CA2741854A1 - Crumple zone package for moisture sensitive products - Google Patents
Crumple zone package for moisture sensitive products Download PDFInfo
- Publication number
- CA2741854A1 CA2741854A1 CA2741854A CA2741854A CA2741854A1 CA 2741854 A1 CA2741854 A1 CA 2741854A1 CA 2741854 A CA2741854 A CA 2741854A CA 2741854 A CA2741854 A CA 2741854A CA 2741854 A1 CA2741854 A1 CA 2741854A1
- Authority
- CA
- Canada
- Prior art keywords
- blister
- package
- cups
- moisture sensitive
- crumple zone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000004806 packaging method and process Methods 0.000 description 9
- 101100441413 Caenorhabditis elegans cup-15 gene Proteins 0.000 description 5
- 239000000306 component Substances 0.000 description 5
- 210000003811 finger Anatomy 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 4
- 108010022901 Heparin Lyase Proteins 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000004108 freeze drying Methods 0.000 description 2
- 230000036571 hydration Effects 0.000 description 2
- 238000006703 hydration reaction Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 210000003813 thumb Anatomy 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 238000004320 controlled atmosphere Methods 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 230000013632 homeostatic process Effects 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000005426 pharmaceutical component Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D77/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
- B65D77/04—Articles or materials enclosed in two or more containers disposed one within another
- B65D77/048—Articles or materials enclosed in two or more containers disposed one within another the inner and outer containers being rigid and the outer container being of curved cross-section, e.g. cylindrical
- B65D77/0486—Articles or materials enclosed in two or more containers disposed one within another the inner and outer containers being rigid and the outer container being of curved cross-section, e.g. cylindrical the inner container being coaxially disposed within the outer container
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
- A61J1/035—Blister-type containers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
- B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
- B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
- B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
- B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
- B65D75/327—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D2575/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes or webs of flexible sheet material, e.g. in folded wrappers
- B65D2575/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by association or interconnecting two or more sheets or blanks
- B65D2575/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
- B65D2575/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
- B65D2575/3209—Details
- B65D2575/3218—Details with special means for gaining access to the contents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/18—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient
Description
CRUMPLE ZONE PACKAGE FOR
MOISTURE SENSITIVE PRODUCTS
FIELD OF THE INVENTION
The present invention relates to packaging and more particularly, relates to a package for moisture sensitive components and to a method for packaging such moisture sensitive components.
BACKGROUND OF THE INVENTION
Particularly, in the pharmaceutical field, there are some materials which are both temperature and humidity sensitive. These components must be kept at a certain temperature (usually below ambient) and the humidity level needs to be controlled.
One type of product which is sensitive to humidity is a lyophilized component.
The product starts out in a liquid form and is then frozen and lyophilized to emerge in its dry form.
One particular pharmaceutical component which undergoes a lyophilization is heparinase which is an enzyme that breaks down heparin. It is used in the monitoring of homeostasis.
The current package format for heparinase comprises packaging 20 cups along with their pins which rest in a tray in a box with a shrink wrap film covering the box. Once the package is open, the seal is broken and all 20 cups are exposed to the ambient environment which may not be benign to the active ingredient. The cups and their pins are held in place in the tray by gravity alone. The configuration is such that the operator has to take great care to keep the tray flat so that none of the cups and/or pins fall out of the box which would contaminate them and render the cup and pin unusable.
In a current production process, following controlled rehydration, the cups (without their pins) are shipped in bulk under controlled conditions to a secondary manufacturing site where the cups are put in trays of 20. Pins are inserted and the package is sealed. It is necessary to maintain a desired level of moisture or humidity in the product.
However, one disadvantage is that once the package is opened, the moisture level of the products in the remaining cups may be affected.
SUMMARY OF THE INVENTION
It is an object of the present invention to provide a package for a humidity sensitive product.
It is a further object of the present invention to provide a method for the packaging of a humidity sensitive product.
According to one aspect of the present invention, each cup along with its pin is sealed in a unit dose package at the time of manufacture whereby the end user may break off one or more cups without affecting the integrity of the other cups.
