CA2737449C - Ion guide array - Google Patents

Ion guide array Download PDF

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Publication number
CA2737449C
CA2737449C CA2737449A CA2737449A CA2737449C CA 2737449 C CA2737449 C CA 2737449C CA 2737449 A CA2737449 A CA 2737449A CA 2737449 A CA2737449 A CA 2737449A CA 2737449 C CA2737449 C CA 2737449C
Authority
CA
Canada
Prior art keywords
ion guide
ions
ion
guide section
section
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2737449A
Other languages
English (en)
French (fr)
Other versions
CA2737449A1 (en
Inventor
John Brian Hoyes
David Langridge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Micromass UK Ltd
Original Assignee
Micromass UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micromass UK Ltd filed Critical Micromass UK Ltd
Publication of CA2737449A1 publication Critical patent/CA2737449A1/en
Application granted granted Critical
Publication of CA2737449C publication Critical patent/CA2737449C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/062—Ion guides
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/062—Ion guides
    • H01J49/065—Ion guides having stacked electrodes, e.g. ring stack, plate stack
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry
    • G01N27/623—Ion mobility spectrometry combined with mass spectrometry
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/062—Ion guides
    • H01J49/063—Multipole ion guides, e.g. quadrupoles, hexapoles
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/40—Time-of-flight spectrometers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/40—Time-of-flight spectrometers
    • H01J49/408—Time-of-flight spectrometers with multiple changes of direction, e.g. by using electric or magnetic sectors, closed-loop time-of-flight

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
CA2737449A 2008-09-18 2009-09-17 Ion guide array Active CA2737449C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0817115.9 2008-09-18
GBGB0817115.9A GB0817115D0 (en) 2008-09-18 2008-09-18 Mass spectrometer
US10002508P 2008-09-25 2008-09-25
US61/100,025 2008-09-25
PCT/GB2009/002232 WO2010032015A1 (en) 2008-09-18 2009-09-17 Ion guide array

Publications (2)

Publication Number Publication Date
CA2737449A1 CA2737449A1 (en) 2010-03-25
CA2737449C true CA2737449C (en) 2017-06-06

Family

ID=39951817

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2737449A Active CA2737449C (en) 2008-09-18 2009-09-17 Ion guide array

Country Status (7)

Country Link
US (3) US8384027B2 (enExample)
EP (3) EP2450940B1 (enExample)
JP (1) JP5249421B2 (enExample)
AT (1) ATE548749T1 (enExample)
CA (1) CA2737449C (enExample)
GB (2) GB0817115D0 (enExample)
WO (1) WO2010032015A1 (enExample)

