CA2764600A1

CA2764600A1 - Crystalline forms of febuxostat

Info

Publication number: CA2764600A1
Application number: CA2764600A
Authority: CA
Inventors: Maytal Piran; Leonid Metsger
Original assignee: Teva Pharmaceutical Industries Ltd
Current assignee: Teva Pharmaceutical Industries Ltd
Priority date: 2009-06-10
Filing date: 2010-06-10
Publication date: 2010-12-16
Also published as: EP2398784A1; IL216648A0; PT2398784E; DE202010017868U1; US20130245077A1; ES2395381T3; CN102803240A; PL2398784T3; US20100317702A1; HRP20121028T1; KR20120140267A; US20130178504A1; US8742129B2; EP2532654A1; JP2012529537A; KR20120034077A; JP5215505B2; WO2010144685A1; US8609856B2; US8415481B2

Abstract

New forms of Febuxostat have been prepared and characterized. These forms are useful, for example, in the chronic management of hyperuricemia in patients with gout.

Description

Crystalline Forms of Febuxostat Cross-Reference To Related Applications [0001] This application claims the benefit of U.S. Provisional Patent Application Serial Nos. 61/185,775, filed June 10, 2009; 61/222,583, filed July 2, 2009;
61/233,552, filed August 13, 2009; and 61/235,481, filed August 20, 2009, which are incorporated herein by reference.
Field of the Invention [0002] The present invention encompasses crystalline forms of 2-(3-cyano-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid.

Background of the Invention [0003] Febuxostat, 2-(3-cyano-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid, having the following formula;

CII H::

Nf:
~.
~CIzz SOH
is a xanthine oxidase (XO) inhibitor indicated for the chronic management of hyperuricemia in patients with gout. Febuxostat is not recommended for the treatment of asymptomatic hyperuricemia. Febuxostat is administrated in the form of tablets that are marketed in the USA and the EU under the name ULORIC .

[0004] PCT publication no. WO 1992/109279 describes Febuxostat. PCT
publication no. WO 1999/065885, PCT publication no. WO 2003/082279, PCT publication no. WO
2008/067773, CN 100546985, CN 101139325, CN 101085761, CN 101412700, CN
101386605, CN101648926, CN101671314, CN 101684107 and Hetrocycles, 47, 2, 857-describe crystalline forms of Febuxostat including forms A, B, C, D G, H, I, J, K and M, as well as an amorphous form.

[0005] The present invention relates to the solid state physical properties of Febuxostat, 2-[3-cyano-4-(2-methylpropoxy) phenyl]-4-methylthiazole-5-carboxylic acid.

These properties can be influenced by controlling the conditions under which 2-[3-cyano-4-(2-methylpropoxy) phenyl]-4-methylthiazole-5-carboxylic acid is obtained in solid form.

[0006] Polymorphism, the occurrence of different crystal forms, is a property of some molecules and molecular complexes. A single molecule may give rise to a variety of polymorphs having distinct crystal structures and physical properties like melting point, thermal behaviours (e.g. measured by thermogravimetric analysis - "TGA", or differential scanning calorimetry - "DSC"), X-ray diffraction pattern, infrared absorption fingerprint, and solid state NMR spectrum. One or more of these techniques may be used to distinguish different polymorphic forms of a compound.

[0007] Discovering new polymorphic forms and solvates of a pharmaceutical product can provide materials having desirable processing properties, such as ease of handling, ease of processing, storage stability, ease of purification or as desirable intermediate crystal forms that facilitate conversion to other polymorphic forms. New polymorphic forms and solvates of a pharmaceutically useful compound can also provide an opportunity to improve the performance characteristics of a pharmaceutical product. It enlarges the repertoire of materials that a formulation scientist has available for formulation optimization, for example by providing a product with different properties, e.g., better processing or handling characteristics, improved dissolution profile, or improved shelf-life. For at least these reasons, there is a need for additional polymorphs of Febuxostat.

Summary of the Invention [0008] In one embodiment, the present invention encompasses crystalline Febuxostat, designated as form F 1. Form F 1 can be characterized by data selected from: a powder XRD
pattern with peaks at 5.8 , 6.8 , 8.1 , 11.8 and 17.4 0.2 20; an XRPD
pattern substantially as depicted in Figure 1; a solid-state 13C NMR spectrum with signals at 123.8, 163.1 and 168.5 0.2 ppm; a solid-state 13C NMR spectrum having chemical shift differences between the signal exhibiting the lowest chemical shift and another in the chemical shift range of 100 to 180 ppm of 23.4, 62.7 and 68.1 0.1 ppm; a solid-state 13C
NMR spectrum substantially as depicted in Figures 2 or 3; and combinations thereof.

[0009] In another embodiment, the present invention encompasses crystalline Febuxostat, designated as form F2. Form F2 can be characterized by data selected from: a powder XRD pattern with peaks at 3.0 , 5.9 , 8.8 , 11.8 and 12.5 0.2 20;
an XRPD

pattern substantially as depicted in Figure 4 or Figure 5; a solid-state 13C
NMR spectrum with signals at 112.3, 163.9, 168.8 0.2 ppm; a solid-state 13C NMR spectrum having chemical shifts differences between the signal exhibiting the lowest chemical shift and another in the chemical shift range of 100 to 180 ppm of 11.5, 63.1 and 68.0 0.1 ppm; a solid-state 13C
NMR spectrum substantially as depicted in Figures 6 or 7; and combinations thereof.

[0010] In yet another embodiment, the present invention encompasses crystalline Febuxostat, designated as Form F10. Form Flo can be characterized by data selected from:
an X-ray powder diffraction pattern having peaks at 6.7 , 7.7 , 12.8 , 13.3 and 20.0 0.2 20; an X-ray powder diffraction pattern substantially as depicted in Figure 8;
a solid-state 13C
NMR spectrum with signals at 112.7, 125.7, 132.4 and 168.3 0.2 ppm; a solid-state 13C
NMR spectrum having chemical shifts differences between the signal exhibiting the lowest chemical shift and another in the chemical shift range of 100 to 180 ppm of 11.7, 24.7, 31.4 and 67.3 0.1 ppm; a solid-state 13C NMR spectrum substantially as depicted in Figures 9 or 10; and combinations thereof.
[0011] In one embodiment, the present invention provides a pharmaceutical composition comprising any one, or combination, of the Febuxostat crystalline Forms described above and at least one pharmaceutically acceptable excipient.

[0012] In another embodiment, the present invention provides the use of any one of the above pharmaceutical compositions for the treatment of hyperuricemia in patients with gout. In another embodiment, the invention provides a method of treating hyperuricemia in patients with gout, comprising administering a therapeutically effective amount of at least one of the above pharmaceutical compositions to a patient with gout. In another embodiment, the invention provides the use of any one of the forms of Febuxostat described above in the manufacture of a medicament for the treatment of hyperuricemia in patients with gout.

Brief Description of the Drawings [0013] Figure 1 shows an X-ray powder diffractogram of Febuxostat Form F 1.

[0014] Figure 2 shows a solid-state 13C NMR spectrum of Febuxostat Form Fl in the 0-200 ppm range.

