CA2927181A1 - Scutellaria for improving compositions for energy, focus, and thermogenesis - Google Patents
Scutellaria for improving compositions for energy, focus, and thermogenesis Download PDFInfo
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- CA2927181A1 CA2927181A1 CA2927181A CA2927181A CA2927181A1 CA 2927181 A1 CA2927181 A1 CA 2927181A1 CA 2927181 A CA2927181 A CA 2927181A CA 2927181 A CA2927181 A CA 2927181A CA 2927181 A1 CA2927181 A1 CA 2927181A1
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Abstract
A method for supporting the efficacy of compositions for increasing energy, focus, or thermogenesis is provided by administration of Scutellaria. Scutellaria administered proximal to the administration of the composition for increasing energy, focus, or thermogenesis, acts to support the effectiveness of the composition.
Description
SCUTELLARIA FOR IMPROVING COMPOSITIONS FOR ENERGY, FOCUS, AND
THERMOGENESIS
Field of the Invention [1] The present invention relates generally to methods and compositions for improving energy, focus, or thermogenesis. More specifically, the present invention relates to supporting the effectiveness of dietary supplements for improving energy, focus, or thermogenesis by administering Scutellaria.
Background of the Invention
THERMOGENESIS
Field of the Invention [1] The present invention relates generally to methods and compositions for improving energy, focus, or thermogenesis. More specifically, the present invention relates to supporting the effectiveness of dietary supplements for improving energy, focus, or thermogenesis by administering Scutellaria.
Background of the Invention
[2] It is becoming increasingly common for individuals to consume dietary supplements for a variety of reasons. Some of the most popular uses of dietary supplements are for increasing energy, both physical and mental, increasing mental focus, and for increasing thermogenesis. Supplements, as such, may be used for a number of reasons including countering/preventing mental and/or physical fatigue, improving physical activity such as physical labor or exercise, and assisting with weight loss or weight maintenance.
[3] Individual responses to such supplements vary due to a number of reasons including differences in physiological sensitivity to specific ingredients, tolerance due to chronic use, and subjective expectations. There is a need for improved compositions for supporting energy, focus, or thermogenesis.
Summary of the Invention
Summary of the Invention
[4] The disclosed dietary supplements and methods of administering the same can advantageously be used by subjects who desire increased energy, improved mental focus, and/or increased thermogenic effects.
[5] In an embodiment of the present invention, there is provided a method of supporting at least one of energy, focus, or thermogenesis in a subject desiring of such. A determination is made for the need to increase at least one of energy, focus, or thermogenesis in a subject and a composition for increasing at least one of energy, focus, or thermogenesis is taken by the subject at an appropriate time. Scutellaria is taken by the subject proximal to the composition for supporting the efficacy of the composition.
[6] In some aspects, the Scutellaria is incorporated within the composition for increasing energy, focus, or thermogenesis. In other aspects, the Scutellaria is taken as a separate composition proximal to the composition for increasing energy, focus, or thermogenesis.
[7] In some aspects, the Scutellaria is taken before a meal. In other aspects, the Scutellaria is taken before exercise.
[8] In another embodiment, there is provided a composition for supporting any of energy, focus, or thermogenesis comprising in Scutellaria and ingredients for increasing at least one of energy, focus, or thermogenesis.
Detailed Description of the Embodiments
Detailed Description of the Embodiments
[9] Scutellaria are mostly perennial herbs occurring in many regions with species indigenous to North America and Europe. Some species have been used for anxiolytic, antispasmodic, sedative and diuretic properties. Bioactive components include monoterpenes, diterpenes, and several flavonoids including baicalein, baicalin, scutellarein,and scutellarin.
[10] The present invention relates to the surprising discovery that Scutellaria lateriflora added to compositions for increasing energy, focus, or thermogenesis supports the efficacy of the compositions without reducing the effectiveness of the compositions, in some instances enhancing effectiveness. Particularly surprising was the efficacy of the compositions administered prior to exercise and in individuals accustomed to using supplements for energy, focus, or thermogenesis.
[11] A used herein, the terms "supplements" includes dietary supplements, diet supplements, nutritional supplements, supplemental compositions and supplemental dietary compositions or those similarly envisioned and termed compositions not belonging to the conventional definition of pharmaceutical interventions as is known in the art. Furthermore, "supplements" as disclosed herein belong to category of compositions having at least one intended . .
physiological function when administered to a subject by conventional routes of administration.
physiological function when administered to a subject by conventional routes of administration.
