CA3082604A1 - Procedes de mesure de la production equivalente de reduction par des tissus pour determiner des taux metaboliques et procedes d'utilisation - Google Patents
Procedes de mesure de la production equivalente de reduction par des tissus pour determiner des taux metaboliques et procedes d'utilisation Download PDFInfo
- Publication number
- CA3082604A1 CA3082604A1 CA3082604A CA3082604A CA3082604A1 CA 3082604 A1 CA3082604 A1 CA 3082604A1 CA 3082604 A CA3082604 A CA 3082604A CA 3082604 A CA3082604 A CA 3082604A CA 3082604 A1 CA3082604 A1 CA 3082604A1
- Authority
- CA
- Canada
- Prior art keywords
- animal
- metabolic rate
- production
- reducing equivalent
- animals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000037323 metabolic rate Effects 0.000 title claims abstract description 184
- 238000000034 method Methods 0.000 title claims abstract description 141
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 131
- 241001465754 Metazoa Species 0.000 claims abstract description 256
- 210000001519 tissue Anatomy 0.000 claims abstract description 165
- 210000002027 skeletal muscle Anatomy 0.000 claims abstract description 73
- 235000013336 milk Nutrition 0.000 claims abstract description 69
- 210000004080 milk Anatomy 0.000 claims abstract description 69
- 239000008267 milk Substances 0.000 claims abstract description 69
- 229940079593 drug Drugs 0.000 claims abstract description 62
- 239000003814 drug Substances 0.000 claims abstract description 62
- 238000009395 breeding Methods 0.000 claims abstract description 21
- 230000001488 breeding effect Effects 0.000 claims abstract description 21
- 235000013372 meat Nutrition 0.000 claims abstract description 6
- 235000005911 diet Nutrition 0.000 claims description 71
- 230000037213 diet Effects 0.000 claims description 67
- 230000008859 change Effects 0.000 claims description 61
- 239000000203 mixture Substances 0.000 claims description 53
- 235000015872 dietary supplement Nutrition 0.000 claims description 45
- 230000000694 effects Effects 0.000 claims description 42
- 230000002503 metabolic effect Effects 0.000 claims description 33
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 claims description 31
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical group C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 claims description 30
- YPZRHBJKEMOYQH-UYBVJOGSSA-L FADH2(2-) Chemical group C1=NC2=C(N)N=CN=C2N1[C@@H]([C@H](O)[C@@H]1O)O[C@@H]1COP([O-])(=O)OP([O-])(=O)OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C(NC(=O)NC2=O)=C2NC2=C1C=C(C)C(C)=C2 YPZRHBJKEMOYQH-UYBVJOGSSA-L 0.000 claims description 25
- 235000017471 coenzyme Q10 Nutrition 0.000 claims description 22
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical group COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims description 22
- XJLXINKUBYWONI-NNYOXOHSSA-O NADP(+) Chemical group NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-NNYOXOHSSA-O 0.000 claims description 20
- 239000000047 product Substances 0.000 claims description 8
- 244000144980 herd Species 0.000 claims description 5
- 241000894007 species Species 0.000 claims description 5
- 230000008092 positive effect Effects 0.000 claims description 3
- 244000144987 brood Species 0.000 claims description 2
- 238000007918 intramuscular administration Methods 0.000 claims description 2
- 210000005075 mammary gland Anatomy 0.000 abstract description 9
- 235000013601 eggs Nutrition 0.000 abstract description 7
- 235000016709 nutrition Nutrition 0.000 abstract description 7
- 230000035764 nutrition Effects 0.000 abstract description 3
- 235000021004 dietary regimen Nutrition 0.000 abstract 1
- 235000013305 food Nutrition 0.000 abstract 1
- 210000002268 wool Anatomy 0.000 abstract 1
- 239000000523 sample Substances 0.000 description 38
- 241000283690 Bos taurus Species 0.000 description 31
- 229920002472 Starch Polymers 0.000 description 29
- 239000008107 starch Substances 0.000 description 29
- 235000019698 starch Nutrition 0.000 description 29
- 238000001574 biopsy Methods 0.000 description 24
- 238000011282 treatment Methods 0.000 description 24
- 239000000835 fiber Substances 0.000 description 17
- PLXBWHJQWKZRKG-UHFFFAOYSA-N Resazurin Chemical compound C1=CC(=O)C=C2OC3=CC(O)=CC=C3[N+]([O-])=C21 PLXBWHJQWKZRKG-UHFFFAOYSA-N 0.000 description 14
- 238000003556 assay Methods 0.000 description 14
- 238000001964 muscle biopsy Methods 0.000 description 13
- 210000004767 rumen Anatomy 0.000 description 13
- 238000012360 testing method Methods 0.000 description 13
- 241000282412 Homo Species 0.000 description 11
- 238000012423 maintenance Methods 0.000 description 10
- 208000008589 Obesity Diseases 0.000 description 9
- 235000020824 obesity Nutrition 0.000 description 9
- 239000012085 test solution Substances 0.000 description 9
- 206010033307 Overweight Diseases 0.000 description 8
- 238000004458 analytical method Methods 0.000 description 8
- 210000003486 adipose tissue brown Anatomy 0.000 description 7
- 210000000593 adipose tissue white Anatomy 0.000 description 7
- 230000006870 function Effects 0.000 description 7
