CA3068981A1 - Dosage pour la prediction preoperatoire de la recuperation d'une fonction d'organe - Google Patents

Dosage pour la prediction preoperatoire de la recuperation d'une fonction d'organe Download PDF

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Publication number
CA3068981A1
CA3068981A1 CA3068981A CA3068981A CA3068981A1 CA 3068981 A1 CA3068981 A1 CA 3068981A1 CA 3068981 A CA3068981 A CA 3068981A CA 3068981 A CA3068981 A CA 3068981A CA 3068981 A1 CA3068981 A1 CA 3068981A1
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Prior art keywords
genes
surgery
seq
score
gene
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Pending
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CA3068981A
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English (en)
Inventor
Mario DENG
Galyna BONDAR
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University of California
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University of California
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Priority claimed from PCT/US2018/040961 external-priority patent/WO2019010339A1/fr
Publication of CA3068981A1 publication Critical patent/CA3068981A1/fr
Pending legal-status Critical Current

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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'expression génique est mesurée dans un échantillon de cellules mononucléaires du sang périphérique (PBMC) obtenu d'un sujet et utilisé pour prédire la récupération d'une fonction d'organe. Un score de potentiel de récupération de fonction (FRP) est attribué à un échantillon qui reflète le niveau d'expression mesuré des gènes identifiés dans la présente description dans une direction associée à la récupération d'une défaillance d'organe. Le traitement du sujet avec une prise en charge médicale optimale (OMM) et/ou des soins palliatifs (PC) est conseillé lorsque le score de FRP est inférieur à la valeur de référence, et l'orientation du sujet vers un traitement par des thérapies comprenant - mais non exclusivement - une intervention chirurgicale sous assistance circulatoire mécanique (MCS), une intervention chirurgicale de transplantation cardiaque (HTx), ou une autre intervention pour une insuffisance cardiaque avancée est conseillée lorsque le score de FRP est supérieur à la valeur de référence. L'invention concerne également un procédé de développement d'un algorithme d'évaluation par un score de FRP qui prédit la capacité d'un sujet à récupérer d'une intervention médicale pour une défaillance d'organe.
CA3068981A 2017-07-05 2018-07-05 Dosage pour la prediction preoperatoire de la recuperation d'une fonction d'organe Pending CA3068981A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762528748P 2017-07-05 2017-07-05
US62/528,748 2017-07-05
PCT/US2018/040961 WO2019010339A1 (fr) 2017-07-05 2018-07-05 Dosage pour la prédiction préopératoire de la récupération d'une fonction d'organe

Publications (1)

Publication Number Publication Date
CA3068981A1 true CA3068981A1 (fr) 2019-01-10

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ID=69229919

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3068981A Pending CA3068981A1 (fr) 2017-07-05 2018-07-05 Dosage pour la prediction preoperatoire de la recuperation d'une fonction d'organe

Country Status (1)

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CA (1) CA3068981A1 (fr)

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Effective date: 20230609