CA3112410A1 - Procedes et compositions pour la detection d'adn de vph et le diagnostic et la surveillance de cancers associes au vph - Google Patents

Procedes et compositions pour la detection d'adn de vph et le diagnostic et la surveillance de cancers associes au vph Download PDF

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Publication number
CA3112410A1
CA3112410A1 CA3112410A CA3112410A CA3112410A1 CA 3112410 A1 CA3112410 A1 CA 3112410A1 CA 3112410 A CA3112410 A CA 3112410A CA 3112410 A CA3112410 A CA 3112410A CA 3112410 A1 CA3112410 A1 CA 3112410A1
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CA
Canada
Prior art keywords
seq
primer
reverse primer
forward primer
hpv
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3112410A
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English (en)
Inventor
Daniel Smith Higginson
Rama Rao Damerla
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Memorial Sloan Kettering Cancer Center
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Memorial Sloan Kettering Cancer Center
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Publication date
Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Publication of CA3112410A1 publication Critical patent/CA3112410A1/fr
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/708—Specific hybridization probes for papilloma
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention concerne des procédés et des compositions pour la détection d'ADN de VPH dans des échantillons de patient avec une sensibilité et une spécificité élevées. De tels procédés sont utiles dans le criblage de tumeurs malignes associées au VPH. Dans certains modes de réalisation, la présente invention concerne des procédés et des compositions pour la détection d'ADN de HPV-16, HPV-33 et/ou HPV-18. Dans certains modes de réalisation, la présente invention concerne des procédés et des compositions pour la détection d'ADN de VPH à partir de carcinomes de cellules squameuses, tels que des carcinomes de cellules squameuses oropharyngées et des carcinomes de cellules squameuses anales.
CA3112410A 2018-09-10 2019-09-10 Procedes et compositions pour la detection d'adn de vph et le diagnostic et la surveillance de cancers associes au vph Pending CA3112410A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862729321P 2018-09-10 2018-09-10
US62/729,321 2018-09-10
PCT/US2019/050365 WO2020055834A2 (fr) 2018-09-10 2019-09-10 Procédés et compositions pour la détection d'adn de vph et le diagnostic et la surveillance de cancers associés au vph

Publications (1)

Publication Number Publication Date
CA3112410A1 true CA3112410A1 (fr) 2020-03-19

Family

ID=69778362

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3112410A Pending CA3112410A1 (fr) 2018-09-10 2019-09-10 Procedes et compositions pour la detection d'adn de vph et le diagnostic et la surveillance de cancers associes au vph

Country Status (4)

Country Link
US (1) US20220098683A1 (fr)
EP (1) EP3849993A4 (fr)
CA (1) CA3112410A1 (fr)
WO (1) WO2020055834A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220389520A1 (en) * 2021-06-07 2022-12-08 Washington University Systems and methods for integrated analysis of blood and surgical drain fluid biomarkers

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010060103A1 (fr) * 2008-11-24 2010-05-27 Loma Linda University Biomarqueurs pour la détection de tumeurs de la tête et du cou
WO2010125420A1 (fr) * 2009-04-30 2010-11-04 Instituto Nacional De Cancerologia Procédé de détection et d'identification de variants du vph16 au moyen d'amorces et de sondes
RU2558236C2 (ru) * 2010-02-16 2015-07-27 Бектон, Дикинсон энд Кампани Система анализа для обнаружения близкородственных серотипов вируса папилломы человека (впч)
WO2014186147A2 (fr) * 2013-05-13 2014-11-20 Elitech Holding B.V. Pcr numérique à gouttelettes (ddpcr) utilisant de petites sondes courtes cannelées
US11268153B2 (en) * 2015-06-22 2022-03-08 The Johns Hopkins University Head and neck squamous cell carcinoma assays

Also Published As

Publication number Publication date
WO2020055834A3 (fr) 2020-05-22
WO2020055834A2 (fr) 2020-03-19
US20220098683A1 (en) 2022-03-31
EP3849993A2 (fr) 2021-07-21
EP3849993A4 (fr) 2023-02-08

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