[0015] Figure 3 shows a solid-state 13C NMR spectrum of Febuxostat Form Fl in the 100-200 ppm range.

[0016] Figure 4 shows an X-ray powder diffractogram of Febuxostat Form F2.

[0017] Figure 5 shows an X-ray powder diffractogram of Febuxostat Form F2.

[0018] Figure 6 shows a solid-state 13C NMR spectrum of Febuxostat Form F2 in the 0-200 ppm range.

[0019] Figure 7 shows a solid-state 13C NMR spectrum of Febuxostat Form F2 in the 100-200 ppm range.

[0020] Figure 8 shows an X-ray powder diffractogram of Febuxostat Form F10.

[0021] Figure 9 shows a solid-state 13C NMR spectrum of Febuxostat Form Flo in the 0-200 ppm range.

[0022] Figure 10 shows a solid-state 13C NMR spectrum of Febuxostat Form Flo in the 100-200 ppm range.

[0023] Figure 11 shows an X-ray powder diffractogram of Febuxostat Form F3.

[0024] Figure 12 shows a solid-state 13C NMR spectrum of Febuxostat Form F3 in the 0-200 ppm range.

[0025] Figure 13 shows a solid-state 13C NMR spectrum of Febuxostat Form F3 in the 100-200 ppm range.

[0026] Figure 14 shows an X-ray powder diffractogram of Febuxostat Form F4.

[0027] Figure 15 shows a solid-state 13C NMR spectrum of Febuxostat Form F4 in the 0-200 ppm range.

[0028] Figure 16 shows a solid-state 13C NMR spectrum of Febuxostat Form F4 in the 100-200 ppm range.

[0029] Figure 17 shows an X-ray powder diffractogram of Febuxostat Form F5.

[0030] Figure 18 shows an X-ray powder diffractogram of Febuxostat Form F6.

[0031] Figure 19 shows an X-ray powder diffractogram of Febuxostat Form F7.

[0032] Figure 20 shows a solid-state 13C NMR spectrum of Febuxostat Form F7 in the 0-200 ppm range.

[0033] Figure 21 shows a solid-state 13C NMR spectrum of Febuxostat Form F7 in the 100-200 ppm range.

[0034] Figure 22 shows an X-ray powder diffractogram of Febuxostat Form F8.

[0035] Figure 23 shows a solid-state 13C NMR spectrum of Febuxostat Form F8 in the 0-200 ppm range.

[0036] Figure 24 shows a solid-state 13C NMR spectrum of Febuxostat Form F8 in the 100-200 ppm range.

[0037] Figure 25 shows an X-ray powder diffractogram of Febuxostat Form F9.

[0038] Figure 26 shows a solid-state 13C NMR spectrum of Febuxostat Form F9 in the 0-200 ppm range.

[0039] Figure 27 shows a solid-state 13C NMR spectrum of Febuxostat Form F9 in the 100-200 ppm range.

[0040] Figure 28 shows an X-ray powder diffractogram of Febuxostat Form F 11.

[0041] Figure 29 shows an X-ray powder diffractogram of Febuxostat Form F12.

[0042] Figure 30 shows an X-ray powder diffractogram of Febuxostat Form F13.

[0043] Figure 31 shows an X-ray powder diffractogram of Febuxostat Form F14.
Detailed Description of the Invention [0044] The present application relates to new polymorphic forms F1-F14 of Febuxostat. In some embodiments, the polymorphs of Febuxostat of the invention are substantially free of any other polymorphic forms, or of specified polymorphic forms In particular, Forms Fl, F2 and F 10 are substantially free of any other polymorph forms or of specified polymorph forms. In any embodiment of the present invention, by "substantially free" is meant that the forms of the present invention contain 20% (w/w) or less, 10% (w/w) or less, 5% (w/w) or less, 2% (w/w) or less, particularly 1% (w/w) or less, more particularly 0.5% (w/w) or less, and most particularly 0.2% (w/w) or less of any other polymorph or of a specified polymorph. In other embodiments, the polymorphs of Febuxostat of the invention contain from 1% to 20% (w/w), from 5% to 20% (w/w), or from 5% to 10% (w/w) of any other polymorph or of a specified polymorph.

[0045] A crystal form may be referred to herein as being characterized by graphical data "as depicted in" a Figure. Such data include, for example, powder X-ray diffractograms and solid state NMR spectra. The skilled person will understand that such graphical representations of data may be subject to small variations, e.g., in peak relative intensities and peak positions due to factors such as variations in instrument response and variations in sample concentration and purity, which are well known to the skilled person.
Nonetheless, the skilled person would readily be capable of comparing the graphical data in the Figures herein with graphical data generated for an unknown crystal form and confirm whether the two sets of graphical data are characterizing the same crystal form or two different crystal forms.

[0046] As used herein, unless stated otherwise, the XRPD measurements are taken using copper Ka radiation wavelength 1.5418A.

[0047] A thing, e.g., a reaction mixture, may be characterized herein as being at, or allowed to come to "room temperature, often abbreviated "RT." This means that the temperature of the thing is close to, or the same as, that of the space, e.g., the room or fume hood, in which the thing is located. Typically, room temperature is from about 20 C to about 30 C, or about 22 C to about 27 C, or about 25 C.

[0048] A process or step may be referred to herein as being carried out "overnight."
This refers to a time interval, e.g., for the process or step, that spans the time during the night, when that process or step may not be actively observed. This time interval is from about 8 to about 20 hours, or about 10-18 hours, typically about 16 hours.

[0049] As used herein, and unless stated otherwise, the term "anhydrous" in relation to crystalline Febuxostat relates to a crystalline Febuxostat which contains not more than 1.5 % (w/w), or not more than I% (w/w) of either water or organic solvents as measured by TGA, for example, Febuxostat which contains between about 0% to about 1% (w/w) of either water or organic solvents as measured by TGA.

[0050] Unless indicated otherwise, the solid state forms of the present invention can be dried. Drying may be carried out, for example, at elevated temperature under reduced pressure. The crystalline form can be dried at a temperature from about 40 C
to about 60 C, or about 40 C and about 50 C, for example, about 40 C. The drying can be carried out under reduced pressure (i.e., less than 1 atmosphere, for example, about 10 mbar to about 100 mbar, or about 10 mbar to about 25 mbar). The drying can take place over a period of about 8 hours to about 36 hours, or about 10 hours to about 24 hours, for example, about 16 hours.
Drying can be carried out overnight.

[0051] The starting material, Febuxostat, in the processes of the present invention, may be prepared according to the process described in PCT publication no. WO
1992/09279, which is incorporated herein by reference.

[0052] WO 1999/065885 describes crystalline forms of Febuxostat including crystalline form G. Form G of febuxostat shows an X-ray powder diffraction pattern having characteristic peaks at a reflection angle 20 of about 6.86, 8.36, 9.60, 11.76, 13.74, 14.60, 15.94, 16.74, 17.56, 20.00, 21.26, 23.72, 24.78, 25.14, 25.74, 26.06, 26.64, 27.92, 28.60, 29.66 and 29.98 .

