann/rizatriptan did not require rescue medication. These results demonstrated the superiority of nneloxicann/rizatriptan to rizatriptan, an active comparator, in treating migraine.

[0202]
Meloxicann/rizatriptan was statistically significantly superior to rizatriptan on several other secondary endpoints, including Patient Global Impression of Change (PGI-C) (p=0.022), and return to normal functioning at 24 hours (p=0.027).

[0203] Some of the p-values for nneloxicann/rizatriptan versus rizatriptan for various endpoints are listed in Table 10 below, demonstrating the statistically significant superiority of nneloxicann/rizatriptan over rizatriptan in treating migraine.

Table 10. P-Values for Meloxicann/Rizatriptan vs Rizatriptan for Various Endpoints Endpoint P-value Meloxicann/Rizatriptan vs Rizatriptan 1 hour Pain Relief 0.04 2-24 hour Sustained Pain Relief 0.006 2-48 hour Sustained Pain Relief 0.003 2-24 hour Sustained Pain Freedom 0.038 2-48 hour Sustained Pain Freedom 0.003 PGI-C 0.022 Functional Improvement at 24 hours 0.027 Use of Rescue Medication <0.001

[0204] Given that Rizatriptan, an active comparator in the trial, is considered to be the fastest acting oral triptan and one of the most effective medications currently available for the acute treatment of migraine, and that this trial enrolled patients with difficult-to-treat migraine, the observed treatment effects with nneloxicann/rizatriptan that provided greater and more lasting migraine pain relief than rizatriptan, is highly significant.
Many patients experience a suboptimal response to their current acute migraine treatments, placing them at increased risk of headache related disability and progression to chronic migraine, factors associated with increased healthcare costs. The results of this study suggest that nneloxicann/rizatriptan may provide an important treatment option for people with difficult-to-treat migraine.

[0205]
Meloxicann/rizatriptan was safe and well tolerated in the patients studied in the trial. The most commonly reported adverse events with nneloxicann/rizatriptan were nausea, dizziness and somnolence, none of which occurred at a rate greater than placebo or greater than 3%. There was one serious adverse event in the nneloxicann/rizatriptan arm which was deemed by the investigator not to be related to the study drug.

[0206] The results of this trial demonstrate the ability of nneloxicann/rizatriptan to provide unique benefits to migraine patients, with fast, strong, and durable relief of migraine pain as compared to a potent active comparator, rizatriptan, in a stringently designed trial enriched with patients with difficult-to-treat migraine. These results have potentially important implications for patient care based on the high rate of inadequate response to and patient dissatisfaction with current treatments.

[0207]
Meloxicann/rizatriptan incorporates multiple mechanisms of action to address various migraine processes with the goal of providing enhanced effectiveness.
Meloxicann/rizatriptan is thought to act by inhibiting CGRP release, reversing CGRP-mediated vasodilation, and inhibiting neuro-inflammation, pain signal transmission, and central sensitization. The results of this trial validate this approach, demonstrating that nneloxicann/rizatriptan can provide significant benefit that is greater than that of currently available treatments, even in patients with difficult-to-treat migraine.
Meloxicann/rizatriptan may be used for the acute treatment of migraine in adults with or without aura effectively.
Example 12

[0208]
Meloxicarn/rizatriptan is also being evaluated in another Phase 3 trial which is a randomized, double-blind, placebo-controlled study evaluating the early treatment of migraine with nneloxicann/rizatriptan. In contrast to this ongoing trial in which patients with a history of inadequate response treated migraine attacks once they have developed moderate or severe intensity of migraine, in the other trial, patients are to administer nneloxicann/rizatriptan at the earliest sign of migraine pain.

[0209] Eligible patients are randomized in a 1:1 ratio to treatment with nneloxicann/rizatriptan (20 mg nneloxicann/10 mg rizatriptan, with SBEPCD and sodium bicarbonate as described in Example 4 above), or placebo. Adult subjects with an established diagnosis of migraine with or without aura. The treatment with nneloxicann/rizatriptan is initiated at the first sign of migraine pain onset.

