CA2785835C - Mode of action screening method - Google Patents

Mode of action screening method Download PDF

Info

Publication number
CA2785835C
CA2785835C CA2785835A CA2785835A CA2785835C CA 2785835 C CA2785835 C CA 2785835C CA 2785835 A CA2785835 A CA 2785835A CA 2785835 A CA2785835 A CA 2785835A CA 2785835 C CA2785835 C CA 2785835C
Authority
CA
Canada
Prior art keywords
cells
population
contacted
values
action
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2785835A
Other languages
English (en)
French (fr)
Other versions
CA2785835A1 (en
Inventor
John Mclaughlin
Zachary Pincus
Jim Bernstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rigel Pharmaceuticals Inc
Original Assignee
Rigel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rigel Pharmaceuticals Inc filed Critical Rigel Pharmaceuticals Inc
Publication of CA2785835A1 publication Critical patent/CA2785835A1/en
Application granted granted Critical
Publication of CA2785835C publication Critical patent/CA2785835C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/70—Machine learning, data mining or chemometrics
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/50—Molecular design, e.g. of drugs

Landscapes

  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Health & Medical Sciences (AREA)
  • Databases & Information Systems (AREA)
  • Evolutionary Computation (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Artificial Intelligence (AREA)
  • Software Systems (AREA)
  • Data Mining & Analysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Computing Systems (AREA)
  • Theoretical Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Image Processing (AREA)
CA2785835A 2010-01-12 2011-01-05 Mode of action screening method Active CA2785835C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33589710P 2010-01-12 2010-01-12
US61/335,897 2010-01-12
PCT/US2011/020262 WO2011087945A1 (en) 2010-01-12 2011-01-05 Mode of action screening method

Publications (2)

Publication Number Publication Date
CA2785835A1 CA2785835A1 (en) 2011-07-21
CA2785835C true CA2785835C (en) 2020-10-20

Family

ID=44258251

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2785835A Active CA2785835C (en) 2010-01-12 2011-01-05 Mode of action screening method

Country Status (5)

Country Link
US (1) US10311214B2 (enExample)
EP (1) EP2524337B1 (enExample)
JP (1) JP5738894B2 (enExample)
CA (1) CA2785835C (enExample)
WO (1) WO2011087945A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150131887A1 (en) * 2011-04-15 2015-05-14 Fluofarma System and method to visualize and analyze data from image-based cellular assays or high content screening
US20170138924A1 (en) * 2014-06-20 2017-05-18 Connecticut Children's Medical Center Automated cell culture system and corresponding methods
JP6365830B2 (ja) * 2014-07-17 2018-08-01 国立大学法人 新潟大学 抗菌効果判定システム、抗菌効果判定方法及び抗菌効果判定プログラム
EP3611696A4 (en) * 2017-02-16 2021-02-17 Kyoto University CELL EVALUATION DEVICE, CELL EVALUATION METHOD AND CELL EVALUATION PROGRAM
US11715551B2 (en) * 2019-06-19 2023-08-01 Recursion Pharmaceuticals, Inc. Systems and methods for evaluating query perturbations
EP4150633A1 (en) * 2020-05-14 2023-03-22 Universität Heidelberg Single-cell morphology analysis for disease profiling and drug discovery
CN111653322A (zh) * 2020-06-02 2020-09-11 重庆科技学院 一种快速发现Topo1抑制剂分子的筛选方法
KR102301295B1 (ko) * 2020-11-20 2021-09-13 한국과학기술원 모델 추출 공격에 대한 인공신경망 워터마킹의 안전성 평가 방법
KR102589666B1 (ko) * 2020-12-17 2023-10-13 가톨릭대학교 산학협력단 Dapi 염색 기반 세포 영상 분류를 위한 머신러닝 시스템
CN113436686B (zh) * 2021-06-23 2024-02-27 腾讯科技（深圳）有限公司 基于人工智能的化合物库构建方法、装置、设备及存储介质
US12587274B2 (en) 2023-03-28 2026-03-24 Quantum Generative Materials Llc Satellite optimization management system based on natural language input and artificial intelligence
US12368503B2 (en) 2023-12-27 2025-07-22 Quantum Generative Materials Llc Intent-based satellite transmit management based on preexisting historical location and machine learning
US12627372B2 (en) 2023-12-27 2026-05-12 Quantum Generative Materials Llc Advanced mission control predictive systems for low earth orbit semi-autonomous satellites
US12603701B2 (en) 2023-12-27 2026-04-14 Quantum Generative Materials Llc Distributed satellite constellation management and control system