[0053] The present invention addresses a need in the art by providing new crystalline forms Fl-F14 of Febuxostat that have at least one or more favorable properties compared with known forms of Febuxostat. In particular, the solid state forms of the present invention can have improved characteristics such as: higher crystallinity, solubility, dissolution rate, morphology, thermal and mechanical stability to polymorphic conversion and/or to dehydration, storage stability, low content of residual solvent, a lower degree of hygroscopicity, flowability, and advantageous processing and handling characteristics such as compressibility, and bulk density.

[0054] The present invention provides crystalline Febuxostat, designated as Form Fl I.
Form Fl can be characterized by data selected from: a powder XRD pattern with peaks at 5.8 , 6.8 , 8.1 , 11.7 and 17.4 0.2 20; a powder XRD pattern with peaks at 5.8 , 6.8 , 8.1 , 11.8 and 17.4 0.2 20; an XRPD pattern substantially as depicted in Figure 1; a solid-state 13C NMR spectrum with signals at 123.8, 163.1 and 168.5 0.2 ppm;
a solid-state 13C NMR spectrum having chemical shifts differences between the signal exhibiting the lowest chemical shift and another in the chemical shift range of 100 to 180 ppm of 23.4, 62.7 and 68.1 0.1 ppm; a solid-state 13C NMR spectrum substantially as depicted in Figures 2 or 3 ; and combinations thereof. The signal exhibiting the lowest chemical shift in the chemical shift area of 100 to 180 ppm is typically at 100.4 lppm. The Febuxostat form Fl as defined in any of the above data, may be further characterized by XRPD pattern having additional peaks at: 4.7 , 9.4 , 14.2 , 16.2 , and 25.8 0.2 20. Alternatively, the Febuxostat form Fl as defined in any of the above data, may be further characterized by XRPD
pattern having additional peaks at: 4.6 , 9.3 , 14.2 , 16.2 , and 25.8 0.2 20.

[0055] Typically, the febuxostat form Fl is substantially free of Form G, particularly, a powder XRD pattern of form Fl does not have any of the peaks at 21.3 24.8 and 25.1 0.2 20.

[0056] Febuxostat form Fl has advantageous properties selected from at least one of:
chemical purity, flowability, solubility, morphology or crystal habit, stability - such as storage stability, stability to dehydration, stability to polymorphic conversion, low hygroscopicity, low content of residual solvents.

[0057] Febuxostat Form Fl may be prepared by crystallizing Febuxostat from methylisobutylketone ("MIBK"). The process may comprise dissolving Febuxostat in MIBK
to obtain a mixture; precipitating the Febuxostat; and isolating the obtained precipitate. The precipitating may comprise heating; cooling; and optionally maintaining the mixture. The heating may be done to about reflux temperature and the cooling may be done to a temperature of about 40 C to about 0 C, or to about room temperature. The maintaining is typically done at a temperature of about room temperature, for a time of about 1 to about 24 hours, or for about 1 to about 12 hours, for example, for about 1.5 hours. The isolation of the precipitate may be done by filtering and washing with a solvent such as MIBK.
Optionally, the isolated precipitate is further dried.

[0058] The present invention provides a crystalline Febuxostat, designated as Form F2. Form F2 can be characterized by data selected from: a powder XRD pattern with peaks at 2.9 , 5.9 , 8.7 , 11.8 and 12.5 0.2 20; a powder XRD pattern with peaks at 3.0 , 5.9 , 8.8 , 11.8 and 12.5 0.2 20; an XRPD pattern substantially as depicted in Figure 4 or Figure 5; a solid-state 13C NMR spectrum with signals at 112.3, 163.9, 168.8 0.2 ppm; a solid-state 13C NMR spectrum having chemical shifts differences between the signal exhibiting the lowest chemical shift and another in the chemical shift range of 100 to 180 ppm of 11.5, 63.1 and 68.0 0.1 ppm; a solid-state 13C NMR spectrum substantially as depicted in Figures 6 or 7 ; and combinations thereof. The signal exhibiting the lowest chemical shift in the chemical shift area of 100 to 180 ppm is typically at 100.8 0.lppm.
The Febuxostat form F2 as defined in any of the above data, may be further characterized by additional XRPD peaks at: 13.1 , 14.7 , 17.5 , 24.4 and 25.2 0.2 20.
Alternatively, the Febuxostat form F2 as defined in any of the above data, may be further characterized by additional XRPD peaks at: 13.1 , 14.6 , 17.6 , 24.4 and 25.5 0.2 20.

[0059] Febuxostat form F2 may be anhydrous.

[0060] Febuxostat form F2 has advantageous properties selected from at least one of:
chemical purity, flowability, solubility, morphology or crystal habit, stability - such as storage stability, stability to dehydration, stability to polymorphic conversion, low hygroscopicity, low content of residual solvents. In particular, the crystalline Febuxostat form F2 of the present invention has advantageous morphology compared with other crystalline forms such as forms A, B and C of Febuxostat. While forms A, B and C of Febuxostat are all needle shaped, Febuxostat form F2 has plate morphology, and therefore has better technological properties, such as compactability, which may be better for e.g. tablet formulation.

[0061] Febuxostat Form F2 may be prepared by crystallizing Febuxostat from a mixture comprising a solvent selected from: methylethylketone ("MEK") and acetone, in combination with a C5-Cg hydrocarbon.

[0062] The crystallization, which may be done at about room temperature, typically comprises dissolving Febuxostat in a solvent selected from: MEK and acetone;
and adding a C5-Cg hydrocarbon, such as n-heptane or n-hexane, to obtain a mixture comprising Febuxostat crystalline form F2. The mixture may be maintained at about room temperature for a time of about 1 hour to about 48 hours, or for about 1 hour to about 24 hours. The obtained crystalline form may be further recovered, e.g., by filtering and drying.

[0063] The above Febuxostat Form F2 may also be prepared by a process comprising slurrying Febuxostat form F3 as defined below in dichloromethane ("DCM"), at about room temperature, to obtain a mixture. The mixture may be maintained for a time of from about 1 hour to about 48 hours, for example, for about 25 hours. The obtained crystalline form may be further isolated, e.g., by filtration. The isolated crystalline form is further dried.

[0064] The present invention encompasses crystalline Febuxostat, designated as form F10. Form Flo can be characterized by data selected from: an X-ray powder diffraction pattern having peaks at: 6.7 , 7.7 , 12.8 , 13.3 and 20.0 0.2 20; an X-ray powder diffraction pattern substantially as depicted in Figure 8; a solid-state 13C
NMR spectrum with signals at 112.7, 125.7, 132.4 and 168.3 0.2 ppm; a solid-state 13C NMR
spectrum having chemical shifts differences between the signal exhibiting the lowest chemical shift and another in the chemical shift range of 100 to 180 ppm of 11.7, 24.7, 31.4 and 67.3 0.1 ppm;
a solid-state 13C NMR spectrum substantially as depicted in Figures 9 or 10;
and combinations thereof. The signal exhibiting the lowest chemical shift in the chemical shift area of 100 to 180 ppm is typically at 101.0 lppm. The Febuxostat form F10 as defined in any of the above data, may be further characterized by additional XRPD peaks at 3.3 , 16.3 , 16.9 , 24.5 and 25.8 0.2 20.

