CA2928014C - Methode de detection d'un marqueur moleculaire de plasmodium falciparum resistant a l'artemisinine
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Methode de detection d'un marqueur moleculaire de plasmodium falciparum resistant a l'artemisinine
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Publication number
CA2928014C
CA2928014CCA2928014ACA2928014ACA2928014CCA 2928014 CCA2928014 CCA 2928014CCA 2928014 ACA2928014 ACA 2928014ACA 2928014 ACA2928014 ACA 2928014ACA 2928014 CCA2928014 CCA 2928014C
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Canada
Prior art keywords
propeller
nucleic acid
seq
plasmodium
mutated
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Application filed by Centre National de la Recherche Scientifique CNRS, Institut Pasteur, Institut Pasteur du CambodgefiledCriticalCentre National de la Recherche Scientifique CNRS
Priority claimed from PCT/IB2014/002910external-prioritypatent/WO2015071759A1/fr
Publication of CA2928014A1publicationCriticalpatent/CA2928014A1/fr
Application grantedgrantedCritical
Publication of CA2928014CpublicationCriticalpatent/CA2928014C/fr
Selon l'invention, un polymorphisme de K13-propeller est un marqueur moléculaire utile pour suivre l'émergence et la propagation de P. falciparum résistant à l'artémisinine (ART). La présente invention concerne des méthodes, des compositions et des kits de détection et de génotypage de Plasmodium, par exemple de Plasmodium falciparum. Les méthodes, compositions et kits selon l'invention peuvent servir à détecter la présence ou l'absence d'une protéine ou d'un acide nucléique de K-13 propeller mutant dans un échantillon.
CA2928014A2013-11-152014-11-14Methode de detection d'un marqueur moleculaire de plasmodium falciparum resistant a l'artemisinine
ActiveCA2928014C
(fr)
Ex vivo susceptibility to antimalarial drugs and polymorphisms in drug resistance genes of African Plasmodium falciparum, 2016-2023: a genotype-phenotype association study
Polymorphism analysis of propeller domain of k13 gene in Plasmodium ovale curtisi and Plasmodium ovale wallikeri isolates original infection from Myanmar and Africa in Yunnan Province, China
Molecular evaluation of pvdhfr and pvmdr-1 mutants in Plasmodium vivax isolates after treatment with sulfadoxine/pyrimethamine and chloroquine in Iran during 2001–2016