[0210] Co-primary endpoints are freedom from headache pain, and freedom from the most bothersome migraine-associated symptom (nausea, photophobia, or phonophobia), two hours after dosing, for nneloxicann/rizatriptan as compared to placebo.

[0211] Unless otherwise indicated, all numbers expressing quantities of ingredients, properties such as amounts, percentage, and so forth used in the specification and claims are to be understood in all instances as indicating both the exact values as shown and as being modified by the term "about." Accordingly, unless indicated to the contrary, the numerical parameters set forth in the specification and attached claims are approximations that may vary depending upon the desired properties sought to be obtained. At the very least, and not as an attempt to limit the application of the doctrine of equivalents to the scope of the claims, each numerical parameter should at least be construed in light of the number of reported significant digits and by applying ordinary rounding techniques.

[0212] The terms "a," "an," "the" and similar referents used in the context of describing the embodiments (especially in the context of the following claims) are to be construed to cover both the singular and the plural, unless otherwise indicated herein or clearly contradicted by context. All methods described herein can be performed in any suitable order unless otherwise indicated herein or otherwise clearly contradicted by context. The use of any and all examples, or exemplary language (e.g., "such as") provided herein is intended merely to better illuminate the embodiments and does not pose a limitation on the scope of any claim. No language in the specification should be construed as indicating any non-claimed element essential to the practice of the claims.

[0213]
Groupings of alternative elements or embodiments disclosed herein are not to be construed as limitations. Each group member may be referred to and claimed individually or in any combination with other members of the group or other elements found herein. It is anticipated that one or more members of a group may be included in, or deleted from, a group for reasons of convenience and/or to expedite prosecution. When any such inclusion or deletion occurs, the specification is deemed to contain the group as modified thus fulfilling the written description of all Markush groups if used in the appended claims.

[0214] Certain embodiments are described herein, including the best mode known to the inventors for carrying out the claimed embodiments. Of course, variations on these described embodiments will become apparent to those of ordinary skill in the art upon reading the foregoing description. The inventor expects skilled artisans to employ such variations as appropriate, and the inventors intend for the claimed embodiments to be practiced otherwise than specifically described herein. Accordingly, the claims include all modifications and equivalents of the subject matter recited in the claims as permitted by applicable law.
Moreover, any combination of the above-described elements in all possible variations thereof is contemplated unless otherwise indicated herein or otherwise clearly contradicted by context.

[0215] In closing, it is to be understood that the embodiments disclosed herein are illustrative of the principles of the claims. Other modifications that may be employed are within the scope of the claims. Thus, by way of example, but not of limitation, alternative embodiments may be utilized in accordance with the teachings herein.
Accordingly, the claims are not limited to embodiments precisely as shown and described.

Claims

PCT/US2020/017046

1. A method of treating migraine comprising: selecting a human migraine patient with a history of inadequate response to prior migraine treatments, and orally administering a dosage form to the migraine patient, wherein the dosage form comprises a combination of:
1) a complex of meloxicam with a sulfobutyl ether p-cyclodextrin (SBEPCD), 2) a bicarbonate, and 3) a rizatriptan.

2. The method of claim 1, wherein the human migraine patient experiences relief of the migraine pain as a result of orally administering the dosage form to the migraine patient.

3. The method of claim 1 or 2, wherein the human migraine patient is free of migraine pain two hours after the dosage form is orally administered to the human migraine patient.

4. The method of claim 1, 2, or 3, wherein the migraine patient experiences a reduction in nausea as a result of orally administering the dosage form to the migraine patient.

5. The method of claim 1, 2,3, or 4, wherein the human migraine patient is free of nausea two hours after the dosage form is orally administered to the human migraine patient.