According to a further aspect of the present invention, there is provided a method for the packaging of heparinase containing formulations following lyophilization.
The packaging is done in a suitable controlled atmosphere room. Following rehydration, the cups and pins are placed in the blister trays having purpose designed in a number suited to the application.
The diecut, perforated blisters are sealed with printed, peelable foil/paper lidding, having matching diecuts and perforations, so that they can easily be separated by first separating at the unit dose packages at the matching diecut, recessed area.
The diecut area has been designed so that four of the blister's peelable areas are connected for better diecutting production control. Each of the unit dose blisters are printed with the same
MOISTURE SENSITIVE PRODUCTS
FIELD OF THE INVENTION
The present invention relates to packaging and more particularly, relates to a package for moisture sensitive components and to a method for packaging such moisture sensitive components.
BACKGROUND OF THE INVENTION
Particularly, in the pharmaceutical field, there are some materials which are both temperature and humidity sensitive. These components must be kept at a certain temperature (usually below ambient) and the humidity level needs to be controlled.
One type of product which is sensitive to humidity is a lyophilized component.
The product starts out in a liquid form and is then frozen and lyophilized to emerge in its dry form.
One particular pharmaceutical component which undergoes a lyophilization is heparinase which is an enzyme that breaks down heparin. It is used in the monitoring of homeostasis.
The current package format for heparinase comprises packaging 20 cups along with their pins which rest in a tray in a box with a shrink wrap film covering the box. Once the package is open, the seal is broken and all 20 cups are exposed to the ambient environment which may not be benign to the active ingredient. The cups and their pins are held in place in the tray by gravity alone. The configuration is such that the operator has to take great care to keep the tray flat so that none of the cups and/or pins fall out of the box which would contaminate them and render the cup and pin unusable.
In a current production process, following controlled rehydration, the cups (without their pins) are shipped in bulk under controlled conditions to a secondary manufacturing site where the cups are put in trays of 20. Pins are inserted and the package is sealed. It is necessary to maintain a desired level of moisture or humidity in the product.
However, one disadvantage is that once the package is opened, the moisture level of the products in the remaining cups may be affected.
SUMMARY OF THE INVENTION
It is an object of the present invention to provide a package for a humidity sensitive product.
It is a further object of the present invention to provide a method for the packaging of a humidity sensitive product.
According to one aspect of the present invention, each cup along with its pin is sealed in a unit dose package at the time of manufacture whereby the end user may break off one or more cups without affecting the integrity of the other cups.
According to a further aspect of the present invention, there is provided a method for the packaging of heparinase containing formulations following lyophilization.
The packaging is done in a suitable controlled atmosphere room. Following rehydration, the cups and pins are placed in the blister trays having purpose designed in a number suited to the application.
The diecut, perforated blisters are sealed with printed, peelable foil/paper lidding, having matching diecuts and perforations, so that they can easily be separated by first separating at the unit dose packages at the matching diecut, recessed area.
The diecut area has been designed so that four of the blister's peelable areas are connected for better diecutting production control. Each of the unit dose blisters are printed with the same
-2-information with the lot and expiry date. The blisters are then each filled with one cup and one pin and the lidding heat-sealed in the cold room. The lids are heat sealed only when the hydration of the product in the cups reaches a precise hydration point. The sealed blister along with a technical paper insert is inserted into a carton with a suitable security seal.
The cases are then stored in a refrigerated atmosphere. With the new innovative packaging, the technician can separate one sealed unit dose blister from the other sealed unit dose blisters in the refrigerator, bring only as many unit dose blisters as are necessary to the blood coagulation analyzer. One very important aspect of the innovation is the crumple zone area of the blister. The unit does blisters without the crumple zone would have to be 30% larger in order to reach in and hold one cup and pin to be removed from the packaging. This innovation is an environmentally friendly solution to reducing size and subsequently material usage, reducing refrigeration space, reducing energy consumption, ensuring error free, technically friendly packaging.