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GB0718468D0 (en) * 2007-09-21 2007-10-31 Micromass Ltd Mass spectrometer
GB0817115D0 (en) * 2008-09-18 2008-10-29 Micromass Ltd Mass spectrometer
JP5815533B2 (ja) * 2010-08-31 2015-11-17 アトナープ株式会社 イオン移動度センサーに供給するサンプルを調製する装置
GB201104220D0 (en) * 2011-03-14 2011-04-27 Micromass Ltd Ion guide with orthogonal sampling
GB201104665D0 (en) 2011-03-18 2011-05-04 Shimadzu Res Lab Europe Ltd Ion analysis apparatus and methods
GB201111560D0 (en) * 2011-07-06 2011-08-24 Micromass Ltd Photo-dissociation of proteins and peptides in a mass spectrometer
GB201111569D0 (en) * 2011-07-06 2011-08-24 Micromass Ltd Apparatus and method of mass spectrometry
GB201122267D0 (en) * 2011-12-23 2012-02-01 Micromass Ltd Multi-pass ion mobility separation device with moving exit aperture
GB201122251D0 (en) * 2011-12-23 2012-02-01 Micromass Ltd Multi-pass ion mobility separation device
WO2013098613A1 (en) * 2011-12-30 2013-07-04 Dh Technologies Development Pte. Ltd. Creating an ion-ion reaction region within a low-pressure linear ion trap
CN103515183B (zh) * 2012-06-20 2017-06-23 株式会社岛津制作所 离子导引装置和离子导引方法
US20140117248A1 (en) * 2012-10-23 2014-05-01 Kaveh Kahen Ion flow guide devices and methods
US8809769B2 (en) * 2012-11-29 2014-08-19 Bruker Daltonics, Inc. Apparatus and method for cross-flow ion mobility spectrometry
US8835839B1 (en) 2013-04-08 2014-09-16 Battelle Memorial Institute Ion manipulation device
GB2528152B (en) * 2014-04-11 2016-09-21 Micromass Ltd Ion entry/exit device
WO2016108142A1 (en) * 2014-12-30 2016-07-07 Dh Technologies Development Pte. Ltd. Electron induced dissociation devices and methods
US9704701B2 (en) 2015-09-11 2017-07-11 Battelle Memorial Institute Method and device for ion mobility separations
GB201517068D0 (en) * 2015-09-28 2015-11-11 Micromass Ltd Ion guide
EP3812755A1 (en) 2015-10-07 2021-04-28 Battelle Memorial Institute Method and apparatus for ion mobility separations utilizing alternating current waveforms
GB2562690B (en) * 2016-09-27 2022-11-02 Micromass Ltd Post-separation mobility analyser
CN109003876B (zh) * 2017-06-06 2020-10-16 岛津分析技术研发（上海）有限公司 离子迁移率分析器及分析方法
US10497552B2 (en) 2017-08-16 2019-12-03 Battelle Memorial Institute Methods and systems for ion manipulation
US10692710B2 (en) 2017-08-16 2020-06-23 Battelle Memorial Institute Frequency modulated radio frequency electric field for ion manipulation
US10804089B2 (en) 2017-10-04 2020-10-13 Batelle Memorial Institute Methods and systems for integrating ion manipulation devices
GB2575770B (en) * 2018-05-17 2022-06-22 Thermo Fisher Scient Bremen Gmbh Ion guide
GB2575342B (en) 2018-05-17 2022-08-10 Thermo Fisher Scient Bremen Gmbh Ion guide
GB201808892D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Mass spectrometer
GB201808932D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Bench-top time of flight mass spectrometer
WO2019229469A1 (en) 2018-05-31 2019-12-05 Micromass Uk Limited Mass spectrometer
GB201808936D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Bench-top time of flight mass spectrometer
GB201808949D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Bench-top time of flight mass spectrometer
GB201808893D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Bench-top time of flight mass spectrometer
GB201808894D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Mass spectrometer
US11373849B2 (en) 2018-05-31 2022-06-28 Micromass Uk Limited Mass spectrometer having fragmentation region
GB201808912D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Bench-top time of flight mass spectrometer
GB201808890D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Bench-top time of flight mass spectrometer
EP3972726A4 (en) 2019-05-21 2023-05-10 Mobilion Systems, Inc. VOLTAGE CONTROL FOR ION MOBILITY SEPARATION
US11543384B2 (en) 2019-11-22 2023-01-03 MOBILion Systems, Inc. Mobility based filtering of ions
US12163920B2 (en) 2020-04-06 2024-12-10 MOBILion Systems, Inc. Systems and methods for two-dimensional mobility based filtering of ions
US11953466B2 (en) 2020-05-22 2024-04-09 MOBILion Systems, Inc. Methods and apparatus for trapping and accumulation of ions
WO2021247820A1 (en) 2020-06-05 2021-12-09 MOBILion Systems, Inc. Apparatus and methods for ion manipulation having improved duty cycle
US12163919B2 (en) * 2021-03-22 2024-12-10 Bruker Scientific Llc Laterally-extended trapped ion mobility spectrometer
GB202105251D0 (en) * 2021-04-13 2021-05-26 Thermo Fisher Scient Bremen Gmbh Ion mobility spectrometry
CN115223844B (zh) * 2021-04-21 2025-10-14 株式会社岛津制作所 离子迁移率分析装置
EP4339996A1 (en) * 2022-09-15 2024-03-20 Analytik Jena GmbH+Co. KG System for analyzing a sample
CN120221382A (zh) * 2023-12-26 2025-06-27 株式会社岛津制作所 串联离子迁移谱仪及离子迁移率分析方法
CN120280330A (zh) * 2024-01-08 2025-07-08 株式会社岛津制作所 串联u型离子迁移谱仪及离子迁移率分析方法