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USH1060H (en) * 1990-07-02 1992-05-05 The United States Of America As Represented By The Secretary Of The Navy Microstructure correlation counter
USH1080H (en) * 1990-11-13 1992-07-07 The United States Of America As Represented By The Secretary Of The Army Electronic light beam switch
ES2122950T1 (es) * 1994-09-20 1999-01-01 Neopath Inc Aparato de auto calibrado del sistema de analisis biologico.
US6759206B1 (en) * 1997-02-27 2004-07-06 Cellomics, Inc. System for cell-based screening
JP4532675B2 (ja) * 2000-06-06 2010-08-25 キヤノン株式会社 画像処理装置、画像処理システム、画像処理方法、及び記憶媒体
US7546210B2 (en) * 2000-06-08 2009-06-09 The Regents Of The University Of California Visual-servoing optical microscopy
US7123764B2 (en) 2000-11-08 2006-10-17 Surface Logix Inc. Image processing method for use in analyzing data of a chemotaxis or haptotaxis assay
US6519355B2 (en) * 2001-03-28 2003-02-11 Alan C. Nelson Optical projection imaging system and method for automatically detecting cells having nuclear and cytoplasmic densitometric features associated with disease
US7561971B2 (en) * 2002-03-28 2009-07-14 Exagen Diagnostics, Inc. Methods and devices relating to estimating classifier performance
WO2004105573A2 (en) * 2003-05-21 2004-12-09 The Wistar Institute Of Anatomy And Biology Method of diagnosis of cancer based on gene expression profiles in cells
US20050233448A1 (en) * 2003-06-18 2005-10-20 Oh Steve K W Materials and methods to produce stem cells
CN101194260A (zh) * 2005-01-24 2008-06-04 利兰·斯坦福青年大学托管委员会 使用贝叶斯网络建立细胞信号传导系统模型的方法
AU2006239141A1 (en) 2005-04-26 2006-11-02 Karyon-Ctt Ltd Diagnostic and therapeutic agents
US20070082327A1 (en) * 2005-09-09 2007-04-12 Cytokinetics, Inc. A Delaware Corporation Cellular phenotype
US20080195322A1 (en) * 2007-02-12 2008-08-14 The Board Of Regents Of The University Of Texas System Quantification of the Effects of Perturbations on Biological Samples
US7897363B2 (en) * 2007-06-12 2011-03-01 Phylonix Pharmaceuticals, Inc. Methods of screening an agent for an activity in an isolated eye of a teleost
GB0909461D0 (en) * 2009-06-02 2009-07-15 Ge Healthcare Uk Ltd Image analysis

Also Published As

Publication number Publication date
US10311214B2 (en) 2019-06-04
US20110169937A1 (en) 2011-07-14
EP2524337B1 (en) 2022-10-26
WO2011087945A1 (en) 2011-07-21
EP2524337A1 (en) 2012-11-21
CA2785835A1 (en) 2011-07-21
JP5738894B2 (ja) 2015-06-24
JP2013517459A (ja) 2013-05-16
EP2524337A4 (en) 2016-07-06

Similar Documents

Publication Publication Date Title
US10311214B2 (en) Mode of action screening method
Méndez-Lucio et al. The many roles of molecular complexity in drug discovery
Wehling Principles of translational science in medicine: From bench to bedside
Futamura et al. Morphobase, an encyclopedic cell morphology database, and its use for drug target identification
De Bruyn et al. Structure-based identification of OATP1B1/3 inhibitors
Harper et al. Methods for mining HTS data
Sugimoto et al. Bioinformatics tools for mass spectroscopy-based metabolomic data processing and analysis
Laurinavicius et al. Bimodality of intratumor Ki67 expression is an independent prognostic factor of overall survival in patients with invasive breast carcinoma
Du et al. Temporal expression of wound healing–related genes inform wound age estimation in rats after a skeletal muscle contusion: a multivariate statistical model analysis
Miller Essential statistical methods for medical statistics
Lopez-Cortes et al. Unraveling druggable cancer-driving proteins and targeted drugs using artificial intelligence and multi-omics analyses
Wu et al. NMR-based serum metabolomics study reveals a innovative diagnostic model for missed abortion
Tian et al. Metabolomic profiling identifies signatures and biomarkers linking air pollution to dementia risk: A prospective cohort study
Choi et al. Analytical performance of Envisia: a genomic classifier for usual interstitial pneumonia
Wang et al. Association of the psoriatic microenvironment with treatment response
Cabello-Pinedo et al. Development of a novel non-invasive metabolomics assay to predict implantation potential of human embryos
Zhu et al. Identification of diagnostic markers in synovial tissue of osteoarthritis by weighted gene coexpression network
Markey et al. Spatial mapping of gene signatures in hematoxylin and eosin-stained images: A proof of concept for interpretable predictions using additive multiple instance learning
US20190249251A1 (en) Algorithm and an in vitro method based on rna editing to select particular effect induced by active compounds
Maverakis et al. Glycan biomarkers of autoimmunity and bile acid-associated alterations of the human glycome: Primary biliary cirrhosis and primary sclerosing cholangitis-specific glycans
Zhu et al. Exploration of differential expression and biological significance of amino acid metabolism genes in osteoarthritis
Lumley Compound selection and filtering in library design
Li et al. Investigation into the molecular mechanism of obesity: an integrated approach of multi-omics analysis, machine learning and experimental validation
Guo et al. Identification of potential biomarkers in cardiovascular calcification based on bioinformatics combined with single-cell RNA-seq and multiple machine learning analysis
CN116246707A (zh) 评估her2阳性胃癌的交叉耐药基因集、评分模型及其构建方法和应用

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20151222

H11 Ip right ceased following rejected request for revival

Free format text: ST27 STATUS EVENT CODE: T-6-6-H10-H11-H101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: TIME LIMIT FOR REVERSAL EXPIRED

Effective date: 20240816