CA2959512A1 - Dispositifs et procedes medicaux a reseau de pixels - Google Patents
Dispositifs et procedes medicaux a reseau de pixels Download PDFInfo
- Publication number
- CA2959512A1 CA2959512A1 CA2959512A CA2959512A CA2959512A1 CA 2959512 A1 CA2959512 A1 CA 2959512A1 CA 2959512 A CA2959512 A CA 2959512A CA 2959512 A CA2959512 A CA 2959512A CA 2959512 A1 CA2959512 A1 CA 2959512A1
- Authority
- CA
- Canada
- Prior art keywords
- scalpet
- skin
- site
- incised
- skin pixels
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/32—Surgical cutting instruments
- A61B17/322—Skin grafting apparatus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
- A61B17/205—Vaccinating by means of needles or other puncturing devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/32—Surgical cutting instruments
- A61B17/3205—Excision instruments
- A61B17/32053—Punch like cutting instruments, e.g. using a cylindrical or oval knife
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00747—Dermatology
- A61B2017/00752—Hair removal or transplantation
Landscapes
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Transplantation (AREA)
- Surgical Instruments (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Radiation-Therapy Devices (AREA)
- Massaging Devices (AREA)
- Prostheses (AREA)
Abstract
L'invention concerne des systèmes, des instruments et des procédés dans lesquels un appareil comprend un boîtier comprenant un dispositif à scalpel. Le dispositif à scalpel comprend un arrangement de plusieurs scalpels qui comprend des scalpels disposés selon un motif. Les scalpels peuvent être déployés à partir du boîtier pour générer des pixels de peau incisés au niveau d'un site cible. Le boîtier est positionné et l'arrangement de scalpels est déployé dans un tissu au niveau du site cible. Des pixels de peau incisés sont générés lorsque le site cible est un site donneur, et les défauts de la peau sont générés lorsque le site cible est un site receveur. Les pixels de peau incisés sont récoltés.
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462044078P | 2014-08-29 | 2014-08-29 | |
| US201462044102P | 2014-08-29 | 2014-08-29 | |
| US201462044060P | 2014-08-29 | 2014-08-29 | |
| US201462044089P | 2014-08-29 | 2014-08-29 | |
| US62/044,102 | 2014-08-29 | ||
| US62/044,078 | 2014-08-29 | ||
| US62/044,060 | 2014-08-29 | ||
| US62/044,089 | 2014-08-29 | ||
| US14/505,090 US10076354B2 (en) | 2010-12-17 | 2014-10-02 | Pixel array medical devices and methods |
| US14/505,090 | 2014-10-02 | ||
| PCT/US2015/047695 WO2016033584A1 (fr) | 2014-08-29 | 2015-08-31 | Dispositifs et procédés médicaux à réseau de pixels |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2959512A1 true CA2959512A1 (fr) | 2016-03-03 |
Family
ID=55400735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2959512A Pending CA2959512A1 (fr) | 2014-08-29 | 2015-08-31 | Dispositifs et procedes medicaux a reseau de pixels |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP3185788A4 (fr) |
| JP (1) | JP2017528216A (fr) |
| KR (1) | KR20170101184A (fr) |
| CN (1) | CN107405164B (fr) |
| AU (2) | AU2015308582A1 (fr) |
| BR (1) | BR112017004112A2 (fr) |
| CA (1) | CA2959512A1 (fr) |
| MX (1) | MX2017002661A (fr) |
| PH (1) | PH12017500349A1 (fr) |
| SG (1) | SG11201701521RA (fr) |
| WO (2) | WO2016033584A1 (fr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0922629A2 (pt) | 2008-12-02 | 2016-01-05 | Allergan Inc | dispositivo de injeção |
| US10543127B2 (en) | 2013-02-20 | 2020-01-28 | Cytrellis Biosystems, Inc. | Methods and devices for skin tightening |
| US20140350516A1 (en) | 2013-05-23 | 2014-11-27 | Allergan, Inc. | Mechanical syringe accessory |
| US20140350518A1 (en) | 2013-05-23 | 2014-11-27 | Allergan, Inc. | Syringe extrusion accessory |
| KR102349218B1 (ko) | 2013-08-09 | 2022-01-10 | 사이트렐리스 바이오시스템즈, 인크. | 비-열적 조직 절제를 사용한 피부 치료를 위한 방법 및 기구 |
| WO2015095675A1 (fr) | 2013-12-19 | 2015-06-25 | Cytrellis Biosystems, Inc. | Procédés et dispositifs pour manipuler la graisse sous-cutanée |
| US10029048B2 (en) | 2014-05-13 | 2018-07-24 | Allergan, Inc. | High force injection devices |
| US10226585B2 (en) | 2014-10-01 | 2019-03-12 | Allergan, Inc. | Devices for injection and dosing |
