CA3024491A1 - Forehead cooling method and device to stimulate the parasympathetic nervous system for the treatment of insomnia - Google Patents
Forehead cooling method and device to stimulate the parasympathetic nervous system for the treatment of insomnia Download PDFInfo
- Publication number
- CA3024491A1 CA3024491A1 CA3024491A CA3024491A CA3024491A1 CA 3024491 A1 CA3024491 A1 CA 3024491A1 CA 3024491 A CA3024491 A CA 3024491A CA 3024491 A CA3024491 A CA 3024491A CA 3024491 A1 CA3024491 A1 CA 3024491A1
- Authority
- CA
- Canada
- Prior art keywords
- sleep
- temperature
- subject
- applicator
- thermal transfer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 title claims abstract description 145
- 206010022437 insomnia Diseases 0.000 title claims abstract description 145
- 238000001816 cooling Methods 0.000 title claims description 138
- 210000001061 forehead Anatomy 0.000 title claims description 120
- 210000001002 parasympathetic nervous system Anatomy 0.000 title abstract description 21
- 238000011282 treatment Methods 0.000 title description 55
- 230000007958 sleep Effects 0.000 claims abstract description 598
- 238000000034 method Methods 0.000 claims abstract description 121
- 230000009189 diving Effects 0.000 claims abstract description 69
- 230000011514 reflex Effects 0.000 claims abstract description 69
- 230000002708 enhancing effect Effects 0.000 claims abstract description 30
- 238000012546 transfer Methods 0.000 claims description 166
- 230000002631 hypothermal effect Effects 0.000 claims description 79
- 210000003128 head Anatomy 0.000 claims description 72
- 239000012530 fluid Substances 0.000 claims description 59
- 210000005153 frontal cortex Anatomy 0.000 claims description 48
- 210000002442 prefrontal cortex Anatomy 0.000 claims description 39
- 238000002560 therapeutic procedure Methods 0.000 claims description 36
- 230000001603 reducing effect Effects 0.000 claims description 31
- 230000007423 decrease Effects 0.000 claims description 21
- 230000033001 locomotion Effects 0.000 claims description 13
- 238000004891 communication Methods 0.000 claims description 12
- 238000012423 maintenance Methods 0.000 claims description 12
- 231100000430 skin reaction Toxicity 0.000 claims description 6
- 210000004369 blood Anatomy 0.000 claims description 4
- 239000008280 blood Substances 0.000 claims description 4
- 238000006213 oxygenation reaction Methods 0.000 claims description 2
- 230000036387 respiratory rate Effects 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 86
- 230000001965 increasing effect Effects 0.000 abstract description 45
- 230000004044 response Effects 0.000 abstract description 26
- 230000001105 regulatory effect Effects 0.000 abstract description 19
- 230000001734 parasympathetic effect Effects 0.000 abstract description 14
- 210000003403 autonomic nervous system Anatomy 0.000 abstract description 9
- 210000002820 sympathetic nervous system Anatomy 0.000 abstract description 9
- 230000001225 therapeutic effect Effects 0.000 abstract description 9
- 230000002829 reductive effect Effects 0.000 abstract description 6
- 230000002889 sympathetic effect Effects 0.000 abstract description 5
- 230000002459 sustained effect Effects 0.000 abstract description 2
- 230000008454 sleep-wake cycle Effects 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 description 54
- 210000004556 brain Anatomy 0.000 description 52
- 239000000463 material Substances 0.000 description 49
- 206010021113 Hypothermia Diseases 0.000 description 46
- 230000009467 reduction Effects 0.000 description 34
- 230000006870 function Effects 0.000 description 32
- 230000037007 arousal Effects 0.000 description 27
- 230000004620 sleep latency Effects 0.000 description 27
- 230000036385 rapid eye movement (rem) sleep Effects 0.000 description 26
- 230000002360 prefrontal effect Effects 0.000 description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 24
- 230000002490 cerebral effect Effects 0.000 description 23
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 23
- 208000035475 disorder Diseases 0.000 description 23
- 230000001720 vestibular Effects 0.000 description 23
- 230000002618 waking effect Effects 0.000 description 23
- 206010062519 Poor quality sleep Diseases 0.000 description 22
- 230000008667 sleep stage Effects 0.000 description 20
- 208000019116 sleep disease Diseases 0.000 description 19
- 230000000638 stimulation Effects 0.000 description 19
- 238000004458 analytical method Methods 0.000 description 18
- 230000008859 change Effects 0.000 description 18
- 229940079593 drug Drugs 0.000 description 16
- 239000003814 drug Substances 0.000 description 16
