CA3119863A1 - Instrument electrochirurgical - Google Patents
Instrument electrochirurgical Download PDFInfo
- Publication number
- CA3119863A1 CA3119863A1 CA3119863A CA3119863A CA3119863A1 CA 3119863 A1 CA3119863 A1 CA 3119863A1 CA 3119863 A CA3119863 A CA 3119863A CA 3119863 A CA3119863 A CA 3119863A CA 3119863 A1 CA3119863 A1 CA 3119863A1
- Authority
- CA
- Canada
- Prior art keywords
- electrosurgical instrument
- distal
- instrument according
- electrosurgical
- distal end
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000004520 electroporation Methods 0.000 claims abstract description 61
- 238000003780 insertion Methods 0.000 claims abstract description 19
- 230000037431 insertion Effects 0.000 claims abstract description 19
- 239000004020 conductor Substances 0.000 claims description 88
- 230000005540 biological transmission Effects 0.000 claims description 52
- 239000003989 dielectric material Substances 0.000 claims description 15
- MCMNRKCIXSYSNV-UHFFFAOYSA-N Zirconium dioxide Chemical compound O=[Zr]=O MCMNRKCIXSYSNV-UHFFFAOYSA-N 0.000 claims description 14
- HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical compound [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 claims description 14
- 229910001000 nickel titanium Inorganic materials 0.000 claims description 14
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- VRBFTYUMFJWSJY-UHFFFAOYSA-N 28804-46-8 Chemical compound ClC1CC(C=C2)=CC=C2C(Cl)CC2=CC=C1C=C2 VRBFTYUMFJWSJY-UHFFFAOYSA-N 0.000 claims description 2
- 229920000052 poly(p-xylylene) Polymers 0.000 claims description 2
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- 229920002530 polyetherether ketone Polymers 0.000 description 3
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- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
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- 206010073071 hepatocellular carcinoma Diseases 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/1477—Needle-like probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00137—Details of operation mode
- A61B2017/00154—Details of operation mode pulsed
- A61B2017/00181—Means for setting or varying the pulse energy
- A61B2017/00185—Means for setting or varying the pulse height
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00137—Details of operation mode
- A61B2017/00154—Details of operation mode pulsed
- A61B2017/00181—Means for setting or varying the pulse energy
- A61B2017/0019—Means for setting or varying the pulse width
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
- A61B2017/00867—Material properties shape memory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00053—Mechanical features of the instrument of device
- A61B2018/00059—Material properties
- A61B2018/00071—Electrical conductivity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00053—Mechanical features of the instrument of device
- A61B2018/00107—Coatings on the energy applicator
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00053—Mechanical features of the instrument of device
- A61B2018/00107—Coatings on the energy applicator
- A61B2018/0013—Coatings on the energy applicator non-sticking
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00053—Mechanical features of the instrument of device
- A61B2018/00107—Coatings on the energy applicator
- A61B2018/00148—Coatings on the energy applicator with metal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00053—Mechanical features of the instrument of device
- A61B2018/00172—Connectors and adapters therefor
- A61B2018/00178—Electrical connectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00482—Digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00529—Liver
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00577—Ablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00613—Irreversible electroporation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00696—Controlled or regulated parameters
- A61B2018/00726—Duty cycle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00982—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body combined with or comprising means for visual or photographic inspections inside the body, e.g. endoscopes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00994—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body combining two or more different kinds of non-mechanical energy or combining one or more non-mechanical energies with ultrasound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
