CA2738025A1

CA2738025A1 - Inhibiteurs de proteases

Inhibiteurs de proteases Download PDF

Info

Publication number: CA2738025A1
Authority: CA; Canada
Prior art keywords: methyl; fluoro; alkyl; compound according; mmol
Prior art date: 2008-09-24
Legal status : Abandoned

Application number

CA2738025A

Other languages

English (en)

Inventor

Vladimir Ivanov

Bertil Samuelsson

Per-Ola Johansson

Pia Kahnberg

Horst Wahling

Current Assignee

Medivir AB

Original Assignee

Medivir AB

Priority date

2008-09-24

Filing date

2009-09-24

Publication date

2010-04-01

2009-09-24 Application filed by Medivir AB filed Critical Medivir AB

2010-04-01 Publication of CA2738025A1 publication Critical patent/CA2738025A1/fr

Status Abandoned legal-status Critical Current

Links

229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title description 2
239000000137 peptide hydrolase inhibitor Substances 0.000 title description 2
150000001875 compounds Chemical class 0.000 claims abstract description 100
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 30
125000001153 fluoro group Chemical group F* 0.000 claims abstract description 26
108090000625 Cathepsin K Proteins 0.000 claims abstract description 21
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims abstract description 18
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 17
150000003839 salts Chemical class 0.000 claims abstract description 15
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206010039073 rheumatoid arthritis Diseases 0.000 claims abstract description 6
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125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract description 6
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QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims abstract description 4
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