- 230000002503 metabolic effect Effects 0.000 description 16
- 210000004761 scalp Anatomy 0.000 description 16
- 230000037322 slow-wave sleep Effects 0.000 description 16
- 230000008901 benefit Effects 0.000 description 15
- 238000013461 design Methods 0.000 description 15
- 230000036757 core body temperature Effects 0.000 description 14
- 230000008569 process Effects 0.000 description 14
- 206010041349 Somnolence Diseases 0.000 description 13
- 238000012544 monitoring process Methods 0.000 description 13
- 230000035807 sensation Effects 0.000 description 13
- 235000019615 sensations Nutrition 0.000 description 13
- 208000019901 Anxiety disease Diseases 0.000 description 12
- 208000002193 Pain Diseases 0.000 description 12
- 239000000853 adhesive Substances 0.000 description 12
- 230000001070 adhesive effect Effects 0.000 description 12
- 230000009850 completed effect Effects 0.000 description 12
- 230000007717 exclusion Effects 0.000 description 12
- 238000012360 testing method Methods 0.000 description 12
- 208000010340 Sleep Deprivation Diseases 0.000 description 11
- 238000004422 calculation algorithm Methods 0.000 description 11
- 230000003247 decreasing effect Effects 0.000 description 11
- 230000007246 mechanism Effects 0.000 description 11
- 238000011160 research Methods 0.000 description 11
- 230000035882 stress Effects 0.000 description 11
- 208000032140 Sleepiness Diseases 0.000 description 10
- 238000010438 heat treatment Methods 0.000 description 10
- 238000012216 screening Methods 0.000 description 10
- 230000037321 sleepiness Effects 0.000 description 10
- 230000036506 anxiety Effects 0.000 description 9
- 210000000133 brain stem Anatomy 0.000 description 9
- 230000000747 cardiac effect Effects 0.000 description 9
- 238000005259 measurement Methods 0.000 description 9
- 230000007935 neutral effect Effects 0.000 description 9
- 238000002600 positron emission tomography Methods 0.000 description 9
- 230000002040 relaxant effect Effects 0.000 description 9
- 238000010792 warming Methods 0.000 description 9
- 230000002567 autonomic effect Effects 0.000 description 8
- 230000036772 blood pressure Effects 0.000 description 8
- 230000001149 cognitive effect Effects 0.000 description 8
- 210000001508 eye Anatomy 0.000 description 8
- 238000007654 immersion Methods 0.000 description 8
- 239000006187 pill Substances 0.000 description 8
- 230000003595 spectral effect Effects 0.000 description 8
- 230000002411 adverse Effects 0.000 description 7
- 230000009286 beneficial effect Effects 0.000 description 7
- 230000036471 bradycardia Effects 0.000 description 7
- 208000006218 bradycardia Diseases 0.000 description 7
- 230000001276 controlling effect Effects 0.000 description 7
- 230000001419 dependent effect Effects 0.000 description 7
- 230000004153 glucose metabolism Effects 0.000 description 7
- 208000028173 post-traumatic stress disease Diseases 0.000 description 7
- 208000011117 substance-related disease Diseases 0.000 description 7
- 230000002123 temporal effect Effects 0.000 description 7
- 206010019233 Headaches Diseases 0.000 description 6
- 208000028017 Psychotic disease Diseases 0.000 description 6
- 206010047139 Vasoconstriction Diseases 0.000 description 6
- 230000004075 alteration Effects 0.000 description 6
- 230000004087 circulation Effects 0.000 description 6
- 239000012809 cooling fluid Substances 0.000 description 6
- 231100000869 headache Toxicity 0.000 description 6
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 6
- 230000006872 improvement Effects 0.000 description 6
- 238000002483 medication Methods 0.000 description 6
- 238000011084 recovery Methods 0.000 description 6
- 230000004617 sleep duration Effects 0.000 description 6
- 208000020685 sleep-wake disease Diseases 0.000 description 6
- 230000007704 transition Effects 0.000 description 6
- 208000000094 Chronic Pain Diseases 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 5
- 230000033228 biological regulation Effects 0.000 description 5
- 230000000059 bradycardiac effect Effects 0.000 description 5
- 230000006735 deficit Effects 0.000 description 5
- 239000007789 gas Substances 0.000 description 5
- 239000008103 glucose Substances 0.000 description 5
- 230000036541 health Effects 0.000 description 5
- 230000003284 homeostatic effect Effects 0.000 description 5
- 239000000017 hydrogel Substances 0.000 description 5
- 230000002209 hydrophobic effect Effects 0.000 description 5
- 210000003016 hypothalamus Anatomy 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 230000036961 partial effect Effects 0.000 description 5
- 230000002093 peripheral effect Effects 0.000 description 5
- 230000004622 sleep time Effects 0.000 description 5
