CA2785835C - Mode of action screening method - Google Patents

Mode of action screening method Download PDF

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Publication number
CA2785835C
CA2785835C CA2785835A CA2785835A CA2785835C CA 2785835 C CA2785835 C CA 2785835C CA 2785835 A CA2785835 A CA 2785835A CA 2785835 A CA2785835 A CA 2785835A CA 2785835 C CA2785835 C CA 2785835C
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CA
Canada
Prior art keywords
cells
population
contacted
values
action
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2785835A
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English (en)
French (fr)
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CA2785835A1 (en
Inventor
John Mclaughlin
Zachary Pincus
Jim Bernstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rigel Pharmaceuticals Inc
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Rigel Pharmaceuticals Inc
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Publication of CA2785835A1 publication Critical patent/CA2785835A1/en
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Publication of CA2785835C publication Critical patent/CA2785835C/en
Active legal-status Critical Current
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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/70—Machine learning, data mining or chemometrics
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/50—Molecular design, e.g. of drugs

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  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Health & Medical Sciences (AREA)
  • Databases & Information Systems (AREA)
  • Evolutionary Computation (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Artificial Intelligence (AREA)
  • Software Systems (AREA)
  • Data Mining & Analysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Computing Systems (AREA)
  • Theoretical Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Image Processing (AREA)
CA2785835A 2010-01-12 2011-01-05 Mode of action screening method Active CA2785835C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33589710P 2010-01-12 2010-01-12
US61/335,897 2010-01-12
PCT/US2011/020262 WO2011087945A1 (en) 2010-01-12 2011-01-05 Mode of action screening method

Publications (2)

Publication Number Publication Date
CA2785835A1 CA2785835A1 (en) 2011-07-21
CA2785835C true CA2785835C (en) 2020-10-20

Family

ID=44258251

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2785835A Active CA2785835C (en) 2010-01-12 2011-01-05 Mode of action screening method

Country Status (5)

Country Link
US (1) US10311214B2 (https=)
EP (1) EP2524337B1 (https=)
JP (1) JP5738894B2 (https=)
CA (1) CA2785835C (https=)
WO (1) WO2011087945A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150131887A1 (en) * 2011-04-15 2015-05-14 Fluofarma System and method to visualize and analyze data from image-based cellular assays or high content screening
EP3158487A1 (en) * 2014-06-20 2017-04-26 Connecticut Children's Medical Center Automated cell culture system and corresponding methods
JP6365830B2 (ja) * 2014-07-17 2018-08-01 国立大学法人 新潟大学 抗菌効果判定システム、抗菌効果判定方法及び抗菌効果判定プログラム
US11436719B2 (en) 2017-02-16 2022-09-06 Kyoto University Cell evaluation method, cell evaluation device, and recording medium storing cell evaluation program
DE112020002936T5 (de) * 2019-06-19 2022-04-07 Recursion Pharmaceuticals, Inc. Systeme und verfahren zur auswertung von abfragestörungen
US20230352149A1 (en) * 2020-05-14 2023-11-02 Universität Heidelberg Single-cell morphology analysis for disease profiling and drug discovery
CN111653322A (zh) * 2020-06-02 2020-09-11 重庆科技学院 一种快速发现Topo1抑制剂分子的筛选方法
KR102301295B1 (ko) * 2020-11-20 2021-09-13 한국과학기술원 모델 추출 공격에 대한 인공신경망 워터마킹의 안전성 평가 방법
KR102589666B1 (ko) * 2020-12-17 2023-10-13 가톨릭대학교 산학협력단 Dapi 염색 기반 세포 영상 분류를 위한 머신러닝 시스템
US12587274B2 (en) 2023-03-28 2026-03-24 Quantum Generative Materials Llc Satellite optimization management system based on natural language input and artificial intelligence
US12368503B2 (en) 2023-12-27 2025-07-22 Quantum Generative Materials Llc Intent-based satellite transmit management based on preexisting historical location and machine learning
US12603701B2 (en) 2023-12-27 2026-04-14 Quantum Generative Materials Llc Distributed satellite constellation management and control system

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USH1060H (en) * 1990-07-02 1992-05-05 The United States Of America As Represented By The Secretary Of The Navy Microstructure correlation counter
USH1080H (en) * 1990-11-13 1992-07-07 The United States Of America As Represented By The Secretary Of The Army Electronic light beam switch
JPH10506484A (ja) * 1994-09-20 1998-06-23 ネオパス，インク． 生物学分析系自己校正装置
US6759206B1 (en) * 1997-02-27 2004-07-06 Cellomics, Inc. System for cell-based screening
JP4532675B2 (ja) * 2000-06-06 2010-08-25 キヤノン株式会社 画像処理装置、画像処理システム、画像処理方法、及び記憶媒体
US7546210B2 (en) * 2000-06-08 2009-06-09 The Regents Of The University Of California Visual-servoing optical microscopy
US7123764B2 (en) 2000-11-08 2006-10-17 Surface Logix Inc. Image processing method for use in analyzing data of a chemotaxis or haptotaxis assay
US6519355B2 (en) * 2001-03-28 2003-02-11 Alan C. Nelson Optical projection imaging system and method for automatically detecting cells having nuclear and cytoplasmic densitometric features associated with disease
US7561971B2 (en) * 2002-03-28 2009-07-14 Exagen Diagnostics, Inc. Methods and devices relating to estimating classifier performance
US7640114B2 (en) * 2003-05-21 2009-12-29 The Wistar Institute Of Anatomy & Biology Method of diagnosis of cancer based on gene expression profiles in cells
US20050233448A1 (en) * 2003-06-18 2005-10-20 Oh Steve K W Materials and methods to produce stem cells
JP2008528975A (ja) * 2005-01-24 2008-07-31 ザ・ボード・オブ・トラスティーズ・オブ・ザ・レランド・スタンフォード・ジュニア・ユニバーシティ 細胞シグナル伝達系のモデリングのためのベイジアンネットワークの使用
JP2008539209A (ja) 2005-04-26 2008-11-13 カリヨン−シーティーティー リミテッド 診断及び治療剤
WO2007030795A2 (en) * 2005-09-09 2007-03-15 Cytokinetics, Inc. Cellular phenotype
US20080195322A1 (en) * 2007-02-12 2008-08-14 The Board Of Regents Of The University Of Texas System Quantification of the Effects of Perturbations on Biological Samples
US7897363B2 (en) * 2007-06-12 2011-03-01 Phylonix Pharmaceuticals, Inc. Methods of screening an agent for an activity in an isolated eye of a teleost
GB0909461D0 (en) * 2009-06-02 2009-07-15 Ge Healthcare Uk Ltd Image analysis

Also Published As

Publication number Publication date
EP2524337B1 (en) 2022-10-26
US20110169937A1 (en) 2011-07-14
US10311214B2 (en) 2019-06-04
EP2524337A4 (en) 2016-07-06
EP2524337A1 (en) 2012-11-21
CA2785835A1 (en) 2011-07-21
WO2011087945A1 (en) 2011-07-21
JP2013517459A (ja) 2013-05-16
JP5738894B2 (ja) 2015-06-24

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