CA2965400A1 - Nouvelle composition et solution ayant un niveau d'ions calcium controle, procede associe et son utilisation en reperfusion - Google Patents
Nouvelle composition et solution ayant un niveau d'ions calcium controle, procede associe et son utilisation en reperfusion Download PDFInfo
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- CA2965400A1 CA2965400A1 CA2965400A CA2965400A CA2965400A1 CA 2965400 A1 CA2965400 A1 CA 2965400A1 CA 2965400 A CA2965400 A CA 2965400A CA 2965400 A CA2965400 A CA 2965400A CA 2965400 A1 CA2965400 A1 CA 2965400A1
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- heart
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- reperfusion
- calcium
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- 230000000745 ion overload Effects 0.000 description 1
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 229940099584 lactobionate Drugs 0.000 description 1
- JYTUSYBCFIZPBE-AMTLMPIISA-N lactobionic acid Chemical compound OC(=O)[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O JYTUSYBCFIZPBE-AMTLMPIISA-N 0.000 description 1
- 210000005246 left atrium Anatomy 0.000 description 1
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- 230000033001 locomotion Effects 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
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- 210000004088 microvessel Anatomy 0.000 description 1
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- 238000012986 modification Methods 0.000 description 1
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- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 230000003562 morphometric effect Effects 0.000 description 1
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- 210000003365 myofibril Anatomy 0.000 description 1
- 229940049964 oleate Drugs 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 230000008816 organ damage Effects 0.000 description 1
- 239000002357 osmotic agent Substances 0.000 description 1
- 230000004792 oxidative damage Effects 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 230000006461 physiological response Effects 0.000 description 1
- BIRNWOIQDVFTSP-WWNCWODVSA-M potassium (2R,3R,4R,5R)-2,3,5,6-tetrahydroxy-4-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexanoate Chemical compound [K+].OC[C@@H](O)[C@@H](O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)[C@H](O)[C@@H](O)C([O-])=O BIRNWOIQDVFTSP-WWNCWODVSA-M 0.000 description 1
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
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- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 235000021283 resveratrol Nutrition 0.000 description 1
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- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Medicinal Chemistry (AREA)
- Dentistry (AREA)
- Physiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Biophysics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Cette invention concerne une solution comprenant un mélange de conservation comprenant une source d'ions calcium ; et un tampon pour maintenir le pH de la solution. La concentration molaire en ions calcium (Ca2+) dans la solution est de 0,18 à 0,26 mmol/L, et son pH est inférieur à 7,4 et supérieur à 6,6. Une composition pour la préparation de la solution peut comprendre de l'adénosine, de la lidocaïne, et une source de calcium, le rapport molaire adénosine:calcium étant de 0,3:0,26 à 0,45:0,18, et le rapport molaire lidocaïne:calcium étant de 0,04: 0,26 à 0,09:0.18. Un cur de donneur peut être reperfusé à l'aide de cette solution. La solution peut être utilisée pour la reperfusion d'un cur de donneur, p. ex. à une température d'environ 25 à environ 37°C, ledit donneur pouvant être un donneur après mort circulatoire.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462068524P | 2014-10-24 | 2014-10-24 | |
| US62/068,524 | 2014-10-24 | ||
| CAPCT/CA2015/050297 | 2015-04-10 | ||
| PCT/CA2015/050297 WO2015154193A1 (fr) | 2014-04-10 | 2015-04-10 | Modulation d'homéostase d'ions de calcium dans des cœurs transplantables récoltés |