- 238000001228 spectrum Methods 0.000 description 5
- 230000028016 temperature homeostasis Effects 0.000 description 5
- 230000008542 thermal sensitivity Effects 0.000 description 5
- 230000001515 vagal effect Effects 0.000 description 5
- CEGXZKXILQSJHO-AKNDJLBFSA-N (3R,4S,5R)-3,4,5,6-tetrahydroxyhexan(18F)oyl fluoride Chemical compound [18F]C(=O)C[C@@H](O)[C@H](O)[C@H](O)CO CEGXZKXILQSJHO-AKNDJLBFSA-N 0.000 description 4
- 206010020674 Hypermetabolism Diseases 0.000 description 4
- 208000019695 Migraine disease Diseases 0.000 description 4
- 208000019022 Mood disease Diseases 0.000 description 4
- 208000012902 Nervous system disease Diseases 0.000 description 4
- 238000013459 approach Methods 0.000 description 4
- 206010003246 arthritis Diseases 0.000 description 4
- 230000006399 behavior Effects 0.000 description 4
- 230000001914 calming effect Effects 0.000 description 4
- 230000019771 cognition Effects 0.000 description 4
- 230000001054 cortical effect Effects 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 208000024732 dysthymic disease Diseases 0.000 description 4
- 210000005069 ears Anatomy 0.000 description 4
- 239000003326 hypnotic agent Substances 0.000 description 4
- 230000000147 hypnotic effect Effects 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 238000007726 management method Methods 0.000 description 4
- 238000002610 neuroimaging Methods 0.000 description 4
- 230000001936 parietal effect Effects 0.000 description 4
- 230000003389 potentiating effect Effects 0.000 description 4
- 208000020016 psychiatric disease Diseases 0.000 description 4
- 230000000284 resting effect Effects 0.000 description 4
- 238000010183 spectrum analysis Methods 0.000 description 4
- 230000004936 stimulating effect Effects 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 230000002791 sympathovagal effect Effects 0.000 description 4
- 210000000689 upper leg Anatomy 0.000 description 4
- 230000025033 vasoconstriction Effects 0.000 description 4
- 230000000007 visual effect Effects 0.000 description 4
- 208000017164 Chronobiology disease Diseases 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 206010019196 Head injury Diseases 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 208000025966 Neurological disease Diseases 0.000 description 3
- 206010037660 Pyrexia Diseases 0.000 description 3
- 229920002334 Spandex Polymers 0.000 description 3
- 208000009205 Tinnitus Diseases 0.000 description 3
- 230000003213 activating effect Effects 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 210000001367 artery Anatomy 0.000 description 3
- 230000001174 ascending effect Effects 0.000 description 3
- 239000002876 beta blocker Substances 0.000 description 3
- 229940097320 beta blocking agent Drugs 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 230000003925 brain function Effects 0.000 description 3
- 210000005013 brain tissue Anatomy 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 230000002124 endocrine Effects 0.000 description 3
- 210000003743 erythrocyte Anatomy 0.000 description 3
- 210000004209 hair Anatomy 0.000 description 3
- 210000001320 hippocampus Anatomy 0.000 description 3
- 229960000890 hydrocortisone Drugs 0.000 description 3
- 230000001976 improved effect Effects 0.000 description 3
- 230000000977 initiatory effect Effects 0.000 description 3
- 210000002414 leg Anatomy 0.000 description 3
- 230000009021 linear effect Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000001404 mediated effect Effects 0.000 description 3
- 230000036651 mood Effects 0.000 description 3
- 210000003205 muscle Anatomy 0.000 description 3
- 230000000324 neuroprotective effect Effects 0.000 description 3
- 230000001991 pathophysiological effect Effects 0.000 description 3
- 230000001766 physiological effect Effects 0.000 description 3
- 230000035479 physiological effects, processes and functions Effects 0.000 description 3
- 238000002106 pulse oximetry Methods 0.000 description 3
- 238000012023 real time release testing Methods 0.000 description 3
- 230000029058 respiratory gaseous exchange Effects 0.000 description 3
- 230000004799 sedative–hypnotic effect Effects 0.000 description 3
- 208000022925 sleep disturbance Diseases 0.000 description 3
- 230000008665 sleep physiology Effects 0.000 description 3
- 239000004759 spandex Substances 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 210000001103 thalamus Anatomy 0.000 description 3
- 231100000886 tinnitus Toxicity 0.000 description 3
- 230000032258 transport Effects 0.000 description 3
- 230000002792 vascular Effects 0.000 description 3
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 3
- 229920002554 vinyl polymer Polymers 0.000 description 3
