CA3077428A1 - Bordetella strains expressing serotype 3 fimbriae - Google Patents

Bordetella strains expressing serotype 3 fimbriae Download PDF

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Publication number
CA3077428A1
CA3077428A1 CA3077428A CA3077428A CA3077428A1 CA 3077428 A1 CA3077428 A1 CA 3077428A1 CA 3077428 A CA3077428 A CA 3077428A CA 3077428 A CA3077428 A CA 3077428A CA 3077428 A1 CA3077428 A1 CA 3077428A1
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CA
Canada
Prior art keywords
functional
live attenuated
fim3
vaccine
bordetella strain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3077428A
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English (en)
French (fr)
Inventor
Anne-Sophie Debrie
Dominique Raze
Camille Locht
Original Assignee
Institut Pasteur de Lille
Institut National de la Sante et de la Recherche Medicale INSERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut Pasteur de Lille, Institut National de la Sante et de la Recherche Medicale INSERM filed Critical Institut Pasteur de Lille
Publication of CA3077428A1 publication Critical patent/CA3077428A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/099—Bordetella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA3077428A 2017-10-18 2018-10-18 Bordetella strains expressing serotype 3 fimbriae Pending CA3077428A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762574068P 2017-10-18 2017-10-18
US62/574,068 2017-10-18
PCT/EP2018/078522 WO2019077028A1 (en) 2017-10-18 2018-10-18 BORDETELLA STRAINS EXPRESSING SERO-TYPE FIMBRIAE 3

Publications (1)

Publication Number Publication Date
CA3077428A1 true CA3077428A1 (en) 2019-04-25

Family

ID=64664226

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3077428A Pending CA3077428A1 (en) 2017-10-18 2018-10-18 Bordetella strains expressing serotype 3 fimbriae

Country Status (8)

Country Link
US (2) US11446372B2 (https=)
EP (1) EP3697439A1 (https=)
JP (2) JP7335874B2 (https=)
CN (2) CN118979003A (https=)
AU (1) AU2018353409B2 (https=)
CA (1) CA3077428A1 (https=)
SG (1) SG11202003333WA (https=)
WO (1) WO2019077028A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9119804B2 (en) 2006-03-10 2015-09-01 Institut Pasteur De Lille Live attenuated bordetella strains as a single dose vaccine against whooping cough
SG175803A1 (en) 2009-04-28 2011-12-29 Pasteur Institut Vaccine for prophylaxis or treatment of an allergen-driven airway pathology
SG11202003333WA (en) * 2017-10-18 2020-05-28 Pasteur Institut Bordetella strains expressing serotype 3 fimbriae
EP4247397A4 (en) 2020-11-17 2024-11-06 Iliad Biotechnologies, LLC TREATMENT AND PREVENTION OF NEUROPATHOLOGY ASSOCIATED WITH NEURODEGENERATIVE DISEASES