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US5576540A (en) * 1995-08-11 1996-11-19 Mds Health Group Limited Mass spectrometer with radial ejection
WO1997043036A1 (en) * 1996-05-14 1997-11-20 Analytica Of Branford, Inc. Ion transfer from multipole ion guides into multipole ion guides and ion traps
US6417511B1 (en) * 2000-07-17 2002-07-09 Agilent Technologies, Inc. Ring pole ion guide apparatus, systems and method
CA2346526A1 (en) * 2000-11-29 2002-05-29 Micromass Limited Mass spectrometers and methods of mass spectrometry
US6791078B2 (en) 2002-06-27 2004-09-14 Micromass Uk Limited Mass spectrometer
US6838666B2 (en) * 2003-01-10 2005-01-04 Purdue Research Foundation Rectilinear ion trap and mass analyzer system and method
GB0427634D0 (en) 2004-12-17 2005-01-19 Micromass Ltd Mass spectrometer
US7323683B2 (en) * 2005-08-31 2008-01-29 The Rockefeller University Linear ion trap for mass spectrometry
GB0522933D0 (en) * 2005-11-10 2005-12-21 Micromass Ltd Mass spectrometer
GB0524972D0 (en) 2005-12-07 2006-01-18 Micromass Ltd Mass spectrometer
DE102006040000B4 (de) * 2006-08-25 2010-10-28 Bruker Daltonik Gmbh Speicherbatterie für Ionen
US7982183B2 (en) * 2006-11-07 2011-07-19 Thermo Fisher Scientific (Bremen) Gmbh Ion transfer tube with spatially alternating DC fields
US20090283674A1 (en) * 2006-11-07 2009-11-19 Reinhold Pesch Efficient Atmospheric Pressure Interface for Mass Spectrometers and Method
GB0703378D0 (en) * 2007-02-21 2007-03-28 Micromass Ltd Mass spectrometer
GB0703682D0 (en) 2007-02-26 2007-04-04 Micromass Ltd Mass spectrometer
GB2457556B (en) * 2007-02-26 2010-02-17 Micromass Ltd Helical ion guide
GB0718468D0 (en) * 2007-09-21 2007-10-31 Micromass Ltd Mass spectrometer
GB0723183D0 (en) * 2007-11-23 2008-01-09 Micromass Ltd Mass spectrometer
GB0820308D0 (en) * 2008-11-06 2008-12-17 Micromass Ltd Mass spectrometer
GB0817115D0 (en) * 2008-09-18 2008-10-29 Micromass Ltd Mass spectrometer

Also Published As

Publication number Publication date
GB2464592B (en) 2013-03-27
US8384027B2 (en) 2013-02-26
EP2450940B1 (en) 2014-06-04
GB0817115D0 (en) 2008-10-29
EP2450941B1 (en) 2014-06-04
CA2737449A1 (en) 2010-03-25
GB2464592A (en) 2010-04-28
GB0916355D0 (en) 2009-10-28
EP2450941A1 (en) 2012-05-09
US20140027627A1 (en) 2014-01-30
EP2329512B1 (en) 2012-03-07
EP2450940A1 (en) 2012-05-09
EP2329512A1 (en) 2011-06-08
ATE548749T1 (de) 2012-03-15
US20130140469A1 (en) 2013-06-06
JP2012503286A (ja) 2012-02-02
US20110266435A1 (en) 2011-11-03
JP5249421B2 (ja) 2013-07-31
US8546755B2 (en) 2013-10-01
WO2010032015A1 (en) 2010-03-25
US8829464B2 (en) 2014-09-09

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