CA2792471A1 - Cellular blood markers for early diagnosis of als and for als progression - Google Patents
Cellular blood markers for early diagnosis of als and for als progression Download PDFInfo
- Publication number
- CA2792471A1 CA2792471A1 CA2792471A CA2792471A CA2792471A1 CA 2792471 A1 CA2792471 A1 CA 2792471A1 CA 2792471 A CA2792471 A CA 2792471A CA 2792471 A CA2792471 A CA 2792471A CA 2792471 A1 CA2792471 A1 CA 2792471A1
- Authority
- CA
- Canada
- Prior art keywords
- cells
- level
- als
- cd11b
- lin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 210000004369 blood Anatomy 0.000 title claims abstract description 70
- 239000008280 blood Substances 0.000 title claims abstract description 70
- 230000001413 cellular effect Effects 0.000 title abstract description 4
- 238000013399 early diagnosis Methods 0.000 title abstract description 4
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims abstract description 176
- 238000000034 method Methods 0.000 claims abstract description 53
- 238000011282 treatment Methods 0.000 claims abstract description 42
- 210000004027 cell Anatomy 0.000 claims description 219
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 67
- 210000004985 myeloid-derived suppressor cell Anatomy 0.000 claims description 61
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims description 41
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims description 41
- 210000005259 peripheral blood Anatomy 0.000 claims description 29
- 239000011886 peripheral blood Substances 0.000 claims description 29
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims description 24
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims description 24
- 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 claims description 21
- 102100022338 Integrin alpha-M Human genes 0.000 claims description 21
- 230000000770 proinflammatory effect Effects 0.000 claims description 19
- 238000012360 testing method Methods 0.000 claims description 18
- 210000003289 regulatory T cell Anatomy 0.000 claims description 16
- 230000004075 alteration Effects 0.000 claims description 14
- 210000002074 inflammatory monocyte Anatomy 0.000 claims description 14
- 210000000066 myeloid cell Anatomy 0.000 claims description 14
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims description 13
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims description 13
- 210000000822 natural killer cell Anatomy 0.000 claims description 13
- 230000008859 change Effects 0.000 claims description 12
- 239000003795 chemical substances by application Substances 0.000 claims description 12
- 210000000278 spinal cord Anatomy 0.000 claims description 12
- 102100035248 Alpha-(1,3)-fucosyltransferase 4 Human genes 0.000 claims description 11
- 101001022185 Homo sapiens Alpha-(1,3)-fucosyltransferase 4 Proteins 0.000 claims description 11
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims description 11
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims description 11
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 claims description 11
- 102000000018 Chemokine CCL2 Human genes 0.000 claims description 9
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims description 9
- 108700013048 CCL2 Proteins 0.000 claims description 6
- 108010072051 Glatiramer Acetate Proteins 0.000 claims description 6
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims description 6
- 239000003153 chemical reaction reagent Substances 0.000 claims description 5
- 230000001939 inductive effect Effects 0.000 claims description 5
- 102100022749 Aminopeptidase N Human genes 0.000 claims description 4
- 101000757160 Homo sapiens Aminopeptidase N Proteins 0.000 claims description 4
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims description 4
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims description 4
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims description 4
- 102100026236 Interleukin-8 Human genes 0.000 claims description 4
- BNRNXUUZRGQAQC-UHFFFAOYSA-N sildenafil Chemical compound CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 BNRNXUUZRGQAQC-UHFFFAOYSA-N 0.000 claims description 4
- 101001055222 Homo sapiens Interleukin-8 Proteins 0.000 claims description 3
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims description 3
