CA2985511A1 - Combinaison d'analogues ou de derives de dianhydrogalactitol avec des agents anticancereux contenant du platine pour traiter le cancer - Google Patents
Combinaison d'analogues ou de derives de dianhydrogalactitol avec des agents anticancereux contenant du platine pour traiter le cancerInfo
- Publication number
- CA2985511A1 CA2985511A1 CA2985511A CA2985511A CA2985511A1 CA 2985511 A1 CA2985511 A1 CA 2985511A1 CA 2985511 A CA2985511 A CA 2985511A CA 2985511 A CA2985511 A CA 2985511A CA 2985511 A1 CA2985511 A1 CA 2985511A1
- Authority
- CA
- Canada
- Prior art keywords
- dianhydrogalactitol
- alkyl
- group
- aryl
- platinum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'utilisation de dianhydrogalactitol fournit une nouvelle modalité thérapeutique pour le traitement du carcinome pulmonaire non à petites cellules et du cancer de l'ovaire, ainsi que d'autres types de tumeurs malignes, y compris les métastases cérébrales d'un cancer pulmonaire non à petites cellules. Le dianhydrogalactitol agit en tant qu'agent alkylant sur l'ADN, ce qui donne lieu à une méthylation N7. Le dianhydrogalactitol se révèle efficace pour inhiber le développement de cellules souches cancéreuses et est actif contre les tumeurs réfractaires au témozolomide, au cisplatine et aux inhibiteurs de la tyrosine kinase. Ce médicament agit indépendamment du mécanisme de réparation par la MGMT. Le dianhydrogalactitol peut être utilisé conjointement avec d'autres agents anti-néoplasiques et peut présenter des effets cumulatifs ou super-cumulatifs.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/710,240 | 2015-05-12 | ||
| US14/710,240 US11541027B2 (en) | 2014-04-04 | 2015-05-12 | Use of dianhydrogalactitol and analogs or derivatives thereof in combination with platinum-containing antineoplastic agents to treat non-small-cell carcinoma of the lung and brain metastases |
| PCT/US2016/032120 WO2016183331A1 (fr) | 2014-04-04 | 2016-05-12 | Combinaison d'analogues ou de dérivés de dianhydrogalactitol avec des agents anticancéreux contenant du platine pour traiter le cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2985511A1 true CA2985511A1 (fr) | 2016-11-17 |
Family
ID=60421889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2985511A Abandoned CA2985511A1 (fr) | 2015-05-12 | 2016-05-12 | Combinaison d'analogues ou de derives de dianhydrogalactitol avec des agents anticancereux contenant du platine pour traiter le cancer |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2985511A1 (fr) |
-
2016
- 2016-05-12 CA CA2985511A patent/CA2985511A1/fr not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11541027B2 (en) | Use of dianhydrogalactitol and analogs or derivatives thereof in combination with platinum-containing antineoplastic agents to treat non-small-cell carcinoma of the lung and brain metastases | |
| US9687466B2 (en) | Use of dianhydrogalactitol and analogs and derivatives thereof to treat glioblastoma multiforme | |
| CA2914025C (fr) | Utilisation de dianhydrogalacticol et d'analogues et de derives de celui-ci pour traiter un gliome malin recurrent ou une tumeur cerebrale secondaire progressive | |
| AU2015346598B2 (en) | Dianhydrogalactitol together with radiation to treat non-small-cell carcinoma of the lung and glioblastoma multiforme | |
| US20160067241A1 (en) | Compositions and methods to improve the therapeutic benefit of suboptimally administered chemical compounds including substituted naphthalimides such as amonafide for the treatment of immunological, metabolic, infectious, and benign or neoplastic hyperproliferative disease conditions | |
| US20190091195A1 (en) | Use of dianhydrogalactitol and derivatives thereof in the treatment of glioblastoma, lung cancer, and ovarian cancer | |
| CA2985511A1 (fr) | Combinaison d'analogues ou de derives de dianhydrogalactitol avec des agents anticancereux contenant du platine pour traiter le cancer | |
| CN108024987A (zh) | 用于治疗癌症的二去水卫矛醇的类似物或衍生物与含铂抗肿瘤药物的组合 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20220301 |