CA3078939A1 - Methodes pour le traitement du vhc - Google Patents
Methodes pour le traitement du vhc Download PDFInfo
- Publication number
- CA3078939A1 CA3078939A1 CA3078939A CA3078939A CA3078939A1 CA 3078939 A1 CA3078939 A1 CA 3078939A1 CA 3078939 A CA3078939 A CA 3078939A CA 3078939 A CA3078939 A CA 3078939A CA 3078939 A1 CA3078939 A1 CA 3078939A1
- Authority
- CA
- Canada
- Prior art keywords
- weeks
- hcv
- patient
- daas
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention concerne d'une manière générale des thérapies sans interféron pour le traitement du VHC. De préférence, le traitement se déroule sur une durée plus courte, telle qu'une durée inférieure ou égale à 16, 12 ou 8 semaines. Selon un aspect, le traitement comprend l'administration d'au moins deux agents antiviraux à action directe et de ribavirine à un sujet présentant une infection par le VHC, le traitement durant 12 semaines et ne comprenant pas d'administration d'interféron, et lesdits au moins deux agents antiviraux à action directe comprenant (a) le composé 1 ou un sel pharmaceutiquement acceptable de celui-ci et (b) le composé 2 ou un sel pharmaceutiquement acceptable de celui-ci. En outre, des composés supplémentaires tels que le sofosbuvir, ou son sel pharmaceutiquement acceptable, peuvent être utilisés pour le retraitement de patients atteints du VHC chez qui une polythérapie comprenant le glécaprévir et le pibrentasvir a été un échec.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2017/056298 WO2019074507A1 (fr) | 2017-10-12 | 2017-10-12 | Méthodes pour le traitement du vhc |
Publications (1)
Publication Number | Publication Date |
---|---|
CA3078939A1 true CA3078939A1 (fr) | 2019-04-18 |
Family
ID=60162320
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA3078939A Abandoned CA3078939A1 (fr) | 2017-10-12 | 2017-10-12 | Methodes pour le traitement du vhc |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP3694512A1 (fr) |
JP (1) | JP2020536909A (fr) |
AU (1) | AU2017435897A1 (fr) |
CA (1) | CA3078939A1 (fr) |
WO (1) | WO2019074507A1 (fr) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9394279B2 (en) | 2009-06-11 | 2016-07-19 | Abbvie Inc. | Anti-viral compounds |
PE20140015A1 (es) | 2010-09-21 | 2014-02-16 | Enanta Pharm Inc | Inhibidores de las proteasas de serina del vhc derivados de prolinas macrociclicas |
EA201490836A1 (ru) | 2011-10-21 | 2014-11-28 | Эббви Инк. | Комбинационное лечение (например, с abt-072 или abt-333) с помощью daa для применения при лечении hcv |
CA2943054A1 (fr) * | 2014-04-02 | 2015-10-08 | Abbvie Inc. | Methodes de traitement du vhc |
-
2017
- 2017-10-12 EP EP17788070.5A patent/EP3694512A1/fr not_active Withdrawn
- 2017-10-12 JP JP2020520456A patent/JP2020536909A/ja active Pending
- 2017-10-12 WO PCT/US2017/056298 patent/WO2019074507A1/fr unknown
- 2017-10-12 AU AU2017435897A patent/AU2017435897A1/en not_active Abandoned
- 2017-10-12 CA CA3078939A patent/CA3078939A1/fr not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2019074507A1 (fr) | 2019-04-18 |
EP3694512A1 (fr) | 2020-08-19 |
JP2020536909A (ja) | 2020-12-17 |
AU2017435897A1 (en) | 2020-04-30 |
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Effective date: 20240123 |