CA3031737A1 - Efficacite d'un conjugue anticorps-medicament anti-hla-dr (hl243-cl2a-sn -38) dans le traitement des cancers hla-dr positifs - Google Patents
Efficacite d'un conjugue anticorps-medicament anti-hla-dr (hl243-cl2a-sn -38) dans le traitement des cancers hla-dr positifs Download PDFInfo
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- CA3031737A1 CA3031737A1 CA3031737A CA3031737A CA3031737A1 CA 3031737 A1 CA3031737 A1 CA 3031737A1 CA 3031737 A CA3031737 A CA 3031737A CA 3031737 A CA3031737 A CA 3031737A CA 3031737 A1 CA3031737 A1 CA 3031737A1
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- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
L'invention concerne des immunoconjugués thérapeutiques comprenant SN-38 fixé à un anticorps anti-HLA-DR ou à un fragment d'anticorps de liaison à l'antigène. L'immunoconjugué peut être administré à une dose comprise entre 3 mg/kg et 18 mg/kg, de préférence 4, 6, 8, 9, 12, 12, 16 ou 18 mg/kg, de préférence encore 8, 10 ou 12 mg/kg. Lorsqu'il est administré à des dosages et posologies spécifiés, l'immunoconjugué peut réduire la taille de tumeurs solides, réduire ou éliminer les métastases et est efficace pour traiter les cancers résistant aux thérapies standard, telles que la radiothérapie, la chimiothérapie ou l'immunothérapie. Les procédés et les compositions sont particulièrement utiles pour traiter l'AML, l'ALL ou le myélome multiple.
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662373591P | 2016-08-11 | 2016-08-11 | |
US62/373,591 | 2016-08-11 | ||
US15/281,453 US10130626B2 (en) | 2012-12-13 | 2016-09-30 | Dosages of immunoconjugates of antibodies and SN-38 for improved efficacy and decreased toxicity |
US15/281,453 | 2016-09-30 | ||
US201662428231P | 2016-11-30 | 2016-11-30 | |
US62/428,231 | 2016-11-30 | ||
US15/484,308 | 2017-04-11 | ||
US15/484,308 US10058621B2 (en) | 2015-06-25 | 2017-04-11 | Combination therapy with anti-HLA-DR antibodies and kinase inhibitors in hematopoietic cancers |
PCT/US2017/045516 WO2018031408A1 (fr) | 2016-08-11 | 2017-08-04 | Efficacité d'un conjugué anticorps-médicament anti-hla-dr (hl243-cl2a-sn -38) dans le traitement des cancers hla-dr positifs |
Publications (1)
Publication Number | Publication Date |
---|---|
CA3031737A1 true CA3031737A1 (fr) | 2018-02-15 |
Family
ID=61163070
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA3031737A Pending CA3031737A1 (fr) | 2016-08-11 | 2017-08-04 | Efficacite d'un conjugue anticorps-medicament anti-hla-dr (hl243-cl2a-sn -38) dans le traitement des cancers hla-dr positifs |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP3496754A4 (fr) |
CN (1) | CN109562172B (fr) |
CA (1) | CA3031737A1 (fr) |
WO (1) | WO2018031408A1 (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018187074A1 (fr) * | 2017-04-03 | 2018-10-11 | Immunomedics, Inc. | Administration par voie sous-cutanée de conjugués anticorps-médicament à titre de thérapie anticancéreuse |
FR3072880A1 (fr) * | 2017-10-30 | 2019-05-03 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Formulation liposomale et son utilisation en therapie anti-tumorale |
TW202003047A (zh) * | 2018-03-23 | 2020-01-16 | 美商西雅圖遺傳學公司 | 包括微管蛋白破壞劑之抗體藥物結合物治療實體腫瘤之用途 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7585491B2 (en) * | 2002-12-13 | 2009-09-08 | Immunomedics, Inc. | Immunoconjugates with an intracellularly-cleavable linkage |
US7591994B2 (en) * | 2002-12-13 | 2009-09-22 | Immunomedics, Inc. | Camptothecin-binding moiety conjugates |
CN101171034B (zh) * | 2005-03-03 | 2014-06-18 | 免疫医疗公司 | 人源化l243抗体 |
EP2550975A1 (fr) * | 2011-07-29 | 2013-01-30 | Sanofi | Polythérapie pour le traitement de symptômes de malignités CD19+lymphocytes B comprenant un immunoconjugué anti-CD19 maytansinoïde et du rituximab |
WO2013043800A1 (fr) * | 2011-09-22 | 2013-03-28 | Immunomedics, Inc. | Anticorps anti-hla-dr inhibant les réactions immunitaires allogènes et xénogènes en cas de greffe d'organe |
HRP20220399T1 (hr) * | 2012-12-13 | 2022-05-13 | Immunomedics, Inc. | Režim doziranja imunokonjugata protutijela i sn-38 za poboljšanu učinkovitost i smanjenu toksičnost |
US9107960B2 (en) * | 2012-12-13 | 2015-08-18 | Immunimedics, Inc. | Antibody-SN-38 immunoconjugates with a CL2A linker |
CA2914438C (fr) * | 2013-07-23 | 2022-06-14 | Immunomedics, Inc. | Immunoconjugues anticorps-sn-38 avec un lieur cl2a |
-
2017
- 2017-08-04 WO PCT/US2017/045516 patent/WO2018031408A1/fr unknown
- 2017-08-04 CA CA3031737A patent/CA3031737A1/fr active Pending
- 2017-08-04 EP EP17840061.0A patent/EP3496754A4/fr not_active Withdrawn
- 2017-08-04 CN CN201780048367.2A patent/CN109562172B/zh active Active
Also Published As
Publication number | Publication date |
---|---|
WO2018031408A1 (fr) | 2018-02-15 |
EP3496754A4 (fr) | 2020-04-15 |
EP3496754A1 (fr) | 2019-06-19 |
CN109562172B (zh) | 2022-08-16 |
CN109562172A (zh) | 2019-04-02 |
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