CA3034540A1 - Polymeric metal chelating compositions and methods of preparing same for controlling growth and activities of living cells and organisms - Google Patents

Polymeric metal chelating compositions and methods of preparing same for controlling growth and activities of living cells and organisms Download PDF

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Publication number
CA3034540A1
CA3034540A1 CA3034540A CA3034540A CA3034540A1 CA 3034540 A1 CA3034540 A1 CA 3034540A1 CA 3034540 A CA3034540 A CA 3034540A CA 3034540 A CA3034540 A CA 3034540A CA 3034540 A1 CA3034540 A1 CA 3034540A1
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CA
Canada
Prior art keywords
group
chelating
compound
independently selected
chelating composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3034540A
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English (en)
French (fr)
Inventor
Bruce E. Holbein
M. Trisha C. ANG
Dnyaneshwar Vithoba PALASKAR
Ganugapati Satyanarayana
Gireesh MAHANDRU
S. Vijaya Bhaskara REDDY
Sazid ALI
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CHELATION PARTNERS Inc
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CHELATION PARTNERS Inc
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Filing date
Publication date
Application filed by CHELATION PARTNERS Inc filed Critical CHELATION PARTNERS Inc
Publication of CA3034540A1 publication Critical patent/CA3034540A1/en
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/69Two or more oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/74Synthetic polymeric materials
    • A61K31/785Polymers containing nitrogen
    • A61K31/787Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/04Chelating agents
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52Amides or imides
    • C08F220/54Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52Amides or imides
    • C08F220/54Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F220/60Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing nitrogen in addition to the carbonamido nitrogen
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F226/00Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • C08F226/06Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a heterocyclic ring containing nitrogen
    • C08F226/10N-Vinyl-pyrrolidone
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2438/00Living radical polymerisation
    • C08F2438/03Use of a di- or tri-thiocarbonylthio compound, e.g. di- or tri-thioester, di- or tri-thiocarbamate, or a xanthate as chain transfer agent, e.g . Reversible Addition Fragmentation chain Transfer [RAFT] or Macromolecular Design via Interchange of Xanthates [MADIX]

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polymerisation Methods In General (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Materials For Medical Uses (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA3034540A 2016-08-26 2017-08-25 Polymeric metal chelating compositions and methods of preparing same for controlling growth and activities of living cells and organisms Pending CA3034540A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662380047P 2016-08-26 2016-08-26
US62/380,047 2016-08-26
PCT/CA2017/050999 WO2018035613A1 (en) 2016-08-26 2017-08-25 Polymeric metal chelating compositions and methods of preparing same for controlling growth and activities of living cells and organisms

Publications (1)

Publication Number Publication Date
CA3034540A1 true CA3034540A1 (en) 2018-03-01

Family

ID=61245905

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3034540A Pending CA3034540A1 (en) 2016-08-26 2017-08-25 Polymeric metal chelating compositions and methods of preparing same for controlling growth and activities of living cells and organisms

Country Status (6)

Country Link
US (2) US11059785B2 (https=)
EP (1) EP3504188A4 (https=)
JP (1) JP7387429B2 (https=)
AU (2) AU2017314880B2 (https=)
CA (1) CA3034540A1 (https=)
WO (1) WO2018035613A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7387429B2 (ja) * 2016-08-26 2023-11-28 キレーション パートナーズ インコーポレイテッド 生細胞および生物の増殖および活性を制御するためのポリマー性金属キレート組成物およびその調製方法
CN108276303A (zh) * 2018-03-14 2018-07-13 中国科学院青岛生物能源与过程研究所 一种含糖聚合物单体n-(2-d-葡萄糖酰胺基乙基)甲基丙烯酰胺的合成方法
US20220390470A1 (en) * 2019-11-11 2022-12-08 Oxford University Innovation Limited Biomarkers for the prediction and identification of parkinson's disease
CN111995567B (zh) * 2020-07-24 2022-11-25 浙江工业大学 具潜在多靶点抗ad活性的甲酰胺吡啶酮类铁螯合剂衍生物及其制备方法与应用
JP2025510226A (ja) * 2022-03-24 2025-04-14 フィー ファーマシューティカルズ(カナダ)インコーポレイテッド ポリマー鉄結合組成物及び過剰な損傷反応性鉄に関連する疾患を治療するための使用方法
EP4619007A1 (en) * 2022-11-18 2025-09-24 Fe Pharmaceuticals (Canada) Inc. Compositions for attenuating anti-infective resistance, uses and methods thereof
CA3226246A1 (en) * 2023-02-17 2025-05-02 Infineum International Limited Multipurpose oxypyridinones and their functional use
CN118955773B (zh) * 2024-07-31 2025-09-26 浙江大学 高聚合度的金属螯合聚合物抗体标签载体材料的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8454934B2 (en) * 2006-05-25 2013-06-04 Canadian Blood Services High molecular weight chelation structure
KR101764427B1 (ko) 2008-05-13 2017-08-02 유니버시티 오브 워싱톤 미셀성 어셈블리
US10709784B2 (en) 2011-06-08 2020-07-14 Chelation Partners Incorporated Metal chelating compositions and methods for controlling the growth or activities of a living cell or organism
JP7387429B2 (ja) * 2016-08-26 2023-11-28 キレーション パートナーズ インコーポレイテッド 生細胞および生物の増殖および活性を制御するためのポリマー性金属キレート組成物およびその調製方法

Also Published As

Publication number Publication date
WO2018035613A1 (en) 2018-03-01
US20220002250A1 (en) 2022-01-06
AU2017314880B2 (en) 2021-07-29
AU2021204603A1 (en) 2021-07-29
EP3504188A4 (en) 2020-04-22
EP3504188A1 (en) 2019-07-03
JP7387429B2 (ja) 2023-11-28
US12024490B2 (en) 2024-07-02
JP2019526671A (ja) 2019-09-19
AU2017314880A1 (en) 2019-04-11
AU2021204603B2 (en) 2023-02-23
US20190169126A1 (en) 2019-06-06
US11059785B2 (en) 2021-07-13

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