- 238000003466 welding Methods 0.000 description 3
- 229930003347 Atropine Natural products 0.000 description 2
- 208000008035 Back Pain Diseases 0.000 description 2
- 208000020925 Bipolar disease Diseases 0.000 description 2
- 101100437784 Drosophila melanogaster bocks gene Proteins 0.000 description 2
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 2
- 208000011688 Generalised anxiety disease Diseases 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 description 2
- 206010021079 Hypopnoea Diseases 0.000 description 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 2
- 208000019693 Lung disease Diseases 0.000 description 2
- 206010027603 Migraine headaches Diseases 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 2
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 description 2
- 241000097929 Porphyria Species 0.000 description 2
- 208000010642 Porphyrias Diseases 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 230000005856 abnormality Effects 0.000 description 2
- 208000011930 active peptic ulcer disease Diseases 0.000 description 2
- 230000006978 adaptation Effects 0.000 description 2
- 201000005255 adrenal gland hyperfunction Diseases 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 235000013334 alcoholic beverage Nutrition 0.000 description 2
- 210000004727 amygdala Anatomy 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 2
- 239000000935 antidepressant agent Substances 0.000 description 2
- 229940005513 antidepressants Drugs 0.000 description 2
- 229940125715 antihistaminic agent Drugs 0.000 description 2
- 239000000739 antihistaminic agent Substances 0.000 description 2
- 239000000164 antipsychotic agent Substances 0.000 description 2
- 229940005529 antipsychotics Drugs 0.000 description 2
- 239000002249 anxiolytic agent Substances 0.000 description 2
- 230000000949 anxiolytic effect Effects 0.000 description 2
- 229940005530 anxiolytics Drugs 0.000 description 2
- 208000008784 apnea Diseases 0.000 description 2
- 238000013528 artificial neural network Methods 0.000 description 2
- RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 description 2
- 229960000396 atropine Drugs 0.000 description 2
- 230000002238 attenuated effect Effects 0.000 description 2
- 238000013542 behavioral therapy Methods 0.000 description 2
- 229940049706 benzodiazepine Drugs 0.000 description 2
- 150000001557 benzodiazepines Chemical class 0.000 description 2
- 230000002146 bilateral effect Effects 0.000 description 2
- 208000028683 bipolar I disease Diseases 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 230000008499 blood brain barrier function Effects 0.000 description 2
- 210000001218 blood-brain barrier Anatomy 0.000 description 2
- 210000000746 body region Anatomy 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 208000015114 central nervous system disease Diseases 0.000 description 2
- 210000003710 cerebral cortex Anatomy 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 210000000038 chest Anatomy 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 238000009535 clinical urine test Methods 0.000 description 2
- 239000003246 corticosteroid Substances 0.000 description 2
- 229960001334 corticosteroids Drugs 0.000 description 2
- 239000000850 decongestant Substances 0.000 description 2
- 229940124581 decongestants Drugs 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 230000000517 effect on sleep Effects 0.000 description 2
- 238000002570 electrooculography Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 206010015037 epilepsy Diseases 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 210000005200 frontal scalp Anatomy 0.000 description 2
- 208000029364 generalized anxiety disease Diseases 0.000 description 2
- 230000002489 hematologic effect Effects 0.000 description 2
- 230000002267 hypothalamic effect Effects 0.000 description 2
- 238000005286 illumination Methods 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 238000009413 insulation Methods 0.000 description 2
- 238000012562 intraclass correlation Methods 0.000 description 2
- 230000001788 irregular Effects 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- HCZHHEIFKROPDY-UHFFFAOYSA-N kynurenic acid Chemical compound C1=CC=C2NC(C(=O)O)=CC(=O)C2=C1 HCZHHEIFKROPDY-UHFFFAOYSA-N 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 208000024714 major depressive disease Diseases 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 230000013011 mating Effects 0.000 description 2
- 230000037323 metabolic rate Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 201000006417 multiple sclerosis Diseases 0.000 description 2
- 210000003928 nasal cavity Anatomy 0.000 description 2
