CA2972782C - Procedes et compositions de detection de neoplasies oesophagiennes et/ou de metaplasies oesophagiennes - Google Patents

Procedes et compositions de detection de neoplasies oesophagiennes et/ou de metaplasies oesophagiennes

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Publication number
CA2972782C
CA2972782C CA2972782A CA2972782A CA2972782C CA 2972782 C CA2972782 C CA 2972782C CA 2972782 A CA2972782 A CA 2972782A CA 2972782 A CA2972782 A CA 2972782A CA 2972782 C CA2972782 C CA 2972782C
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Prior art keywords
sequence
sequences
seq
sample
esophagus
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CA2972782A
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English (en)
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CA2972782A1 (fr
Inventor
Sanford D. Markowitz
Joseph E. Willis
Helen Moinova
Thomas LaFramboise
Omar de la Cruz Cabrera
Amitabh Chak
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Case Western Reserve University
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Priority claimed from PCT/US2015/068131 external-priority patent/WO2016109712A1/fr
Publication of CA2972782A1 publication Critical patent/CA2972782A1/fr
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Publication of CA2972782C publication Critical patent/CA2972782C/fr
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Abstract

La présente invention concerne des procédés d'identification de loci génomiques qui sont différentiellement méthylés dans les cancers néoplasiques, par exemple, les cancers de l'sophage. L'identification de loci génomiques méthylés, et facultativement en combinaison avec l'identification de mutations somatiques dans TP53, a de nombreuses utilisations, y compris par exemple, pour caractériser un risque de maladie, pour prédire la sensibilité à une thérapie, pour réaliser un diagnostic non invasif chez des sujets et pour traiter des sujets dont il a été déterminé qu'ils présentaient des néoplasies gastro-intestinales.
CA2972782A 2014-12-31 2015-12-30 Procedes et compositions de detection de neoplasies oesophagiennes et/ou de metaplasies oesophagiennes Active CA2972782C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462099021P 2014-12-31 2014-12-31
US62/099,021 2014-12-31
PCT/US2015/068131 WO2016109712A1 (fr) 2014-12-31 2015-12-30 Procédés et compositions de détection de néoplasies œsophagiennes et/ou de métaplasies œsophagiennes

Publications (2)

Publication Number Publication Date
CA2972782A1 CA2972782A1 (fr) 2016-07-07
CA2972782C true CA2972782C (fr) 2026-03-03

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