CA2881729C - Drug delivery composition comprising proteins and biodegradable polyesteramides - Google Patents
Drug delivery composition comprising proteins and biodegradable polyesteramides Download PDFInfo
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- CA2881729C CA2881729C CA2881729A CA2881729A CA2881729C CA 2881729 C CA2881729 C CA 2881729C CA 2881729 A CA2881729 A CA 2881729A CA 2881729 A CA2881729 A CA 2881729A CA 2881729 C CA2881729 C CA 2881729C
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- 229960005460 teriparatide Drugs 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- RGYLYUZOGHTBRF-BIHRQFPBSA-N tetragastrin Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C2=CC=CC=C2NC=1)CCSC)C(N)=O)C1=CC=CC=C1 RGYLYUZOGHTBRF-BIHRQFPBSA-N 0.000 description 1
- 239000003868 thrombin inhibitor Substances 0.000 description 1
- 229960000902 thyrotropin alfa Drugs 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 229960000575 trastuzumab Drugs 0.000 description 1
- YWBFPKPWMSWWEA-UHFFFAOYSA-O triazolopyrimidine Chemical compound BrC1=CC=CC(C=2N=C3N=CN[N+]3=C(NCC=3C=CN=CC=3)C=2)=C1 YWBFPKPWMSWWEA-UHFFFAOYSA-O 0.000 description 1
- GSXRBRIWJGAPDU-BBVRJQLQSA-N tyrocidine A Chemical compound C([C@H]1C(=O)N[C@H](C(=O)N[C@@H](CCCN)C(=O)N[C@H](C(N[C@H](CC=2C=CC=CC=2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N1)=O)CC(C)C)C(C)C)C1=CC=C(O)C=C1 GSXRBRIWJGAPDU-BBVRJQLQSA-N 0.000 description 1
- YYSFXUWWPNHNAZ-PKJQJFMNSA-N umirolimus Chemical compound C1[C@@H](OC)[C@H](OCCOCC)CC[C@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 YYSFXUWWPNHNAZ-PKJQJFMNSA-N 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 229950007952 vapiprost Drugs 0.000 description 1
- 229960003726 vasopressin Drugs 0.000 description 1
- 229960003048 vinblastine Drugs 0.000 description 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/44—Polyester-amides
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L77/00—Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Compositions of derivatives of such polymers
- C08L77/12—Polyester-amides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y111/00—Oxidoreductases acting on a peroxide as acceptor (1.11)
- C12Y111/01—Peroxidases (1.11.1)
- C12Y111/01007—Peroxidase (1.11.1.7), i.e. horseradish-peroxidase
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12186915 | 2012-10-02 | ||
| EP12186915.0 | 2012-10-02 | ||
| EP13173634 | 2013-06-25 | ||
| EP13173634.0 | 2013-06-25 | ||
| PCT/EP2013/070543 WO2014053542A1 (en) | 2012-10-02 | 2013-10-02 | Drug delivery composition comprising proteins and biodegradable polyesteramides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2881729A1 CA2881729A1 (en) | 2014-04-10 |
| CA2881729C true CA2881729C (en) | 2021-05-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2881729A Active CA2881729C (en) | 2012-10-02 | 2013-10-02 | Drug delivery composition comprising proteins and biodegradable polyesteramides |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9789189B2 (OSRAM) |
| EP (1) | EP2903592B1 (OSRAM) |
| JP (1) | JP6330815B2 (OSRAM) |
| CN (1) | CN104717962B (OSRAM) |
| CA (1) | CA2881729C (OSRAM) |
| IN (1) | IN2015DN01153A (OSRAM) |
| WO (1) | WO2014053542A1 (OSRAM) |
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| US9873765B2 (en) | 2011-06-23 | 2018-01-23 | Dsm Ip Assets, B.V. | Biodegradable polyesteramide copolymers for drug delivery |
| EP3159368B1 (en) | 2011-06-23 | 2024-07-24 | DSM IP Assets B.V. | New biodegradable polyesteramide copolymers for drug delivery |