| WO2018148214A2 (fr) * | 2014-10-02 | 2018-08-16 | Srgi Holdings, Llc | Systèmes, dispositifs et procédés médicaux de réseaux de pixels |
| KR102670286B1 (ko) | 2014-11-14 | 2024-05-30 | 사이트렐리스 바이오시스템즈, 인크. | 피부 절제를 위한 디바이스 및 방법 |
| CA2976544A1 (fr) | 2015-03-10 | 2016-09-15 | Allergan Pharmaceuticals Holdings (Ireland) Unlimited Company | Injecteur a aiguilles multiples |
| KR20230117470A (ko) | 2016-03-29 | 2023-08-08 | 사이트렐리스 바이오시스템즈, 인크. | 미용 피부 리설페이싱용 디바이스 및 방법 |
| KR102232054B1 (ko) | 2016-04-08 | 2021-03-26 | 알레간 인코포레이티드 | 흡인 및 주입 디바이스 |
| WO2017192723A1 (fr) * | 2016-05-03 | 2017-11-09 | Srgi Holdings, Llc | Systèmes, dispositifs et procédés médicaux de réseaux de pixels |
| CN106166090B (zh) * | 2016-07-30 | 2018-10-02 | 汕头大学医学院 | 毛囊移植中转储存器 |
| KR102515836B1 (ko) | 2016-09-21 | 2023-03-31 | 사이트렐리스 바이오시스템즈, 인크. | 미용 피부 리설페이싱용 디바이스 및 방법 |
| DE102017106310B4 (de) * | 2017-03-23 | 2018-10-11 | Lavenir Bioscience Ag | Vorrichtung und Verfahren zur Erzeugung einer Mikrograftmatrix aus Vollhaut |
| USD867582S1 (en) | 2017-03-24 | 2019-11-19 | Allergan, Inc. | Syringe device |
| DE102020129157A1 (de) | 2020-11-05 | 2022-05-05 | Lavenir Bioscience Ag | Vorrichtung zur Entfernung wenigstens eines Objekts oder einer Agglomeration von Objek-ten aus der Haut |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6669685B1 (en) * | 1997-11-06 | 2003-12-30 | Biolase Technology, Inc. | Tissue remover and method |
| US5922000A (en) * | 1997-11-19 | 1999-07-13 | Redfield Corp. | Linear punch |
| US6589202B1 (en) * | 2000-06-29 | 2003-07-08 | Becton Dickinson And Company | Method and apparatus for transdermally sampling or administering a substance to a patient |
| US6440096B1 (en) * | 2000-07-14 | 2002-08-27 | Becton, Dickinson And Co. | Microdevice and method of manufacturing a microdevice |
| KR101134434B1 (ko) * | 2003-05-01 | 2012-04-09 | 메드제닉스 인코포레이티드 | 진피 미세 기관, 그를 생산 및 이용하기 위한 방법 및 장치 |
| US8535299B2 (en) * | 2004-01-23 | 2013-09-17 | Joseph Giovannoli | Method and apparatus for skin reduction |
| BRPI0814191A2 (pt) * | 2007-06-26 | 2015-01-27 | Restoration Robotics Inc | Ferramentas de captação de unidade folicular incluindo dispositivos e seu uso para remover o tecido conectivo |
| US20100121307A1 (en) * | 2007-08-24 | 2010-05-13 | Microfabrica Inc. | Microneedles, Microneedle Arrays, Methods for Making, and Transdermal and/or Intradermal Applications |
| CN102958460B (zh) * | 2010-05-07 | 2016-06-15 | 通用医疗公司 | 用于组织移植和复制的装置 |
| US9610093B2 (en) * | 2010-08-06 | 2017-04-04 | Kci Licensing, Inc. | Microblister skin grafting |
| CN103547226B (zh) * | 2011-01-28 | 2018-04-17 | 通用医疗公司 | 用于皮肤再表面化的装置 |
| US9468459B2 (en) * | 2011-04-20 | 2016-10-18 | Kci Licensing, Inc. | Skin graft devices and methods |
| US20120323325A1 (en) * | 2011-06-16 | 2012-12-20 | Fulton Judith A | Autologous in situ tissue engineering |
| US20120323139A1 (en) * | 2011-06-17 | 2012-12-20 | Will Richardson | Kit and method for extracting and storing a skin tissue sample |
| US11717317B2 (en) * | 2012-08-14 | 2023-08-08 | The General Hospital Corporation | Method and apparatus for tissue harvesting |
| KR102238227B1 (ko) * | 2012-12-06 | 2021-04-12 | 에스알쥐아이 홀딩스 엘엘씨 | 픽셀 어레이 의료용 장치 및 방법 |
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- 2015-08-31 SG SG11201701521RA patent/SG11201701521RA/en unknown
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- 2015-08-31 WO PCT/US2015/047721 patent/WO2016033586A1/fr active Application Filing
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- 2015-08-31 AU AU2015308582A patent/AU2015308582A1/en not_active Abandoned
- 2015-08-31 EP EP15836045.3A patent/EP3185788A4/fr not_active Withdrawn
- 2015-08-31 BR BR112017004112A patent/BR112017004112A2/pt not_active IP Right Cessation
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| CN107405164B (zh) | 2021-02-09 |
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| WO2016033586A1 (fr) | 2016-03-03 |
| MX2017002661A (es) | 2018-01-25 |
| SG11201701521RA (en) | 2017-03-30 |
| EP3185788A1 (fr) | 2017-07-05 |
| PH12017500349A1 (en) | 2017-07-17 |
| AU2015308582A1 (en) | 2017-04-20 |
| CN107405164A (zh) | 2017-11-28 |
| AU2020202310A1 (en) | 2020-04-23 |
| EP3185788A4 (fr) | 2018-02-07 |
| BR112017004112A2 (pt) | 2017-12-05 |
| KR20170101184A (ko) | 2017-09-05 |
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