CA3028343C - Conjugues de bisphosphonate quinolone et leurs utilisations - Google Patents

Conjugues de bisphosphonate quinolone et leurs utilisations

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Publication number
CA3028343C
CA3028343C CA3028343A CA3028343A CA3028343C CA 3028343 C CA3028343 C CA 3028343C CA 3028343 A CA3028343 A CA 3028343A CA 3028343 A CA3028343 A CA 3028343A CA 3028343 C CA3028343 C CA 3028343C
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CA
Canada
Prior art keywords
substituted
compound
bone
alkyl
hydroxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
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CA3028343A
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English (en)
Other versions
CA3028343A1 (fr
Inventor
Frank H. Ebetino
Shuting Sun
Mark W. Lundy
Charles E. McKenna
Eric Richard
Parish SEDGHIZADEH
Keivan SADRERAFI
Original Assignee
Biovinc LLC
University of Southern California USC
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Application filed by Biovinc LLC, University of Southern California USC filed Critical Biovinc LLC
Priority claimed from PCT/US2017/035764 external-priority patent/WO2017210611A1/fr
Publication of CA3028343A1 publication Critical patent/CA3028343A1/fr
Application granted granted Critical
Publication of CA3028343C publication Critical patent/CA3028343C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Abstract

Des composés comprenant un diphosphonate et un composé de quinolone sont décrits, de même que des compositions pharmaceutiques connexes. La quinolone est raccordée de manière inévitable au diphosphonate au moyen d'un carbamate, S-thiocarbamate ou O-thiocarbamate, un oxygène ou un soufre de l'un de ces trois éléments étant raccordé à un aryle, lui-même directement ou indirectement raccordé au diphosphonate pour créer un lien d'arylcarbamate, de S-thioarylcarbamate ou de O-thioarylcarbamate de la quinolone au diphosphonate, la quinolone étant raccordée au diphosphonate au moyen d'un azote du lien, l'azote étant raccordé à un substitut raccordé à la position 7 sur le groupe quinolone, la position 1 sur le groupe quinolone étant l'emplacement de l'azote sur la bague de roulement de carbonyle du groupe quinolone et la position 3 sur le groupe quinolone étant l'emplacement du carboxylate sur le groupe quinolone. Selon certains modes de réalisation, le diphosphonate peut présenter la formule suivante (voir formule ci-haut).
CA3028343A 2016-06-03 2017-06-02 Conjugues de bisphosphonate quinolone et leurs utilisations Active CA3028343C (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662345370P 2016-06-03 2016-06-03
US62/345,370 2016-06-03
US201662357727P 2016-07-01 2016-07-01
US62/357,727 2016-07-01
US201762448060P 2017-01-19 2017-01-19
US62/448,060 2017-01-19
PCT/US2017/035764 WO2017210611A1 (fr) 2016-06-03 2017-06-02 Conjugués de bisphosphonate quinolone et leurs utilisations

Publications (2)

Publication Number Publication Date
CA3028343A1 CA3028343A1 (fr) 2017-12-07
CA3028343C true CA3028343C (fr) 2026-03-31

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