| WO2014053542A1 (en) | 2012-10-02 | 2014-04-10 | Dsm Ip Assets B.V. | Drug delivery composition comprising proteins and biodegradable polyesteramides |
| WO2014096339A1 (en) * | 2012-12-20 | 2014-06-26 | Dsm Ip Assets B.V. | Coating comprising polyesteramide copolymers for drug delivery |
| AU2015366355B2 (en) * | 2014-12-18 | 2020-05-28 | Dsm Ip Assets B.V. | Drug delivery system for delivery of acid sensitive drugs |
| US10500318B1 (en) | 2018-07-03 | 2019-12-10 | Temple Therapeutics BV | Dosing regimens for treating hypoxia-associated tissue damage |
| MX2021010599A (es) | 2019-03-05 | 2021-12-10 | Aerie Pharmaceuticals Inc | Composiciones farmaceuticas para el tratamiento de enfermedades o trastornos oculares. |
| AU2022271004A1 (en) | 2021-05-07 | 2023-11-16 | Temple Therapeutics BV | Methods of treating fibrosis and hypoxia-associated damage to peripheral nerves |
| WO2025163204A1 (en) | 2024-02-01 | 2025-08-07 | Temple Therapeutics BV | Glutamine source for use in methods and compositions for reducing or preventing synovial joint adhesions or fibrosis |
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| US4550730A (en) | 1981-12-07 | 1985-11-05 | Ethicon, Inc. | Flexible monofilament surgical sutures comprising poly(polymethylene terephthalate, isophthalate or cyclohexane-1,4-dicarboxylate-co-dimerate) |
| EP0926184A1 (en) | 1997-12-25 | 1999-06-30 | Mitsui Chemicals, Inc. | Process for production of polyamino acid derivative |
| EP1091761A1 (en) | 1998-06-30 | 2001-04-18 | Amgen Inc. | Thermosensitive biodegradable hydrogels for sustained delivery of biologically active agents |
| US6503538B1 (en) | 2000-08-30 | 2003-01-07 | Cornell Research Foundation, Inc. | Elastomeric functional biodegradable copolyester amides and copolyester urethanes |
| US20060177416A1 (en) | 2003-10-14 | 2006-08-10 | Medivas, Llc | Polymer particle delivery compositions and methods of use |
| US7304122B2 (en) | 2001-08-30 | 2007-12-04 | Cornell Research Foundation, Inc. | Elastomeric functional biodegradable copolyester amides and copolyester urethanes |
| CA2513443A1 (en) | 2003-02-26 | 2004-09-10 | Medivas, Llc | Bioactive stents and methods for use thereof |
| JP2005139139A (ja) | 2003-11-07 | 2005-06-02 | Idemitsu Technofine Co Ltd | 化粧料組成物 |
| AU2005244848A1 (en) | 2004-05-12 | 2005-12-01 | Medivas, Llc | Wound healing polymer compositions and methods for use thereof |
| US20050271700A1 (en) | 2004-06-03 | 2005-12-08 | Desnoyer Jessica R | Poly(ester amide) coating composition for implantable devices |
| US20060009498A1 (en) | 2004-07-12 | 2006-01-12 | Allergan, Inc. | Ophthalmic compositions and methods for treating ophthalmic conditions |
| US7390497B2 (en) | 2004-10-29 | 2008-06-24 | Advanced Cardiovascular Systems, Inc. | Poly(ester amide) filler blends for modulation of coating properties |
| US20060159918A1 (en) | 2004-12-22 | 2006-07-20 | Fiber Innovation Technology, Inc. | Biodegradable fibers exhibiting storage-stable tenacity |
| CN100551950C (zh) | 2005-03-21 | 2009-10-21 | 中国科学院成都有机化学有限公司 | 一种可降解聚酯酰胺共聚物的制备方法 |
| JP5178520B2 (ja) | 2005-09-22 | 2013-04-10 | メディバス エルエルシー | 固体ポリマー送達組成物およびその使用法 |
| EP1926780B1 (en) | 2005-09-22 | 2013-08-14 | Medivas, LLC | Bis-( -amino)-diol-diester-containing poly(ester amide) and poly(ester urethane) compositions and methods of use |
| CA2670355A1 (en) | 2005-11-21 | 2008-04-24 | Medivas, Llc | Polymer particles for delivery of macromolecules and methods of use |
| US8974815B2 (en) | 2005-12-16 | 2015-03-10 | Cornell University | Fibrous membrane for biomedical application based on poly(ester-amide)s |
