CA2868629A1 - Combination therapy for the treatment of cancer - Google Patents
Combination therapy for the treatment of cancer Download PDFInfo
- Publication number
- CA2868629A1 CA2868629A1 CA2868629A CA2868629A CA2868629A1 CA 2868629 A1 CA2868629 A1 CA 2868629A1 CA 2868629 A CA2868629 A CA 2868629A CA 2868629 A CA2868629 A CA 2868629A CA 2868629 A1 CA2868629 A1 CA 2868629A1
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- Prior art keywords
- thioridazine
- cytarabine
- subject
- cell
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261616658P | 2012-03-28 | 2012-03-28 | |
| US61/616,658 | 2012-03-28 | ||
| US13/837,115 | 2013-03-15 | ||
| US13/837,115 US8809299B2 (en) | 2012-03-28 | 2013-03-15 | Combination therapy for the treatment of cancer |
| PCT/CA2013/050255 WO2013143000A1 (en) | 2012-03-28 | 2013-03-28 | Combination therapy for the treatment of cancer |
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| CA2868629A1 true CA2868629A1 (en) | 2013-10-03 |
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| CA2868629A Abandoned CA2868629A1 (en) | 2012-03-28 | 2013-03-28 | Combination therapy for the treatment of cancer |
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| EP (1) | EP2830633A4 (enExample) |
| JP (1) | JP2015516378A (enExample) |
| CA (1) | CA2868629A1 (enExample) |
| WO (1) | WO2013143000A1 (enExample) |
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| AU2012222812A1 (en) * | 2011-02-28 | 2013-05-02 | Mcmaster University | Treatment of cancer with dopamine receptor antagonists |
| US8809299B2 (en) | 2012-03-28 | 2014-08-19 | Mcmaster University | Combination therapy for the treatment of cancer |
| WO2015080681A1 (en) * | 2013-11-29 | 2015-06-04 | Andac Ahmet Cenk | Phenothiazine-pyrimidine-2,4(1 h, 3h)-dione compounds for the treatment of cancer |
| EP2932969A1 (en) | 2014-04-17 | 2015-10-21 | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts | Pancreatic cancer therapy and diagnosis |
| US10874685B2 (en) | 2014-04-17 | 2020-12-29 | The Royal Institution For The Advancement Of Learning/Mcgill University | Pancreatic cancer therapy and diagnosis |
| EP3148547B1 (en) * | 2014-06-02 | 2024-01-03 | National Yang-Ming University | Method for treating drug resistant cancer |
| US20170152569A1 (en) * | 2014-06-19 | 2017-06-01 | Hidenseq | Polymorphism in the bcl2 gene determines response to chemotherapy |
| WO2018022823A1 (en) * | 2016-07-28 | 2018-02-01 | Asieris Pharmaceutical Technologies Co., Ltd. | Uses of dopamine beta-hydroxylase (dbh) inhibitors and serotonin receptor (5-ht) antagonists for the treatment of cancer |
| CN110507653B (zh) * | 2019-08-02 | 2022-12-02 | 北京赛而生物药业有限公司 | 多潘立酮及其与紫杉醇联用在制备治疗癌症的药物中的应用 |
| US11993775B2 (en) * | 2020-07-27 | 2024-05-28 | National Cheng Kung University | Ubiquitin-specific peptidase 24 inhibitor, medicinal composition and method of delaying or reversing multidrug resistance in cancers using the same |
| US11827611B2 (en) | 2020-07-27 | 2023-11-28 | National Cheng Kung University | Ubiquitin-specific peptidase 24 inhibitor, medicinal composition including the same and method of delaying or reversing multidrug resistance in cancers using the same |
| KR102315103B1 (ko) * | 2021-01-21 | 2021-10-20 | 주식회사 뉴캔서큐어바이오 | 티오리다진 및 퍼헥실린을 유효성분으로 포함하는 암 예방 또는 치료용 약학적 조성물 |
| CN114031574A (zh) * | 2021-11-08 | 2022-02-11 | 复旦大学附属肿瘤医院 | 哌罗匹隆及其衍生物在制备抗肿瘤药物中的应用 |
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| US20040072824A1 (en) | 2001-06-01 | 2004-04-15 | Adam Telerman | Methods and compositions for the treatment of cancer |
| HRP20050115A2 (en) * | 2002-07-11 | 2005-10-31 | Combinatorx | Combinations of drugs for the treatment of neoplasms |
| AU2004273910A1 (en) * | 2003-09-18 | 2005-03-31 | Combinatorx, Incorporated | Combinations of drugs for the treatment of neoplasms |
| US20050158320A1 (en) * | 2003-11-12 | 2005-07-21 | Nichols M. J. | Combinations for the treatment of proliferative diseases |
| WO2009148623A2 (en) | 2008-06-05 | 2009-12-10 | Stc.Unm | Methods and related compositions for the treatment of cancer |
| AU2012222812A1 (en) * | 2011-02-28 | 2013-05-02 | Mcmaster University | Treatment of cancer with dopamine receptor antagonists |
| US8809299B2 (en) | 2012-03-28 | 2014-08-19 | Mcmaster University | Combination therapy for the treatment of cancer |
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2013
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- 2013-03-28 EP EP13769023.6A patent/EP2830633A4/en not_active Withdrawn
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2014
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2016
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| US20130261074A1 (en) | 2013-10-03 |
| US8809299B2 (en) | 2014-08-19 |
| US9486471B2 (en) | 2016-11-08 |
| US20170071971A1 (en) | 2017-03-16 |
| JP2015516378A (ja) | 2015-06-11 |
| EP2830633A1 (en) | 2015-02-04 |
| WO2013143000A1 (en) | 2013-10-03 |
| EP2830633A4 (en) | 2015-08-26 |
| US20150038450A1 (en) | 2015-02-05 |
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