- 244000309465 heifer Species 0.000 description 7
- 230000007246 mechanism Effects 0.000 description 7
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 6
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 6
- 240000008042 Zea mays Species 0.000 description 6
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 6
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 6
- 238000002835 absorbance Methods 0.000 description 6
- 235000005822 corn Nutrition 0.000 description 6
- 230000002068 genetic effect Effects 0.000 description 6
- 238000011534 incubation Methods 0.000 description 6
- 210000004185 liver Anatomy 0.000 description 6
- 235000015097 nutrients Nutrition 0.000 description 6
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 5
- 230000000378 dietary effect Effects 0.000 description 5
- 239000008103 glucose Substances 0.000 description 5
- 210000003205 muscle Anatomy 0.000 description 5
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- 239000000902 placebo Substances 0.000 description 4
- 229940068196 placebo Drugs 0.000 description 4
- 238000006722 reduction reaction Methods 0.000 description 4
- 230000035945 sensitivity Effects 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 239000005515 coenzyme Substances 0.000 description 3
- 230000004907 flux Effects 0.000 description 3
- 210000002216 heart Anatomy 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 235000016068 Berberis vulgaris Nutrition 0.000 description 2
- 241000335053 Beta vulgaris Species 0.000 description 2
- 239000005996 Blood meal Substances 0.000 description 2
- 241000282472 Canis lupus familiaris Species 0.000 description 2
- 241000282326 Felis catus Species 0.000 description 2
- 108010068370 Glutens Proteins 0.000 description 2
- 240000005979 Hordeum vulgare Species 0.000 description 2
- 235000007340 Hordeum vulgare Nutrition 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 2
- 241000282849 Ruminantia Species 0.000 description 2
- 235000019764 Soybean Meal Nutrition 0.000 description 2
- 230000006978 adaptation Effects 0.000 description 2
- 239000000808 adrenergic beta-agonist Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000001186 cumulative effect Effects 0.000 description 2
- 235000013365 dairy product Nutrition 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 230000005284 excitation Effects 0.000 description 2
- 238000012248 genetic selection Methods 0.000 description 2
- 235000021312 gluten Nutrition 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 210000002239 ischium bone Anatomy 0.000 description 2
- 229940039009 isoproterenol Drugs 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 238000012317 liver biopsy Methods 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 238000013178 mathematical model Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 229950006238 nadide Drugs 0.000 description 2
- 230000035935 pregnancy Effects 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 230000031070 response to heat Effects 0.000 description 2
- 239000004460 silage Substances 0.000 description 2
- 239000004455 soybean meal Substances 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 208000031648 Body Weight Changes Diseases 0.000 description 1
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 description 1
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 208000016546 Distal 16p11.2 microdeletion syndrome Diseases 0.000 description 1
- -1 FADH7 Chemical compound 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 1
- 238000000585 Mann–Whitney U test Methods 0.000 description 1
- 241000237852 Mollusca Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 101150013568 US16 gene Proteins 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 description 1
- 229960000723 ampicillin Drugs 0.000 description 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
- 239000012805 animal sample Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 229940064804 betadine Drugs 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000004579 body weight change Effects 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 230000003833 cell viability Effects 0.000 description 1
- 238000003570 cell viability assay Methods 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 235000013330 chicken meat Nutrition 0.000 description 1
- 229960005091 chloramphenicol Drugs 0.000 description 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
- 238000011284 combination treatment Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000013256 coordination polymer Substances 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000000881 depressing effect Effects 0.000 description 1
- 235000021045 dietary change Nutrition 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 235000019621 digestibility Nutrition 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011067 equilibration Methods 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 238000001506 fluorescence spectroscopy Methods 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000004110 gluconeogenesis Effects 0.000 description 1