- 108090001007 Interleukin-8 Proteins 0.000 claims description 3
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims description 3
- FHEAIOHRHQGZPC-KIWGSFCNSA-N acetic acid;(2s)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2s)-2-aminopentanedioic acid;(2s)-2-aminopropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound CC(O)=O.C[C@H](N)C(O)=O.NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CCC(O)=O.OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 FHEAIOHRHQGZPC-KIWGSFCNSA-N 0.000 claims description 3
- 230000003190 augmentative effect Effects 0.000 claims description 3
- 229940038717 copaxone Drugs 0.000 claims description 3
- 230000002596 correlated effect Effects 0.000 claims description 3
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims description 3
- 229960005277 gemcitabine Drugs 0.000 claims description 3
- 229960003776 glatiramer acetate Drugs 0.000 claims description 3
- 230000005012 migration Effects 0.000 claims description 3
- 238000013508 migration Methods 0.000 claims description 3
- 230000000638 stimulation Effects 0.000 claims description 3
- SECKRCOLJRRGGV-UHFFFAOYSA-N Vardenafil Chemical compound CCCC1=NC(C)=C(C(N=2)=O)N1NC=2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(CC)CC1 SECKRCOLJRRGGV-UHFFFAOYSA-N 0.000 claims description 2
- 229960003310 sildenafil Drugs 0.000 claims description 2
- 229960000835 tadalafil Drugs 0.000 claims description 2
- IEHKWSGCTWLXFU-IIBYNOLFSA-N tadalafil Chemical compound C1=C2OCOC2=CC([C@@H]2C3=C([C]4C=CC=CC4=N3)C[C@H]3N2C(=O)CN(C3=O)C)=C1 IEHKWSGCTWLXFU-IIBYNOLFSA-N 0.000 claims description 2
- 229960002381 vardenafil Drugs 0.000 claims description 2
- 238000012544 monitoring process Methods 0.000 abstract description 4
- 206010028980 Neoplasm Diseases 0.000 description 35
- 210000003169 central nervous system Anatomy 0.000 description 24
- 210000000274 microglia Anatomy 0.000 description 24
- 241000699670 Mus sp. Species 0.000 description 22
- 210000001616 monocyte Anatomy 0.000 description 22
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 20
- 210000002161 motor neuron Anatomy 0.000 description 20
- 201000010099 disease Diseases 0.000 description 19
- 201000011510 cancer Diseases 0.000 description 18
- 230000006378 damage Effects 0.000 description 18
- 206010061218 Inflammation Diseases 0.000 description 14
- 230000004054 inflammatory process Effects 0.000 description 13
- 230000004770 neurodegeneration Effects 0.000 description 13
- 210000004475 gamma-delta t lymphocyte Anatomy 0.000 description 12
- 210000001519 tissue Anatomy 0.000 description 12
- 102000006354 HLA-DR Antigens Human genes 0.000 description 11
- 108010058597 HLA-DR Antigens Proteins 0.000 description 11
- 230000005965 immune activity Effects 0.000 description 11
- 210000000987 immune system Anatomy 0.000 description 11
- 208000024827 Alzheimer disease Diseases 0.000 description 10
- 108091008874 T cell receptors Proteins 0.000 description 10
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 10
- 230000028993 immune response Effects 0.000 description 10
- 210000004479 myeloid suppressor cell Anatomy 0.000 description 10
- 208000015122 neurodegenerative disease Diseases 0.000 description 10
- 239000000427 antigen Substances 0.000 description 9
- 210000001185 bone marrow Anatomy 0.000 description 9
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 9
- 108010012715 Superoxide dismutase Proteins 0.000 description 8
- 210000004556 brain Anatomy 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 102000019197 Superoxide Dismutase Human genes 0.000 description 7
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 description 7
- 230000007246 mechanism Effects 0.000 description 7
- 238000001565 modulated differential scanning calorimetry Methods 0.000 description 7
- 208000024891 symptom Diseases 0.000 description 7
- 206010061818 Disease progression Diseases 0.000 description 6
- 238000000692 Student's t-test Methods 0.000 description 6
- 210000000612 antigen-presenting cell Anatomy 0.000 description 6
- 230000007812 deficiency Effects 0.000 description 6
- 210000004443 dendritic cell Anatomy 0.000 description 6
- 230000005750 disease progression Effects 0.000 description 6
- 238000001943 fluorescence-activated cell sorting Methods 0.000 description 6
- 210000002865 immune cell Anatomy 0.000 description 6