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4883761A (en) * 1986-03-25 1989-11-28 The United States Of America As Represented By The Department Of Health And Human Services Pertussis toxin gene: cloning and expression of protective antigen
US6713072B1 (en) 1987-11-02 2004-03-30 Chiron S.R.L. Immunologically active polypeptides with altered toxicity useful for the preparation of an antipertussis vaccine
IT1236971B (it) * 1989-11-03 1993-05-07 Eniricerche Spa Regione promotore dei geni codificanti le subunita' piliniche fim2, fm3 e fimx di bordetella pertussis e loro impiego per l'espressione di geni che codificano una proteina di interesse.
GB9115332D0 (en) 1991-07-16 1991-08-28 Connaught Lab Manipulation of gene copy number in bordetella
FR2718750B1 (fr) 1994-04-19 1996-06-14 Pasteur Institut Protéines recombinantes de l'hémagglutinine filamenteuse de Bordetella, notamment, B. Pertussis, production et application à la production de protéines étrangères ou de principes actifs vaccinants.
FR2754543B1 (fr) * 1996-10-11 1998-12-31 Pasteur Institut Souche de bordetella deficiente dans la production de toxine et exprimant une proteine hydride, liposomes comprenant de la fha et leurs utilisations comme vaccins, et utilisation de la fha pour stimuler les reponses immunitaires
FR2840319B1 (fr) 2002-05-30 2004-08-20 Pasteur Institut Souches de bordetella rendues deficientes par attenuation genetique
EP1617805A4 (en) 2003-04-11 2012-07-04 Medimmune Llc METHODS FOR PREVENTING OR TREATING RESPIRATORY CONDITIONS
GB0402131D0 (en) * 2004-01-30 2004-03-03 Isis Innovation Delivery method
US9119804B2 (en) * 2006-03-10 2015-09-01 Institut Pasteur De Lille Live attenuated bordetella strains as a single dose vaccine against whooping cough
CA2669485C (en) 2006-11-15 2017-01-03 Folia Biotech Inc. Papaya mosaic virus-based vaccines for influenza
EP2134359A4 (en) 2007-02-23 2010-06-16 Penn State Res Found USE OF A NONVIRULENT BORDETELLA MUTANT AS LIVING VACCINE VECTOR
CN100537767C (zh) * 2007-04-29 2009-09-09 中国药品生物制品检定所 百日咳疫苗保护性抗原的重组表达及其应用
WO2008156753A1 (en) 2007-06-18 2008-12-24 Hemispherx Biopharma Early intervention of viral infections with immune activators
SG175803A1 (en) 2009-04-28 2011-12-29 Pasteur Institut Vaccine for prophylaxis or treatment of an allergen-driven airway pathology
DK2442826T3 (en) 2009-06-15 2015-09-21 Univ Singapore Influenza vaccine, composition and methods of using
DK2773371T3 (da) * 2011-11-02 2020-03-09 Nat Univ Singapore Virkning af en svækket bordetella-stamme mod allergisk sygdom
AU2013301312A1 (en) * 2012-08-06 2015-03-19 Glaxosmithkline Biologicals S.A. Method for eliciting in infants an immune response against RSV and B. pertussis
EP2722338A1 (en) * 2012-10-17 2014-04-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Novel recombinant Bordetella strains
US9655959B2 (en) * 2014-10-01 2017-05-23 National University Of Singapore Adenylate cyclase deficient bordetella strains
EP4541809A3 (en) 2016-03-29 2025-06-25 Institut Pasteur de Lille Mutant bordetella strains and methods of use
US10799573B2 (en) * 2016-03-30 2020-10-13 Regents Of The University Of Minnesota Pertussis vaccines and methods of making and using
US20200171169A1 (en) * 2017-05-15 2020-06-04 Vanderbilt University LONG-CIRCULATING ZWITTERIONIC POLYPLEXES FOR siRNA DELIVERY
CN111032078A (zh) * 2017-07-18 2020-04-17 血清研究所印度私人有限公司 具有改善的稳定性、增强的免疫原性和降低的反应原性的免疫原性组合物及其制备方法
SG11202003333WA (en) * 2017-10-18 2020-05-28 Pasteur Institut Bordetella strains expressing serotype 3 fimbriae
US12036405B2 (en) * 2018-03-23 2024-07-16 The Board Of Regents Of The University Of Oklahoma System and method of electric-induced acoustic tomography for electrotherapy monitoring
WO2020049133A1 (en) 2018-09-05 2020-03-12 National University Of Singapore Adenylate cyclase catalytic domain deficient bordetella strains

Also Published As

Publication number Publication date
CN111278456B (zh) 2024-08-09
CN111278456A (zh) 2020-06-12
JP2021500325A (ja) 2021-01-07
JP2023109996A (ja) 2023-08-08
SG11202003333WA (en) 2020-05-28
WO2019077028A4 (en) 2019-06-27
AU2018353409A1 (en) 2020-04-16
US20200297833A1 (en) 2020-09-24
AU2018353409B2 (en) 2025-07-17
JP7335874B2 (ja) 2023-08-30
US11446372B2 (en) 2022-09-20
EP3697439A1 (en) 2020-08-26
WO2019077028A1 (en) 2019-04-25
JP7812352B2 (ja) 2026-02-09
CN118979003A (zh) 2024-11-19
US20220362369A1 (en) 2022-11-17
US12403188B2 (en) 2025-09-02

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