[0065] Febuxostat form Flo may be anhydrous.

[0066] Febuxostat form F 10 has advantageous properties selected from at least one of. chemical purity, flowability, solubility, morphology or crystal habit, stability - such as storage stability, stability to dehydration, stability to polymorphic conversion, low hygroscopicity, low content of residual solvents. In particular, the crystalline Febuxostat form F 10 of the present invention has better solubility in ethanol compared to other crystalline forms.

[0067] The present invention also encompasses a process for preparing Febuxostat Form Flo comprising crystallizing Febuxostat from a mixture comprising methylisobutylketone ("MIBK") and a C5-Cg hydrocarbon.

[0068] The crystallization may comprise dissolving Febuxostat in MIBK; and adding a C5-Cg hydrocarbon such as n-heptane or n-hexane, to obtain a mixture comprising said crystalline form. The addition of the C5-Cg hydrocarbon may be done dropwise, at about reflux temperature. The dissolution is typically done while heating, e.g., to about reflux temperature.

[0069] The process may further comprise cooling to a temperature of about 40 C
to about 0 C, or to about room temperature. The obtained crystalline form may be further isolated, e.g., by filtering and drying.

[0070] The present invention provides a crystalline Febuxostat, designated as Form F3. Form F3 can be characterized by data selected from: a powder XRD pattern with peaks at 8.2 , 9.5 , 12.9 , 17.1 and 19.2 0.2 20; an XRPD pattern substantially as depicted in Figure 11; a solid-state 13C NMR spectrum with signals at 131.4, 162.3 and 165.4 0.2 ppm;
a solid-state 13C NMR spectrum having chemical shifts differences between the signal exhibiting the lowest chemical shift and another in the chemical shift range of 100 to 180 ppm of 30.3, 61.2 and 64.3 0.1 ppm; a solid-state 13C NMR spectrum substantially as depicted in Figures 12 or 13; and combinations thereof. The signal exhibiting the lowest chemical shift in the chemical shift area of 100 to 180 ppm is typically at 101.1 lppm. The Febuxostat Form F3 as defined in any of the above data may be further characterized by additional XRPD peaks at: 21.6 , 23.5 , 24.3 , 26.0 and 26.9 0.2 20.

[0071] The present invention encompasses a process for preparing Febuxostat Form F3 comprising crystallizing Febuxostat from EtOH. The crystallization may comprise:
dissolving Febuxostat in EtOH; heating to a temperature such as reflux temperature; cooling to a temperature such as, about 30 C to about 0 C, or to a temperature of about 15 C to about C, for example, to a temperature of about 5 C. The process may further comprise a maintaining step at a temperature such as, about 0 C to about 30 C, or at a temperature of about 5 C to about 15 C, for example, at a temperature of about 5 C, for a time interval such as, about 1 hour to about 48 hours, or about 1 hour to about 24 hours, for example, about 1.5 hours, to obtain crystalline form F3 of Febuxostat. The obtained crystalline form may be further recovered, e.g., by filtering and drying.

[0072] The present invention encompasses crystalline Febuxostat, designated as Form F4. Form F4 can be characterized by data selected from: an X-ray powder diffraction pattern having peaks at 7.4 , 11.2 , 14.8 , 16.8 and 22.3 0.2 20; an X-ray powder diffraction pattern substantially as depicted in Figure 14; a solid-state 13C NMR spectrum with signals at 156.5, 170.2 and 178.4 0.2 ppm; a solid-state 13C NMR spectrum having chemical shifts differences between the signal exhibiting the lowest chemical shift and another in the chemical shift range of 100 to 180 ppm of 55.2, 68.9 and 77.1 0.1 ppm; a solid-state 13C

NMR spectrum substantially as depicted in Figures 15 or 16; and combinations thereof. The signal exhibiting the lowest chemical shift in the chemical shift area of 100 to 180 ppm is at 101.3 lppm. The Febuxostat Form F4 as defined in any of the above data, may be further characterized by additional X-ray powder diffraction pattern peaks at 11.9 , 17.7 , 18.4 , 23.5 and 26.1 0.2 20.

[0073] The above Febuxostat Form F4 may be prepared by a process comprising precipitating Febuxostat from acetic acid ("AcOH"). In one embodiment, the precipitation may comprise slurrying Febuxostat form F3 in AcOH, at a temperature such as about room temperature, to obtain a mixture. The mixture may be maintained at about room temperature for a time interval such as about 1 hour to about 48 hours, or for about 20 hours to about 30 hours, for example, for about 25 hours.

[0074] In another embodiment, the precipitation comprises crystallizing Febuxostat from AcOH. The crystallization may comprise dissolving, typically, while heating to a temperature such as reflux temperature; and then cooling to a temperature such as about 0 C
to about 40 C, or to about room temperature to obtain said crystalline form.
The process may further comprise a maintaining step wherein the cooled mixture is maintained at a temperature, e.g., about room temperature, for a time of about 1 hour to about 48 hours, or for about 1 hour to about 24 hours, for example, for about 3.5 hours. The obtained crystalline form may be further isolated, e.g., by filtration.

[0075] The present invention encompasses crystalline Febuxostat designated as Form F5. Form F5 can be characterized by data selected from: an X-ray powder diffraction pattern having peaks at 5.9 , 6.5 , 8.5 , 11.6 and 18.0 0.2 20; an X-ray powder diffraction pattern substantially as depicted in Figure 17; and combinations thereof. The Febuxostat Form F5 as defined in any of the above data, may be further characterized by additional XRPD peaks at 11.0 , 12.4 , 17.5 , 20.7 and 23.3 0.2 20.

[0076] The present invention also encompasses a process for preparing Febuxostat Form F5 comprising crystallizing Febuxostat from a mixture comprising dimethylacetamide ("DMA") and n-heptane. The crystallization may comprise dissolving Febuxostat in DMA;
and adding n-heptane to obtain said crystalline form. The process may be done at about room temperature. The process may further comprise a maintaining step, wherein the mixture is maintained, e.g., at about room temperature, for about 1 hour to about 72 hours, or for about 1 hour to about 48 hours, for example, for about 43 hours.

[0077] The present invention encompasses crystalline Febuxostat, designated as Form F6. Form F6 can be characterized by data selected from: an X-ray powder diffraction pattern having peaks at 2.9 , 6.4 , 9.7 , 11.7 and 12.8 0.2 20; an X-ray powder diffraction pattern substantially as depicted in Figure 18; and a combination thereof. The Febuxostat Form F6 as defined in any of the above data, may be further characterized by additional XRPD peaks at 3.2 , 10.2 , 15.0 , 19.7 and 20.3 0.2 20.

