CA2940177C - Selective photo activation of amino acids for single step peptide coupling - Google Patents
Selective photo activation of amino acids for single step peptide coupling Download PDFInfo
- Publication number
- CA2940177C CA2940177C CA2940177A CA2940177A CA2940177C CA 2940177 C CA2940177 C CA 2940177C CA 2940177 A CA2940177 A CA 2940177A CA 2940177 A CA2940177 A CA 2940177A CA 2940177 C CA2940177 C CA 2940177C
- Authority
- CA
- Canada
- Prior art keywords
- coupling
- molecule
- substrate
- carboxylic acid
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/063—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha-amino functions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
- C07K1/086—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents containing sulfur
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/10—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using coupling agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461942903P | 2014-02-21 | 2014-02-21 | |
| US61/942,903 | 2014-02-21 | ||
| US201462048689P | 2014-09-10 | 2014-09-10 | |
| US62/048,689 | 2014-09-10 | ||
| PCT/US2015/017173 WO2015127409A1 (en) | 2014-02-21 | 2015-02-23 | Selective photo activation of amino acids for single step peptide coupling |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2940177A1 CA2940177A1 (en) | 2015-08-27 |
| CA2940177C true CA2940177C (en) | 2020-02-25 |
Family
ID=53879126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2940177A Active CA2940177C (en) | 2014-02-21 | 2015-02-23 | Selective photo activation of amino acids for single step peptide coupling |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10040818B2 (https=) |
| EP (2) | EP3805207B1 (https=) |
| JP (1) | JP6619362B2 (https=) |
| AU (3) | AU2015218635B2 (https=) |
| CA (1) | CA2940177C (https=) |
| NZ (1) | NZ724210A (https=) |
| WO (1) | WO2015127409A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6012767B2 (ja) | 2012-02-07 | 2016-10-25 | ヴィブラント ホールディングス リミテッド ライアビリティ カンパニー | 基板、ペプチドアレイ、および方法 |
| US10006909B2 (en) | 2012-09-28 | 2018-06-26 | Vibrant Holdings, Llc | Methods, systems, and arrays for biomolecular analysis |
| US10286376B2 (en) | 2012-11-14 | 2019-05-14 | Vibrant Holdings, Llc | Substrates, systems, and methods for array synthesis and biomolecular analysis |
| AU2015218635B2 (en) * | 2014-02-21 | 2017-08-31 | Vibrant Holdings, Llc | Selective photo activation of amino acids for single step peptide coupling |
| CN107427514B (zh) * | 2015-03-16 | 2021-07-13 | 豪夫迈·罗氏有限公司 | 使用tlr7激动剂和hbv衣壳装配抑制剂的组合治疗 |
| CA3000509C (en) | 2015-10-29 | 2021-07-27 | Vibrant Holdings, Llc | Methods, tools, and tool assemblies for biomolecular analysis using microarrays |
| EP3402897A4 (en) * | 2015-12-28 | 2019-06-19 | Vibrant Holdings, LLC | SUBSTRATES, SYSTEMS AND METHODS FOR NUCLEINE ACIDIFICATION SYNTHESIS |
| US10538808B2 (en) | 2017-05-26 | 2020-01-21 | Vibrant Holdings, Llc | Photoactive compounds and methods for biomolecule detection and sequencing |
| EP3790985B1 (en) | 2018-05-09 | 2026-04-15 | Vibrant Holdings, LLC | Methods of synthesizing a polynucleotide array using photactivated agents |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5240811A (en) * | 1991-04-15 | 1993-08-31 | Ocg Microelectronic Materials, Inc. | Photogenerated polycarbodiimides from poly(tetrazole-5-thiones) and use in the preparation of coatings and deep-UV photoresists |
| EP0702707A1 (en) | 1993-05-26 | 1996-03-27 | Akzo Nobel N.V. | Coating composition including a uv-deblockable basic catalyst |
| JP4503828B2 (ja) * | 1998-02-11 | 2010-07-14 | ユニバーシティー オブ ヒューストン | 光生成試薬を用いる化学反応および生化学反応のための方法および装置 |
