CA2859865A1 - Identification d'arnmi specifiques a des metastases et signatures d'hypomethylation dans le cancer colorectal humain - Google Patents

Identification d'arnmi specifiques a des metastases et signatures d'hypomethylation dans le cancer colorectal humain Download PDF

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Publication number
CA2859865A1
CA2859865A1 CA2859865A CA2859865A CA2859865A1 CA 2859865 A1 CA2859865 A1 CA 2859865A1 CA 2859865 A CA2859865 A CA 2859865A CA 2859865 A CA2859865 A CA 2859865A CA 2859865 A1 CA2859865 A1 CA 2859865A1
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CA
Canada
Prior art keywords
mir
expression
colorectal cancer
level
metastasis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2859865A
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English (en)
Inventor
Ajay Goel
Richard C. Boland
Keun Hur
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baylor Research Institute
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Baylor Research Institute
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Publication date
Application filed by Baylor Research Institute filed Critical Baylor Research Institute
Publication of CA2859865A1 publication Critical patent/CA2859865A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention concerne des procédés et des biomarqueurs destinés au diagnostic ou à la détection de métastases du cancer colorectal chez un sujet humain en comparant le niveau de méthylation de la répétition Alu dans un échantillon biologique à un niveau témoin de méthylation de la répétition Alu provenant d'un échantillon normal non cancéreux d'un sujet humain, une diminution du niveau de méthylation de la répétition Alu étant indicatrice de cancer colorectal et de métastases du cancer colorectal. L'invention inclut également des procédés et des biomarqueurs destinés au diagnostic ou à la détection de métastases du cancer colorectal (CCR) chez un sujet humain par la détermination d'un niveau d'expression de let-7i, miR-10b, miR-320a et miR-221 dans l'échantillon provenant d'un ou de plusieurs échantillons biologiques et par la comparaison du niveau d'expression de let-7i, miR-10b, miR-320a et miR-221 dans l'échantillon au niveau d'expression de let-7i, miR-10b, miR-320a et miR-221 provenant d'un tissu colorectal normal ; l'expression élevée d'au moins un parmi let-7i ou miR-320a est indicatrice d'un bon pronostic concernant le CCR, alors que la faible expression d'au moins un parmi miR-10b ou miR-221 est indicatrice d'un bon pronostic concernant le CCR ou des métastases de CCR.
CA2859865A 2011-12-22 2012-12-21 Identification d'arnmi specifiques a des metastases et signatures d'hypomethylation dans le cancer colorectal humain Abandoned CA2859865A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161579361P 2011-12-22 2011-12-22
US61/579,361 2011-12-22
US201213725402A 2012-12-21 2012-12-21
US13/725,402 2012-12-21
PCT/US2012/071455 WO2013096888A1 (fr) 2011-12-22 2012-12-21 Identification d'arnmi spécifiques à des métastases et signatures d'hypométhylation dans le cancer colorectal humain

Publications (1)

Publication Number Publication Date
CA2859865A1 true CA2859865A1 (fr) 2013-06-27

Family

ID=48669578

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2859865A Abandoned CA2859865A1 (fr) 2011-12-22 2012-12-21 Identification d'arnmi specifiques a des metastases et signatures d'hypomethylation dans le cancer colorectal humain

Country Status (3)

Country Link
AU (1) AU2012358200B2 (fr)
CA (1) CA2859865A1 (fr)
WO (1) WO2013096888A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103616518B (zh) * 2013-11-25 2016-03-02 赵海涛 一种miRNA分子作为肝癌预后的生物标记物的用途
EP3108012A4 (fr) 2014-02-18 2017-10-11 Baylor Research Institute Mir-320e et cancer colorectal

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2268832A2 (fr) * 2008-03-06 2011-01-05 Asuragen, INC. Marqueurs microrna pour la récurrence d un cancer colorectal
US20110183859A1 (en) 2008-09-25 2011-07-28 The United States Of America, As Represented By The Secretary, Inflammatory genes and microrna-21 as biomarkers for colon cancer prognosis
EP2196542A1 (fr) * 2008-12-15 2010-06-16 Koninklijke Philips Electronics N.V. Compositions et méthodes pour l'établissement de profils d'expression de micro-ADN dans le cancer colorectale
US20130137593A1 (en) * 2010-04-15 2013-05-30 Hadasit Medical Research Services And Development Ltd. Early detection and staging of colorectal cancer using a panel of micro rnas

Also Published As

Publication number Publication date
AU2012358200A1 (en) 2014-08-07
WO2013096888A1 (fr) 2013-06-27
AU2012358200B2 (en) 2018-08-30

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20171213

FZDE Discontinued

Effective date: 20220201