[12] As used herein, "support" or "supporting" refers to overall improvement in the desired goal e.g. increased or improved energy, focus, or thermogenesis.
"Supporting" may be used to refer to beneficial synergistic effects resulting in increases or improvements in the desired goal. The increases or improvements may be absolute increases in the desired goal such as increases in energy, focus, or thermogenesis, or may be reductions in experienced or perceived negative (side) effects resulting in overall improvements in the goal of increased energy, focus, or thermogenesis. Thus, with reference to energy, focus or thermogenesis, "supporting" may be used to mean an increase beyond a normal or native state; it may also be used to mean a reduction in a decreased or deficit state below a normal or native state.
"Supporting" may be used to refer to beneficial synergistic effects resulting in increases or improvements in the desired goal. The increases or improvements may be absolute increases in the desired goal such as increases in energy, focus, or thermogenesis, or may be reductions in experienced or perceived negative (side) effects resulting in overall improvements in the goal of increased energy, focus, or thermogenesis. Thus, with reference to energy, focus or thermogenesis, "supporting" may be used to mean an increase beyond a normal or native state; it may also be used to mean a reduction in a decreased or deficit state below a normal or native state.
[13] The methods of the present invention are intended for use with any subject that may experience the benefits of the methods of the invention. It will be understood that the subject to which a compound of the invention is administered need not suffer from a specific undesirable state or condition.
Indeed, the compounds of the invention may be administered prophylactically, prior to any development of symptoms or to benefit generally healthy subjects wishing to achieve greater desired effects. Such subjects may include athletes (professional or recreational) or individuals merely wishing to improve health or physical or mental performance, either acutely or chronically.
Indeed, the compounds of the invention may be administered prophylactically, prior to any development of symptoms or to benefit generally healthy subjects wishing to achieve greater desired effects. Such subjects may include athletes (professional or recreational) or individuals merely wishing to improve health or physical or mental performance, either acutely or chronically.
[14] Preferred materials and methods are herein described. However, any suitable materials and/or methods known to those of skill can be utilized in carrying out the present invention. Materials and ingredients to which reference is made in the following description and examples are obtainable from commercial sources, unless otherwise noted.
[15] In aspects of the invention, Scutellaria may be obtained from unprocessed plant material. Preferably, Scutellaria is in the form of an extract from plant material where it may be obtained from extracts of whole plant or from particular plant parts, preferably from the root. Suitable extraction procedures are well-known in the art. Preferably, the Scutellaria will contain baicalin. For extracts, suitable solvents will be known to those skilled in the art. The preferred species is Scutellaria lateriflora, however other species may be used, such as Scutellaria baicalensis.
[16] The compositions of the present invention may be manufactured according to common methods known to those of skill in the art and may be used in administration formats common in the art including pills, tablets, caplets, capsules, liquids, or powders. The compositions may also be incorporated in foods or beverages.
[17] The compositions of the present invention may be directed to a number of different uses for which it would be desirable to increase energy, focus, or thermogenesis. Such uses include, but are not limited to, improving body composition, improving exercise performance, improving mental performance, and countering physical or mental fatigue. Uses may not be mutually exclusive.
For example, a subject may wish to lose weight by reducing body fat through exercise, such exercise performance, and thus weight loss, improved by the methods and compositions of the present invention.
For example, a subject may wish to lose weight by reducing body fat through exercise, such exercise performance, and thus weight loss, improved by the methods and compositions of the present invention.
[18] Supplements for increasing energy, as referred to herein, may contain ingredients to directly provide energy (e.g. calories) or by effecting metabolism, either by increasing metabolism to provide more energy or by altering metabolism to provide energy differently. Supplements typically associated with increasing energy include, but are not limited to, caffeine (and sources thereof), green tea, synephrine (and sources thereof, e.g. bitter orange), Panax ginseng, coenzyme Q10, B vitamins, creatine (and various salts or derivatives thereof), amino acids (particularly branched chain amino acids leucine, valine, and isoleucine), carnitine, glucose and other carbohydrates. Energy supplements may be taken prior to the need for increased energy (e.g. prior to exercise, or pre-workout) to provide energy for activity. Alternatively, energy supplements may be taken after energy expenditure (e.g. post-workout) to help replenish energy stores.
[19] Dietary supplements for enhancing focus, as referred to herein, are typically used to increase some aspect(s) of mental function such as concentration, attention, and cognition. Broadly, such ingredients are either stimulants or non-stimulants. Non-stimulant focus-enhancing ingredients are often termed `nootropics'. Ingredients purported to have efficacy at enhancing focus include, but are not limited to, Bacopa monnieri, Salvia miltiorrhiza, Panax ginseng, Ginkgo biloba, and Myristica fragrans.