- 208000014674 injury Diseases 0.000 description 6
- 210000002540 macrophage Anatomy 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 231100000331 toxic Toxicity 0.000 description 6
- 230000002588 toxic effect Effects 0.000 description 6
- 208000027418 Wounds and injury Diseases 0.000 description 5
- 230000004913 activation Effects 0.000 description 5
- 108091007433 antigens Proteins 0.000 description 5
- 102000036639 antigens Human genes 0.000 description 5
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 5
- 230000003247 decreasing effect Effects 0.000 description 5
- 230000008030 elimination Effects 0.000 description 5
- 238000003379 elimination reaction Methods 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 230000013632 homeostatic process Effects 0.000 description 5
- 230000036039 immunity Effects 0.000 description 5
- 230000001506 immunosuppresive effect Effects 0.000 description 5
- 210000002569 neuron Anatomy 0.000 description 5
- 230000002093 peripheral effect Effects 0.000 description 5
- 230000004083 survival effect Effects 0.000 description 5
- 230000009885 systemic effect Effects 0.000 description 5
- 230000005867 T cell response Effects 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- -1 e.g. Proteins 0.000 description 4
- 230000037451 immune surveillance Effects 0.000 description 4
- 230000008595 infiltration Effects 0.000 description 4
- 238000001764 infiltration Methods 0.000 description 4
- 230000002757 inflammatory effect Effects 0.000 description 4
- 238000010172 mouse model Methods 0.000 description 4
- 210000004498 neuroglial cell Anatomy 0.000 description 4
- 231100000189 neurotoxic Toxicity 0.000 description 4
- 230000002887 neurotoxic effect Effects 0.000 description 4
- 230000007115 recruitment Effects 0.000 description 4
- 210000000130 stem cell Anatomy 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 102000004452 Arginase Human genes 0.000 description 3
- 108700024123 Arginases Proteins 0.000 description 3
- 206010062016 Immunosuppression Diseases 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 208000006265 Renal cell carcinoma Diseases 0.000 description 3
- 108010021188 Superoxide Dismutase-1 Proteins 0.000 description 3
- 102000008221 Superoxide Dismutase-1 Human genes 0.000 description 3
- 230000001154 acute effect Effects 0.000 description 3
- 230000033289 adaptive immune response Effects 0.000 description 3
- 230000001684 chronic effect Effects 0.000 description 3
- 230000034994 death Effects 0.000 description 3
- 230000001627 detrimental effect Effects 0.000 description 3
- 208000019995 familial amyotrophic lateral sclerosis Diseases 0.000 description 3
- 230000014509 gene expression Effects 0.000 description 3
- 230000007365 immunoregulation Effects 0.000 description 3
- 230000000977 initiatory effect Effects 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 201000006417 multiple sclerosis Diseases 0.000 description 3
- 230000035772 mutation Effects 0.000 description 3
- 230000007170 pathology Effects 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 230000008439 repair process Effects 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 208000023275 Autoimmune disease Diseases 0.000 description 2
- 102000004219 Brain-derived neurotrophic factor Human genes 0.000 description 2
- 108090000715 Brain-derived neurotrophic factor Proteins 0.000 description 2
- 101710155857 C-C motif chemokine 2 Proteins 0.000 description 2
- 102000019034 Chemokines Human genes 0.000 description 2
- 108010012236 Chemokines Proteins 0.000 description 2
- 102000005598 Chondroitin Sulfate Proteoglycans Human genes 0.000 description 2
- 108010059480 Chondroitin Sulfate Proteoglycans Proteins 0.000 description 2
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 2
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 description 2
- 102000004890 Interleukin-8 Human genes 0.000 description 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 2
- 206010050513 Metastatic renal cell carcinoma Diseases 0.000 description 2
- 206010056677 Nerve degeneration Diseases 0.000 description 2
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 2
- 208000018737 Parkinson disease Diseases 0.000 description 2
- 101000702641 Picea abies Superoxide dismutase [Cu-Zn], chloroplastic Proteins 0.000 description 2
- 108010067787 Proteoglycans Proteins 0.000 description 2
