CA2994790A1 - Tlr4 agonists and compositions thereof and their use in the treatment of cancer - Google Patents
Tlr4 agonists and compositions thereof and their use in the treatment of cancer Download PDFInfo
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- CA2994790A1 CA2994790A1 CA2994790A CA2994790A CA2994790A1 CA 2994790 A1 CA2994790 A1 CA 2994790A1 CA 2994790 A CA2994790 A CA 2994790A CA 2994790 A CA2994790 A CA 2994790A CA 2994790 A1 CA2994790 A1 CA 2994790A1
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- A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
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- Public Health (AREA)
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- Biochemistry (AREA)
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- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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| US201562201912P | 2015-08-06 | 2015-08-06 | |
| US62/201,912 | 2015-08-06 | ||
| PCT/IB2016/053290 WO2017021792A1 (en) | 2015-08-06 | 2016-06-03 | Tlr4 agonists and compositions thereof and their use in the treatment of cancer |
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| CA2994790A1 true CA2994790A1 (en) | 2017-02-09 |
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| EP (1) | EP3331565A1 (OSRAM) |
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| KR (1) | KR20180032642A (OSRAM) |
| CN (1) | CN108136024A (OSRAM) |
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| CA (1) | CA2994790A1 (OSRAM) |
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| WO2018209270A1 (en) | 2017-05-11 | 2018-11-15 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (snas) |
| IL276608B2 (en) | 2018-02-12 | 2024-04-01 | Inimmune Corp | Toll-like receptor ligands |
| WO2020007760A1 (en) * | 2018-07-03 | 2020-01-09 | Glaxosmithkline Intellectual Property Development Limited | Tlr4 compounds or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions or formulations, methods of preparation, treatment or uses |
| WO2020031087A1 (en) * | 2018-08-06 | 2020-02-13 | Glaxosmithkline Intellectual Property Development Limited | Combination therapy |
| CN116457364A (zh) * | 2020-11-11 | 2023-07-18 | 第一三共株式会社 | 新型氨基烷基氨基葡糖苷4-磷酸酯衍生物 |
| CN117018195B (zh) * | 2023-08-04 | 2024-05-21 | 中国人民解放军海军军医大学 | 小分子化合物或组合在制备启动肝脏原位再生药物中的应用 |
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| JPS57106673A (en) | 1980-12-24 | 1982-07-02 | Chugai Pharmaceut Co Ltd | Dibenzo(b,f)(1,4)oxazepin derivative |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5681835A (en) | 1994-04-25 | 1997-10-28 | Glaxo Wellcome Inc. | Non-steroidal ligands for the estrogen receptor |
| US6113918A (en) | 1997-05-08 | 2000-09-05 | Ribi Immunochem Research, Inc. | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
| GB9716557D0 (en) | 1997-08-06 | 1997-10-08 | Glaxo Group Ltd | Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity |
| NZ522755A (en) | 2000-05-19 | 2004-05-28 | Corixa Corp | Prophylactic and therapeutic treatment of infectious and other diseases with mono- and disaccharide-based compounds being administered in absence of exogenous antigen |
| CA2417806C (en) | 2000-08-04 | 2011-05-10 | Corixa Corporation | New immunoeffector compounds |
| US20050089932A1 (en) | 2001-04-26 | 2005-04-28 | Avidia Research Institute | Novel proteins with targeted binding |
| US20050053973A1 (en) | 2001-04-26 | 2005-03-10 | Avidia Research Institute | Novel proteins with targeted binding |
| US7030094B2 (en) * | 2002-02-04 | 2006-04-18 | Corixa Corporation | Immunostimulant compositions comprising an aminoalkyl glucosaminide phosphate and QS-21 |
| US6525028B1 (en) | 2002-02-04 | 2003-02-25 | Corixa Corporation | Immunoeffector compounds |
| US6911434B2 (en) | 2002-02-04 | 2005-06-28 | Corixa Corporation | Prophylactic and therapeutic treatment of infectious and other diseases with immunoeffector compounds |
| US7288640B2 (en) | 2002-07-08 | 2007-10-30 | Corixa Corporation | Processes for the production of aminoalkyl glucosaminide phosphate and disaccharide immunoeffectors, and intermediates therefor |
| US7960522B2 (en) * | 2003-01-06 | 2011-06-14 | Corixa Corporation | Certain aminoalkyl glucosaminide phosphate compounds and their use |
| AU2004284090A1 (en) | 2003-10-24 | 2005-05-06 | Avidia, Inc. | LDL receptor class A and EGF domain monomers and multimers |
| WO2010075545A1 (en) * | 2008-12-23 | 2010-07-01 | Glaxosmithkline Biologicals S.A. | Method for inducing a trif-bias |
| US8741295B2 (en) * | 2009-02-09 | 2014-06-03 | Universite De La Mediterranee | PD-1 antibodies and PD-L1 antibodies and uses thereof |
| US20110293700A1 (en) * | 2010-05-26 | 2011-12-01 | Selecta Biosciences, Inc. | Nanocarrier compositions with uncoupled adjuvant |
| US20120321694A1 (en) | 2010-10-27 | 2012-12-20 | Daniel Larocque | Compositions and uses |
| GB201101331D0 (en) * | 2011-01-26 | 2011-03-09 | Glaxosmithkline Biolog Sa | Compositions and uses |
| KR102039520B1 (ko) * | 2013-04-18 | 2019-11-01 | 이뮨 디자인 코포레이션 | 암 치료에 이용하기 위한 gla 단일요법 |
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| EP3331565A1 (en) | 2018-06-13 |
| RU2018107930A3 (OSRAM) | 2019-12-06 |
| KR20180032642A (ko) | 2018-03-30 |
| US20180221399A1 (en) | 2018-08-09 |
| AU2016303387A1 (en) | 2018-02-22 |
| AU2016303387B2 (en) | 2019-03-21 |
| WO2017021792A1 (en) | 2017-02-09 |
| US10765690B2 (en) | 2020-09-08 |
| RU2018107930A (ru) | 2019-09-06 |
| JP2018522053A (ja) | 2018-08-09 |
| CN108136024A (zh) | 2018-06-08 |
| BR112018002520A2 (pt) | 2018-09-18 |
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| FZDE | Discontinued |
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