[0078] The present invention encompasses a process for preparing Febuxostat Form F6 comprising crystallizing Febuxostat from chloroform. The crystallization may comprise dissolving Febuxostat in chloroform; heating; and then cooling to obtain a suspension comprising said crystalline form. The heating may be done to a temperature such as about reflux temperature, and the cooling may be done to a temperature of about 40 C
to about 0 C, or to about room temperature. The process may further comprise a maintaining step, wherein the cooled mixture is maintained, e.g., at about room temperature, for a time such as about 1 hour to about 48 hours, or about 1 hour to about 24 hours, for example, about 1 hour.

[0079] The obtained crystalline form may be further isolated, e.g., by filtration.

[0080] The present invention encompasses crystalline Febuxostat, designated as Form F7. Form F7 can be characterized by data selected from: an X-ray powder diffraction pattern having peaks at 6.7 , 8.1 , 10.1 , 12.8 , and 18.2 0.2 20.; an X-ray powder diffraction pattern substantially as depicted in Figure 19; a solid-state 13C NMR spectrum with signals at 128.6, 131.3 and 162.7 0.2 ppm; a solid-state 13C NMR spectrum having chemical shifts differences between the signal exhibiting the lowest chemical shift and another in the chemical shift range of 100 to 180 ppm of 28.5, 31.3 and 62.6 0.1 ppm; a solid-state 13C
NMR spectrum substantially as depicted in Figures 20 or 21; and combinations thereof. The signal exhibiting the lowest chemical shift in the chemical shift area of 100 to 180 ppm is typically at 100.1 lppm. The Febuxostat Form F7 as defined in any of the above data, may be further characterized by additional XRPD peaks at 15.6 , 15.9 , 18.8 , 23.0 and 24.7 0.2 20.

[0081] The present invention also encompasses a process for preparing Febuxostat Form F7 comprising crystallizing Febuxostat from a mixture comprising dimethylformamide ("DMF") and n-heptane. The crystallization, typically done at about room temperature, may comprise dissolving Febuxostat in DMF and then adding n-heptane to obtain said crystalline form. The process may further comprise a maintaining step wherein the mixture is maintained, e.g.,at about room temperature, for a time such as about 1 hour to about 72 hours, or about 1 hour to about 48 hours, for example, about 43.5 hours.

[0082] The present invention encompasses crystalline Febuxostat, designated as Form F8. Form F8 can be characterized by data selected from: an X-ray powder diffraction pattern having peaks at 4.0 , 7.3 , 7.7 , 9.9 and 17.3 0.2 20; an X-ray powder diffraction pattern substantially as depicted in Figure 22; a solid-state 13C NMR spectrum with signals at 100.0,127.9 and 134.7 0.2 ppm; a solid-state 13C NMR spectrum having chemical shifts differences between the signal exhibiting the lowest chemical shift and another in the chemical shift range of 100 to 180 ppm of 0.0, 27.9 and 34.7 0.1 ppm; a solid-state 13C
NMR spectrum substantially as depicted in Figures 23 or 24 and combinations thereof. The signal exhibiting the lowest chemical shift in the chemical shift area of 100 to 180 ppm is typically at 100.0 lppm. The Febuxostat Form F8 as defined in any of the above data, may be further characterized by additional XRPD peaks at 11.9 , 13.0 , 14.5 , 16.5 and 24.4 0.2 20.

[0083] The present invention encompasses a process for preparing Febuxostat Form F8 comprising slurrying Febuxostat form F3 in methyl benzoate. The slurrying may be done at a temperature such as about room temperature. A maintaining step may be done, wherein the slurry may be maintained, e.g., at about room temperature, for about lhour to about 48 hours, for example, for about 25 hours.

[0084] The obtained crystalline form may be further isolated, e.g., by filtration. The isolated crystalline form may further be dried.

[0085] The present invention encompasses crystalline Febuxostat, designated as Form F9. Form F9 can be characterized by data selected from: an X-ray powder diffraction pattern having peaks at 7.2 , 10.7 , 14.0 , 14.4 and 16.3 0.2 20.; an X-ray powder diffraction pattern substantially as depicted in Figure 25; a solid-state 13C NMR spectrum with signals at 123.1, 124.8 and 132.8 0.2 ppm; a solid-state 13C NMR spectrum having chemical shifts differences between the signal exhibiting the lowest chemical shift and another in the chemical shift range of 100 to 180 ppm of 11.2, 12.9 and 20.9 0.1 ppm; a solid-state 13C
NMR spectrum substantially as depicted in Figures 26 or 27; and combinations thereof. The signal exhibiting the lowest chemical shift in the chemical shift area of 100 to 180 ppm is typically at 111.9 lppm. The Febuxostat Form F9 as defined in any of the above data, may be further characterized by additional XRPD peaks at 11.9 , 17.0 , 19.5 , 23.7 and 26.5 0.2 20.

[0086] The present invention encompasses a process for preparing Febuxostat Form F9 comprising slurrying Febuxostat form F3 in dimethylsulfoxide ("DMSO"). The slurrying may be done at a temperature such as about room temperature. The process may further comprise a maintaining step for a time such as about lhour to about 48 hours, for example, about 46 hours. The obtained crystalline form may be further isolated, e.g., by filtration.

[0087] The present invention encompasses crystalline Febuxostat, designated as form F11. Form Fl 1 can be characterized by data selected from: an X-ray powder diffraction pattern having peaks at: 4.3 , 6.0 , 8.6 , 11.4 and 12.2 0.2 20; an X-ray powder diffraction pattern substantially as depicted in Figure 28; and a combination thereof.
Febuxostat form Fl l as defined in any of the above data, may further be characterized by additional XRPD peaks at 17.1 and 25.4 0.2 20.

[0088] The present invention also encompasses a process for preparing Febuxostat Form Fl 1 comprising precipitating Febuxostat from tert-butanol. The precipitation may comprise dissolving Febuxostat in tert-butanol; and lyophilizing to obtain febuxsostate crystalline form F 11. The dissolving step may be done by heating to a temperature such as from about 35 C to about 82 C, or from about 35 C to about 40 C.
Lyophilization is typically done by a process comprising cooling the solution to obtain a frozen mixture, and evaporating the solvent while maintaining the mixture frozen at low temperatures. The lyophilizing step may be done under vacuum, at a pressure of from about 2mm Hg to about 14.8mm Hg. The cooling may be done to a temperature such as from about 0 C to about -50 C, or from about -6 C to about -42 C.

[0089] The present invention encompasses crystalline Febuxostat, designated as form F12. Form F12 can be characterized by data selected from: an X-ray powder diffraction pattern having peaks at: 3.9 , 7.9 , 10.0 , 11.7 and 12.9 0.2 20; an X-ray powder diffraction pattern substantially as depicted in Figure 29; and a combination thereof. The Febuxostat form F12 as defined in any of the above data, may further be characterized by additional XRPD peaks at 15.7 , 16.2 , 17.6 , 19.9 and 22.8 0.2 20.

[0090] The present invention also encompasses a process for preparing Febuxostat Form F12 comprising crystallizing Febuxostat from a mixture of dioxane and water. The crystallization may comprise dissolving Febuxostat in dioxane at about room temperature;
and adding water to obtain said crystalline form. The process may further comprise a maintaining step at a temperature such as about room temperature, for a time of about 1 hour to about 12 hours, for example, for about 2 hours. The obtained crystalline form may be further isolated, e.g., by filtration.

