CA2975072A1 - Procede de production d'un compose pyrazine carboxamide, et intermediaire de synthese de ce dernier - Google Patents

Procede de production d'un compose pyrazine carboxamide, et intermediaire de synthese de ce dernier Download PDF

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Publication number
CA2975072A1
CA2975072A1 CA2975072A CA2975072A CA2975072A1 CA 2975072 A1 CA2975072 A1 CA 2975072A1 CA 2975072 A CA2975072 A CA 2975072A CA 2975072 A CA2975072 A CA 2975072A CA 2975072 A1 CA2975072 A1 CA 2975072A1
Authority
CA
Canada
Prior art keywords
compound
salt
formula
production method
methylpiperazin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2975072A
Other languages
English (en)
Inventor
Takahiro AKIBA
Hiroaki Hoshii
Itsuro Shimada
Kousuke Komenoi
Kentaro Nishikawa
Yasuhiro Morinaga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of CA2975072A1 publication Critical patent/CA2975072A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CA2975072A 2015-01-28 2016-01-27 Procede de production d'un compose pyrazine carboxamide, et intermediaire de synthese de ce dernier Abandoned CA2975072A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2015014533 2015-01-28
JP2015-014533 2015-01-28
PCT/JP2016/052229 WO2016121777A1 (fr) 2015-01-28 2016-01-27 Procédé de production d'un composé pyrazine carboxamide, et intermédiaire de synthèse de ce dernier

Publications (1)

Publication Number Publication Date
CA2975072A1 true CA2975072A1 (fr) 2016-08-04

Family

ID=56543388

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2975072A Abandoned CA2975072A1 (fr) 2015-01-28 2016-01-27 Procede de production d'un compose pyrazine carboxamide, et intermediaire de synthese de ce dernier

Country Status (6)

Country Link
JP (1) JPWO2016121777A1 (fr)
KR (1) KR20170105021A (fr)
CN (1) CN107207468A (fr)
CA (1) CA2975072A1 (fr)
MX (1) MX2017009714A (fr)
WO (1) WO2016121777A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2018079570A1 (ja) * 2016-10-26 2019-09-19 アステラス製薬株式会社 安定な医薬組成物
TW202146406A (zh) * 2020-06-01 2021-12-16 大陸商微境生物醫藥科技(上海)有限公司 新型吡嗪化合物
US11945785B2 (en) 2021-12-30 2024-04-02 Biomea Fusion, Inc. Pyrazine compounds as inhibitors of FLT3

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5754177A (ja) * 1980-09-19 1982-03-31 Teikoku Hormone Mfg Co Ltd Chikanchiazoorujudotai
JP3534903B2 (ja) * 1995-06-09 2004-06-07 鐘淵化学工業株式会社 １−［３−クロロ−（２ｓ）−メチルプロピオニル］−ピロリジン−（２ｓ）−カルボン酸の製造方法
WO2013108754A1 (fr) * 2012-01-17 2013-07-25 アステラス製薬株式会社 Composé pyrazine carboxamide

Also Published As

Publication number Publication date
KR20170105021A (ko) 2017-09-18
WO2016121777A1 (fr) 2016-08-04
CN107207468A (zh) 2017-09-26
MX2017009714A (es) 2017-11-17
JPWO2016121777A1 (ja) 2017-11-02

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Effective date: 20200128