CA2905816C - Regeneration osseuse utilisant des materiaux nanocomposites polymeres biodegradables et applications associees - Google Patents

Regeneration osseuse utilisant des materiaux nanocomposites polymeres biodegradables et applications associees Download PDF

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Publication number
CA2905816C
CA2905816C CA2905816A CA2905816A CA2905816C CA 2905816 C CA2905816 C CA 2905816C CA 2905816 A CA2905816 A CA 2905816A CA 2905816 A CA2905816 A CA 2905816A CA 2905816 C CA2905816 C CA 2905816C
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CA
Canada
Prior art keywords
polymer
biocompatible structure
bone
cells
hap
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2905816A
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English (en)
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CA2905816A1 (fr
Inventor
Alexandru S. Biris
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Arkansas
Original Assignee
University of Arkansas
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Filing date
Publication date
Application filed by University of Arkansas filed Critical University of Arkansas
Priority claimed from US13/947,770 external-priority patent/US8936805B2/en
Publication of CA2905816A1 publication Critical patent/CA2905816A1/fr
Application granted granted Critical
Publication of CA2905816C publication Critical patent/CA2905816C/fr
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A61F2002/30224—Three-dimensional shapes cylindrical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2002/30971—Laminates, i.e. layered products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention concerne une structure et une méthode de production d'une structure biocompatible pour la régénération osseuse et tissulaire. La méthode consiste à dissoudre un polymère de polyuréthane dans le méthanol, à ajouter des nanoparticules d'hydroxyapatite (HAP) pour former un mélange uniforme, à appliquer le mélange sur une surface de polytétrafluoroéthylène (PTFE) pour former un film polymère, à découper le film polymère en bandes, à empiler les bandes en y intercalant des couches de particules osseuses, à recouvrir l'empilement de bandes et de couches du mélange et à laisser sécher, à ajouter des particules osseuses au revêtement, et à traiter par plasma la structure pour former la structure biocompatible. Un pourcentage pondéral des nanoparticules de HAP sur le polymère est compris entre environ 5 et 50 % de sorte que la vitesse de résorption de la structure biocompatible coïncide sensiblement avec la vitesse de régénération tissulaire dans la structure biocompatible.
CA2905816A 2013-03-15 2013-07-22 Regeneration osseuse utilisant des materiaux nanocomposites polymeres biodegradables et applications associees Active CA2905816C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361800588P 2013-03-15 2013-03-15
US61/800,588 2013-03-15
PCT/US2013/051520 WO2014143131A1 (fr) 2013-03-15 2013-07-22 Régénération osseuse utilisant des matériaux nanocomposites polymères biodégradables et applications associées
US13/947,770 2013-07-22
US13/947,770 US8936805B2 (en) 2005-09-09 2013-07-22 Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same

Publications (2)

Publication Number Publication Date
CA2905816A1 CA2905816A1 (fr) 2014-09-18
CA2905816C true CA2905816C (fr) 2018-08-14

Family

ID=51537418

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2905816A Active CA2905816C (fr) 2013-03-15 2013-07-22 Regeneration osseuse utilisant des materiaux nanocomposites polymeres biodegradables et applications associees

Country Status (4)

Country Link
CN (1) CN105283207B (fr)
CA (1) CA2905816C (fr)
IL (1) IL241398B (fr)
WO (1) WO2014143131A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9763788B2 (en) 2005-09-09 2017-09-19 Board Of Trustees Of The University Of Arkansas Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same
CA2964107C (fr) * 2014-10-08 2021-02-02 Board Of Trustees Of The University Of Arkansas Regeneration osseuse a l'aide de materiaux nanocomposites polymeres biodegradables et applications associees
DE102016211201A1 (de) * 2016-06-22 2017-12-28 Aesculap Ag Medizinisches Produkt, vorzugsweise zur Anwendung bei der Behandlung einer Knochenkavität, Verfahren zur Herstellung des medizinischen Produkts sowie medizinisches Kit
EP3621666A4 (fr) * 2017-05-10 2021-01-20 Board of Trustees of the University of Arkansas Structure biocompatible pour régénération de tissu et ses procédés de fabrication et d'utilisation
PL3691700T3 (pl) * 2017-10-06 2022-01-10 Dsm Ip Assets B.V. Sposób wytwarzania osteokondukcyjnego wyrobu włóknistego i implantu medycznego zawierającego taki osteokondukcyjny wyrób włóknisty
TW201932145A (zh) * 2017-10-18 2019-08-16 瑞士商Ｂｖｗ控股公司 具有經微結構所調介之吸收概貌之裝置
CN111671972B (zh) * 2020-07-30 2021-10-29 中国人民解放军空军军医大学 复合外泌体Nidogen-1的组织工程支架及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI374036B (en) * 2004-06-10 2012-10-11 Sean Kerr Flexible bone composite
US8518123B2 (en) 2005-09-09 2013-08-27 Board Of Trustees Of The University Of Arkansas System and method for tissue generation and bone regeneration
US20100104652A1 (en) * 2008-10-27 2010-04-29 University Of Arkansas Use of advanced nanomaterials for increasing sepecific cell functions
US8741318B2 (en) * 2011-09-09 2014-06-03 Board Of Trustees Of The University Of Arkansas Multicomponent and biocompatible nanocomposite materials, methods of synthesizing same and applications of same

Also Published As

Publication number Publication date
CN105283207B (zh) 2017-12-01
IL241398A0 (en) 2015-11-30
CA2905816A1 (fr) 2014-09-18
CN105283207A (zh) 2016-01-27
IL241398B (en) 2020-08-31
WO2014143131A1 (fr) 2014-09-18

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