[20] Thermogenic dietary supplements, as referred to herein, contain ingredients to increase thermogenesis, the process of producing heat in or by the body of the subject, and are typically used to help weight loss and/or to provide energy. Thermogenesis may be increased by a number of mechanisms including, but not limited to diet-induced thermogenesis, exercise-induced thermogenesis, and non-exercise-associated thermogenesis. Common thermogenic ingredients or ingredients associated with thermogenic supplements include, but are not limited to, caffeine (and various sources of caffeine), (32-adrenergic receptor agonists (e.g. synephrine and sources thereof, e.g. bitter orange), green tea (and various components thereof e.g. EGCG), Zin giber officinale (Ginger), green coffee bean, capsaicinoids/capsinoids (and sources thereof, e.g. cayenne peppers), salicylates, pyruvate, carnitine, conjugated linoleic acid (CLA), forskolin (e.g. from Coleus forskohlii), and yohimbine (e.g.
from Yohimbe). As dietary supplements, thermogenic formulae are often referred to as, and used as, fat burners.
from Yohimbe). As dietary supplements, thermogenic formulae are often referred to as, and used as, fat burners.
[21] As can readily be appreciated, there may be overlap in supplements intended to increase energy, focus, and thermogenesis, as to the ingredients compositions may contain, and in the situations such compositions may be used.
[22] In some aspects the compositions may comprise pharmaceutically acceptable additives. Such pharmaceutically acceptable additives are well-known in the art and include excipients, coatings, absorption delaying agents, binders, adhesives, lubricants, disintergrants, coloring agents, flavoring agents, absorbants, detergents, and emulsifying agents.
, , . .
, , . .
[23] Scutellaria may be taken with compositions for increasing energy, for increasing focus, or for increasing thermogenesis, or combinations thereof.
The Scutellaria should be taken proximal to taking the composition for increasing energy, focus, or thermogenesis. The Scutellaria may be incorporated within the composition or may be taken discretely. If taken discretely, the Scutellaria will be taken proximal to the time the composition for increasing energy, focus, or thermogenesis is taken, preferably at approximately the same time (e.g. within minutes), or co-administered (i.e. taken together, at the same time).
Preferably, the Scutellaria is incorporated within the composition for increasing energy, focus, or thermogenesis.
The Scutellaria should be taken proximal to taking the composition for increasing energy, focus, or thermogenesis. The Scutellaria may be incorporated within the composition or may be taken discretely. If taken discretely, the Scutellaria will be taken proximal to the time the composition for increasing energy, focus, or thermogenesis is taken, preferably at approximately the same time (e.g. within minutes), or co-administered (i.e. taken together, at the same time).
Preferably, the Scutellaria is incorporated within the composition for increasing energy, focus, or thermogenesis.
[24] The present invention provides compositions comprising components intended to provide increases in any of energy, focus, and thermogenesis, the compositions further comprising Scutellaria, wherein the Scutellaria supports the energy, focus or thermogenesis of the composition. The Scutellaria acts to potentiate, increase, or otherwise improve the overall efficacy of the composition.
The compositions may be used to increase any of energy, focus, and thermogenesis in methods including, but not limited to, enhancing weight loss, preventing weight gain, improving pre-exercise performance, ameliorating post-exercise recovery, countering the effects of mental and/or physical fatigue, and improve concentration.
The compositions may be used to increase any of energy, focus, and thermogenesis in methods including, but not limited to, enhancing weight loss, preventing weight gain, improving pre-exercise performance, ameliorating post-exercise recovery, countering the effects of mental and/or physical fatigue, and improve concentration.
[25] A determination may be made by a subject as to the need to increase energy, focus, or thermogenesis for a specific goal and as to the appropriate time to consume or administer a composition for increasing energy, focus, or thermogenesis so as to achieve the desired result at a beneficial or optimal time.
For example, a subject may determine the need to increase energy for improved performance during an exercise session or a particular sporting event; a subject may wish to increase focus prior to taking a test or engaging in exercise; a subject may wish to increase thermogenesis prior to, or after, a meal or an exercise session. In specific cases where a goal in an increase in energy, focus, or thermogenesis for aiding in physical activity (e.g. exercise), the composition for increasing energy, focus, or thermogenesis may be taken from about between 30 to 60 minutes prior to the activity. Where the goal is an increase in thermogenesis to aid in weight management, the compositions for increasing thermogenesis may be taken from about between 30 to 60 minutes before a meal. The determination of other activities, goals, or situations requiring increased energy, focus, or thermogenesis and the determination of an appropriate time for consuming a composition for increasing such will be apparent to those skilled in the art and by individuals desirous of such.