- 230000001537 neural effect Effects 0.000 description 2
- 231100000189 neurotoxic Toxicity 0.000 description 2
- 230000002887 neurotoxic effect Effects 0.000 description 2
- 230000007135 neurotoxicity Effects 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 230000002450 orbitofrontal effect Effects 0.000 description 2
- 210000003300 oropharynx Anatomy 0.000 description 2
- 208000019906 panic disease Diseases 0.000 description 2
- 230000002085 persistent effect Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000003716 rejuvenation Effects 0.000 description 2
- 230000000241 respiratory effect Effects 0.000 description 2
- 210000004189 reticular formation Anatomy 0.000 description 2
- 238000012552 review Methods 0.000 description 2
- 230000001020 rhythmical effect Effects 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 230000001953 sensory effect Effects 0.000 description 2
- 238000004904 shortening Methods 0.000 description 2
- 201000009032 substance abuse Diseases 0.000 description 2
- 231100000736 substance abuse Toxicity 0.000 description 2
- 230000035900 sweating Effects 0.000 description 2
- 230000001331 thermoregulatory effect Effects 0.000 description 2
- 238000012795 verification Methods 0.000 description 2
- 208000007848 Alcoholism Diseases 0.000 description 1
- 208000000044 Amnesia Diseases 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 102000010831 Cytoskeletal Proteins Human genes 0.000 description 1
- 108010037414 Cytoskeletal Proteins Proteins 0.000 description 1
- 206010012335 Dependence Diseases 0.000 description 1
- 208000030814 Eating disease Diseases 0.000 description 1
- 241001669679 Eleotris Species 0.000 description 1
- 206010016275 Fear Diseases 0.000 description 1
- 208000019454 Feeding and Eating disease Diseases 0.000 description 1
- 206010016352 Feeling of relaxation Diseases 0.000 description 1
- 208000001640 Fibromyalgia Diseases 0.000 description 1
- 229920002527 Glycogen Polymers 0.000 description 1
- 229920000544 Gore-Tex Polymers 0.000 description 1
- 102000002812 Heat-Shock Proteins Human genes 0.000 description 1
- 108010004889 Heat-Shock Proteins Proteins 0.000 description 1
- 206010020100 Hip fracture Diseases 0.000 description 1
- 206010021034 Hypometabolism Diseases 0.000 description 1
- 108700002232 Immediate-Early Genes Proteins 0.000 description 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 1
- 206010024511 Limited symptom panic attack Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 208000026139 Memory disease Diseases 0.000 description 1
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 description 1
- -1 NOS activity Proteins 0.000 description 1
- 206010029350 Neurotoxicity Diseases 0.000 description 1
- 208000008705 Nocturnal Myoclonus Syndrome Diseases 0.000 description 1
- 206010029897 Obsessive thoughts Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 108010064719 Oxyhemoglobins Proteins 0.000 description 1
- 238000012879 PET imaging Methods 0.000 description 1
- 206010034912 Phobia Diseases 0.000 description 1
- 102000003923 Protein Kinase C Human genes 0.000 description 1
- 108090000315 Protein Kinase C Proteins 0.000 description 1
- 208000003782 Raynaud disease Diseases 0.000 description 1
- 208000012322 Raynaud phenomenon Diseases 0.000 description 1
- 208000022841 Sleep Arousal disease Diseases 0.000 description 1
- 206010041250 Social phobia Diseases 0.000 description 1
- 206010041347 Somnambulism Diseases 0.000 description 1
- 208000014584 Specific learning disability Diseases 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 208000001871 Tachycardia Diseases 0.000 description 1
- 206010068932 Terminal insomnia Diseases 0.000 description 1
- 208000024799 Thyroid disease Diseases 0.000 description 1
- 102000011923 Thyrotropin Human genes 0.000 description 1
- 108010061174 Thyrotropin Proteins 0.000 description 1
- 206010044221 Toxic encephalopathy Diseases 0.000 description 1
- 206010069828 Trigemino-cardiac reflex Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010047141 Vasodilatation Diseases 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000037328 acute stress Effects 0.000 description 1
- 238000011360 adjunctive therapy Methods 0.000 description 1
- 201000007930 alcohol dependence Diseases 0.000 description 1
- 238000004164 analytical calibration Methods 0.000 description 1
- 230000003466 anti-cipated effect Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 235000019568 aromas Nutrition 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000037424 autonomic function Effects 0.000 description 1