- 102000016611 Proteoglycans Human genes 0.000 description 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 2
- 102100040247 Tumor necrosis factor Human genes 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 229940124599 anti-inflammatory drug Drugs 0.000 description 2
- 230000000259 anti-tumor effect Effects 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000005784 autoimmunity Effects 0.000 description 2
- 238000010322 bone marrow transplantation Methods 0.000 description 2
- 229940077737 brain-derived neurotrophic factor Drugs 0.000 description 2
- 208000037976 chronic inflammation Diseases 0.000 description 2
- 230000006020 chronic inflammation Effects 0.000 description 2
- 231100000433 cytotoxic Toxicity 0.000 description 2
- 230000001472 cytotoxic effect Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 230000007123 defense Effects 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 239000002158 endotoxin Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000002518 glial effect Effects 0.000 description 2
- 229930195712 glutamate Natural products 0.000 description 2
- 210000003714 granulocyte Anatomy 0.000 description 2
- 239000003102 growth factor Substances 0.000 description 2
- 230000001900 immune effect Effects 0.000 description 2
- 230000008629 immune suppression Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 229920006008 lipopolysaccharide Polymers 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- DYKFCLLONBREIL-KVUCHLLUSA-N minocycline Chemical compound C([C@H]1C2)C3=C(N(C)C)C=CC(O)=C3C(=O)C1=C(O)[C@@]1(O)[C@@H]2[C@H](N(C)C)C(O)=C(C(N)=O)C1=O DYKFCLLONBREIL-KVUCHLLUSA-N 0.000 description 2
- 229960004023 minocycline Drugs 0.000 description 2
- 210000005087 mononuclear cell Anatomy 0.000 description 2
- 230000004693 neuron damage Effects 0.000 description 2
- 230000002981 neuropathic effect Effects 0.000 description 2
- 230000004112 neuroprotection Effects 0.000 description 2
- 230000000324 neuroprotective effect Effects 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 230000000750 progressive effect Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 102000005962 receptors Human genes 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 208000020431 spinal cord injury Diseases 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000011830 transgenic mouse model Methods 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- 230000000472 traumatic effect Effects 0.000 description 2
- 230000005748 tumor development Effects 0.000 description 2
- PLRACCBDVIHHLZ-UHFFFAOYSA-N 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Chemical compound C1N(C)CCC(C=2C=CC=CC=2)=C1 PLRACCBDVIHHLZ-UHFFFAOYSA-N 0.000 description 1
- 102000006306 Antigen Receptors Human genes 0.000 description 1
- 108010083359 Antigen Receptors Proteins 0.000 description 1
- 108091008875 B cell receptors Proteins 0.000 description 1
- 102000019260 B-Cell Antigen Receptors Human genes 0.000 description 1
- 108010012919 B-Cell Antigen Receptors Proteins 0.000 description 1
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 description 1
- 210000001266 CD8-positive T-lymphocyte Anatomy 0.000 description 1
- 229920001287 Chondroitin sulfate Polymers 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 206010018338 Glioma Diseases 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 description 1
- 101000934372 Homo sapiens Macrosialin Proteins 0.000 description 1
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 description 1
- 102100037852 Insulin-like growth factor I Human genes 0.000 description 1
- 108010002352 Interleukin-1 Proteins 0.000 description 1
- 102100025136 Macrosialin Human genes 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699660 Mus musculus Species 0.000 description 1
- 206010061309 Neoplasm progression Diseases 0.000 description 1
- 208000036110 Neuroinflammatory disease Diseases 0.000 description 1
- 206010029350 Neurotoxicity Diseases 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 208000007400 Relapsing-Remitting Multiple Sclerosis Diseases 0.000 description 1
- 108700013394 SOD1 G93A Proteins 0.000 description 1
- 238000011831 SOD1-G93A transgenic mouse Methods 0.000 description 1
- 230000006052 T cell proliferation Effects 0.000 description 1
- 230000006043 T cell recruitment Effects 0.000 description 1