- 230000001890 gluconeogenic effect Effects 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- KQNPFQTWMSNSAP-UHFFFAOYSA-N isobutyric acid Chemical compound CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 description 1
- 229960004194 lidocaine Drugs 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 210000005228 liver tissue Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000013188 needle biopsy Methods 0.000 description 1
- 230000033116 oxidation-reduction process Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000036284 oxygen consumption Effects 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000000384 rearing effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 229940070710 valerate Drugs 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/008—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions for determining co-enzymes or co-factors, e.g. NAD, ATP
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06Q—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
- G06Q50/00—Information and communication technology [ICT] specially adapted for implementation of business processes of specific business sectors, e.g. utilities or tourism
- G06Q50/02—Agriculture; Fishing; Forestry; Mining
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Polymers & Plastics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pathology (AREA)
- Animal Husbandry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Birds (AREA)
- Business, Economics & Management (AREA)
- Wood Science & Technology (AREA)
- Agronomy & Crop Science (AREA)
- General Engineering & Computer Science (AREA)
- Primary Health Care (AREA)
- Strategic Management (AREA)
- Tourism & Hospitality (AREA)
- General Business, Economics & Management (AREA)
- Marine Sciences & Fisheries (AREA)
- Theoretical Computer Science (AREA)
- Genetics & Genomics (AREA)
- Marketing (AREA)
- Toxicology (AREA)
Abstract
L'invention concerne des procédés d'identification d'animaux qui sont génétiquement supérieurs, des médicaments, des stratégies nutritionnelles, ou des manipulations physiologiques qui améliorent l'efficacité d'alimentation ou la productivité d'animaux, par exemple, la sélection d'animaux qui sont génétiquement supérieurs pour une efficacité ou une productivité d'alimentation en fonction des taux métaboliques de tissus particuliers, les taux métaboliques de certains tissus tels que le muscle squelettique étant inversement proportionnels à l'efficacité de l'alimentation, tandis que les taux métaboliques d'autres tissus tels que la glande mammaire sont directement proportionnels à la production de lait. Ainsi, les animaux à faible taux métabolique du muscle squelettique sont généralement plus efficaces pour l'alimentation, par exemple, le gain de poids par unité d'aliment. Les procédés de l'invention peuvent être utilisés pour améliorer la génétique, la nutrition et la manipulation ou des animaux ou des produits à base d'animaux produits de manière plus efficace, par exemple la production de viande, la production de lait, la production d'ufs, la production de laine, etc. Les procédés de l'invention peuvent également être utilisés pour déterminer des valeurs de reproduction estimées d'animaux à des fins d'efficacité d'alimentation, de croissance ou de production.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762586578P | 2017-11-15 | 2017-11-15 | |
| US62/586,578 | 2017-11-15 | ||
| US201815754126A | 2018-02-21 | 2018-02-21 | |
| US15/754,126 | 2018-02-21 | ||
| PCT/US2018/061349 WO2019099717A1 (fr) | 2017-11-15 | 2018-11-15 | Procédés de mesure de la production équivalente de réduction par des tissus pour déterminer des taux métaboliques et procédés d'utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3082604A1 true CA3082604A1 (fr) | 2019-05-23 |
Family
ID=66540389
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3082604A Pending CA3082604A1 (fr) | 2017-11-15 | 2018-11-15 | Procedes de mesure de la production equivalente de reduction par des tissus pour determiner des taux metaboliques et procedes d'utilisation |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP3709818A4 (fr) |
| CN (1) | CN111491520A (fr) |
| AU (1) | AU2018370021B2 (fr) |
| BR (1) | BR112020009559A2 (fr) |
| CA (1) | CA3082604A1 (fr) |
| WO (1) | WO2019099717A1 (fr) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003032234A1 (fr) * | 2001-06-27 | 2003-04-17 | Board Of Trustees Of The University Of Arkansas | Evaluation d'echantillons sanguins et tissulaires d'une fonction mitochondriale, et biochimie, en tant qu'outil de selection pour une efficacite d'alimentation et d'autres parametres de production |
| US20040241723A1 (en) * | 2002-03-18 | 2004-12-02 | Marquess Foley Leigh Shaw | Systems and methods for improving protein and milk production of dairy herds |
| US7897749B2 (en) * | 2005-07-13 | 2011-03-01 | Wisconsin Alumni Research Foundation | Dairy cattle breeding for improved milk production traits in cattle |
| BRPI0923636A2 (pt) * | 2008-12-24 | 2016-07-26 | Fonterra Co Operative Group | seleção de animais para ocmposição desejada de leite e/ou tecido |