- 210000002453 autonomic neuron Anatomy 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000004820 blood count Methods 0.000 description 1
- 230000008081 blood perfusion Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 230000008344 brain blood flow Effects 0.000 description 1
- 230000008309 brain mechanism Effects 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 230000001201 calcium accumulation Effects 0.000 description 1
- 230000002612 cardiopulmonary effect Effects 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 210000001638 cerebellum Anatomy 0.000 description 1
- 230000003727 cerebral blood flow Effects 0.000 description 1
- 230000009636 circadian regulation Effects 0.000 description 1
- 230000027288 circadian rhythm Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000007278 cognition impairment Effects 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 230000009699 differential effect Effects 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000009429 distress Effects 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 239000013013 elastic material Substances 0.000 description 1
- 238000010291 electrical method Methods 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 230000002996 emotional effect Effects 0.000 description 1
- 230000037149 energy metabolism Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000011067 equilibration Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 210000004709 eyebrow Anatomy 0.000 description 1
- 210000000887 face Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 235000021588 free fatty acids Nutrition 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 230000009760 functional impairment Effects 0.000 description 1
- 229940096919 glycogen Drugs 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 210000004884 grey matter Anatomy 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 210000004326 gyrus cinguli Anatomy 0.000 description 1
- 230000002650 habitual effect Effects 0.000 description 1
- 230000013632 homeostatic process Effects 0.000 description 1
- 238000009220 hypothermia therapy Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000012482 interaction analysis Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 238000012729 kappa analysis Methods 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 229960004194 lidocaine Drugs 0.000 description 1
- 230000003859 lipid peroxidation Effects 0.000 description 1
- 238000007449 liver function test Methods 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 206010025135 lupus erythematosus Diseases 0.000 description 1
- 210000001595 mastoid Anatomy 0.000 description 1
- 238000010297 mechanical methods and process Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000006984 memory degeneration Effects 0.000 description 1
- 208000023060 memory loss Diseases 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000004630 mental health Effects 0.000 description 1
- 206010027599 migraine Diseases 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000001483 mobilizing effect Effects 0.000 description 1
- 238000012806 monitoring device Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 238000000491 multivariate analysis Methods 0.000 description 1
- 210000000118 neural pathway Anatomy 0.000 description 1
- 230000010004 neural pathway Effects 0.000 description 1
- 230000003955 neuronal function Effects 0.000 description 1
- 230000003961 neuronal insult Effects 0.000 description 1
- 231100000228 neurotoxicity Toxicity 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 230000037000 normothermia Effects 0.000 description 1
- 210000001331 nose Anatomy 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 210000005195 occipital scalp Anatomy 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000000803 paradoxical effect Effects 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 208000023515 periodic limb movement disease Diseases 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 208000022821 personality disease Diseases 0.000 description 1
- 239000012782 phase change material Substances 0.000 description 1
- 238000001126 phototherapy Methods 0.000 description 1
- 230000008288 physiological mechanism Effects 0.000 description 1
- 238000009428 plumbing Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000009822 protein phosphorylation Effects 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000011012 sanitization Methods 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 230000010332 selective attention Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000012781 shape memory material Substances 0.000 description 1
- 208000033914 shift work type circadian rhythm sleep disease Diseases 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- 201000002859 sleep apnea Diseases 0.000 description 1