- 102100024219 T-cell surface glycoprotein CD1a Human genes 0.000 description 1
- 102100039360 Toll-like receptor 4 Human genes 0.000 description 1
- 206010044221 Toxic encephalopathy Diseases 0.000 description 1
- 102100027654 Transcription factor PU.1 Human genes 0.000 description 1
- 108700019146 Transgenes Proteins 0.000 description 1
- 102100023935 Transmembrane glycoprotein NMB Human genes 0.000 description 1
- 102000011016 Type 5 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 description 1
- 108010037581 Type 5 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 description 1
- 241001024096 Uleiota Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000002679 ablation Methods 0.000 description 1
- 230000003044 adaptive effect Effects 0.000 description 1
- 210000005006 adaptive immune system Anatomy 0.000 description 1
- 230000004721 adaptive immunity Effects 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 238000011861 anti-inflammatory therapy Methods 0.000 description 1
- 230000005809 anti-tumor immunity Effects 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000002798 bone marrow cell Anatomy 0.000 description 1
- 210000000133 brain stem Anatomy 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 230000004186 co-expression Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 210000004395 cytoplasmic granule Anatomy 0.000 description 1
- 231100000050 cytotoxic potential Toxicity 0.000 description 1
- 230000008260 defense mechanism Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 210000005064 dopaminergic neuron Anatomy 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 210000003162 effector t lymphocyte Anatomy 0.000 description 1
- 230000005713 exacerbation Effects 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 238000000684 flow cytometry Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 208000029824 high grade glioma Diseases 0.000 description 1
- 210000003630 histaminocyte Anatomy 0.000 description 1
- 230000003284 homeostatic effect Effects 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 208000026278 immune system disease Diseases 0.000 description 1
- 238000009169 immunotherapy Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 230000015788 innate immune response Effects 0.000 description 1
- 210000005007 innate immune system Anatomy 0.000 description 1
- 238000011813 knockout mouse model Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 210000003563 lymphoid tissue Anatomy 0.000 description 1
- 230000007257 malfunction Effects 0.000 description 1
- 201000011614 malignant glioma Diseases 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000006724 microglial activation Effects 0.000 description 1
- 230000002025 microglial effect Effects 0.000 description 1
- 230000037023 motor activity Effects 0.000 description 1
- 210000000337 motor cortex Anatomy 0.000 description 1
- 210000003643 myeloid progenitor cell Anatomy 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 230000012177 negative regulation of immune response Effects 0.000 description 1
- 210000001178 neural stem cell Anatomy 0.000 description 1
- 230000004766 neurogenesis Effects 0.000 description 1
- 230000003959 neuroinflammation Effects 0.000 description 1
- 230000002232 neuromuscular Effects 0.000 description 1
- 230000016273 neuron death Effects 0.000 description 1
- 230000006576 neuronal survival Effects 0.000 description 1
- 231100000228 neurotoxicity Toxicity 0.000 description 1
- 230000007135 neurotoxicity Effects 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000008289 pathophysiological mechanism Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 231100000683 possible toxicity Toxicity 0.000 description 1
- 238000011886 postmortem examination Methods 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 108010008929 proto-oncogene protein Spi-1 Proteins 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
- 239000003642 reactive oxygen metabolite Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000003716 rejuvenation Effects 0.000 description 1
- 230000008458 response to injury Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000007507 senile plaque formation Effects 0.000 description 1
- 208000022288 senile plaque formation Diseases 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000003393 splenic effect Effects 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 229940021747 therapeutic vaccine Drugs 0.000 description 1
