CA2785835C - Mode of action screening method - Google Patents

Mode of action screening method Download PDF

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Publication number
CA2785835C
CA2785835C CA2785835A CA2785835A CA2785835C CA 2785835 C CA2785835 C CA 2785835C CA 2785835 A CA2785835 A CA 2785835A CA 2785835 A CA2785835 A CA 2785835A CA 2785835 C CA2785835 C CA 2785835C
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CA
Canada
Prior art keywords
cells
population
contacted
values
action
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2785835A
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English (en)
French (fr)
Other versions
CA2785835A1 (en
Inventor
John Mclaughlin
Zachary Pincus
Jim Bernstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rigel Pharmaceuticals Inc
Original Assignee
Rigel Pharmaceuticals Inc
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Publication date
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Publication of CA2785835A1 publication Critical patent/CA2785835A1/en
Application granted granted Critical
Publication of CA2785835C publication Critical patent/CA2785835C/en
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    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16CCOMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/70Machine learning, data mining or chemometrics
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16CCOMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/50Molecular design, e.g. of drugs

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  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Health & Medical Sciences (AREA)
  • Databases & Information Systems (AREA)
  • Evolutionary Computation (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Artificial Intelligence (AREA)
  • Software Systems (AREA)
  • Data Mining & Analysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Computing Systems (AREA)
  • Theoretical Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Image Processing (AREA)
CA2785835A 2010-01-12 2011-01-05 Mode of action screening method Active CA2785835C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33589710P 2010-01-12 2010-01-12
US61/335,897 2010-01-12
PCT/US2011/020262 WO2011087945A1 (en) 2010-01-12 2011-01-05 Mode of action screening method

Publications (2)

Publication Number Publication Date
CA2785835A1 CA2785835A1 (en) 2011-07-21
CA2785835C true CA2785835C (en) 2020-10-20

Family

ID=44258251

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2785835A Active CA2785835C (en) 2010-01-12 2011-01-05 Mode of action screening method

Country Status (5)

Country Link
US (1) US10311214B2 (enExample)
EP (1) EP2524337B1 (enExample)
JP (1) JP5738894B2 (enExample)
CA (1) CA2785835C (enExample)
WO (1) WO2011087945A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150131887A1 (en) * 2011-04-15 2015-05-14 Fluofarma System and method to visualize and analyze data from image-based cellular assays or high content screening
CN106471508A (zh) * 2014-06-20 2017-03-01 康涅狄格儿童医疗中心 自动化细胞培养系统及对应的方法
JP6365830B2 (ja) * 2014-07-17 2018-08-01 国立大学法人 新潟大学 抗菌効果判定システム、抗菌効果判定方法及び抗菌効果判定プログラム
EP3611696A4 (en) * 2017-02-16 2021-02-17 Kyoto University CELL EVALUATION PROCESS, CELL EVALUATION DEVICE AND CELL EVALUATION PROGRAM
DE112020002936T5 (de) * 2019-06-19 2022-04-07 Recursion Pharmaceuticals, Inc. Systeme und verfahren zur auswertung von abfragestörungen
EP4150633A1 (en) * 2020-05-14 2023-03-22 Universität Heidelberg Single-cell morphology analysis for disease profiling and drug discovery
CN111653322A (zh) * 2020-06-02 2020-09-11 重庆科技学院 一种快速发现Topo1抑制剂分子的筛选方法
KR102301295B1 (ko) * 2020-11-20 2021-09-13 한국과학기술원 모델 추출 공격에 대한 인공신경망 워터마킹의 안전성 평가 방법
KR102589666B1 (ko) * 2020-12-17 2023-10-13 가톨릭대학교 산학협력단 Dapi 염색 기반 세포 영상 분류를 위한 머신러닝 시스템
US12368503B2 (en) 2023-12-27 2025-07-22 Quantum Generative Materials Llc Intent-based satellite transmit management based on preexisting historical location and machine learning

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USH1060H (en) 1990-07-02 1992-05-05 The United States Of America As Represented By The Secretary Of The Navy Microstructure correlation counter
USH1080H (en) * 1990-11-13 1992-07-07 The United States Of America As Represented By The Secretary Of The Army Electronic light beam switch
ES2122950T1 (es) 1994-09-20 1999-01-01 Neopath Inc Aparato de auto calibrado del sistema de analisis biologico.
US6759206B1 (en) * 1997-02-27 2004-07-06 Cellomics, Inc. System for cell-based screening
JP4532675B2 (ja) * 2000-06-06 2010-08-25 キヤノン株式会社 画像処理装置、画像処理システム、画像処理方法、及び記憶媒体
US7546210B2 (en) * 2000-06-08 2009-06-09 The Regents Of The University Of California Visual-servoing optical microscopy
US7123764B2 (en) 2000-11-08 2006-10-17 Surface Logix Inc. Image processing method for use in analyzing data of a chemotaxis or haptotaxis assay
US6519355B2 (en) * 2001-03-28 2003-02-11 Alan C. Nelson Optical projection imaging system and method for automatically detecting cells having nuclear and cytoplasmic densitometric features associated with disease
US7561971B2 (en) 2002-03-28 2009-07-14 Exagen Diagnostics, Inc. Methods and devices relating to estimating classifier performance
WO2004105573A2 (en) * 2003-05-21 2004-12-09 The Wistar Institute Of Anatomy And Biology Method of diagnosis of cancer based on gene expression profiles in cells
US20050233448A1 (en) * 2003-06-18 2005-10-20 Oh Steve K W Materials and methods to produce stem cells
CA2593355A1 (en) * 2005-01-24 2006-07-27 The Board Of Trustees Of The Leland Stanford Junior University Method for modeling cell signaling systems by means of bayesian networks
AU2006239141A1 (en) 2005-04-26 2006-11-02 Karyon-Ctt Ltd Diagnostic and therapeutic agents
US20070082327A1 (en) * 2005-09-09 2007-04-12 Cytokinetics, Inc. A Delaware Corporation Cellular phenotype
US20080195322A1 (en) * 2007-02-12 2008-08-14 The Board Of Regents Of The University Of Texas System Quantification of the Effects of Perturbations on Biological Samples
US7897363B2 (en) * 2007-06-12 2011-03-01 Phylonix Pharmaceuticals, Inc. Methods of screening an agent for an activity in an isolated eye of a teleost
GB0909461D0 (en) 2009-06-02 2009-07-15 Ge Healthcare Uk Ltd Image analysis

Also Published As

Publication number Publication date
EP2524337A4 (en) 2016-07-06
JP2013517459A (ja) 2013-05-16
JP5738894B2 (ja) 2015-06-24
US10311214B2 (en) 2019-06-04
US20110169937A1 (en) 2011-07-14
EP2524337A1 (en) 2012-11-21
CA2785835A1 (en) 2011-07-21
EP2524337B1 (en) 2022-10-26
WO2011087945A1 (en) 2011-07-21

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