BRIEF DESCRIPTION OF THE DRAWINGS
Having thus generally described the invention, reference will be made to the accompanying drawings illustrating an embodiment thereof, in which:
Figure 1 is a top plan view of a blister package according to the present invention;
Figure 2 is a side elevational view thereof;
Figure 3 is a side elevational view showing the placement of a pin in the blister cavity;
Figure 4 is a photograph of a non sealed blister pack having pins located therein; and Figure 5 is a photograph showing the blister being crumpled by having two fingers pressing down on the finger depressions to gain access to hold the cup a pin and remove
The cases are then stored in a refrigerated atmosphere. With the new innovative packaging, the technician can separate one sealed unit dose blister from the other sealed unit dose blisters in the refrigerator, bring only as many unit dose blisters as are necessary to the blood coagulation analyzer. One very important aspect of the innovation is the crumple zone area of the blister. The unit does blisters without the crumple zone would have to be 30% larger in order to reach in and hold one cup and pin to be removed from the packaging. This innovation is an environmentally friendly solution to reducing size and subsequently material usage, reducing refrigeration space, reducing energy consumption, ensuring error free, technically friendly packaging.
BRIEF DESCRIPTION OF THE DRAWINGS
Having thus generally described the invention, reference will be made to the accompanying drawings illustrating an embodiment thereof, in which:
Figure 1 is a top plan view of a blister package according to the present invention;
Figure 2 is a side elevational view thereof;
Figure 3 is a side elevational view showing the placement of a pin in the blister cavity;
Figure 4 is a photograph of a non sealed blister pack having pins located therein; and Figure 5 is a photograph showing the blister being crumpled by having two fingers pressing down on the finger depressions to gain access to hold the cup a pin and remove
-3-them from the unit dose blister.
DETAILED DESCRIPTION OF THE INVENTION
A blister pack according to the present invention is illustrated in Figure 1 and designated generally by reference numeral 10. Blister pack 10 has a plurality of blisters 12 as may be seen in Figures 2 and 3. Overlying blister cups 12 is a top layer 14. A plurality of perforations 16 are formed in top layer 14 and a blister layer as may be seen in Figure 4.
Perforations 16 extend horizontally in both directions to divide a package into individual blisters 12. As such, each blister12 may be broken off from adjacent cups.
There are also provided a plurality of cuts 18 which extend through top layer 14 to provide a corner top layer 14. Top layer 14 may be peeled back to facilitate removal of the same.
Within each blister 12, there is provided a cup 15 having a freeze dried component at the bottom and a pin which comprises a pin head 20 and a pin shaft 22.
Each blister cup is defined by upper blister wall 24 and a lower blister wall 26 with an inwardly angled section 28 joining the blister wall 24 with lower blister wall 26. There is also a bottom wall designated by reference numeral 30.
In order to use a package of the present invention, an individual blister 12 is broken off from the remaining blisters. Top layer 14 may then be peeled back to gain access to the cup 15. Pressure would be exerted on a top periphery of the blister and as a result, the lower blister wall 26 would tend to crumple thereby permit access to cup 15.
It will be noted that there are provided recesses 32 about a top of each blister 12. This enables the finger of the user to access cup 15.
As seen in Figure 5, the design of the recesses is such that after removable of the
DETAILED DESCRIPTION OF THE INVENTION
A blister pack according to the present invention is illustrated in Figure 1 and designated generally by reference numeral 10. Blister pack 10 has a plurality of blisters 12 as may be seen in Figures 2 and 3. Overlying blister cups 12 is a top layer 14. A plurality of perforations 16 are formed in top layer 14 and a blister layer as may be seen in Figure 4.
Perforations 16 extend horizontally in both directions to divide a package into individual blisters 12. As such, each blister12 may be broken off from adjacent cups.
There are also provided a plurality of cuts 18 which extend through top layer 14 to provide a corner top layer 14. Top layer 14 may be peeled back to facilitate removal of the same.
Within each blister 12, there is provided a cup 15 having a freeze dried component at the bottom and a pin which comprises a pin head 20 and a pin shaft 22.