- 230000002992 thymic effect Effects 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 108091007466 transmembrane glycoproteins Proteins 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 230000005851 tumor immunogenicity Effects 0.000 description 1
- 230000005751 tumor progression Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70546—Integrin superfamily, e.g. VLAs, leuCAM, GPIIb/GPIIIa, LPAM
- G01N2333/70553—Integrin beta2-subunit-containing molecules, e.g. CD11, CD18
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Virology (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Gastroenterology & Hepatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Developmental Biology & Embryology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31233510P | 2010-03-10 | 2010-03-10 | |
| US61/312,335 | 2010-03-10 | ||
| PCT/IL2011/000227 WO2011111043A1 (en) | 2010-03-10 | 2011-03-10 | Cellular blood markers for early diagnosis of als and for als progression |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2792471A1 true CA2792471A1 (en) | 2011-09-15 |
Family
ID=43971347
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2792471A Abandoned CA2792471A1 (en) | 2010-03-10 | 2011-03-10 | Cellular blood markers for early diagnosis of als and for als progression |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20130230499A1 (enExample) |
| EP (1) | EP2545381A1 (enExample) |
| JP (1) | JP5904953B2 (enExample) |
| CA (1) | CA2792471A1 (enExample) |
| WO (1) | WO2011111043A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2819174T3 (es) * | 2012-03-26 | 2021-04-15 | Yeda Res & Dev | Marcadores celulares para el diagnóstico de la enfermedad de Alzheimer y para la progresión de la enfermedad de Alzheimer |
| EP3645040A4 (en) | 2017-06-27 | 2021-05-05 | Neuracle Science Co., Ltd | USE OF ANTI-FAM19A5 ANTIBODIES FOR THE TREATMENT OF CANCERS |
| WO2019217916A1 (en) * | 2018-05-10 | 2019-11-14 | The Methodist Hospital | Methods for prognosis and management of disease |
| DE102019121344A1 (de) * | 2019-08-07 | 2021-02-11 | ToposNomos Ltd. | Verfahren und Durchflusszytometer zum Untersuchen einer menschlichen oder tierischen Zellprobe sowie Computerprogrammprodukt |
| CN118541152A (zh) * | 2021-11-02 | 2024-08-23 | 特朗奎斯治疗股份有限公司 | 具有循环髓样细胞炎性表型的受试者的选择和治疗 |
| WO2025058005A1 (ja) * | 2023-09-15 | 2025-03-20 | 国立大学法人徳島大学 | 筋萎縮性側索硬化症（ａｌｓ）と関連するバイオマーカー |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5426028A (en) * | 1991-07-05 | 1995-06-20 | Rush-Presbyterian-St. Lukes Medical Center | Screening method for chronic immune dysfunction syndrome |
| US7410773B2 (en) * | 1995-02-02 | 2008-08-12 | Ghazi Jaswinder Dhoot | Method of preparing an undifferentiated cell |
| DK1248643T3 (da) * | 2000-01-20 | 2005-11-07 | Yeda Res & Dev | Anvendelse af copolymer 1 og beslægtede peptider og polypeptider og T-celler behandlet dermed til neurobeskyttende terapi |
| US20020081635A1 (en) * | 2000-05-11 | 2002-06-27 | Thomas Terry E. | Novel antibody compositions for preparing enriched T cell preparations |
| US20020155511A1 (en) * | 2000-09-08 | 2002-10-24 | Carolyn Horrocks | Novel antibody compositions for the negative selection of specific rat leukocyte subsets |
| US20030077576A1 (en) * | 2001-03-20 | 2003-04-24 | Joann Trial | Use of monoclonal antibodies and functional assays for prediction of risk of opportunistic infection |
| US7273888B2 (en) * | 2001-11-16 | 2007-09-25 | Als Therapy Development Foundation, Inc. | Use of difluoromethylornithine (DFMO) for the treatment of amyotrophic lateral sclerosis |
| US7105183B2 (en) * | 2004-02-03 | 2006-09-12 | The Regents Of The University Of California | Chlorite in the treatment of neurodegenerative disease |
| BRPI0616561A2 (pt) * | 2005-09-12 | 2012-12-25 | Council Scient Ind Res | utilizaÇço dos derivados do composto de bipiridina "caerulomicina a" e seus equivalentes como agentes imunossupressores |
| KR20070113088A (ko) * | 2006-05-24 | 2007-11-28 | 코아스템(주) | 운동신경원질환 치료용 조성물 및 그 치료방법 |
| US20120269774A1 (en) * | 2006-09-21 | 2012-10-25 | Medistem Laboratories, Inc | Allogeneic stem cell transplants in non-conditioned recipients |
| EP2073009A1 (en) * | 2007-12-19 | 2009-06-24 | Cell Med Research GMBH | Method for T, NK and NKT cells |