[0091] The present invention encompasses crystalline Febuxostat, designated as form F13. Form F13 can be characterized by data selected from: an X-ray powder diffraction pattern having peaks at: 2.9 , 5.8 , 9.8 , 15.2 and 19.2 0.2 20; an X-ray powder diffraction pattern substantially as depicted in Figure 30; and combinations thereof. The Febuxostat form F13 as defined in any of the above data, may further be characterized by additional XRPD peaks at 16.8 , 17.5 , 19.9 , 20.4 and 22.8 0.2 20.

[0092] The present invention encompasses a process for preparing Febuxostat Form F13 comprising crystallizing Febuxostat from chloroform. The crystallization may comprise dissolving Febuxostat in chloroform to obtain a mixture; precipitating the Febuxostat; and isolating the obtained precipitate. The precipitating may be done by adding a C5-Cg hydrocarbon, such as n-heptane or n-hexane to the reaction mixture or by heating; cooling;
and optionally maintaining the mixture. The heating may be done to a temperature such as about the reflux temperature for a time of about lmin to about lhr, or for about 20 minutes.
The cooling may be done to a temperature such as about 40 C to about 0 C, or about room temperature. The maintaining is typically done at a temperature of at about 0 C to about 40 C
for a time such as about lmin to about 24 hours, for example, for about 1.25 hours. The isolation of the precipitate may be done by filtering.

[0093] The present invention encompasses crystalline Febuxostat, designated as form F14. Form F14 can be characterized by data selected from: an X-ray powder diffraction pattern having peaks at: 3.2 , 5.1 , 7.0 , 11.8 and 25.5 0.2 20; an X-ray powder diffraction pattern substantially as depicted in Figure 31; and combinations thereof.

[0094] The present invention also encompasses a process for preparing Febuxostat form F14 comprising crystallizing Febuxostat from a mixture comprising chloroform and a C5-Cg hydrocarbon or water. The crystallization may comprise dissolving Febuxostat in chloroform; and adding a solvent selected from: water and a C5-Cg hydrocarbon to obtain said crystalline form. Suitable C5-Cg hydrocarbons include, for example, n-heptane and n-hexane.

[0095] The process may further comprise maintaining the mixture, e.g. at about room temperature, for a time such as about 1 hour to about 24 hours, or about 1 hour to about 5 hours. The obtained crystalline form may be further isolated, e.g., by filtering and drying.

[0096] The above crystalline forms of Febuxostat can be used in the preparation of a pharmaceutical composition comprising any one, or combinations of, the forms of Febuxostat described above, and at least one pharmaceutically acceptable excipient.

[0097] The present invention further provides 1) a pharmaceutical composition comprising any one, or combination, of Febuxostat crystalline Forms described above and a pharmaceutically acceptable excipient ; 2) the use of any one of the above pharmaceutical compositions for the treatment of hyperuricemia in patients with gout and 3) methods of treatment of a patient with gout, comprising administering to said patient an effective amount of a pharmaceutical composition comprising any one, or combinations of the forms of Febuxostat described herein.

[0098] The pharmaceutical composition of the present invention can be in a solid or liquid form. If the pharmaceutical composition is in a liquid form, the one, or combination, of the Febuxostat crystalline Forms described above are retained as solid(s) in the liquid pharmaceutical composition, e.g., as a suspension.

[0099] Having described the invention with reference to certain preferred embodiments, other embodiments will become apparent to one skilled in the art from consideration of the specification. The invention is further defined by reference to the following examples describing in detail the preparation of the composition and methods of use of the invention. It will be apparent to those skilled in the art that many modifications, both to materials and methods, may be practiced without departing from the scope of the invention.

Instrumentation X-ray powder diffraction:

[00100] The X-ray powder diffraction was performed on a Bruker X-ray powder diffractometer model D8 advance equipped with a lynxeye detector or an ARL
powder diffractometer model X'TRA-019, equipped with round standard aluminum sample holder with round zero background quartz plate. The scanning parameters used were:
Copper Kul radiation (X=1.5418 A), range: 2-40 degrees 20; scan mode: continuous scan.

[00101] The peak positions were determined by using silicon powder as internal standard in an admixture with the sample measured. The position of the silicon (111) peak was corrected to be 28.45 degrees two theta. The positions of the peaks were corrected respectively (no corrections were performed on the presented diffractograms in the figures).

13C NMR spectra:

[00102] 13C NMR at 125MHz using Bruker Avance IF 500. SB probe using 4mm rotors [00103] Magic angle was set using KBr. Homogeneity of magnetic field checked using adamantane. Parameters for Cross polarization optimized using glycine.

[00104] Spectral reference set according to glycine as external standard (176.03 ppm for low field carboxyl signal).
Magic Angle Spinning Rate:l 1 kHz Pulse Program: cp with tppml5 during decoupling Delay time: 5s (except for Forms F7, F8 and F9 of Febuxostat, wherein the delay time was 2s) Contact time: 2 msec.
Number of Scans: 1024 (except for Forms F8 and F9 of Febuxostat, wherein the number of scans was 2048) [00105] The term "V" relates to ml of solvent or antisolvent per g of starting material febuxostat.

Examples Example 1: Preparation of Febuxostat Form F 1 [00106] Febuxostat (1 g) was placed in a 50 ml round bottom flask equipped with a magnetic stirrer and a reflux condenser. Methylisobutylketone (MIBK) (10 ml) was added and the resulting mixture was heated to reflux using an oil bath to give clear yellowish solution. Then, the heating was stopped, the oil bath was removed and the mixture was allowed to cool to RT and stirred at RT for 1.5 h. A white precipitate formed during the cooling. The mixture was then filtered and the separated solid was washed with MIBK (1 ml) to provide a wet white solid (0.64 g ). A portion (0.44 g) was dried in vacuo at 50 C over 22.5 h to provide the product as a white solid (0.33 g).

Example 2: Preparation of Febuxostat Form F2 [00107] Febuxostat (1 g ) was placed in a 250 ml round bottom flask equipped with a magnetic stirrer. Methylethylketone (MEK) (35 ml, 35V) was added and the resulting mixture was stirred at RT to give a clear yellowish solution. N-heptane (175 ml) was added and the resulting solution was stirred at RT over 20 h. The mixture was then filtered to provide a wet white solid (1.03 g ), which was then dried in vacuo at 40 C
over 24 h to give white solid (0.43 g).

Example 3: Preparation of Febuxostat Form F2 [00108] Febuxostat (0.5 g) was placed in a 250 ml round bottom flask equipped with a magnetic stirrer. Acetone (11.5 ml, 23V) was added and the resulting mixture was stirred at RT to give a clear yellowish solution. n-Heptane (126.5 ml, 253V) was added and the resulting solution was stirred at RT over 16.25 h. The mixture was then filtered to provide a wet white solid (0.31 g). The solid was dried in vacuo at 50 C over 22 h to provide a white solid (0.23 g).

