CA2897020A1 - Fused antigen vaccines and compositions against streptococcus pneumoniae - Google Patents

Fused antigen vaccines and compositions against streptococcus pneumoniae Download PDF

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Publication number
CA2897020A1
CA2897020A1 CA2897020A CA2897020A CA2897020A1 CA 2897020 A1 CA2897020 A1 CA 2897020A1 CA 2897020 A CA2897020 A CA 2897020A CA 2897020 A CA2897020 A CA 2897020A CA 2897020 A1 CA2897020 A1 CA 2897020A1
Authority
CA
Canada
Prior art keywords
fusion protein
seq
immunogenic
amino acid
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2897020A
Other languages
English (en)
French (fr)
Inventor
Jessica Flechtner
Richard Malley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Childrens Hospital
Genocea Biosciences Inc
Original Assignee
Boston Childrens Hospital
Genocea Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Childrens Hospital, Genocea Biosciences Inc filed Critical Boston Childrens Hospital
Publication of CA2897020A1 publication Critical patent/CA2897020A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA2897020A 2012-01-20 2013-01-18 Fused antigen vaccines and compositions against streptococcus pneumoniae Abandoned CA2897020A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261589267P 2012-01-20 2012-01-20
US61/589,267 2012-01-20
PCT/US2013/022309 WO2013109995A2 (en) 2012-01-20 2013-01-18 Fused antigen vaccines and compositions against streptococcus pneumoniae

Publications (1)

Publication Number Publication Date
CA2897020A1 true CA2897020A1 (en) 2013-07-25

Family

ID=48799816

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2897020A Abandoned CA2897020A1 (en) 2012-01-20 2013-01-18 Fused antigen vaccines and compositions against streptococcus pneumoniae

Country Status (6)

Country Link
US (1) US9765125B2 (enExample)
EP (1) EP2804627B1 (enExample)
JP (2) JP6379041B2 (enExample)
AU (1) AU2013209513B2 (enExample)
CA (1) CA2897020A1 (enExample)
WO (1) WO2013109995A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108884134A (zh) * 2015-12-10 2018-11-23 加拿大全国研究委员会 脂化肺炎链球菌抗原组合物、制备方法和用途

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014124228A1 (en) 2013-02-07 2014-08-14 Children's Medical Center Corporation Protein antigens that provide protection against pneumococcal colonization and/or disease
US10738338B2 (en) 2016-10-18 2020-08-11 The Research Foundation for the State University Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate
CN106822885B (zh) * 2017-02-16 2020-06-30 清华大学 肺炎链球菌疫苗
WO2020104690A1 (en) * 2018-11-23 2020-05-28 Quine Medical Ab Bi-specific conjugates
WO2025012364A1 (en) * 2023-07-12 2025-01-16 Virometix Ag Compositions of pneumococcal antigens

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2059692C (en) 1991-01-28 2004-11-16 Peter J. Kniskern Pneumoccoccal polysaccharide conjugate vaccine
US5371197A (en) 1991-09-24 1994-12-06 Merck & Co., Inc. Protein-dimeric polysaccharide conjugate vaccine
US5505947A (en) 1994-05-27 1996-04-09 The University Of North Carolina At Chapel Hill Attenuating mutations in Venezuelan Equine Encephalitis virus
US6800744B1 (en) 1997-07-02 2004-10-05 Genome Therapeutics Corporation Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
US6248558B1 (en) 1998-03-31 2001-06-19 Vanderbilt University Sequence and method for genetic engineering of proteins with cell membrane translocating activity
US6783939B2 (en) 2000-07-07 2004-08-31 Alphavax, Inc. Alphavirus vectors and virosomes with modified HIV genes for use in vaccines
GB0107658D0 (en) * 2001-03-27 2001-05-16 Chiron Spa Streptococcus pneumoniae
KR100886095B1 (ko) 2001-04-16 2009-02-27 와이어쓰 홀딩스 코포레이션 폴리펩티드 항원을 암호화하는 신규한 스트렙토코쿠스 뉴모니애 개방형 판독 프레임 및 이를 포함하는 조성물
EP1490104B1 (en) 2002-04-02 2012-06-06 Ben-Gurion University Of The Negev Research And Development Authority Protein-based streptococcus pneumoniae vaccines
JP2008530037A (ja) 2005-02-11 2008-08-07 エース バイオサイエンシズ エー／エス 表面に位置したＳｔｒｅｐｔｏｃｏｃｃｕｓｐｎｅｕｍｏｎｉａｅのポリペプチド
WO2008020335A2 (en) 2006-06-09 2008-02-21 Novartis Ag Immunogenic compositions for streptococcus agalactiae
US8128939B2 (en) 2007-04-13 2012-03-06 The Board Of Regents Of The University Of Oklahoma Mutants of cholesterol-dependent cytolysins and uses thereof
MX2012000158A (es) * 2009-06-29 2012-06-08 Genocea Biosciences Inc Vacunas y composiciones contra streptococcus pneumoniae.
CN105833260A (zh) * 2011-01-20 2016-08-10 健诺西生物科学公司 针对肺炎链球菌（Streptococcus Pneumoniae）的疫苗和组合物
WO2012134975A1 (en) 2011-03-28 2012-10-04 St. Jude Children's Research Hospital Methods and compositions employing immunogenic fusion proteins
WO2013134656A1 (en) 2012-03-09 2013-09-12 Genocea Biosciences, Inc. Induction of th17 immune response

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108884134A (zh) * 2015-12-10 2018-11-23 加拿大全国研究委员会 脂化肺炎链球菌抗原组合物、制备方法和用途

Also Published As

Publication number Publication date
EP2804627B1 (en) 2019-08-14
JP2017160238A (ja) 2017-09-14
WO2013109995A2 (en) 2013-07-25
US20150056239A1 (en) 2015-02-26
JP2015513314A (ja) 2015-05-07
EP2804627A2 (en) 2014-11-26
EP2804627A4 (en) 2015-12-30
AU2013209513A1 (en) 2014-07-24
JP6379041B2 (ja) 2018-08-22
WO2013109995A9 (en) 2014-09-12
US9765125B2 (en) 2017-09-19
WO2013109995A3 (en) 2015-02-05
AU2013209513B2 (en) 2017-10-05

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20190118