- 230000003860 sleep quality Effects 0.000 description 1
- 238000010321 sleep therapy Methods 0.000 description 1
- 230000037046 slow wave activity Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 201000001716 specific phobia Diseases 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 230000003319 supportive effect Effects 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 230000006794 tachycardia Effects 0.000 description 1
- 210000000779 thoracic wall Anatomy 0.000 description 1
- 238000009601 thyroid function test Methods 0.000 description 1
- 230000001748 thyrotropin Effects 0.000 description 1
- 229960000874 thyrotropin Drugs 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 238000002562 urinalysis Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
- 210000003273 vestibular nerve Anatomy 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
- A61M21/02—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis for inducing sleep or relaxation, e.g. by direct nerve stimulation, hypnosis, analgesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
- A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/007—Heating or cooling appliances for medical or therapeutic treatment of the human body characterised by electric heating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/0085—Devices for generating hot or cold treatment fluids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0001—Body part
- A61F2007/0002—Head or parts thereof
- A61F2007/0007—Forehead, e.g. headbands
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0054—Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0054—Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water
- A61F2007/0056—Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water for cooling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/007—Heating or cooling appliances for medical or therapeutic treatment of the human body characterised by electric heating
- A61F2007/0075—Heating or cooling appliances for medical or therapeutic treatment of the human body characterised by electric heating using a Peltier element, e.g. near the spot to be heated or cooled
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0225—Compresses or poultices for effecting heating or cooling connected to the body or a part thereof
- A61F2007/0226—Compresses or poultices for effecting heating or cooling connected to the body or a part thereof adhesive, self-sticking
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0225—Compresses or poultices for effecting heating or cooling connected to the body or a part thereof
- A61F2007/0228—Compresses or poultices for effecting heating or cooling connected to the body or a part thereof with belt or strap, e.g. with buckle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
- A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
- A61M2021/0066—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus with heating or cooling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/04—Heartbeat characteristics, e.g. ECG, blood pressure modulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/08—Other bio-electrical signals
- A61M2230/10—Electroencephalographic signals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/40—Respiratory characteristics
- A61M2230/42—Rate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/63—Motion, e.g. physical activity
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Anesthesiology (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Cardiology (AREA)
- Physiology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Acoustics & Sound (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Thermal Sciences (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
- Medicinal Preparation (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662337279P | 2016-05-16 | 2016-05-16 | |
| US62/337,279 | 2016-05-16 | ||
| PCT/US2017/032964 WO2017201088A1 (en) | 2016-05-16 | 2017-05-16 | Forehead cooling method and device to stimulate the parasympathetic nervous system for the treatment of insomnia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3024491A1 true CA3024491A1 (en) | 2017-11-23 |
Family
ID=60325496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3024491A Abandoned CA3024491A1 (en) | 2016-05-16 | 2017-05-16 | Forehead cooling method and device to stimulate the parasympathetic nervous system for the treatment of insomnia |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP3457923A4 (enExample) |
| JP (1) | JP2019523660A (enExample) |
| AU (1) | AU2017268269A1 (enExample) |
| CA (1) | CA3024491A1 (enExample) |
