CA3099782A1 - Matrices d'hydrogel biosensibles et procedes d'utilisation - Google Patents

Matrices d'hydrogel biosensibles et procedes d'utilisation Download PDF

Info

Publication number
CA3099782A1
CA3099782A1 CA3099782A CA3099782A CA3099782A1 CA 3099782 A1 CA3099782 A1 CA 3099782A1 CA 3099782 A CA3099782 A CA 3099782A CA 3099782 A CA3099782 A CA 3099782A CA 3099782 A1 CA3099782 A1 CA 3099782A1
Authority
CA
Canada
Prior art keywords
inhibitor
cancer
hydrochloride
bioresponsive
ido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3099782A
Other languages
English (en)
Inventor
Zhen GU
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
North Carolina State University
Original Assignee
North Carolina State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by North Carolina State University filed Critical North Carolina State University
Publication of CA3099782A1 publication Critical patent/CA3099782A1/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne des compositions et des méthodes de traitement du cancer au moyen d'une matrice d'hydrogel comprenant un agent chimiothérapeutique et un inhibiteur de blocage. L'invention concerne des matrices d'hydrogel biosensibles comprenant un piégeur d'espèces réactives de l'oxygène.
CA3099782A 2018-05-11 2019-05-13 Matrices d'hydrogel biosensibles et procedes d'utilisation Pending CA3099782A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862670632P 2018-05-11 2018-05-11
US62/670,632 2018-05-11
PCT/US2019/031971 WO2019217954A1 (fr) 2018-05-11 2019-05-13 Matrices d'hydrogel biosensibles et procédés d'utilisation

Publications (1)

Publication Number Publication Date
CA3099782A1 true CA3099782A1 (fr) 2019-11-14

Family

ID=68467614

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3099782A Pending CA3099782A1 (fr) 2018-05-11 2019-05-13 Matrices d'hydrogel biosensibles et procedes d'utilisation

Country Status (6)

Country Link
US (1) US20210100744A1 (fr)
EP (1) EP3810087A4 (fr)
JP (1) JP7470988B2 (fr)
CN (1) CN112334127A (fr)
CA (1) CA3099782A1 (fr)
WO (1) WO2019217954A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019118686A1 (fr) * 2017-12-13 2019-06-20 North Carolina State University Compositions comprenant des agents chimiothérapeutiques et des inhibiteurs de points de contrôle et procédés d'utilisation
WO2023096899A1 (fr) * 2021-11-24 2023-06-01 Amacathera Compositions pharmaceutiques à hydrogel
WO2023122653A1 (fr) * 2021-12-23 2023-06-29 Arizona Board Of Regents On Behalf Of Arizona State University Compositions et procédés d'administration d'il-2 et d'anticorps anti-il-2 pour le traitement de la polyarthrite rhumatoïde
WO2024097992A2 (fr) 2022-11-04 2024-05-10 Umoja Biopharma, Inc. Particules présentant des fusions de molécules d'adhésion
WO2024098028A2 (fr) 2022-11-04 2024-05-10 Umoja Biopharma, Inc. Particules lentivirales affichant des molécules de fusion et leurs utilisations

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6004573A (en) * 1997-10-03 1999-12-21 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
IL159273A0 (en) * 2003-12-09 2004-06-01 Transpharma Medical Ltd Transdermal delivery system for sustained release of polypeptides
FR2898898B1 (fr) * 2006-03-22 2008-06-06 Polyintell Sarl Empreintes moleculaires pour une reconnaissance en milieu aqueux, leurs procedes de preparation et leurs utilisations
WO2008088922A2 (fr) * 2007-01-19 2008-07-24 Genentech, Inc. Prévention d'une perte de viscosité d'un hydrogel
EP2236617A1 (fr) * 2009-03-31 2010-10-06 Leukocare Ag Procédés de stérilisation de terminal de compositions biofonctionnelles
CA3012602A1 (fr) * 2015-01-30 2016-08-04 President And Fellows Of Harvard College Materiaux peritumoraux et intratumoraux pour traitement anticancereux
CN104829830B (zh) * 2015-04-22 2017-11-28 中国科学院长春应用化学研究所 一种甲硫氨酸嵌段共聚物、其制备方法及水凝胶

Also Published As

Publication number Publication date
US20210100744A1 (en) 2021-04-08
JP7470988B2 (ja) 2024-04-19
WO2019217954A1 (fr) 2019-11-14
EP3810087A1 (fr) 2021-04-28
CN112334127A (zh) 2021-02-05
JP2021523173A (ja) 2021-09-02
EP3810087A4 (fr) 2022-02-23

Similar Documents

Publication Publication Date Title
JP7470988B2 (ja) 生物応答性ヒドロゲルマトリックス及び使用方法
US20210077620A1 (en) Compositions comprising chemotherapeutic agents and checkpoint inhibitors and methods of use
US20210000750A1 (en) Engineered nanovesicles as checkpoint blockade for cancer immunotherapy
JP7497087B2 (ja) 治療剤送達のための血小板組成物及び方法
EP3606559B1 (fr) Compositions bio-orthogonales
EP3773742A1 (fr) Administration d'inhibiteurs de points de contrôle médiée par un ensemble de cellules destinée à l'immunothérapie anticancéreuse
US20220143179A1 (en) Drug delivery for combination of epigenetic modulation and immune checkpoint blockade
WO2022187631A1 (fr) Hydrogels thermosensibles libérant des micelles utilisés en tant que système d'administration thérapeutique
US20230136350A1 (en) Enhanced viral transduction of mammalian cells using material scaffolds
US20220169725A1 (en) Bio-responsive antibody complexes for enhanced immunotherapy
US20210260187A1 (en) In situ sprayed bioresponsive immunotherapeutic gel for post-surgical treatment
US20230257463A1 (en) In situ thiol-maleimide crosslinked hydrogel for immune checkpoint blockade delivery
WO2023197014A2 (fr) Polythérapie comprenant une cellule nk à pd-l1 inactivé et des anticorps anti-pdl1
WO2023044432A2 (fr) Ciblage de kras mutant avec un iga spécifique de mutation
WO2021051066A1 (fr) Thérapie par dc1 pulsées avec her3