CA2965163A1 - Method to identify genes under positive selection - Google Patents

Method to identify genes under positive selection Download PDF

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Publication number
CA2965163A1
CA2965163A1 CA2965163A CA2965163A CA2965163A1 CA 2965163 A1 CA2965163 A1 CA 2965163A1 CA 2965163 A CA2965163 A CA 2965163A CA 2965163 A CA2965163 A CA 2965163A CA 2965163 A1 CA2965163 A1 CA 2965163A1
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CA
Canada
Prior art keywords
mutations
scores
distributions
genes
phenotype
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2965163A
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English (en)
French (fr)
Inventor
Olivier Lichtarge
Teng-Kuei Hsu
Panagiotis KATSONIS
Amanda Michele Koire
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baylor College of Medicine
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Baylor College of Medicine
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Filing date
Publication date
Application filed by Baylor College of Medicine filed Critical Baylor College of Medicine
Publication of CA2965163A1 publication Critical patent/CA2965163A1/en
Abandoned legal-status Critical Current

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    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F17/00—Digital computing or data processing equipment or methods, specially adapted for specific functions
    • G06F17/10—Complex mathematical operations
    • G06F17/11—Complex mathematical operations for solving equations, e.g. nonlinear equations, general mathematical optimization problems
    • G06F17/13—Differential equations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B10/00—ICT specially adapted for evolutionary bioinformatics, e.g. phylogenetic tree construction or analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/60—In silico combinatorial chemistry
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/40—Population genetics; Linkage disequilibrium

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  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Theoretical Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Biotechnology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Molecular Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Mathematical Physics (AREA)
  • Pure & Applied Mathematics (AREA)
  • Computational Mathematics (AREA)
  • Mathematical Analysis (AREA)
  • Mathematical Optimization (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Data Mining & Analysis (AREA)
  • Medicinal Chemistry (AREA)
  • Physiology (AREA)
  • Computing Systems (AREA)
  • Library & Information Science (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Software Systems (AREA)
  • Algebra (AREA)
  • Operations Research (AREA)
  • General Engineering & Computer Science (AREA)
  • Databases & Information Systems (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CA2965163A 2014-10-22 2015-10-21 Method to identify genes under positive selection Abandoned CA2965163A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462067294P 2014-10-22 2014-10-22
US62/067,294 2014-10-22
PCT/US2015/056646 WO2016064995A1 (en) 2014-10-22 2015-10-21 Method to identify genes under positive selection

Publications (1)

Publication Number Publication Date
CA2965163A1 true CA2965163A1 (en) 2016-04-28

Family

ID=54541186

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2965163A Abandoned CA2965163A1 (en) 2014-10-22 2015-10-21 Method to identify genes under positive selection

Country Status (6)

Country Link
US (1) US10886005B2 (cg-RX-API-DMAC7.html)
EP (1) EP3210141A1 (cg-RX-API-DMAC7.html)
JP (1) JP6707081B2 (cg-RX-API-DMAC7.html)
AU (1) AU2015336005B2 (cg-RX-API-DMAC7.html)
CA (1) CA2965163A1 (cg-RX-API-DMAC7.html)
WO (1) WO2016064995A1 (cg-RX-API-DMAC7.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3210141A1 (en) 2014-10-22 2017-08-30 Baylor College of Medicine Method to identify genes under positive selection
US10395759B2 (en) 2015-05-18 2019-08-27 Regeneron Pharmaceuticals, Inc. Methods and systems for copy number variant detection
JP6765433B2 (ja) 2016-02-12 2020-10-07 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 異常な核型の検出のための方法
US11281977B2 (en) * 2017-07-31 2022-03-22 Cognizant Technology Solutions U.S. Corporation Training and control system for evolving solutions to data-intensive problems using epigenetic enabled individuals
CN110782947A (zh) * 2019-10-18 2020-02-11 湖南大学 基于蛋白质序列功能区域的癌症驱动识别
US20230139964A1 (en) * 2020-03-06 2023-05-04 The Research Institute at Nationwide Childern's Hospital Genome dashboard
CN113643754B (zh) * 2021-08-11 2023-12-29 苏州赛美科基因科技有限公司 一种错义变异基因的评分处理方法、优化评分方法及装置
CN116897723A (zh) * 2022-08-01 2023-10-20 中国农业科学院都市农业研究所 一种基于植物感光基因调节的光源排列系统及方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001016860A2 (en) 1999-08-27 2001-03-08 Iris Bio Technologies, Inc. Artificial intelligence system for genetic analysis
US20040023296A1 (en) 2001-11-28 2004-02-05 Baylor College Of Medicine Use of quantitative evolutionary trace analysis to determine functional residues
KR101325736B1 (ko) * 2010-10-27 2013-11-08 삼성에스디에스 주식회사 바이오 마커 추출 장치 및 방법
WO2014007863A1 (en) 2012-07-03 2014-01-09 Baylor College Of Medicine Biological action of missense genotype perturbations on phenotype
EP3210141A1 (en) 2014-10-22 2017-08-30 Baylor College of Medicine Method to identify genes under positive selection

Also Published As

Publication number Publication date
WO2016064995A1 (en) 2016-04-28
JP2017537380A (ja) 2017-12-14
US20170316148A1 (en) 2017-11-02
EP3210141A1 (en) 2017-08-30
AU2015336005B2 (en) 2018-07-26
AU2015336005A1 (en) 2017-05-11
JP6707081B2 (ja) 2020-06-10
US10886005B2 (en) 2021-01-05

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Legal Events

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EEER Examination request

Effective date: 20200804

FZDE Discontinued

Effective date: 20221229

FZDE Discontinued

Effective date: 20221229