6. The method of claim 1, 2, 3, 4, or 5, wherein the migraine patient experiences a reduction in photophobia as a result of orally administering the dosage form to the migraine patient.

7. The method of claim 1, 2, 3, 4, 5, or 6, wherein the human migraine patient is free of photophobia two hours after the dosage form is orally administered to the human migraine patient.

8. The method of claim 1, 2, 3, 4, 5, 6, or 7, wherein the migraine patient experiences a reduction in phonophobia as a result of orally administering the dosage form to the migraine patient.

9. The method of claim 1, 2, 3, 4, 5, 6, 7, or 8, wherein the human migraine patient is free of phonophobia two hours after the dosage form is orally administered to the human migraine patient.

10. The method of claim 1, 2, 3, 4, 5, 6, 7, 8, or 9, wherein the dosage form contains 400 mg to 600 mg of the bicarbonate.

11. The method of claim 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10, wherein the dosage form contains about 5 mg to about 50 mg of meloxicam.

12. The method of claim 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or 11, wherein the dosage form contains about 50 mg to about 200 mg of the SBEPCD.

13. The method of claim 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12, wherein the dosage form is a solid oral dosage form having a shorter Tmax of meloxicam in the human being than a reference dosage form that: 1) contains the same amount of meloxicam, 2) does not contain an SBEPCD, and 3) does not contain a bicarbonate.

14. The method of claim 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, or 13, wherein about 1 mg to about 50 mg of the rizatriptan is present in the oral dosage form based upon the weight of the rizatriptan in the free base form.

15. The method of claim 14, wherein the rizatriptan is present in a salt form in an amount that is a molar equivalent of about 10 mg of the rizatriptan in the free base form.

16. The method of claim 14 or 15, wherein the rizatriptan is present as rizatriptan benzoate.

17. The method of claim 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 16, wherein the oral dosage form contains about 10 mg to about 30 mg of meloxicam.

18. The method of claim 17, wherein the oral dosage form contains about 20 mg of meloxicam.

19. The method of claim 17, wherein the oral dosage form contains about 15 mg of meloxicam.

20. The method of claim 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, or 19, wherein the SBEPCD has about 6 to about 7 sulfobutyl ether groups for each molecule of 13-cyclodextrin.

21. The method of claim 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20, wherein the oral dosage form contains about 50 mg to about 150 mg of the SBEPCD.

22. The method of claim 21, wherein the oral dosage form contains about 100 mg of the SBEPCD.

23. The method of claim 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, or 22, wherein the molar ratio of the SBEPCD to meloxicam is about 0.5 to about 2.

24. The method of claim 23, wherein the molar ratio of the SBEPCD to meloxicam is about 0.8 to about 1.2.

25. The method of claim 23, wherein the molar ratio of the SBEPCD to meloxicam is about 1.

26. The method of claim 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or 25, wherein the oral dosage form contains about 10 mg to about 40 mg of meloxicam, and about 5 mg to about 50 mg of rizatriptan.

27. The method of claim 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, or 26, wherein the oral dosage form contains SBEPCD that is in a weight ratio to rizatriptan that is within a range of about 1 to about 100.

28. The method of claim 27, wherein the oral dosage form contains SBEPCD
that is in a weight ratio to rizatriptan that is about 10.

29. The method of claim 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, or 28, wherein the bicarbonate comprises sodium bicarbonate.

30. The method of claim 29, wherein the oral dosage form contains 500 mg of sodium bicarbonate.

31. The method of claim 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30, wherein the oral dosage form has been shown to have a median Tmax of meloxicam that is less than about 90 minutes in fasted human subjects.

32. The method of claim 31, wherein the oral dosage form has been shown to have a median Tmax of meloxicam that is less than about 2 hours in fasted human subjects.

33. The method of claim 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, or 32, wherein the oral dosage form has been shown to have faster time to therapeutic plasma concentration in the human being as compared to the reference dosage form.