Example 4: Preparation of Febuxostat Form F2 [00109] A mixture of Febuxostat (0.5 g) and acetone (12.5 ml, 25V) was prepared to obtain yellow solution. n-Hexane (75m1, 150V) was added to the solution and a white suspension was formed. The suspension was stirred for 3h at 25 C, whereupon it was filtered. The filtered solid was analyzed by XRD and form F2 was obtained.

Example 5: Preparation of Febuxostat Form F2 [00110] A mixture of Febuxostat (0.5 g) and acetone (12.5 ml, 25V) was prepared to obtain a yellow solution. n-Hexane (75m1, 150V) was added to the solution and a white suspension was formed. The suspension was stirred for 3h at 25 C, whereupon it was filtered. The filter cake thus obtained was dried 16h at 50 C. The solid was analyzed by XRD
and form F2 was obtained.

Example 6: Preparation of Febuxostat Form F2 [00111] Febuxostat crystalline form F3 (1.00 g) was placed in a 50 ml round bottom flask equipped with a magnetic stirrer. DCM (15 ml, 15V) was added and the resulting mixture (a white slurry) was stirred at RT for 25 h. The mixture was then filtered to provide a wet white solid (0.81 g). A portion (0.15 g) of the wet solid was taken for polymorphism analysis and was identified as Febuxostat Form F2, and the rest was dried in vacuo at 50 C
over 18 h to provide a white solid (0.50 g).

Example 7: Preparation of Febuxostat Form F3 [00112] A mixture of Febuxostat (96 g) and EtOH (770 ml, 8V) was heated to 78 C to form a yellow solution. The solution was then cooled to 5 C and an off-white suspension was obtained. The suspension was stirred for lh at 5 C, whereupon it was filtered.
The filter cake thus obtained was dried 16h at 40 C.

Example 8: Preparation of Febuxostat Form F4 [00113] Febuxostat F3 (0.50 g ) was placed in a 50 ml round bottom flask equipped with a magnetic stirrer. Acetic-acid ("AcOH") (7.5 ml, 15V) was added and the mixture (a white slurry) was stirred at RT over 25 h. The mixture was then filtered to give a wet white solid (0.49 g). The wet solid was analyzed by XRD.

Example 9: Preparation of Febuxostat Form F4 [00114] Febuxostat (0.50 g) was placed in a 50 ml round bottom flask equipped with a magnetic stirrer and a reflux condenser. AcOH (10 ml, 20V) was added while heating to reflux on an oil bath, to give a clear yellowish solution. Then the heating was stopped, the oil bath was removed and the mixture was allowed to cool to RT. After 3.5 h of stirring at RT, a wet white solid (0.51 g) was collected by filtration. The wet solid was analyzed by XRD.
Example 10: Preparation of Febuxostat Form F5 [00115] Febuxostat (0.50 g) was placed in a 100 ml round bottom flask equipped with a magnetic stirrer. Dimethylacetamide ("DMA") (0.5 ml, IV) was added and the mixture was stirred at RT to give a clear yellowish solution. n-Heptane (10 ml, 20V) was added, and the resulting clear mixture was stirred at RT over 43 h. During this time a precipitate formed.
The precipitate was separated by filtration to provide a wet solid. The wet solid was analyzed by XRD.

Example 11: Preparation of Febuxostat Form F6 [00116] A mixture of Febuxostat (0.5 g) and chloroform (4.5 ml, 9V) was heated to 61 C (reflux) to obtain yellow solution. The solution was then cooled to 25 C
and a white suspension was obtained. The suspension was then stirred for lh at 25 C, whereupon it was filtered. The filtered solid was analyzed by XRD.

Example 12: Preparation of Febuxostat Form F7 [00117] Febuxostat (0.50 g) was placed in a 100 ml round bottom flask equipped with a magnetic stirrer. Dimethylformamide ("DMF") (1 ml, 2V) was added and the mixture was stirred at RT to give a clear yellowish solution. n-Heptane (20 ml, 40V) was added and the resulting clear mixture was stirred at RT over 43.5 h. During this time a precipitate formed.
The precipitate was separated by filtration to provide a wet solid. The wet solid was analyzed by XRD.

Example 13: Preparation of Febuxostat Form F8 [00118] Febuxostat form F3 (0.50 g) was placed in a 20 ml vial equipped with a magnetic stirrer. Methyl benzoate (5 ml, l OV) was added, and the mixture (a white slurry) was stirred at RT over 25 h. During this time a precipitate formed. The precipitate was separated by filtration to provide a wet solid (1.35 g). The solid was dried in vacuo at 50 C
over 17 h to give a white solid (0.34 g).

Example 14: Preparation of Febuxostat Form F9 [00119] Febuxostat form F3 (0.50 g) was placed in a 20 ml vial equipped with a magnetic stirrer. Dimethylsulfoxide ("DMSO") (2.5 ml, 5V) was added, and the mixture was stirred at RT over 46 h. During this time a precipitate formed. The precipitate was separated by filtration to provide a wet solid (0.27 g). The wet solid was analyzed by XRD.

Example 15: Preparation of Febuxostat Form Flo [00120] Febuxostat (20.00 g) was placed in a 1L round bottom flask equipped with a magnetic stirrer and a reflux condenser. MIBK (200 ml, l OV) was added. The mixture was heated to reflux on an oil bath and stirred at reflux for 5 min to form a solution. n-Heptane (300 ml, 15V) was added to the clear yellowish solution, in portions during 10 min and a white precipitate formed. Then, the heating was stopped and the mixture was allowed to cool and stir at RT for 1.5 h. A wet white solid formed and was collected (32.36 g) by filtration.
The sample was dried in vacuo at 50 C over 24 h to give white solid (17.07 g).

Example 16: Preparation of Febuxostat Form Flo [00121] Febuxostat (5.00 g) was placed in a 500 ml round bottom flask equipped with a magnetic stirrer and a reflux condenser. MIBK (50 ml, l OV) was added. The mixture was heated to reflux on an oil bath and stirred at reflux for 5 min. N-hexane (150 ml, 30V) was added to the resulted clear yellowish solution, in portions during 10 min and a white precipitate was formed. Then the heating was stopped and the mixture was allowed to cool and stir at RT during 1 h. A wet white solid formed and was collected (5.04 g) by filtration.
The sample was dried in vacuo at 50 C over 23.5 h to give white solid (4.15 g).

Example 17: Preparation of Febuxostat Form F11 [00122] Febuxostat (5.00 g) was dissolved in tert-butanol (500 g) at 35 C-40 C. The clear colorless solution was lyophilized at -42 C-(-6 C) under vacuum of 2-14.8 mmHg for 24 h. A bulky white solid was collected (5.5 g).

Example 18: Preparation of Febuxostat Form F12 [00123] Febuxostat (1.00 g) was dissolved in dioxane (8 ml, 8V) in a 100 ml round bottom flask equipped with a magnetic stirrer. Tap water (8 ml, 8V) was added to the clear solution and a white precipitate formed. The mixture was stirred at RT over 2 h. . During this time a precipitate formed. The precipitate was separated by filtration to provide a wet solid (2.43 g).