For example, a subject may determine the need to increase energy for improved performance during an exercise session or a particular sporting event; a subject may wish to increase focus prior to taking a test or engaging in exercise; a subject may wish to increase thermogenesis prior to, or after, a meal or an exercise session. In specific cases where a goal in an increase in energy, focus, or thermogenesis for aiding in physical activity (e.g. exercise), the composition for increasing energy, focus, or thermogenesis may be taken from about between 30 to 60 minutes prior to the activity. Where the goal is an increase in thermogenesis to aid in weight management, the compositions for increasing thermogenesis may be taken from about between 30 to 60 minutes before a meal. The determination of other activities, goals, or situations requiring increased energy, focus, or thermogenesis and the determination of an appropriate time for consuming a composition for increasing such will be apparent to those skilled in the art and by individuals desirous of such.
[26] Example 1
[27] The inventors sought to examine the efficacy of adding Scutellaria lateriflora to supplemental compositions for increasing energy, focus, and thermogenesis. Multiple supplement compositions containing common ingredients for increasing energy, focus, or thermogenesis were tested with the addition of Scutellaria lateriflora. In particular, Test Supplement 1 containing the following, per serving, was formulated:
caffeine anhydrous ¨ 300mg green coffee bean extract ¨ 200mg Coleus forskohlii extract powder with 10% forskolin ¨ 100mg Yohimbe bark extract powder with 6% yohimbine ¨ 40mg Scutellaria lateriflora root extract powder (containing not less than 20%
baicalin) ¨ 75mg.
Test Supplement 1 was used as a test composition as these ingredients (with the exception of Scutellaria lateriflora) represent a selection that could be used to increase energy, focus, and thermogenesis. Nine (9) healthy male subjects between the age of 20 and 40 were selected based on familiarity with, and regular use of, supplements to increase energy, focus, and thermogenesis, similar to Test Supplement 1 (without Scutellaria lateriflora). Subjects knew that the Test Supplement contained ingredients to increase energy, focus, or thermogenesis, but did not know the specific ingredients, thus they were instructed not to take the sample with other supplements for the same purpose or stimulants. Subjects reported their experience with taking Test Supplement 1 generally, and in comparison to other similarly purposed supplements.
caffeine anhydrous ¨ 300mg green coffee bean extract ¨ 200mg Coleus forskohlii extract powder with 10% forskolin ¨ 100mg Yohimbe bark extract powder with 6% yohimbine ¨ 40mg Scutellaria lateriflora root extract powder (containing not less than 20%
baicalin) ¨ 75mg.
Test Supplement 1 was used as a test composition as these ingredients (with the exception of Scutellaria lateriflora) represent a selection that could be used to increase energy, focus, and thermogenesis. Nine (9) healthy male subjects between the age of 20 and 40 were selected based on familiarity with, and regular use of, supplements to increase energy, focus, and thermogenesis, similar to Test Supplement 1 (without Scutellaria lateriflora). Subjects knew that the Test Supplement contained ingredients to increase energy, focus, or thermogenesis, but did not know the specific ingredients, thus they were instructed not to take the sample with other supplements for the same purpose or stimulants. Subjects reported their experience with taking Test Supplement 1 generally, and in comparison to other similarly purposed supplements.
[28] Feedback from Test Supplement 1: Eight out of nine subjects were pleased, overall, with Test Supplement 1. Specific benefits, in terms of energy, focus, and thermogenesis differed among subjects, however all eight subjects pleased with Test Supplement 1 noted some aspect of energy improved. Four of the eight subjects also noted improved aspects of focus. Of the total subjects, three reported improved thermogenesis.
[29] Example 2
[30] Similar to Test Supplement 1, Test Supplement 2 was formulated, each serving containing the following:
caffeine anhydrous ¨ 250mg green coffee bean extract ¨ 200mg Salvia miltiorrhiza ¨ 50mg Ornithine HCI ¨ 500mg Scutellaria laterfflora root extract powder (containing not less than 20%
baicalin) ¨ 50mg.