- A61B2018/183—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves characterised by the type of antenna
- A61B2018/1853—Monopole antennas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
- A61B2018/1861—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves with an instrument inserted into a body lumen or cavity, e.g. a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
- A61B2018/1869—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves with an instrument interstitially inserted into the body, e.g. needles
Landscapes
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Otolaryngology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Plasma & Fusion (AREA)
- Electromagnetism (AREA)
- Cardiology (AREA)
- Surgical Instruments (AREA)
Abstract
L'invention concerne un instrument électrochirurgical présentant une partie de pointe rayonnante en mesure de réaliser une ablation de tissu à l'aide d'énergie à micro-ondes et d'électroporation (par exemple une électroporation irréversible non thermique) d'une manière minimalement invasive. L'instrument électrochirurgical peut être utilisé pour réaliser une ablation par micro-ondes et une électroporation séparément (par exemple séquentiellement) ou simultanément. La partie de pointe rayonnante peut être dimensionnée pour pouvoir être insérée de manière appropriée dans un pancréas par l'intermédiaire d'un dispositif d'endoscopie chirurgicale, pour fournir une variante rapide et précise aux techniques d'ablation par RF connues. Grâce à la possibilité de traitement de tumeurs dans le pancréas à l'aide d'une procédure minimalement invasive, l'utilisation d'un traitement d'ablation et/ou d'électroporation peut être une option viable, pour des raisons à la fois curatives et palliatives.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1819683.2 | 2018-12-03 | ||
| GB1819683.2A GB2579561B (en) | 2018-12-03 | 2018-12-03 | Electrosurgical instrument |
| PCT/EP2019/082885 WO2020114878A1 (fr) | 2018-12-03 | 2019-11-28 | Instrument électrochirurgical |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3119863A1 true CA3119863A1 (fr) | 2020-06-11 |
Family
ID=65024908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3119863A Pending CA3119863A1 (fr) | 2018-12-03 | 2019-11-28 | Instrument electrochirurgical |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20220008129A1 (fr) |
| EP (1) | EP3890639B1 (fr) |
| JP (1) | JP7454266B2 (fr) |
| KR (1) | KR20210099559A (fr) |
| CN (1) | CN113164202B (fr) |
| AU (1) | AU2019391266A1 (fr) |
| BR (1) | BR112021009450A2 (fr) |
| CA (1) | CA3119863A1 (fr) |
| ES (1) | ES2963235T3 (fr) |
| GB (1) | GB2579561B (fr) |
| IL (1) | IL283323A (fr) |
| SG (1) | SG11202105470PA (fr) |
| WO (1) | WO2020114878A1 (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021255604A1 (fr) * | 2020-06-17 | 2021-12-23 | Baylis Medical Company Inc. | Dispositif et système de perforation |
| US12076071B2 (en) | 2020-08-14 | 2024-09-03 | Kardium Inc. | Systems and methods for treating tissue with pulsed field ablation |
| CN114052886B (zh) * | 2022-01-17 | 2023-02-07 | 北京微刀医疗科技有限公司 | 自适应消融装置的控制方法 |
| WO2024081361A1 (fr) * | 2022-10-14 | 2024-04-18 | Cardiovascular Systems, Inc. | Dispositifs et systèmes de lithotripsie intravasculaire à électrodes tournées vers l'avant et agencements de circuit souple |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9904373D0 (en) * | 1999-02-25 | 1999-04-21 | Microsulis Plc | Radiation applicator |
| WO2005034783A1 (fr) * | 2003-10-03 | 2005-04-21 | Microsulis Limited | Dispositif et methode de traitement de structures anatomiques creuses |
| US11389235B2 (en) * | 2006-07-14 | 2022-07-19 | Neuwave Medical, Inc. | Energy delivery systems and uses thereof |
| US20080033422A1 (en) * | 2006-08-04 | 2008-02-07 | Turner Paul F | Microwave applicator with margin temperature sensing element |
| GB0624658D0 (en) * | 2006-12-11 | 2007-01-17 | Medical Device Innovations Ltd | Electrosurgical ablation apparatus and a method of ablating biological tissue |
| US9486269B2 (en) * | 2007-06-22 | 2016-11-08 | Covidien Lp | Electrosurgical systems and cartridges for use therewith |
| US20090005766A1 (en) * | 2007-06-28 | 2009-01-01 | Joseph Brannan | Broadband microwave applicator |
