CA2872482C - Cell wall protein cwpv (cd0514) as a diagnostic marker for clostridium difficile ribotype 027 - Google Patents

Cell wall protein cwpv (cd0514) as a diagnostic marker for clostridium difficile ribotype 027 Download PDF

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Publication number
CA2872482C
CA2872482C CA2872482A CA2872482A CA2872482C CA 2872482 C CA2872482 C CA 2872482C CA 2872482 A CA2872482 A CA 2872482A CA 2872482 A CA2872482 A CA 2872482A CA 2872482 C CA2872482 C CA 2872482C
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Canada
Prior art keywords
cwpv
ribotype
difficile
antibodies
determining
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CA2872482A
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English (en)
French (fr)
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CA2872482A1 (en
Inventor
Manli Y. Davis
Krista A. Williams
Jocelyn N. Browning
David M. Lyerly
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Techlab Inc
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Techlab Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/33—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Clostridium (G)

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2872482A 2012-05-11 2013-05-09 Cell wall protein cwpv (cd0514) as a diagnostic marker for clostridium difficile ribotype 027 Active CA2872482C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261645964P 2012-05-11 2012-05-11
US61/645,964 2012-05-11
US13/889,670 US9133527B2 (en) 2012-05-11 2013-05-08 Cell wall protein CwpV (CD0514) as a diagnostic marker for Clostridium difficile ribotype 027
US13/889,670 2013-05-08
PCT/US2013/040399 WO2013170065A1 (en) 2012-05-11 2013-05-09 Cell wall protein cwpv (cd0514) as a diagnostic marker for clostridium difficile ribotype 027

Publications (2)

Publication Number Publication Date
CA2872482A1 CA2872482A1 (en) 2013-11-14
CA2872482C true CA2872482C (en) 2017-10-31

Family

ID=49548891

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2872482A Active CA2872482C (en) 2012-05-11 2013-05-09 Cell wall protein cwpv (cd0514) as a diagnostic marker for clostridium difficile ribotype 027

Country Status (8)

Country Link
US (1) US9133527B2 (https=)
EP (1) EP2847590B1 (https=)
JP (1) JP6165238B2 (https=)
AU (1) AU2013259381B2 (https=)
CA (1) CA2872482C (https=)
ES (1) ES2628334T3 (https=)
NZ (1) NZ702383A (https=)
WO (1) WO2013170065A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI126289B (en) 2014-12-19 2016-09-15 Mobidiag Ltd Method for detecting the presence of a hypervirulent strain of Clostridium difficile
CN106814189B (zh) * 2016-12-20 2018-10-26 成都金思唯生物技术有限公司 一种检测艰难梭菌的试剂盒及其用途
US20190211377A1 (en) * 2016-12-22 2019-07-11 Roche Molecular Systems, Inc. Cobra probes to detect a marker for epidemic ribotypes of clostridium difficile

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965375A (en) * 1997-04-04 1999-10-12 Biosite Diagnostics Diagnostic tests and kits for Clostridium difficile
JP5308029B2 (ja) * 2004-11-24 2013-10-09 テクラブ インコーポレイテッド 分析物を検出するための装置および方法
WO2009108652A1 (en) * 2008-02-28 2009-09-03 3M Innovative Properties Company Antibodies to clostridium difficile spores and uses thereof
DE602008002334D1 (de) * 2008-09-16 2010-10-07 Oesterreichische Agentur Fuer PCR-Ribotyping
BRPI1006757A2 (pt) * 2009-04-07 2020-03-10 Koninklijke Philips Electronics N. V. Método para detecção e caracterização de uma cepa de clostridium difficile toxinogênica em uma amostra, cartucho de amplificação de sistema fechado, e kit para execução dos métodos
US8889363B2 (en) 2009-07-27 2014-11-18 Biodics Method for the detection and identification of a variant C. difficile strain in a sample
CA2768528C (en) * 2009-07-27 2017-05-23 Christoph Von Eichel-Streiber Method for detecting and identifying a variant c. difficile strain in a sample
US20120276060A1 (en) 2011-04-29 2012-11-01 Techlab, Inc. Fecal lactoferrin as a biomarker for determining disease severity and for treating infection in patients with clostridium difficile disease
US8790880B2 (en) 2011-09-26 2014-07-29 Techlab, Inc. Cysteine protease Cwp84 (CD2787) as a diagnostic marker for Clostridium difficile

Also Published As

Publication number Publication date
US9133527B2 (en) 2015-09-15
JP6165238B2 (ja) 2017-07-19
EP2847590A4 (en) 2015-11-25
EP2847590B1 (en) 2017-04-05
AU2013259381B2 (en) 2018-08-16
WO2013170065A1 (en) 2013-11-14
EP2847590A1 (en) 2015-03-18
ES2628334T3 (es) 2017-08-02
CA2872482A1 (en) 2013-11-14
JP2015517658A (ja) 2015-06-22
US20130302813A1 (en) 2013-11-14
NZ702383A (en) 2016-12-23
AU2013259381A1 (en) 2014-12-04

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