Example 19: Preparation of Febuxostat Form F13 [00124] Febuxostat (5.00 g) was dissolved in CHC13 (250 ml, 50V) at about 25 C
in a 1L round bottom flask equipped with magnetic stirrer. n-Hexane (250 ml; 50V) was added to form white precipitation. The obtained mixture was stirred during additional 2.5 hours at about 25 C and filtered to give wet white solid (7.15 g).

Example 20: Preparation of Febuxostat Form F13 [00125] A mixture of Febuxostat (5.00 g) and CHC13 (55 ml, 11V) was heated to reflux on an oil bath in a 250 ml round bottom flask equipped with magnetic stirrer and a reflux condenser. After 20 min of stirring at reflux, the heating was stopped, the oil bath was removed and the mixture was allowed to cool and stir at RT over 1.25 h. A
white precipitate formed during the cooling. The mixture was filtered to give wet white solid (4.70 g).

Example 21: Preparation of Febuxostat Form F14 [00126] Febuxostat (1.00 g) was dissolved in CHC13 (50 ml, 50V) in a 500 ml round bottom flask equipped with a magnetic stirrer. To the clear yellowish solution, n-heptane (50 ml, 50V) was added and a white precipitate formed. The mixture was stirred at RT over 2.5 h, and then it was filtered to provide a wet white solid (0.65 g). The solid was dried in vacuo at 50 C over 23 h to give a white solid (0.24 g).

Example 22: Preparation of Febuxostat Form F14 [00127] Febuxostat (1.00 g) was dissolved in CHC13 (50 ml, 50V) in a 500 ml round bottom flask equipped with a magnetic stirrer. n-Hexane (50 ml, 50V) was added to the clear yellowish solution and a white precipitate formed. The mixture was stirred at RT for 2.5 h, and then it was filtered to give a wet white solid (1.28 g). The solid was dried in vacuo at 50 C over 23 h to give a white solid (0.55 g).

Example 23: Preparation of Febuxostat Form F14 [00128] Febuxostat (1.00 g) was dissolved in CHC13 (50 ml, 50V) in a 1L round bottom flask equipped with magnetic stirrer. Tap water (50 ml, 50V) was added to the clear yellowish solution and a white precipitate formed. The mixture was stirred at RT over 2.5 h, and then it was filtered to give 0.72 g of wet white solid. The solid was dried in vacuo at 50 C
over 23 h to give a white solid (0.15 g).

Claims

1. A crystalline Form F10 of Febuxostat.

2. The crystalline form of Febuxostat, designated Form F10, according to claim 1, characterized by data selected from: an X-ray powder diffraction pattern having peaks at 6.7°, 7.7°, 12.8°, BY and 20.0° ~ 0.2°
2.theta.; an X-ray powder diffraction pattern substantially as depicted in Figure 8; a solid-state 13C NMR spectrum with signals at 112.7, 125.7, 132.4 and 168.3 ~ 0.2 ppm; a solid-state 13C NMR spectrum having chemical shifts differences between the signal exhibiting the lowest chemical shift and another in the chemical shift range of 100 to 180 ppm of 11.7, 24.7, 31.4 and 67.3 ~ 0.1 ppm; a solid-state 13C NMR spectrum substantially as depicted in Figure 9 or 10; and combinations thereof.

3. The crystalline form of Febuxostat, designated Form F10, according to claim 2, characterized by an X-ray powder diffraction pattern having peaks at 6.7°, 7.7°, 12.8°, BY and 20.0° ~ 0.2° 2.theta..

4. The crystalline Febuxostat according to claim 2 or claim 3, further characterized by X-ray powder diffraction peaks at 3.3°, 16.3°, 16.9°, 24.5° and 25.8° ~ 0.2° 2.theta..

5. A crystalline Form F1 of Febuxostat.

6. The crystalline form of Febuxostat, designated Form F1, according to claim 5, characterized by data selected from: a powder XRD pattern with peaks at 5.8°, 6.8°, 8.1°, 11.8° and 17.4° ~ 0.2° 2.theta.; an XRPD
pattern substantially as depicted in Figure 1; a solid-state 13C NMR spectrum with signals at 123.8, 163.1 and 168.5~ 0.2 ppm; a solid-state 13C NMR spectrum having chemical shifts differences between the signal exhibiting the lowest chemical shift and another in the chemical shift range of 100 to 180 ppm of 23.4, 62.7 and 68.1 ~ 0.1 ppm; a solid-state 13C NMR spectrum substantially as depicted in Figures 2 or 3; and combinations thereof.

7. The crystalline form of Febuxostat, designated Form F1, according to claim 6, characterized by an X-ray powder diffraction pattern having peaks at 5.8°, 6.8°, 8.1 °, 11.8°and17.4°~ 0.2° 2.theta..

8. The crystalline Febuxostat according to any of claims 5-7, wherein the crystalline form is substantially free of form G.

9. The crystalline Febuxostat according to claim 8, wherein the crystalline form is substantially free of any other polymorphic forms of Febuxostat.

10. The crystalline Febuxostat according to any of claims 6-9, further characterized by additional X-ray powder diffraction peaks at: 4.7°, 9.4°, 14.2°, 16.2°, and 25.8° ~ 0.2°
2.theta..

11. A crystalline Form F2 of Febuxostat.

12. The crystalline form of Febuxostat, designated Form F2, according to claim 11, characterized by data selected from: a powder XRD pattern with peaks at 3.0°, 5.9°, 8.8°, 11.8° and 12.5° ~ 0.2° 2.theta.; an XRPD
pattern substantially as depicted in Figure 4 or Figure 5; a solid-state 13C NMR spectrum with signals at 112.3, 163.9, 168.8 ~ 0.2 ppm; a solid-state 13C NMR spectrum having chemical shifts differences between the signal exhibiting the lowest chemical shift and another in the chemical shift range of 100 to 180 ppm of 1 1.5, 63.1 and 68.0 ~ 0.1 ppm; a solid-state 13C NMR
spectrum substantially as depicted in Figures 6 or 7; and combinations thereof.

13. The crystalline form of Febuxostat, designated Form F2, according to claim 12, characterized by an X-ray powder diffraction pattern having peaks at 3.0°, 5.9°, 8.8°, 11.8° and 12.5° ~ 0.2°2.theta..

14. The crystalline Febuxostat according to claim 12 or claim 13, further characterized by additional X-ray powder diffraction peaks at: 13.1°, 14.7°, 17.5°, 24.4° and 25.2° ~
0.2° 2.theta..

15. A pharmaceutical composition comprising the Febuxostat crystalline form of any one of the preceding claims, and at least one pharmaceutically acceptable excipient.

16. A crystalline form of Febuxostat according to any one of claims 1-14 for use as a pharmaceutical formulation.

17. A process for preparing a pharmaceutical formulation comprising combining the Febuxostat crystalline form of any one of claims 1-14, with at least one pharmaceutically acceptable excipient.

18. The use of the crystalline form according to any of claims 1-14 for the treatment of hyperuricemia in patients with gout.

19. A method of treating a patient with gout, comprising administering to said patient an effective amount of the pharmaceutical composition according to claim 15.