CA3034208A1 - Bioreacteur utilisant des ondes stationnaires acoustiques - Google Patents

Bioreacteur utilisant des ondes stationnaires acoustiques Download PDF

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Publication number
CA3034208A1
CA3034208A1 CA3034208A CA3034208A CA3034208A1 CA 3034208 A1 CA3034208 A1 CA 3034208A1 CA 3034208 A CA3034208 A CA 3034208A CA 3034208 A CA3034208 A CA 3034208A CA 3034208 A1 CA3034208 A1 CA 3034208A1
Authority
CA
Canada
Prior art keywords
cells
bioreactor
standing wave
flow chamber
crystal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3034208A
Other languages
English (en)
Inventor
Bart Lipkens
Louis Masi
Stanley Kowalski, Iii
Walter M. Presz, Jr.
Jason Dionne
Brian DUTRA
Ari MERCADO
Thomas J. Kennedy, Iii
Arthur Martin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Flodesign Sonics Inc
Original Assignee
Flodesign Sonics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flodesign Sonics Inc filed Critical Flodesign Sonics Inc
Publication of CA3034208A1 publication Critical patent/CA3034208A1/fr
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/28—Mechanical auxiliary equipment for acceleration of sedimentation, e.g. by vibrators or the like
    • B01D21/283—Settling tanks provided with vibrators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/14—Bags
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Sustainable Development (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

Un bioréacteur à perfusion comprend au moins un transducteur ultrasonore qui peut générer par voie acoustique une onde stationnaire multidimensionnelle. L'onde stationnaire peut être utilisée pour retenir des cellules dans le bioréacteur et, également, pour déshydrater ou récolter davantage de produit depuis les déchets produits dans un bioréacteur.
CA3034208A 2016-08-16 2016-08-16 Bioreacteur utilisant des ondes stationnaires acoustiques Pending CA3034208A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2016/047217 WO2018034655A1 (fr) 2016-08-16 2016-08-16 Bioréacteur utilisant des ondes stationnaires acoustiques

Publications (1)

Publication Number Publication Date
CA3034208A1 true CA3034208A1 (fr) 2018-02-22

Family

ID=56740583

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3034208A Pending CA3034208A1 (fr) 2016-08-16 2016-08-16 Bioreacteur utilisant des ondes stationnaires acoustiques

Country Status (4)

Country Link
EP (1) EP3500659A1 (fr)
CN (1) CN109844089B (fr)
CA (1) CA3034208A1 (fr)
WO (1) WO2018034655A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
US9458450B2 (en) 2012-03-15 2016-10-04 Flodesign Sonics, Inc. Acoustophoretic separation technology using multi-dimensional standing waves
US10967298B2 (en) 2012-03-15 2021-04-06 Flodesign Sonics, Inc. Driver and control for variable impedence load
US9950282B2 (en) 2012-03-15 2018-04-24 Flodesign Sonics, Inc. Electronic configuration and control for acoustic standing wave generation
WO2015105955A1 (fr) 2014-01-08 2015-07-16 Flodesign Sonics, Inc. Dispositif d'acoustophorèse avec double chambre acoustophorétique
US11021699B2 (en) 2015-04-29 2021-06-01 FioDesign Sonics, Inc. Separation using angled acoustic waves
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
US11459540B2 (en) 2015-07-28 2022-10-04 Flodesign Sonics, Inc. Expanded bed affinity selection
US11474085B2 (en) 2015-07-28 2022-10-18 Flodesign Sonics, Inc. Expanded bed affinity selection
US11085035B2 (en) 2016-05-03 2021-08-10 Flodesign Sonics, Inc. Therapeutic cell washing, concentration, and separation utilizing acoustophoresis
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
CA3041517A1 (fr) 2016-10-19 2018-04-26 Flodesign Sonics, Inc. Extraction par affinite de cellules par un procede acoustique
EP3725092A4 (fr) 2017-12-14 2021-09-22 FloDesign Sonics, Inc. Circuit d'excitation et circuit de commande de transducteur acoustique
CN111154648B (zh) * 2019-12-27 2022-10-25 新乡医学院三全学院 一种干细胞源性外泌体培养装置

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0100820D0 (sv) * 2001-03-09 2001-03-09 Erysave Ab Ideon Particle separation using an acoustic filter
US9416344B2 (en) * 2012-03-15 2016-08-16 Flodesign Sonics, Inc. Bioreactor using acoustic standing waves
EP2825590B1 (fr) * 2012-03-16 2017-04-19 3M Innovative Properties Company Articles de faible poids, compositions composite et procédés de fabrication correspondants
CN107189933B (zh) * 2013-02-07 2021-06-18 弗洛设计声能学公司 利用声驻波的生物反应器系统和相关方法
US20160312168A1 (en) * 2013-12-30 2016-10-27 Ge Healthcare Bio-Sciences Corp. Apparatus for cell cultivation
US9675906B2 (en) * 2014-09-30 2017-06-13 Flodesign Sonics, Inc. Acoustophoretic clarification of particle-laden non-flowing fluids

Also Published As

Publication number Publication date
EP3500659A1 (fr) 2019-06-26
CN109844089A (zh) 2019-06-04
WO2018034655A1 (fr) 2018-02-22
CN109844089B (zh) 2022-08-23

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