| PCT/CA2015/051084 WO2016061700A1 (fr) | 2014-10-24 | 2015-10-23 | Nouvelle composition et solution ayant un niveau d'ions calcium contrôlé, procédé associé et son utilisation en reperfusion |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2965400A1 true CA2965400A1 (fr) | 2016-04-28 |
| CA2965400C CA2965400C (fr) | 2023-03-14 |
Family
ID=55760003
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2965400A Active CA2965400C (fr) | 2014-10-24 | 2015-10-23 | Nouvelle composition et solution ayant un niveau d'ions calcium controle, procede associe et son utilisation en reperfusion |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP3209128A4 (fr) |
| CN (2) | CN113841687A (fr) |
| AU (1) | AU2015336862B2 (fr) |
| BR (1) | BR112017008076B1 (fr) |
| CA (1) | CA2965400C (fr) |
| WO (1) | WO2016061700A1 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT201600120839A1 (it) * | 2016-12-01 | 2018-06-01 | Valentina Valenti | Soluzione cardioplegica con attivatori dell'autofagia per l'arresto diastolico del cuore in corso di interventi cardiochirurgici |
| CN113303325A (zh) * | 2021-05-27 | 2021-08-27 | 南方医科大学南方医院 | 一种灌注液和适用于大鼠供体心脏的常温血液机械灌注系统 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5407793A (en) * | 1991-10-18 | 1995-04-18 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | An aqueous heart preservation and cardioplegia solution |
| FR2785501B1 (fr) * | 1998-11-10 | 2001-01-05 | Centre Nat Rech Scient | Solution de perfusion et/ou de conservation et/ou de reperfusion lors de la transplantation d'organes |
| EP1207753A4 (fr) * | 1999-06-17 | 2005-11-30 | Univ California | Preservation d'organes par perfusion cardiaque continue avec du peg-hb en vue d'une conservation amelioree en hypothermie |
| US20030124503A1 (en) * | 2001-12-28 | 2003-07-03 | Olivencia-Yurvati Albert H. | Pyruvate cardioplegia solutions for administration to the heart during cardiopulmonary surgery and methods of use thereof |
| AUPS312602A0 (en) * | 2002-06-21 | 2002-07-18 | James Cook University | Organ arrest, protection, preservation and recovery |
| FR2975869B1 (fr) * | 2011-05-31 | 2017-03-03 | Hemarina | Composition de preservation d'organe et utilisations |
| AU2015245903A1 (en) * | 2014-04-10 | 2016-11-17 | Darren FREED | Modulation of calcium ion homeostasis in harvested transplantable hearts |
| CN103893205B (zh) * | 2014-04-15 | 2016-03-09 | 青岛大学附属医院 | 一种包含利多卡因和腺苷的心脏停搏液及其制备方法 |
-
2015
- 2015-10-23 EP EP15853016.2A patent/EP3209128A4/fr not_active Withdrawn
- 2015-10-23 BR BR112017008076-1A patent/BR112017008076B1/pt active IP Right Grant
- 2015-10-23 CN CN202111194944.3A patent/CN113841687A/zh active Pending
- 2015-10-23 CA CA2965400A patent/CA2965400C/fr active Active
- 2015-10-23 WO PCT/CA2015/051084 patent/WO2016061700A1/fr active Application Filing
- 2015-10-23 CN CN201580070774.4A patent/CN107105640B/zh active Active
- 2015-10-23 AU AU2015336862A patent/AU2015336862B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BR112017008076A2 (pt) | 2017-12-26 |
| CA2965400C (fr) | 2023-03-14 |
| EP3209128A1 (fr) | 2017-08-30 |
| CN113841687A (zh) | 2021-12-28 |
| WO2016061700A1 (fr) | 2016-04-28 |
| BR112017008076B1 (pt) | 2021-06-29 |
| AU2015336862A1 (en) | 2017-06-01 |
| CN107105640B (zh) | 2021-10-12 |
| EP3209128A4 (fr) | 2018-04-11 |
| AU2015336862B2 (en) | 2018-08-09 |
| CN107105640A (zh) | 2017-08-29 |
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| Publication | Publication Date | Title |
|---|---|---|
| US11033021B2 (en) | Composition and solution with controlled calcium ion level, and related method and use for reperfusion | |
| EP3128836B1 (fr) | Modulation d'homéostase d'ions de calcium dans des coeurs transplantables récoltés | |
| US12082575B2 (en) | Perfusion solution | |
| EP3122180B1 (fr) | Appareil pour conservation de c urs prélevés pour la transplantation | |
| CA2965400C (fr) | Nouvelle composition et solution ayant un niveau d'ions calcium controle, procede associe et son utilisation en reperfusion | |
| US20240090494A1 (en) | Perfusion solution |
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