| AU2010283961A1 (en) * | 2009-08-19 | 2012-04-12 | The University Of New England | System and method for monitoring the feeding practices of individual animals in a grazing environment |
| US20150344974A1 (en) * | 2014-06-02 | 2015-12-03 | The Texas A&M University System | Dna markers for feed efficiency in cattle |
| DK3337904T3 (da) * | 2015-08-21 | 2021-08-30 | Univ Arizona | Fremgangsmåder til måling af væksthastighed i plante- eller vanddyrearter |
| US10961559B2 (en) * | 2016-04-26 | 2021-03-30 | The State of Israel Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center) | Regulation of feed efficiency and methane production in ruminating animals |
-
2018
- 2018-11-15 EP EP18878766.7A patent/EP3709818A4/fr active Pending
- 2018-11-15 CN CN201880081453.8A patent/CN111491520A/zh active Pending
- 2018-11-15 CA CA3082604A patent/CA3082604A1/fr active Pending
- 2018-11-15 BR BR112020009559-1A patent/BR112020009559A2/pt unknown
- 2018-11-15 AU AU2018370021A patent/AU2018370021B2/en active Active
- 2018-11-15 WO PCT/US2018/061349 patent/WO2019099717A1/fr active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| AU2018370021A1 (en) | 2020-07-02 |
| EP3709818A4 (fr) | 2021-07-28 |
| EP3709818A1 (fr) | 2020-09-23 |
| WO2019099717A1 (fr) | 2019-05-23 |
| BR112020009559A2 (pt) | 2020-11-03 |
| CN111491520A (zh) | 2020-08-04 |
| AU2018370021B2 (en) | 2023-11-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11674953B2 (en) | Methods for measuring reducing equivalent production by tissues to determine metabolic rates and methods of use | |
| Bjornvad et al. | Evaluation of a nine-point body condition scoring system in physically inactive pet cats | |
| Kaufman et al. | Association of rumination time with subclinical ketosis in transition dairy cows | |
| Connor et al. | Use of residual feed intake in Holsteins during early lactation shows potential to improve feed efficiency through genetic selection | |
| Montanholi et al. | On the determination of residual feed intake and associations of infrared thermography with efficiency and ultrasound traits in beef bulls | |
| Kelly et al. | Relationship between body measurements, metabolic hormones, metabolites and residual feed intake in performancetested pedigree beef bulls | |
| Ndlovu et al. | A comparison of nutritionally-related blood metabolites among Nguni, Bonsmara and Angus steers raised on sweetveld | |
| Meier et al. | Design and methodology of choice feeding experiments with ruminant livestock | |
| Destrez et al. | Changes of the hindgut microbiota due to high-starch diet can be associated with behavioral stress response in horses | |
| Gonano et al. | The relationship between feed efficiency and the circadian profile of blood plasma analytes measured in beef heifers at different physiological stages | |
| Aguayo-Ulloa et al. | Effect of enriched housing on welfare, production performance and meat quality in finishing lambs: The use of feeder ramps | |
| Schmitz et al. | The effects of energy concentration in roughage and allowance of concentrates on performance, health and energy efficiency of pluriparous dairy cows during early lactation | |
| Nasrollahi et al. | Blood metabolites, body reserves, and feed efficiency of high-producing dairy cows that varied in ruminal pH when fed a high-concentrate diet | |
| Neave et al. | Toward on-farm measurement of personality traits and their relationships to behavior and productivity of grazing dairy cattle | |
| Broadway et al. | Some negative effects of heat stress in feedlot heifers may be mitigated via yeast probiotic supplementation | |
| Allen | Mind over models | |
| Lima et al. | Effects of the buriti (Mauritia flexuosa L.) oil supplementation on crossbred lactating goats: behavioral, physiological, and hematological responses | |
| Singh et al. | Endocrine and hematobiochemical profile of lambs raised in a semiaridregion with different growth potentials during the postweaning period | |
| Eisemann et al. | Physiological response, function of sweat glands, and hair follicle cycling in cattle in response to fescue toxicosis and hair genotype | |
| Metzler-Zebeli et al. | Assessing serum metabolite profiles as predictors for feed efficiency in broiler chickens reared at geographically distant locations | |
| AU2018370021B2 (en) | Methods for measuring reducing equivalent production by tissues to determine metabolic rates and methods of use | |
| Aguilera et al. | Enteric methane production in adult sheep of the Segureña breed fed diets containing alkali-treated olive cake | |
| Maeda et al. | Evaluation of blood adiponectin levels as an index for subacute ruminal acidosis in cows: a preliminary study | |
| Larsen et al. | Effect of a lucerne feeding strategy in the first week postpartum on feed intake and ketone body profiles in blood plasma, urine, and milk in Holstein cows | |
| Enjalbert | Assessment of nutritional adequacy in dairy cows through diet characteristics and animal responses |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20231109 |