| US8280525B2 (en) * | 2007-11-16 | 2012-10-02 | Vivant Medical, Inc. | Dynamically matched microwave antenna for tissue ablation |
| US8343149B2 (en) * | 2008-06-26 | 2013-01-01 | Vivant Medical, Inc. | Deployable microwave antenna for treating tissue |
| US8221411B2 (en) * | 2008-07-28 | 2012-07-17 | Medtronic, Inc. | Systems and methods for cardiac tissue electroporation ablation |
| US20100087808A1 (en) * | 2008-10-03 | 2010-04-08 | Vivant Medical, Inc. | Combined Frequency Microwave Ablation System, Devices and Methods of Use |
| CN107898498B (zh) * | 2008-10-21 | 2021-06-11 | 微立方有限责任公司 | 将能量应用于身体组织的方法及装置 |
| US20100152725A1 (en) * | 2008-12-12 | 2010-06-17 | Angiodynamics, Inc. | Method and system for tissue treatment utilizing irreversible electroporation and thermal track coagulation |
| US8246615B2 (en) * | 2009-05-19 | 2012-08-21 | Vivant Medical, Inc. | Tissue impedance measurement using a secondary frequency |
| DK2459096T3 (en) * | 2009-07-28 | 2015-01-19 | Neuwave Medical Inc | ablation device |
| US8328799B2 (en) * | 2009-08-05 | 2012-12-11 | Vivant Medical, Inc. | Electrosurgical devices having dielectric loaded coaxial aperture with distally positioned resonant structure |
| US9993294B2 (en) * | 2009-11-17 | 2018-06-12 | Perseon Corporation | Microwave coagulation applicator and system with fluid injection |
| WO2011161474A1 (fr) * | 2010-06-24 | 2011-12-29 | Emcision Limited | Appareil d'ablation amélioré |
| GB201021032D0 (en) | 2010-12-10 | 2011-01-26 | Creo Medical Ltd | Electrosurgical apparatus |
| GB2487199A (en) * | 2011-01-11 | 2012-07-18 | Creo Medical Ltd | Electrosurgical device with fluid conduit |
| CA2845795A1 (fr) * | 2011-04-08 | 2013-07-18 | Covidien Lp | Catheters micro-ondes souples pour lumieres naturelles ou artificielles |
| US20120310230A1 (en) * | 2011-06-01 | 2012-12-06 | Angiodynamics, Inc. | Coaxial dual function probe and method of use |
| EP2609887A1 (fr) * | 2011-12-29 | 2013-07-03 | Koninklijke Philips Electronics N.V. | Appareil d'ablation électrochirurgicale |
| GB2503673A (en) * | 2012-07-03 | 2014-01-08 | Creo Medical Ltd | Electrosurgical device with convex under surface |
| US10765477B2 (en) * | 2014-03-10 | 2020-09-08 | Wisconsin Alumni Research Foundation | Microwave ablation antenna system |
| GB2541946B (en) * | 2015-09-07 | 2020-10-28 | Creo Medical Ltd | Electrosurgical snare |
| GB2545465A (en) * | 2015-12-17 | 2017-06-21 | Creo Medical Ltd | Electrosurgical probe for delivering microwave energy |
| GB2552921A (en) * | 2016-04-04 | 2018-02-21 | Creo Medical Ltd | Electrosurgical probe for delivering RF and microwave energy |
| GB2563377A (en) * | 2017-05-04 | 2018-12-19 | Creo Medical Ltd | Electrosurgical apparatus and method of tissue ablation |
-
2018
- 2018-12-03 GB GB1819683.2A patent/GB2579561B/en not_active Expired - Fee Related
-
2019
- 2019-11-28 CA CA3119863A patent/CA3119863A1/fr active Pending
- 2019-11-28 EP EP19839630.1A patent/EP3890639B1/fr active Active
- 2019-11-28 BR BR112021009450-4A patent/BR112021009450A2/pt unknown
- 2019-11-28 AU AU2019391266A patent/AU2019391266A1/en not_active Abandoned
- 2019-11-28 KR KR1020217015324A patent/KR20210099559A/ko unknown
- 2019-11-28 WO PCT/EP2019/082885 patent/WO2020114878A1/fr active Application Filing
- 2019-11-28 JP JP2021529350A patent/JP7454266B2/ja active Active
- 2019-11-28 US US17/294,637 patent/US20220008129A1/en active Pending
- 2019-11-28 ES ES19839630T patent/ES2963235T3/es active Active
- 2019-11-28 SG SG11202105470PA patent/SG11202105470PA/en unknown
- 2019-11-28 CN CN201980077315.7A patent/CN113164202B/zh active Active
-
2021
- 2021-05-20 IL IL283323A patent/IL283323A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL283323A (en) | 2021-07-29 |
| SG11202105470PA (en) | 2021-06-29 |
| AU2019391266A1 (en) | 2021-06-03 |
| WO2020114878A1 (fr) | 2020-06-11 |
| GB2579561A (en) | 2020-07-01 |
| KR20210099559A (ko) | 2021-08-12 |
| CN113164202A (zh) | 2021-07-23 |
| EP3890639A1 (fr) | 2021-10-13 |
| EP3890639B1 (fr) | 2023-08-09 |
| GB2579561B (en) | 2022-10-19 |
| JP2022509813A (ja) | 2022-01-24 |
| JP7454266B2 (ja) | 2024-03-22 |
| CN113164202B (zh) | 2024-07-12 |
| GB201819683D0 (en) | 2019-01-16 |
| EP3890639C0 (fr) | 2023-08-09 |
| ES2963235T3 (es) | 2024-03-25 |
| US20220008129A1 (en) | 2022-01-13 |
| BR112021009450A2 (pt) | 2021-08-10 |
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