| JP4843955B2 (ja) | 2004-02-16 | 2011-12-21 | 三菱瓦斯化学株式会社 | 光塩基発生剤 |
| US20070122841A1 (en) | 2005-11-30 | 2007-05-31 | Rajasekaran John J | Massively parallel synthesis of proteinaceous biomolecules |
| US20070122842A1 (en) | 2005-11-30 | 2007-05-31 | Rajasekaran John J | Massively parallel synthesis of proteinaceous biomolecules |
| US20070154946A1 (en) | 2005-12-29 | 2007-07-05 | Rajasekaran John J | Massively parallel synthesis of biopolymeric arrays |
| WO2008118167A1 (en) | 2006-03-24 | 2008-10-02 | The Regents Of The University Of Michigan | Method for forming molecular sequences on surfaces |
| US9096953B2 (en) | 2006-09-29 | 2015-08-04 | Intel Corporation | Method for high throughput, high volume manufacturing of biomolecule micro arrays |
| US20080108149A1 (en) | 2006-10-23 | 2008-05-08 | Narayan Sundararajan | Solid-phase mediated synthesis of molecular microarrays |
| US20100093554A1 (en) | 2007-06-01 | 2010-04-15 | Keting Chu | Methods for identifying biomarkers, autoantibody signatures, and stratifying subject groups using peptide arrays |
| WO2012154594A1 (en) | 2011-05-09 | 2012-11-15 | Neal Woodbury | Methods for performing patterned chemistry |
| JP6012767B2 (ja) | 2012-02-07 | 2016-10-25 | ヴィブラント ホールディングス リミテッド ライアビリティ カンパニー | 基板、ペプチドアレイ、および方法 |
| CA3088591C (en) | 2012-09-28 | 2023-01-03 | Vibrant Holdings, Llc | Inverted pillar plates for assaying microarrays and methods of using same. |
| US10006909B2 (en) | 2012-09-28 | 2018-06-26 | Vibrant Holdings, Llc | Methods, systems, and arrays for biomolecular analysis |
| CA2891651C (en) * | 2012-11-14 | 2019-01-22 | Vibrant Holdings, Llc | Substrates, systems, and methods for array synthesis and biomolecular analysis |
| AU2015218635B2 (en) * | 2014-02-21 | 2017-08-31 | Vibrant Holdings, Llc | Selective photo activation of amino acids for single step peptide coupling |
-
2015
- 2015-02-23 AU AU2015218635A patent/AU2015218635B2/en active Active
- 2015-02-23 EP EP20191924.8A patent/EP3805207B1/en active Active
- 2015-02-23 CA CA2940177A patent/CA2940177C/en active Active
- 2015-02-23 JP JP2016570929A patent/JP6619362B2/ja active Active
- 2015-02-23 US US15/120,452 patent/US10040818B2/en active Active
- 2015-02-23 NZ NZ724210A patent/NZ724210A/en unknown
- 2015-02-23 EP EP15751793.9A patent/EP3107926B1/en active Active
- 2015-02-23 WO PCT/US2015/017173 patent/WO2015127409A1/en not_active Ceased
-
2017
- 2017-11-28 AU AU2017268546A patent/AU2017268546A1/en not_active Abandoned
-
2018
- 2018-06-26 US US16/019,449 patent/US10577391B2/en active Active
-
2019
- 2019-12-18 AU AU2019283851A patent/AU2019283851A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US10577391B2 (en) | 2020-03-03 |
| EP3107926A1 (en) | 2016-12-28 |
| JP6619362B2 (ja) | 2019-12-11 |
| AU2015218635A2 (en) | 2017-03-16 |
| AU2019283851A1 (en) | 2020-01-23 |
| US20170129918A1 (en) | 2017-05-11 |
| AU2015218635B2 (en) | 2017-08-31 |
| AU2017268546A1 (en) | 2017-12-21 |
| NZ724210A (en) | 2017-10-27 |
| WO2015127409A1 (en) | 2015-08-27 |
| AU2015218635A1 (en) | 2016-10-06 |
| EP3805207B1 (en) | 2023-04-05 |
| EP3805207A1 (en) | 2021-04-14 |
| EP3107926B1 (en) | 2020-09-09 |
| JP2017509696A (ja) | 2017-04-06 |
| CA2940177A1 (en) | 2015-08-27 |
| US10040818B2 (en) | 2018-08-07 |
| US20190023734A1 (en) | 2019-01-24 |
| EP3107926A4 (en) | 2017-10-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20160818 |
|
| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 10TH ANNIV.) - STANDARD Year of fee payment: 10 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20250620 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20250620 |