CA3084809C - Inhibiteurs de la famille nsd et methodes de traitement comprenant ces derniers - Google Patents

Inhibiteurs de la famille nsd et methodes de traitement comprenant ces derniers

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Publication number
CA3084809C
CA3084809C CA3084809A CA3084809A CA3084809C CA 3084809 C CA3084809 C CA 3084809C CA 3084809 A CA3084809 A CA 3084809A CA 3084809 A CA3084809 A CA 3084809A CA 3084809 C CA3084809 C CA 3084809C
Authority
CA
Canada
Prior art keywords
substituted
cancer
date
aromatic ring
ring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3084809A
Other languages
English (en)
Other versions
CA3084809A1 (fr
Inventor
Tomasz Cierpicki
Jolanta Grembecka
Huang Huang
Sergei Zari
Hyo Je Cho
Mykhaylo Potopnyk
Sergii Dudkin
Wenbing Chen
Yassir Adam
Christina Howard
EunGi Kim
Original Assignee
University of Michigan System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Michigan System filed Critical University of Michigan System
Priority claimed from PCT/US2018/064511 external-priority patent/WO2019113469A1/fr
Publication of CA3084809A1 publication Critical patent/CA3084809A1/fr
Application granted granted Critical
Publication of CA3084809C publication Critical patent/CA3084809C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Abstract

L'invention concerne des inhibiteurs à petites molécules de l'activité de NSD1, NSD2 et/ou NSD3, et leurs procédés d'utilisation pour le traitement d'une maladie, y compris la leucémie, le cancer du sein, l'ostéosarcome, les cancers du poumon et de la prostate et d'autres tumeurs solides ainsi que d'autres maladies dépendant de l'activité de NSD1, NSD2 et/ou NSD3.
CA3084809A 2017-12-07 2018-12-07 Inhibiteurs de la famille nsd et methodes de traitement comprenant ces derniers Active CA3084809C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762595617P 2017-12-07 2017-12-07
US201762595616P 2017-12-07 2017-12-07
US62/595,616 2017-12-07
US62/595,617 2017-12-07
PCT/US2018/064511 WO2019113469A1 (fr) 2017-12-07 2018-12-07 Inhibiteurs de la famille nsd et méthodes de traitement comprenant ces derniers

Publications (2)

Publication Number Publication Date
CA3084809A1 CA3084809A1 (fr) 2019-06-13
CA3084809C true CA3084809C (fr) 2026-02-17

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CA3084809C (fr) Inhibiteurs de la famille nsd et methodes de traitement comprenant ces derniers