| WO (1) | WO2017201088A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2636061A (en) * | 2023-11-10 | 2025-06-11 | Whiteley Medical Instruments Ltd | Disposable cover for a cryogenic cooling device |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12290640B2 (en) | 2006-04-20 | 2025-05-06 | University of Pittsburgh—of the Commonwealth System of Higher Education | Noninvasive, regional brain thermal stimulation for inducing relaxation |
| AU2018281308A1 (en) * | 2017-06-06 | 2019-12-12 | Ebb Therapeutics, Inc. | Methods and apparatuses for the thermal treatment of neurologic and psychiatric disorders |
| US11642081B2 (en) | 2019-02-01 | 2023-05-09 | X Development Llc | Electrode headset |
| US11583231B2 (en) | 2019-03-06 | 2023-02-21 | X Development Llc | Adjustable electrode headset |
| CN110403603B (zh) * | 2019-08-07 | 2023-06-23 | 龙岩学院 | 一种用于辅助癫痫手术的监测设备 |
| DE102019129288A1 (de) * | 2019-10-30 | 2021-05-06 | Universitätsmedizin Der Johannes Gutenberg-Universität Mainz | Vorrichtung und Verfahren zur Bestimmung des Schweregrads einer Schlafapnoe |
| CN114828930B (zh) * | 2019-12-09 | 2024-11-08 | 皇家飞利浦有限公司 | 用于递送感觉刺激以促进睡眠开始的系统 |
| JP7464257B2 (ja) * | 2020-03-10 | 2024-04-09 | アイリスオーヤマ株式会社 | 頭部冷却装置 |
| US20250191753A1 (en) * | 2023-12-07 | 2025-06-12 | Samsung Electronics Co., Ltd. | Multi-Modal Insomnia Detection Using a Wearable Device |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4466439A (en) * | 1982-02-08 | 1984-08-21 | Moore John H | Device and method for inducing bradycardia |
| US9211212B2 (en) * | 2006-04-20 | 2015-12-15 | Cerêve, Inc. | Apparatus and method for modulating sleep |
| EP2007334A1 (en) * | 2006-04-20 | 2008-12-31 | University of Pittsburgh | Method and apparatus of noninvasive, regional brain thermal stimuli for the treatment of neurological disorders |
| US8257268B2 (en) * | 2007-07-17 | 2012-09-04 | Macleod Ainslie | Devices and systems for the prevention of sudden infant death syndrome (SIDS) |
| US20120310312A1 (en) * | 2011-06-02 | 2012-12-06 | Thomas Chih-Han Yee | Precision-Controlled Cooling System for Inducing Diving Reflex and Achieving Safe Hypothermic Central Nervous System Protection |
| AU2014204112B2 (en) * | 2013-01-02 | 2018-05-24 | Ebb Therapeutics, Inc. | Systems for enhancing sleep |
-
2017
- 2017-05-16 AU AU2017268269A patent/AU2017268269A1/en not_active Abandoned
- 2017-05-16 EP EP17800040.2A patent/EP3457923A4/en not_active Withdrawn
- 2017-05-16 CA CA3024491A patent/CA3024491A1/en not_active Abandoned
- 2017-05-16 JP JP2018560127A patent/JP2019523660A/ja active Pending
- 2017-05-16 WO PCT/US2017/032964 patent/WO2017201088A1/en not_active Ceased
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2636061A (en) * | 2023-11-10 | 2025-06-11 | Whiteley Medical Instruments Ltd | Disposable cover for a cryogenic cooling device |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3457923A4 (en) | 2020-01-01 |
| AU2017268269A1 (en) | 2018-11-08 |
| EP3457923A1 (en) | 2019-03-27 |
| WO2017201088A1 (en) | 2017-11-23 |
| JP2019523660A (ja) | 2019-08-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10610661B2 (en) | Noninvasive, regional brain thermal stimuli for the treatment of migraine | |
| US20170252534A1 (en) | Forehead cooling method and device to stimulate the parasympathetic nervous system for the treatment of insomnia | |
| US9211212B2 (en) | Apparatus and method for modulating sleep | |
| CA3024491A1 (en) | Forehead cooling method and device to stimulate the parasympathetic nervous system for the treatment of insomnia | |
| US12290640B2 (en) | Noninvasive, regional brain thermal stimulation for inducing relaxation | |
| CA2649875C (en) | Method and apparatus of noninvasive, regional brain thermal stimuli for the treatment of neurological disorders | |
| US9492313B2 (en) | Method and apparatus of noninvasive, regional brain thermal stimuli for the treatment of neurological disorders | |
| US20230046024A1 (en) | Noninvasive, Regional Brain Thermal Stimuli for the Treatment of Neurological Disorders | |
| US20170319815A1 (en) | Method and apparatuses for modulating sleep by chemical activation of temperature receptors | |
| CA3024493A1 (en) | Tetherless wearable thermal devices and methods of using them for treatment of sleeping and neurological disorders | |
| CA2918317C (en) | Apparatus and method for modulating sleep | |
| US20250256057A1 (en) | Noninvasive, Regional Brain Thermal Stimulation for Inducing Relaxation | |
| AU2007240754B2 (en) | Method and apparatus of noninvasive, regional brain thermal stimuli for the treatment of neurological disorders |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20230815 |