| US10114012B2 (en) * | 2008-10-31 | 2018-10-30 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and assays for detecting and quantifying pure subpopulations of white blood cells in immune system disorders |
| EP2416791A1 (en) * | 2009-01-28 | 2012-02-15 | Istituto Oncologico Veneto | Myeloid-derived suppressor cells generated in vitro |
-
2011
- 2011-03-10 CA CA2792471A patent/CA2792471A1/en not_active Abandoned
- 2011-03-10 JP JP2012556645A patent/JP5904953B2/ja not_active Expired - Fee Related
- 2011-03-10 EP EP11714845A patent/EP2545381A1/en not_active Withdrawn
- 2011-03-10 US US13/583,790 patent/US20130230499A1/en not_active Abandoned
- 2011-03-10 WO PCT/IL2011/000227 patent/WO2011111043A1/en not_active Ceased
-
2015
- 2015-04-02 US US14/677,123 patent/US20150209404A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20150209404A1 (en) | 2015-07-30 |
| JP5904953B2 (ja) | 2016-04-20 |
| EP2545381A1 (en) | 2013-01-16 |
| JP2013522589A (ja) | 2013-06-13 |
| WO2011111043A1 (en) | 2011-09-15 |
| US20130230499A1 (en) | 2013-09-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20150209404A1 (en) | Cellular blood markers for early diagnosis of als and for als progression | |
| Spencer et al. | Helper (CD4+) and cytotoxic (CD8+) T cells promote the pathology of dystrophin-deficient muscle | |
| Larbi et al. | Dramatic shifts in circulating CD4 but not CD8 T cell subsets in mild Alzheimer's disease | |
| Richartz et al. | Decline of immune responsiveness: a pathogenetic factor in Alzheimer’s disease? | |
| EP2831584B1 (en) | Cellular markers for diagnosis of alzheimer's disease and for alzheimer's disease progression | |
| US20170184612A1 (en) | Use of leukocytes and novel biomarkers in the diagnosis, confirmation, and treatment of a neurological disorder | |
| US20190022198A1 (en) | Individualized Immunomodulation Therapy for Neurodegenerative Disorders, CNS Injury and Age-Related Dementia | |
| Sarkar et al. | The plasticity of immune cell response complicates dissecting the underlying pathology of multiple sclerosis | |
| Calvo et al. | Involvement of immune response in the pathogenesis of amyotrophic lateral sclerosis: a therapeutic opportunity? | |
| Seksenyan et al. | Thymic involution, a co‐morbidity factor in amyotrophic lateral sclerosis | |
| Turvey et al. | Quantitative proteome profiling of CNS-infiltrating autoreactive CD4+ cells reveals selective changes during experimental autoimmune encephalomyelitis | |
| Mayorova et al. | Autoimmune concept of schizophrenia: historical roots and current facets | |
| Frisullo et al. | The persistency of high levels of pSTAT3 expression in circulating CD4+ T cells from CIS patients favors the early conversion to clinically defined multiple sclerosis | |
| Martínez-Alcantar et al. | Anterior chamber associated immune deviation to cytosolic neural antigens avoids self-reactivity after optic nerve injury and polarizes the retinal environment to an anti-inflammatory profile | |
| Qian et al. | Decreased expression of the immune checkpoint regulator VISTA on neutrophils correlates with disease activity in autoimmune uveitis | |
| RU2828590C2 (ru) | Иммунодоминантные белки и фрагменты при рассеянном склерозе | |
| Badal et al. | Microbiome and Cellular Players in Type 1 Diabetes: From Pathogenesis to Protection | |
| Wang et al. | Inflammation and its role in ageing and disease | |
| Kamyan | INVESTIGATING THE ROLE OF NATURAL KILLER (NK) CELLS IN OZANIMOD-MEDIATED REMISSION IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS (EAE) IN C57BL/6 MICE | |
| Isaacs et al. | Tolerogenic Antigen-Presenting Cells–Modulating Unwanted Immune Response at Their Core | |
| Ghezzi | UNRAVELLING THE ROLE OF MUCOSAL ASSOCIATED INVARIANT T CELLS IN THE PATHOGENESIS OF MULTIPLE SCLEROSIS AND ITS ANIMAL MODEL | |
| Soromenho | Role of S100b in EAE Pathogenesis | |
| Del Rosso et al. | Health-Related Quality of Life and Sexual Health in Patients with Sjögren’s Syndrome and with Not-Sjögren’s Sicca Syndrome | |
| Sakuma et al. | CD4+ CD25high regulatory T cell in childhood ocular myasthenia gravis | |
| Richartz-Salzburger et al. | Decline of Immune Responsiveness: A Pathogenetic Factor in Alzheimer’s Disease? |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20160309 |
|
| FZDE | Discontinued |
Effective date: 20180312 |