Each blister cup is defined by upper blister wall 24 and a lower blister wall 26 with an inwardly angled section 28 joining the blister wall 24 with lower blister wall 26. There is also a bottom wall designated by reference numeral 30.
In order to use a package of the present invention, an individual blister 12 is broken off from the remaining blisters. Top layer 14 may then be peeled back to gain access to the cup 15. Pressure would be exerted on a top periphery of the blister and as a result, the lower blister wall 26 would tend to crumple thereby permit access to cup 15.
It will be noted that there are provided recesses 32 about a top of each blister 12. This enables the finger of the user to access cup 15.
As seen in Figure 5, the design of the recesses is such that after removable of the
-4-peelable lid, a finger and thumb may be inserted at the top of the blister pushing down on the two top opposite sides of the blister. This causes the base of the blister cavity to buckle and allows the finger and thumb to go deeper into the single blister cavity to gain complete access to the cup 15.
It will be understood that the above described embodiments are for purposes of illustration only and that changes and modifications may be made thereto without departing from the spirit and scope of the invention.
It will be understood that the above described embodiments are for purposes of illustration only and that changes and modifications may be made thereto without departing from the spirit and scope of the invention.
-5-
Claims
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2741854A CA2741854A1 (en) | 2011-05-31 | 2011-05-31 | Crumple zone package for moisture sensitive products |
| US13/506,900 US20120325715A1 (en) | 2011-05-31 | 2012-05-23 | Crumple zone package for moisture sensitive products |
| CA2777965A CA2777965A1 (en) | 2011-05-31 | 2012-05-24 | Crumple zone package for moisture sensitive products |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2741854A CA2741854A1 (en) | 2011-05-31 | 2011-05-31 | Crumple zone package for moisture sensitive products |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2741854A1 true CA2741854A1 (en) | 2012-11-30 |
Family
ID=47262842
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2741854A Abandoned CA2741854A1 (en) | 2011-05-31 | 2011-05-31 | Crumple zone package for moisture sensitive products |
| CA2777965A Abandoned CA2777965A1 (en) | 2011-05-31 | 2012-05-24 | Crumple zone package for moisture sensitive products |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2777965A Abandoned CA2777965A1 (en) | 2011-05-31 | 2012-05-24 | Crumple zone package for moisture sensitive products |
Country Status (2)
| Country | Link |
|---|---|
| US (1) | US20120325715A1 (en) |
| CA (2) | CA2741854A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6904738B2 (en) * | 2017-03-14 | 2021-07-21 | 能美防災株式会社 | Embossed tape |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3780856A (en) * | 1971-07-26 | 1973-12-25 | Medi Dose Inc | Medicinal dispensing device |
| US4211326A (en) * | 1978-10-10 | 1980-07-08 | American Can Company | Blister package |
| US4989733A (en) * | 1990-05-21 | 1991-02-05 | Marc Patry | Ready-to-use medical trays |
| EP0662918A1 (en) * | 1992-09-30 | 1995-07-19 | R.P. Scherer Corporation | Stepped-edge blister pack and use of steps |
| US5775505A (en) * | 1996-02-27 | 1998-07-07 | Vasquez; William M. | Blister card package |
| GB9713876D0 (en) * | 1997-06-30 | 1997-09-03 | Glaxo Group Ltd | Device for holding blister pack |
| US6409019B1 (en) * | 1999-12-17 | 2002-06-25 | Trendmasters, Inc. | Three dimensional packaging |
| KR20030062328A (en) * | 2000-11-10 | 2003-07-23 | 뒤부아 리미티드 | Security device for information storage media |
| US20020153266A1 (en) * | 2001-04-13 | 2002-10-24 | Edwin Havens | Case for a disc |
-
2011
- 2011-05-31 CA CA2741854A patent/CA2741854A1/en not_active Abandoned
-
2012
- 2012-05-23 US US13/506,900 patent/US20120325715A1/en not_active Abandoned
- 2012-05-24 CA CA2777965A patent/CA2777965A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2777965A1 (en) | 2012-11-30 |
| US20120325715A1 (en) | 2012-12-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20131224 |