| TWI376239B (en) | 2006-02-01 | 2012-11-11 | Andrew Xian Chen | Vitamin e succinate stabilized pharmaceutical compositions, methods for the preparation and the use thereof |
| EP2019645A4 (en) | 2006-05-02 | 2013-03-06 | Medivas Llc | RELEASE OF OPHTHALMOLOGICAL ACTIVITIES OUTSIDE OR WITHIN THE EYE |
| EP2021141A4 (en) | 2006-05-09 | 2013-07-03 | Medivas Llc | BIODEGRADABLE WATER SOLUBLE POLYMERS |
| US8936780B2 (en) | 2006-08-30 | 2015-01-20 | Advanced Cardiovascular Systems, Inc. | Stimuli responsive polyester amide particles |
| WO2008029917A1 (en) | 2006-09-08 | 2008-03-13 | Nikon Corporation | Mask, exposure apparatus and device manufacturing method |
| US7649022B2 (en) | 2007-03-30 | 2010-01-19 | Medivas, Llc | Bioabsorbable elastomeric polymer networks, cross-linkers and methods of use |
| US9737638B2 (en) * | 2007-06-20 | 2017-08-22 | Abbott Cardiovascular Systems, Inc. | Polyester amide copolymers having free carboxylic acid pendant groups |
| EP2170419A1 (en) | 2007-07-18 | 2010-04-07 | Board Of Trustees Of The University Of Illinois | Temporal release of growth factors from 3d micro rod scaffolds for tissue regeneration |
| CA2774036C (en) | 2009-10-16 | 2018-04-03 | Dsm Ip Assets B.V. | Coatings comprising bis-(alpha-amino-diol-diester) containing polyesteramide |
| US20130142858A1 (en) | 2010-05-17 | 2013-06-06 | Aerie Pharmaceuticals, Inc. | Drug delivery devices for delivery of ocular therapeutic agents |
| US20140179802A1 (en) | 2011-05-02 | 2014-06-26 | Dsm Ip Assets B.V. | Fiber comprising a biodegradable polymer |
| EP2704748B1 (en) | 2011-05-02 | 2018-08-15 | DSM IP Assets B.V. | Bis-(alpha-amino-diol-diester) containing polyesteramide for ophtamology |
| EP3159368B1 (en) | 2011-06-23 | 2024-07-24 | DSM IP Assets B.V. | New biodegradable polyesteramide copolymers for drug delivery |
| WO2013087903A1 (en) | 2011-12-16 | 2013-06-20 | Dsm Ip Assets B.V. | Process for the manufacturing of a drug delivery system based on a polymer comprising a dispersed bioactive agent |
| WO2014053542A1 (en) | 2012-10-02 | 2014-04-10 | Dsm Ip Assets B.V. | Drug delivery composition comprising proteins and biodegradable polyesteramides |
| EP2911647B1 (en) | 2012-10-23 | 2018-03-07 | DSM IP Assets B.V. | Process for the manufacturing of a multilayer drug delivery construct |
| US10538864B2 (en) | 2012-10-24 | 2020-01-21 | Dsm Ip Assets, B.V. | Fibers comprising polyesteramide copolymers for drug delivery |
| WO2014096339A1 (en) | 2012-12-20 | 2014-06-26 | Dsm Ip Assets B.V. | Coating comprising polyesteramide copolymers for drug delivery |
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2013
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- 2013-10-02 EP EP13771490.3A patent/EP2903592B1/en active Active
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- 2013-10-02 US US14/425,487 patent/US9789189B2/en active Active
- 2013-10-02 JP JP2015533638A patent/JP6330815B2/ja active Active
- 2013-10-02 CA CA2881729A patent/CA2881729C/en active Active
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2015
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Also Published As
| Publication number | Publication date |
|---|---|
| US20150216987A1 (en) | 2015-08-06 |
| CN104717962B (zh) | 2017-07-21 |
| WO2014053542A1 (en) | 2014-04-10 |
| JP6330815B2 (ja) | 2018-05-30 |
| JP2015534557A (ja) | 2015-12-03 |
| CA2881729A1 (en) | 2014-04-10 |
| IN2015DN01153A (OSRAM) | 2015-06-26 |
| CN104717962A (zh) | 2015-06-17 |
| EP2903592B1 (en) | 2019-01-23 |
| EP2903592A1 (en) | 2015-08-12 |
| US9789189B2 (en) | 2017-10-17 |
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Effective date: 20180925 |