Twelve (12) healthy subjects between the age of 20 and 40 (11 male, 1 female) were given Test Supplement 2 as for Test Supplement 1.
caffeine anhydrous ¨ 250mg green coffee bean extract ¨ 200mg Salvia miltiorrhiza ¨ 50mg Ornithine HCI ¨ 500mg Scutellaria laterfflora root extract powder (containing not less than 20%
baicalin) ¨ 50mg.
Twelve (12) healthy subjects between the age of 20 and 40 (11 male, 1 female) were given Test Supplement 2 as for Test Supplement 1.
[31] Feedback from Test Supplement 2: Ten out of twelve subjects were pleased, overall, with Test Supplement 2. Of the ten, six subjects reported improved energy, six also reported improved focus (five reporting increases in both energy and focus), and five subjects reported improved thermogenic sensations.
[32] Example 3
[33] The composition of Test Supplement 1 is to be taken 30 to 60 minutes before a meal, twice per day to assist with weight loss.
[34] Example 4
[35] The composition of Test Supplement 1 is to be taken 30 to 60 minutes prior to exercise to improve exercise performance. The composition may also be , .
used to improve muscle building or to assist weight loss through improved exercise performance.
used to improve muscle building or to assist weight loss through improved exercise performance.
[36] Example 5
[37] The composition of Test Supplement 2 is to be taken 30 to 60 minutes before a meal, twice per day to assist with weight loss.
[38] The above-described embodiments are intended to be examples of the present invention and alterations and modifications may be effected thereto, by those of skill in the art. The scope of the claims should not be limited by the preferred embodiments set forth in the examples, but should be given the broadest interpretation consistent with the description as a whole.
Claims (20)
1. A method of supporting at least one of energy, focus, or thermogenesis in a subject desiring of such, comprising the steps of: determining the need to increase at least one of energy, focus, or thermogenesis in a subject;
administering to the subject, at an appropriate time, a composition for increasing at least one of energy, focus, or thermogenesis; and administering to the subject Scutellaria; wherein the Scutellaria is administered to the subject proximal to the composition, and wherein the Scutellaria supports the efficacy of the composition.
administering to the subject, at an appropriate time, a composition for increasing at least one of energy, focus, or thermogenesis; and administering to the subject Scutellaria; wherein the Scutellaria is administered to the subject proximal to the composition, and wherein the Scutellaria supports the efficacy of the composition.
2. The method of claim 1, wherein the Scutellaria is co-administered with the composition.
3. The method of claim 1, wherein the Scutellaria is incorporated within the composition.
4. The method of claim 3, wherein the composition is administered from about 30 to 60 minutes prior to a meal.
5. The method of claim 3, wherein the composition is administered from about 30 to 60 minutes prior to exercise.
6. The method of claim 4 or 5, wherein the composition comprises green coffee bean extract and Scutellaria.
7. A composition for one or more of increasing energy, focus, or thermogenesis comprising components for increasing energy, focus, or thermogenesis and further comprising Scutellaria.
8. The composition of claim 7, wherein the composition comprises green coffee extract.
9. The composition of claim 7, wherein the composition comprises yohimbine.
10. The composition of claim 7, wherein the composition comprises caffeine.
11.The composition of claim 7, wherein the composition comprises Coleus forskohlii.
12.The composition of claim 7, wherein the composition comprises Salvia miltiorrhiza.
13.The composition of claim 7, wherein the composition comprises Myristica fragrans.
14. The composition of claim 7, wherein the composition comprises Zingiber officinale.
15. The composition of claim 14, wherein the composition comprises Salvia miltiorrhiza.
16.A composition comprising Scutellaria, caffeine, green coffee bean, and yohimbine.
17. The method of claim 3, wherein the Scutellaria is Scutellaria lateriflora.
18. The method of claim 5, wherein the Scutellaria is Scutellaria lateriflora.
19. The composition of claim 7, wherein the Scutellaria is Scutellaria lateriflora.
20. The composition of claim 16, wherein the Scutellaria is Scutellaria lateriflora.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562151118P | 2015-04-22 | 2015-04-22 | |
| US62/151,118 | 2015-04-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2927181A1 true CA2927181A1 (en) | 2016-10-22 |
Family
ID=57139674
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2927181A Abandoned CA2927181A1 (en) | 2015-04-22 | 2016-04-15 | Scutellaria for improving compositions for energy, focus, and thermogenesis |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2927181A1 (en) |
-
2016
- 2016-04-15 CA CA2927181A patent/CA2927181A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20190423 |
|
| FZDE | Discontinued |
Effective date: 20210831 |
|
| FZDE | Discontinued |
Effective date: 20210831 |